Dr. Enas Newire
| Name | Dr. Enas Newire |
|---|---|
| Job title | Lecturer in Medical Microbiology |
| Research institute | |
| Primary appointment | Natural Sciences |
| Email address | E.Newire@mdx.ac.uk |
| ORCID | https://orcid.org/0000-0002-4023-8107 |
| Contact category | Academic staff |
Biography
Biography Dr Enas Newire, BSc, MSc, PhD,
AFHEA, MRSB Enas Newire is a molecular microbiologist focused on antimicrobial resistance (AMR). Her research activities focus on AMR emergence and dissemination through Horizontal Gene Transfer (HGT) amongst bacteria; particularly, bacterial evolutionary studies, bacterial plasmid transfer and fitness studies, CRISPR-Cas systems identification, anti-plasmid activity and bioinformatic analysis of bacterial genome sequences. Enas evaluates new antimicrobials efficacy, resistance and spectrum of anti-plasmid activity. Enas is proud of having discovered a plasmid-borne CRISPR-Cas system (Type IV-A CRISPR-Cas) that target other resistance plasmids suggesting a role in inter-plasmid competition - publication: PMID 32903441. Enas also supervises research projects of postgraduate MSc degree students. Enas received her BSc in Biology from the American University in Cairo (AUC), MSc in Infectious Diseases from London School of Hygiene and Tropical Medicine (LSHTM) and PhD in Microbial Diseases from University College London (UCL) in 2018. After her PhD fellowship, Enas started her Post-Doctoral research at the University of Lincoln in 2019 before joining the University of Liverpool in 2020. Enas has previously occupied teaching and research academic positions at UCL, University of Liverpool, University of Essex, AUC and the United States Naval Medical Research Unit-3 (US. NAMRU-3). She handled several molecular and microbiological typing projects and collaborated with lower and middle-income countries (LMIC). - Principal research interests: Bacteriology/ Plasmids/ CRISPR-Cas/ Anti-plasmids novel approaches/ Bacterial genome bioinformatic analysis. - Keywords: AMR, CRISPR-Cas, Anti-plasmid
Teaching - Medical Microbiology. - PG AMR and Infection Control. - PG AMR Research Project Supervisor.
Education and qualifications
Grants
Prizes and Awards
Evidence to public body
External activities
Research outputs
Isolation of an antimicrobial-resistant, biofilm-forming, Klebsiella grimontii isolate from a reusable water bottle
Hubbard, A.T.M., Newire, E., Botelho, J., Reiné, J., Wright, E., Murphy, E.A., Hutton, W. and Roberts, A.P. 2020. Isolation of an antimicrobial-resistant, biofilm-forming, Klebsiella grimontii isolate from a reusable water bottle. MicrobiologyOpen. 9 (6), pp. 1128-1134. https://doi.org/10.1002/mbo3.1023Mobile colistin resistance gene mcr-1 detected on an IncI1 plasmid in Escherichia coli from meat
Brouwer, M.S.M., Goodman, R.N., Kant, A., Newire, E., Roberts, A.P. and Veldman, K.T. 2020. Mobile colistin resistance gene mcr-1 detected on an IncI1 plasmid in Escherichia coli from meat. Journal of Global Antimicrobial Resistance. 23, pp. 145-148. https://doi.org/10.1016/j.jgar.2020.08.018Identification of a Type IV-A CRISPR-Cas system located exclusively on IncHI1B/IncFIB plasmids in Enterobacteriaceae
Newire, E., Aydin, A., Juma, S., Enne, V. and Roberts, A. 2020. Identification of a Type IV-A CRISPR-Cas system located exclusively on IncHI1B/IncFIB plasmids in Enterobacteriaceae. Frontiers in Microbiology. 11. https://doi.org/10.3389/fmicb.2020.01937Presence of Type I-F CRISPR/Cas systems is associated with antimicrobial susceptibility in Escherichia coli
Aydin, S., Personne, Y., Newire, E., Laverrick, R., Russell, O., Roberts, A. and Enne, V. 2017. Presence of Type I-F CRISPR/Cas systems is associated with antimicrobial susceptibility in Escherichia coli . Journal of Antimicrobial Chemotherapy. 72 (8), p. 2213–2218. https://doi.org/10.1093/jac/dkx137Detection of new SHV-12, SHV-5 and SHV-2a variants of extended spectrum Beta-lactamase in Klebsiella pneumoniae in Egypt
Newire, E., Ahmed, S., House, B., Valiente, E. and Pimentel, G. 2013. Detection of new SHV-12, SHV-5 and SHV-2a variants of extended spectrum Beta-lactamase in Klebsiella pneumoniae in Egypt. Annals of Clinical Microbiology and Antimicrobials. 12. https://doi.org/10.1186/1476-0711-12-16Laboratory-based surveillance for acute febrile illness in Egypt: a focus on leptospirosis
Parker, T.M., Ismail, T., Fadeel, M.A., Maksoud, M.A., Morcos, M., Newire, E., Wasfy, M.O., Murray, C.K., Pimentel, G., El-Sayed, N. and Hajjeh, R. 2006. Laboratory-based surveillance for acute febrile illness in Egypt: a focus on leptospirosis. American Society of Tropical Medicine and Hygiene 55th Annual Meeting. Atlanta, Georgia, USA 12 - 16 Nov 2006 American Society of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.2006.75.1New teixobactin analogues with a total lactam ring
Scioli, G., Marinaccio, L., Bauer, M., Kamysz, W., Parmar, A., Newire, E., Singh, I., Stefanucci, A. and Mollica, A. 2023. New teixobactin analogues with a total lactam ring. ACS Medicinal Chemistry Letters. 14 (12), pp. 1603-1892. https://doi.org/10.1021/acsmedchemlett.3c00435Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms
Parmar, A., Lakshminarayanan, R., Iyer, A., Goh, E.T.L., To, T.Y., Yam, J.K.H., Yang, L., Newire, E., Robertson, M.C., Prior, S.H., Breukink, E., Madder, M. and Singh, I. 2023. Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms. European Journal of Medicinal Chemistry. 261. https://doi.org/10.1016/j.ejmech.2023.115853172
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