Structural brain correlates of interpersonal violence: systematic review and voxel-based meta-analysis of neuroimaging studies

Article


Lamsma, J., Mackay, C. and Fazel, S. 2017. Structural brain correlates of interpersonal violence: systematic review and voxel-based meta-analysis of neuroimaging studies. Psychiatry Research: Neuroimaging. 267, pp. 69-73. https://doi.org/10.1016/j.pscychresns.2017.07.006
TypeArticle
TitleStructural brain correlates of interpersonal violence: systematic review and voxel-based meta-analysis of neuroimaging studies
AuthorsLamsma, J., Mackay, C. and Fazel, S.
Abstract

Owing to inconsistent nomenclature and results, we have undertaken a label-based review and anatomical likelihood estimation (ALE) meta-analysis of studies measuring the quantitative association between regional grey matter (GM) volume and interpersonal violence. Following PRISMA guidelines, we identified studies by searching 3 online databases (Embase, Medline, PsycInfo) and reference lists. Thirty-five studies were included in the label-based review, providing information for 1288 participants and 86 brain regions. Per region, 0–57% of the results indicated significant reductions in GM volume, while 0–23% indicated significant increases. The only region for which more than half of all results indicated significant reductions was the parietal lobe. However, these results were dispersed across subregions. The ALE meta-analysis, which included 6 whole-brain voxel-based morphometry studies totaling 278 participants and reporting 144 foci, showed no significant clusters of reduced GM volume. No material differences were observed when excluding experiments using reactive violence as outcome or subjects diagnosed with psychopathy. Possible explanations for these findings are phenomenological and etiological heterogeneity, and insufficient power in the label-based review and ALE metaanalysis to detect small effects. We recommend that future studies distinguish between subtypes of interpersonal violence, and investigate mediation by underlying emotional and cognitive processes.

LanguageEnglish
PublisherElsevier
JournalPsychiatry Research: Neuroimaging
ISSN0925-4927
Publication dates
Online27 Jul 2017
Print30 Sep 2017
Publication process dates
Deposited18 Oct 2019
Accepted25 Jul 2017
Output statusPublished
Publisher's version
License
Supplemental file
File Access Level
Controlled
Digital Object Identifier (DOI)https://doi.org/10.1016/j.pscychresns.2017.07.006
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