Dr. Enas Newire


Dr. Enas Newire
NameDr. Enas Newire
Job titleLecturer in Medical Microbiology
Research institute
Primary appointmentNatural Sciences
Email addressE.Newire@mdx.ac.uk
ORCIDhttps://orcid.org/0000-0002-4023-8107
Contact categoryAcademic staff

Biography

Biography

Dr Enas Newire, BSc, MSc, PhD, AFHEA, MRSB 

Enas Newire is a molecular microbiologist focused on antimicrobial resistance (AMR). Her research activities focus on AMR emergence and dissemination through Horizontal Gene Transfer (HGT) amongst bacteria; particularly, bacterial evolutionary studies, bacterial plasmid transfer and fitness studies, CRISPR-Cas systems identification, anti-plasmid activity and bioinformatic analysis of bacterial genome sequences. Enas evaluates new antimicrobials efficacy, resistance and spectrum of anti-plasmid activity. Enas is proud of having discovered a plasmid-borne CRISPR-Cas system (Type IV-A CRISPR-Cas) that target other resistance plasmids suggesting a role in inter-plasmid competition - publication: PMID 32903441. Enas also supervises research projects of postgraduate MSc degree students.

Enas received her BSc in Biology from the American University in Cairo (AUC), MSc in Infectious Diseases from London School of Hygiene and Tropical Medicine (LSHTM) and PhD in Microbial Diseases from University College London (UCL) in 2018. After her PhD fellowship, Enas started her Post-Doctoral research at the University of Lincoln in 2019 before joining the University of Liverpool in 2020.

Enas has previously occupied teaching and research academic positions at UCL, University of Liverpool, University of Essex, AUC and the United States Naval Medical Research Unit-3 (US. NAMRU-3). She handled several molecular and microbiological typing projects and collaborated with lower and middle-income countries (LMIC).

- Principal research interests: Bacteriology/ Plasmids/ CRISPR-Cas/ Anti-plasmids novel approaches/ Bacterial genome bioinformatic analysis.

- Keywords: AMR, CRISPR-Cas, Anti-plasmid

Teaching

- Medical Microbiology. 

- PG AMR and Infection Control.

- PG AMR Research Project Supervisor.  

Education and qualifications

PhD in Microbial Diseases
18 May 2018
University College London (UCL)
MSc in Infectious Diseases
11 Mar 2011
London School of Hygiene and Tropical Medicine (LSHTM)
BSc Biology (concentration: Molecular Biology)
05 Feb 2005
The American University in Cairo (AUC)
Teaching Associate Fellow of the Higher Education Academy (AFHEA)
14 Mar 2014
University College London (UCL)

Grants

World Antimicrobial Awareness Week - Champion
04 Oct 2024
Microbiology Society
ECR Pump Priming Award
18 Mar 2022
University of Liverpool
Early Career Research ECRR grant
20 Jul 2021
University of Liverpool
Research Grant
30 Sept 2019
Antibiotic Research UK (ANTRUK)

Prizes and Awards

PhD Fellowship

Schlumberger Foundation

Evidence to public body

Full Member
European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
01 Jul 2022
Early Career Member
Royal Society of Tropical Medicine and Hygiene
01 Jan 2021
Full Member
Microbiology Society
01 Jan 2013
Early career scientist
Society for Applied Microbiology
01 Jan 2013
Member
British Society for Antimicrobial Chemotherapy
01 Jan 2014
Postdoctoral Member
American Society for Microbiology
01 Jan 2010
Member
Royal Society of Biology (RSB)
01 Oct 2022

External activities

Impact and Influence Committee Member
External committee
Member
20 Jul 2024

Prokaryotic Division Member
External committee
01 Jul 2023

Knocking Out AMR Memeber
External committee
01 Jan 2024

Member of the Communication Committee
External committee
01 Jul 2024

Building Communities Committee
External committee
01 Jan 2021
01 Jan 2023

Committee on the Status of Women in Microbiology
External committee
01 Jan 2014
01 Jul 2023

Trustee and Director (member of the council)
External committee
British Society of Antimicrobial Chemotherapy (BSAC)
01 Jan 2018
18 Mar 2022

