Menstrual irregularities, hormonal imbalances and obesity in teenage and adolescent girls in Hyderabad, Sindh, Pakistan

Article


Khaskheli, M., Durrani, R., Baloch, S., Baloch, A. and Shah, S. 2023. Menstrual irregularities, hormonal imbalances and obesity in teenage and adolescent girls in Hyderabad, Sindh, Pakistan. Journal of Health Research. 37 (1), pp. 26-32.. https://doi.org/10.56808/2586-940X.1013
TypeArticle
TitleMenstrual irregularities, hormonal imbalances and obesity in teenage and adolescent girls in Hyderabad, Sindh, Pakistan
AuthorsKhaskheli, M., Durrani, R., Baloch, S., Baloch, A. and Shah, S.
Abstract

Background: Obesity in young girls adversely affects reproductive health later in life and it is a serious public health issue. The objective was to study the association of obesity with menstrual irregularities and hormonal imbalance in teenage and adolescent girls.

Method: Participants comprised a convenience sample of 12-19 years old girls (N=83). The study was conducted in outpatient clinics at a university hospital. Data were collected through medical history by interview, physical examination and blood tests. Data were analysed using frequencies, descriptive statistics, Chi Squared tests of Independence and Binary Logistic Regression.

Results: The median age was 16 years (mean 15.9, SD 2.2) and the median BMI was 31.14 (mean 32.04, SD 4.51). Most of the girls were obese (95.2%) and some had a family history of obesity (33.7%), diabetes (28.9%) and cardiovascular disease (20.5 %). Clinical presentations included secondary amenorrhea (34.9%), heavy and irregular periods (22.9%) and oligomenorrhea (16.9%). Girls with a polycystic ovary (54.2%, n=45) had a reversed follicle stimulating hormone (FSH) / luteinizing hormone (LH) ratio (OR 11.33, 95% CI 2.98, 43.04, p < 0.001), an upper limit or raised fasting insulin (OR 7.20, 95% CI 2.33, 22.22, p < 0.001), a raised testosterone (OR=5.16, 95% CI 1.56, 17.11, p = 0.007 and a disturbed lipid profile (OR 5.67, 95% CI 1.72, 18.73, p = 0.004). Obesity was not statistically significantly associated with either polycystic ovary syndrome (PCOS) or any of the measured hormone levels.

Conclusion: Adolescent girls presenting with obesity, menstrual irregularities and hormonal imbalance may suggest manifestation of PCOS, which needs early investigation and proper management.

KeywordsAdolescent gynaecology; Child obesity; Endocrine disorders; Polycystic ovary syndrome; Reproductive health; Teenage obesity
Sustainable Development Goals3 Good health and well-being
Middlesex University ThemeHealth & Wellbeing
PublisherChulalongkorn University
JournalJournal of Health Research
ISSN0857-4421
Electronic2586-940X
Publication dates
Online31 Aug 2022
Publication process dates
Submitted24 Mar 2021
Accepted03 Sep 2021
Deposited25 Mar 2024
Output statusPublished
Publisher's version
License
File Access Level
Open
Copyright Statement

© 2023 The Authors. Published by College of Public Health Sciences, Chulalongkorn University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Digital Object Identifier (DOI)https://doi.org/10.56808/2586-940X.1013
Permalink -

https://repository.mdx.ac.uk/item/112299

Download files


Publisher's version
  • 7
    total views
  • 1
    total downloads
  • 7
    views this month
  • 0
    downloads this month

