Activated partial thromboplastin time and prothrombin time mixing studies: current state of the art
Article
Adcock, D., Moore, G., Montalvão, S., Kershaw, G. and Gosselin, R. 2022. Activated partial thromboplastin time and prothrombin time mixing studies: current state of the art. Seminars in Thrombosis and Hemostasis. https://doi.org/10.1055/s-0042-1756196
Type | Article |
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Title | Activated partial thromboplastin time and prothrombin time mixing studies: current state of the art |
Authors | Adcock, D., Moore, G., Montalvão, S., Kershaw, G. and Gosselin, R. |
Abstract | Mixing studies have long been in the clinical laboratory armamentarium for investigating unexpected, prolonged activated partial thromboplastin time (aPTT) or prothrombin time (PT). The purpose of the mixing study is to identify whether the aPTT/PT prolongation is secondary to a factor deficiency versus an inhibitor, which would present as a “corrected” and “noncorrected” mixing study, respectively. The differentiation between a factor deficiency and inhibitor may likely further direct clinical decisions, including additional diagnostic testing or factor replacement therapy. While aPTT/PT mixing studies are simple tests to perform, there is a lack of standardization for both the testing protocol and the interpretation of what is considered to be a corrected or noncorrected mixing study result. This review will describe the common indications for the mixing test, preanalytic variables that may affect mixing study performance, and describe several methods for interpreting the results of aPTT and PT mixing tests. |
Keywords | activated partial thromboplastin time - prothrombin time - mixing study - factor deficiency - factor inhibitor |
Publisher | Georg Thieme Verlag KG |
Journal | Seminars in Thrombosis and Hemostasis |
ISSN | 0094-6176 |
Electronic | 1098-9064 |
Publication dates | |
Online | 02 Sep 2022 |
Publication process dates | |
Deposited | 12 Sep 2022 |
Digital Object Identifier (DOI) | https://doi.org/10.1055/s-0042-1756196 |
Language | English |
https://repository.mdx.ac.uk/item/89z77
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