Physical mapping of the rat MHC class II genes shows a high level of inter-species conservation.

Article


Carter, C., Murphy, G., Fabre, J. and Lund, T. 1994. Physical mapping of the rat MHC class II genes shows a high level of inter-species conservation. Genomics. 22 (2), pp. 451-455. https://doi.org/10.1006/geno.1994.1409
TypeArticle
TitlePhysical mapping of the rat MHC class II genes shows a high level of inter-species conservation.
AuthorsCarter, C., Murphy, G., Fabre, J. and Lund, T.
Abstract

We report here a pulsed-field gel electrophoresis map of the rat major histocompatibility complex (MHC) class II region. Using probes for the recently discovered Tap-1 and Tap-2 genes and the different MHC class II genes, we found the gene order in the rat MHC (RT1) region to be RT1.H-Tap-1-Tap-2-Bb-Ba-Db-Da. Moreover, the distance between the Tap-1 and the RT1.Da genes is approximately 150 kb. This, together with recent mapping of the RT1 class III region, demonstrates an extensive colinearity in the MHC region of different species.

PublisherAcademic Press
JournalGenomics
ISSN0888-7543
Publication dates
Print15 Jul 1994
Publication process dates
Deposited09 Nov 2010
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1006/geno.1994.1409
LanguageEnglish
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