Research outputs

Isolation of an antimicrobial-resistant, biofilm-forming, Klebsiella grimontii isolate from a reusable water bottle

Hubbard, A.T.M., Newire, E., Botelho, J., Reiné, J., Wright, E., Murphy, E.A., Hutton, W. and Roberts, A.P. 2020. Isolation of an antimicrobial-resistant, biofilm-forming, Klebsiella grimontii isolate from a reusable water bottle. MicrobiologyOpen. 9 (6), pp. 1128-1134. https://doi.org/10.1002/mbo3.1023

Mobile colistin resistance gene mcr-1 detected on an IncI1 plasmid in Escherichia coli from meat

Brouwer, M.S.M., Goodman, R.N., Kant, A., Newire, E., Roberts, A.P. and Veldman, K.T. 2020. Mobile colistin resistance gene mcr-1 detected on an IncI1 plasmid in Escherichia coli from meat. Journal of Global Antimicrobial Resistance. 23, pp. 145-148. https://doi.org/10.1016/j.jgar.2020.08.018

Identification of a Type IV-A CRISPR-Cas system located exclusively on IncHI1B/IncFIB plasmids in Enterobacteriaceae

Newire, E., Aydin, A., Juma, S., Enne, V. and Roberts, A. 2020. Identification of a Type IV-A CRISPR-Cas system located exclusively on IncHI1B/IncFIB plasmids in Enterobacteriaceae. Frontiers in Microbiology. 11. https://doi.org/10.3389/fmicb.2020.01937

Presence of Type I-F CRISPR/Cas systems is associated with antimicrobial susceptibility in Escherichia coli

Aydin, S., Personne, Y., Newire, E., Laverrick, R., Russell, O., Roberts, A. and Enne, V. 2017. Presence of Type I-F CRISPR/Cas systems is associated with antimicrobial susceptibility in Escherichia coli . Journal of Antimicrobial Chemotherapy. 72 (8), p. 2213–2218. https://doi.org/10.1093/jac/dkx137

Detection of new SHV-12, SHV-5 and SHV-2a variants of extended spectrum Beta-lactamase in Klebsiella pneumoniae in Egypt

Newire, E., Ahmed, S., House, B., Valiente, E. and Pimentel, G. 2013. Detection of new SHV-12, SHV-5 and SHV-2a variants of extended spectrum Beta-lactamase in Klebsiella pneumoniae in Egypt. Annals of Clinical Microbiology and Antimicrobials. 12. https://doi.org/10.1186/1476-0711-12-16

Laboratory-based surveillance for acute febrile illness in Egypt: a focus on leptospirosis

Parker, T.M., Ismail, T., Fadeel, M.A., Maksoud, M.A., Morcos, M., Newire, E., Wasfy, M.O., Murray, C.K., Pimentel, G., El-Sayed, N. and Hajjeh, R. 2006. Laboratory-based surveillance for acute febrile illness in Egypt: a focus on leptospirosis. American Society of Tropical Medicine and Hygiene 55th Annual Meeting. Atlanta, Georgia, USA 12 - 16 Nov 2006 American Society of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.2006.75.1

New teixobactin analogues with a total lactam ring

Scioli, G., Marinaccio, L., Bauer, M., Kamysz, W., Parmar, A., Newire, E., Singh, I., Stefanucci, A. and Mollica, A. 2023. New teixobactin analogues with a total lactam ring. ACS Medicinal Chemistry Letters. 14 (12), pp. 1603-1892. https://doi.org/10.1021/acsmedchemlett.3c00435

Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms

Parmar, A., Lakshminarayanan, R., Iyer, A., Goh, E.T.L., To, T.Y., Yam, J.K.H., Yang, L., Newire, E., Robertson, M.C., Prior, S.H., Breukink, E., Madder, M. and Singh, I. 2023. Development of teixobactin analogues containing hydrophobic, non-proteogenic amino acids that are highly potent against multidrug-resistant bacteria and biofilms. European Journal of Medicinal Chemistry. 261. https://doi.org/10.1016/j.ejmech.2023.115853
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