Export as

Related outputs

Recruitment, retention, and training of citizen scientists in translational medicine research: a citizen science initiative on non-alcoholic fatty liver disease
Shah, S., Barrado-Martín, Y., Marjot, T., Tomlinson, J. and Kiparoglou, V. 2024. Recruitment, retention, and training of citizen scientists in translational medicine research: a citizen science initiative on non-alcoholic fatty liver disease. Cureus: Journal of Medical Science. 16 (3). https://doi.org/10.7759/cureus.56038
Adopting a citizen science approach in translational experimental medicine research in non-alcoholic fatty liver disease: a study protocol
Shah, S., Barrado-Martín, Y., Marjot, T., Tomlinson, J. and Kiparoglou, V. 2023. Adopting a citizen science approach in translational experimental medicine research in non-alcoholic fatty liver disease: a study protocol. Citizen Science: Theory and Practice. 8 (1). https://doi.org/10.5334/cstp.555
Stages of gynaecological cancers at the time of first presentation at a large cancer hospital in Pakistan: An observational study
Khaskheli, M., Baloch, S., Khaskheli, S., Durrani, R., Jhatial, N. and Shah, S. 2023. Stages of gynaecological cancers at the time of first presentation at a large cancer hospital in Pakistan: An observational study. Dubai Medical Journal. 6 (4), pp. 274-279. https://doi.org/10.1159/000534211
What incentives encourage local communities to collect and upload mosquito sound data by using smartphones? A mixed methods study in Tanzania
Dam, R., Mponzi, W., Msaky, D., Mwandyala, T., Kaindoa, E., Sinka, M., Kiskin, I., Herreros-Moya, E., Messina, J., Shah, S., Roberts, S. and Willis, K. 2023. What incentives encourage local communities to collect and upload mosquito sound data by using smartphones? A mixed methods study in Tanzania. Global Health Research and Policy. 8 (1). https://doi.org/10.1186/s41256-023-00298-y
Translational researchers' training and development needs, preferences, and barriers: a survey in a National Institute for Health Research Biomedical Research Centre in the United Kingdom
Bell, K., Shah, S., Henderson, L. and Kiparoglou, V. 2022. Translational researchers' training and development needs, preferences, and barriers: a survey in a National Institute for Health Research Biomedical Research Centre in the United Kingdom. Clinical and Translational Science. 15 (7), pp. 1737-1752. https://doi.org/10.1111/cts.13289
Perceptions of gender equity and markers of achievement in a National Institute for Health Research Biomedical Research Centre: a qualitative study
Henderson, L., Dam, R., Shah, S., Ovseiko, P. and Kiparoglou, V. 2022. Perceptions of gender equity and markers of achievement in a National Institute for Health Research Biomedical Research Centre: a qualitative study. Health Research Policy and Systems. 20 (1). https://doi.org/10.1186/s12961-022-00904-4
Evaluation of the effectiveness of digital technology interventions to reduce loneliness in older adults: systematic review and meta-analysis
Shah, S., Nogueras, D., van Woerden, H. and Kiparoglou, V. 2021. Evaluation of the effectiveness of digital technology interventions to reduce loneliness in older adults: systematic review and meta-analysis. Journal of Medical Internet Research. 23 (5). https://doi.org/10.2196/24712
Gender parity in scientific authorship in a National Institute for Health Research Biomedical Research Centre: a bibliometric analysis
Shah, S., Dam, R., Milano, M., Edmunds, L., Henderson, L., Hartley, C., Coxall, O., Ovseiko, P., Buchan, A. and Kiparoglou, V. 2021. Gender parity in scientific authorship in a National Institute for Health Research Biomedical Research Centre: a bibliometric analysis. BMJ Open. 11. https://doi.org/10.1136/bmjopen-2020-037935
A large National Institute for Health Research (NIHR) Biomedical Research Centre facilitates impactful cross-disciplinary and collaborative translational research publications and research collaboration networks: a bibliometric evaluation study
Kiparoglou, V., Brown, L., McShane, H., Channon, K. and Shah, S. 2021. A large National Institute for Health Research (NIHR) Biomedical Research Centre facilitates impactful cross-disciplinary and collaborative translational research publications and research collaboration networks: a bibliometric evaluation study. Journal of Translational Medicine. 19 (1). https://doi.org/10.1186/s12967-021-03149-x
Vaginal discharge during pregnancy and associated adverse maternal and perinatal outcomes
Khaskheli, M., Baloch, S., Baloch, A. and Shah, S. 2021. Vaginal discharge during pregnancy and associated adverse maternal and perinatal outcomes. Pakistan Journal of Medical Sciences. 37 (5), pp. 1302-1308. https://doi.org/10.12669/pjms.37.5.4187