Dr Tatiana Novoselova


NameDr Tatiana Novoselova
Job titleHourly Academic
Research institute
Primary appointmentNatural Sciences
Email addresstatiana6@mdx.ac.uk
Contact categoryAcademic staff (past)

Research outputs

Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization

Romano, L., Aw, W., Hixson, K., Novoselova, T., Havener, T., Howell, S., Taylor-Blake, B., Hall, C., Xing, L., Beri, J., Nethisinghe, S., Perna, L., Hatimy, A., Altadonna, G., Graves, L., Herring, L., Hickey, A., Thalassinos, K., Chapple, J. and Wolter, J. 2022. Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization. Cell Reports. 41 (5). https://doi.org/10.1016/j.celrep.2022.111580

ACTH signalling and adrenal development: lessons from mouse models

Novoselova, T., King, P., Guasti, L., Metherell, L., Clark, A. and Chan, L. 2019. ACTH signalling and adrenal development: lessons from mouse models. Endocrine Connections. 8 (7), pp. R122-R130. https://doi.org/10.1530/ec-19-0190

Isolated glucocorticoid deficiency: genetic causes and animal models

Maharaj, A., Maudhoo, A., Chan, L., Novoselova, T., Prasad, R., Metherell, L. and Guasti, L. 2019. Isolated glucocorticoid deficiency: genetic causes and animal models. Journal of Steroid Biochemistry and Molecular Biology. 189, pp. 73-80. https://doi.org/10.1016/j.jsbmb.2019.02.012

Oncometabolite induced primary cilia loss in pheochromocytoma

O'Toole, S., Watson, D., Novoselova, T., Romano, L., King, P., Bradshaw, T., Thompson, C., Knight, M., Sharp, T., Barnes, M., Srirangalingam, U., Drake, W. and Chapple, J. 2019. Oncometabolite induced primary cilia loss in pheochromocytoma. Endocrine-Related Cancer. 26 (1), pp. 165-180. https://doi.org/10.1530/ERC-18-0134

MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation

Novoselova, T., Hussain, M., King, P., Guasti, L., Metherell, L., Charalambous, M., Clark, A. and Chan, L. 2018. MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. The FASEB Journal. 32 (11), pp. 6186-9196. https://doi.org/10.1096/fj.201701274RR

Pathophysiology of melanocortin receptors and their accessory proteins

Novoselova, T., Chan, L. and Clark, A. 2018. Pathophysiology of melanocortin receptors and their accessory proteins. Best Practice & Research: Clinical Endocrinology & Metabolism. 32 (2), pp. 93-106. https://doi.org/10.1016/j.beem.2018.02.002

Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity

Samuelsson, A., Mullier, A., Maicas, N., Oosterhuis, N., Eun Bae, S., Novoselova, T., Chan, L., Pombo, J., Taylor, P., Joles, J., Coen, C., Balthasar, N. and Poston, L. 2016. Central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity. Proceedings of the National Academy of Sciences. 113 (43), pp. 12298-12303. https://doi.org/10.1073/pnas.1607464113

Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol

Novoselova, T., Larder, R., Rimmington, D., Lelliot, C., Wynn, E., Gorrigan, R., Tate, P., Guasti, L., The Sanger Mouse Genetics Project, O'Rahilly, S., Clark, A., Logan, D., Coll, A. and Chan, L. 2016. Loss of Mrap2 is associated with Sim1 deficiency and increased circulating cholesterol. Journal of Endocrinology. 230 (1), pp. 13-26. https://doi.org/10.1530/JOE-16-0057

Whole-exome sequencing in the differential diagnosis of primary adrenal insufficiency in children

Chan, L., Campbell, D., Novoselova, T., Clark, A. and Metherell, L. 2015. Whole-exome sequencing in the differential diagnosis of primary adrenal insufficiency in children. Frontiers in Endocrinology. 6 (113). https://doi.org/10.3389/fendo.2015.00113

NNT pseudoexon activation as a novel mechanism for disease in two siblings with familial glucocorticoid deficiency

Novoselova, T., Rath, S., Carpenter, K., Pachter, N., Dickinson, J., Price, G., Chan, L., Choong, C. and Metherell, L. 2015. NNT pseudoexon activation as a novel mechanism for disease in two siblings with familial glucocorticoid deficiency. The Journal of Clinical Endocrinology and Metabolism. 100 (2), pp. E350-E354. https://doi.org/10.1210/jc.2014-3641

Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity

Asai, M., Ramachandrappa, S., Joachim, M., Shen, Y., Zhang, R., Nuthalapati, N., Ramanathan, V., Strochlic, D., Ferket, P., Linhart, K., Ho, C., Novoselova, T., Garg, S., Ridderstråle, M., Marcus, C., Hirschhorn, J., Keogh, J., O’Rahilly, S., Chan, L., Clark, A., Farooqi, S. and Majzoub, J. 2013. Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science. 341 (6143), pp. 275-278. https://doi.org/10.1126/science.1233000

Melanocortin receptor accessory proteins in adrenal gland physiology and beyond

Novoselova, T., Jackson, D., Campbell, D., Clark, A. and Chan, L. 2013. Melanocortin receptor accessory proteins in adrenal gland physiology and beyond. Journal of Endocrinology. 217 (1), pp. R1-R11. https://doi.org/10.1530/JOE-12-0501

SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p

Novoselova, T., Rose, R., Marks, H. and Sullivan, J. 2013. SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p. Journal of Biological Chemistry. 288 (15), pp. 10308-10317. https://doi.org/10.1074/jbc.m112.424234

Bul proteins, a nonredundant, antagonistic family of ubiquitin ligase regulatory proteins

Novoselova, T., Zahira, K., Rose, R. and Sullivan, J. 2012. Bul proteins, a nonredundant, antagonistic family of ubiquitin ligase regulatory proteins. Eukaryotic Cell. 11 (4), pp. 463-470. https://doi.org/10.1128/EC.00009-12

The X-linked retinitis pigmentosa protein RP2 facilitates G protein traffic

Schwarz, N., Novoselova, T., Wait, R., Hardcastle, A. and Cheetham, M. 2012. The X-linked retinitis pigmentosa protein RP2 facilitates G protein traffic. Human Molecular Genetics. 21 (4), pp. 863-873. https://doi.org/10.1093/hmg/ddr520

Treatment with extracellular HSP70/HSC70 protein can reduce polyglutamine toxicity and aggregation

Novoselova, T., Margulis, B., Novoselov, S., Sapozhnikov, A., Van Der Spuy, J., Cheetham, M. and Guzhova, I. 2005. Treatment with extracellular HSP70/HSC70 protein can reduce polyglutamine toxicity and aggregation. Journal of Neurochemistry. 94 (3), pp. 597-606. https://doi.org/10.1111/j.1471-4159.2005.03119.x

The balance between Hsp70 and its cochaperones Hdj1 and Bag1 determines its substrate-binding activity

Novoselov, S., Novoselova, T., Verbova, M., Margulis, B. and Guzhova, I. 2005. The balance between Hsp70 and its cochaperones Hdj1 and Bag1 determines its substrate-binding activity. Tsitologiia. 47 (3), pp. 220-229.

Dynamics of chaperone complex Hdj1-Hsp70-Bag1 as a response of erythroleukemia K562 cells to heat stress

Novoselov, S., Novoselova, T., Moskaleva, O., Margulis, B. and Guzhova, I. 2004. Dynamics of chaperone complex Hdj1-Hsp70-Bag1 as a response of erythroleukemia K562 cells to heat stress. Tsitologiia. 46 (7), pp. 620-627.
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