Activated partial thromboplastin time and prothrombin time mixing studies: current state of the art

Article


Adcock, D., Moore, G., Montalvão, S., Kershaw, G. and Gosselin, R. 2022. Activated partial thromboplastin time and prothrombin time mixing studies: current state of the art. Seminars in Thrombosis and Hemostasis. https://doi.org/10.1055/s-0042-1756196
TypeArticle
TitleActivated partial thromboplastin time and prothrombin time mixing studies: current state of the art
AuthorsAdcock, D., Moore, G., Montalvão, S., Kershaw, G. and Gosselin, R.
Abstract

Mixing studies have long been in the clinical laboratory armamentarium for investigating unexpected, prolonged activated partial thromboplastin time (aPTT) or prothrombin time (PT). The purpose of the mixing study is to identify whether the aPTT/PT prolongation is secondary to a factor deficiency versus an inhibitor, which would present as a “corrected” and “noncorrected” mixing study, respectively. The differentiation between a factor deficiency and inhibitor may likely further direct clinical decisions, including additional diagnostic testing or factor replacement therapy. While aPTT/PT mixing studies are simple tests to perform, there is a lack of standardization for both the testing protocol and the interpretation of what is considered to be a corrected or noncorrected mixing study result. This review will describe the common indications for the mixing test, preanalytic variables that may affect mixing study performance, and describe several methods for interpreting the results of aPTT and PT mixing tests.

Keywordsactivated partial thromboplastin time - prothrombin time - mixing study - factor deficiency - factor inhibitor
PublisherGeorg Thieme Verlag KG
JournalSeminars in Thrombosis and Hemostasis
ISSN0094-6176
Electronic1098-9064
Publication dates
Online02 Sep 2022
Publication process dates
Deposited12 Sep 2022
Digital Object Identifier (DOI)https://doi.org/10.1055/s-0042-1756196
LanguageEnglish
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