Elevated cortical glutamate in young people at increased familial risk of depression

Article


Taylor, M., Mannie, Z., Norbury, R., Near, J. and Cowen, P. 2011. Elevated cortical glutamate in young people at increased familial risk of depression. International Journal of Neuropsychopharmacology. 14 (2), pp. 255-259. https://doi.org/10.1017/S1461145710001094
TypeArticle
TitleElevated cortical glutamate in young people at increased familial risk of depression
AuthorsTaylor, M., Mannie, Z., Norbury, R., Near, J. and Cowen, P.
Abstract

Using proton magnetic resonance spectroscopy (MRS), we have demonstrated regional abnormalities in cortical γ-aminobutyric acid (GABA) and glutamate in medication-free recovered depressed patients. It is unclear whether these changes represent an underlying trait vulnerability to depression, or an after-effect of episodes of illness or its treatment. We sought to examine this question by examining a group of high-risk, never-depressed, individuals. We used MRS to measure GABA and glutamate in parieto-occipital cortex in young people (ages 16–21 yr) with a family history of parental depression (n=24) but no personal history of illness and a control group without a history of depression in any first-degree relative (n=28). Participants with a parental history of depression had significantly higher levels of glutamate than controls in parieto-occipital cortex (F1,47=5.5, p=0.02). These findings suggest that abnormalities in glutamate neurotransmission may reflect a trait marker of vulnerability to depression.

Research GroupApplied Health Psychology group
PublisherOxford University Press (OUP)
JournalInternational Journal of Neuropsychopharmacology
ISSN1461-1457
Electronic1469-5111
Publication process dates
Deposited15 Oct 2013
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1017/S1461145710001094
LanguageEnglish
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