Ageing perspective on cognitive outcomes from ancillary reproductive hormone adjustments

Article


Zhang, G., Devo, P., O'Leary, V.B. and Ovsepian, S.V. 2023. Ageing perspective on cognitive outcomes from ancillary reproductive hormone adjustments. Heliyon. 9 (8). https://doi.org/10.1016/j.heliyon.2023.e19050
TypeArticle
TitleAgeing perspective on cognitive outcomes from ancillary reproductive hormone adjustments
AuthorsZhang, G., Devo, P., O'Leary, V.B. and Ovsepian, S.V.
Abstract

In addition to primary reproductive functions, gonadal hormones play an important role in regulating neural mechanisms across the human lifespan. The ageing-related decline in their activity has been linked to cognitive impairments in otherwise healthy women, contributing to higher incidents of post-menopause dementia. Given the growing utility of gonadal steroids for birth control, as well as for compensatory treatment of menopause and oophorectomy symptoms, and adjuvant transgender therapy, their long-term effects on neural mechanisms warrant comprehensive assessment. In this article, we present an ageing perspective on the cognitive outcomes of contraceptive and ancillary medical use of gonadal hormones and discuss their effects on the risk of cognitive impairments and late-life dementia. Despite rising data supporting the ameliorative effects of reproductive hormones on cognitive facilities, their impact varies depending on study design and type of intervention, implying dynamic neuro-endocrine interactions with complex compensatory mechanisms. Elucidating differential effects of reproductive hormone adjustments on cognition is expected not only to shed light on important aspects of brain ageing and dementia but to facilitate their use in personalized medicine with better safety and therapeutic outcomes.

KeywordsNeuroprotection; Oestrogen; Hormone replacement therapy; Healthy ageing; Contraception; Gender transition; Transgender; Cognitive decline
Sustainable Development Goals3 Good health and well-being
Middlesex University ThemeHealth & Wellbeing
PublisherElsevier
JournalHeliyon
ISSN
Electronic2405-8440
Publication dates
Online16 Aug 2023
PrintAug 2023
Publication process dates
Submitted04 Jun 2023
Accepted08 Aug 2023
Deposited27 Sep 2024
Output statusPublished
Publisher's version
License
File Access Level
Open
Copyright Statement

Copyright: Crown Copyright © 2023 Published by Elsevier Ltd.
User License: Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)

Web address (URL)https://www.sciencedirect.com/science/article/pii/S2405844023062588
Digital Object Identifier (DOI)https://doi.org/10.1016/j.heliyon.2023.e19050
LanguageEnglish
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