Ageing perspective on cognitive outcomes from ancillary reproductive hormone adjustments
Article
Zhang, G., Devo, P., O'Leary, V.B. and Ovsepian, S.V. 2023. Ageing perspective on cognitive outcomes from ancillary reproductive hormone adjustments. Heliyon. 9 (8). https://doi.org/10.1016/j.heliyon.2023.e19050
Type | Article |
---|---|
Title | Ageing perspective on cognitive outcomes from ancillary reproductive hormone adjustments |
Authors | Zhang, G., Devo, P., O'Leary, V.B. and Ovsepian, S.V. |
Abstract | In addition to primary reproductive functions, gonadal hormones play an important role in regulating neural mechanisms across the human lifespan. The ageing-related decline in their activity has been linked to cognitive impairments in otherwise healthy women, contributing to higher incidents of post-menopause dementia. Given the growing utility of gonadal steroids for birth control, as well as for compensatory treatment of menopause and oophorectomy symptoms, and adjuvant transgender therapy, their long-term effects on neural mechanisms warrant comprehensive assessment. In this article, we present an ageing perspective on the cognitive outcomes of contraceptive and ancillary medical use of gonadal hormones and discuss their effects on the risk of cognitive impairments and late-life dementia. Despite rising data supporting the ameliorative effects of reproductive hormones on cognitive facilities, their impact varies depending on study design and type of intervention, implying dynamic neuro-endocrine interactions with complex compensatory mechanisms. Elucidating differential effects of reproductive hormone adjustments on cognition is expected not only to shed light on important aspects of brain ageing and dementia but to facilitate their use in personalized medicine with better safety and therapeutic outcomes. |
Keywords | Neuroprotection; Oestrogen; Hormone replacement therapy; Healthy ageing; Contraception; Gender transition; Transgender; Cognitive decline |
Sustainable Development Goals | 3 Good health and well-being |
Middlesex University Theme | Health & Wellbeing |
Publisher | Elsevier |
Journal | Heliyon |
ISSN | |
Electronic | 2405-8440 |
Publication dates | |
Online | 16 Aug 2023 |
Aug 2023 | |
Publication process dates | |
Submitted | 04 Jun 2023 |
Accepted | 08 Aug 2023 |
Deposited | 27 Sep 2024 |
Output status | Published |
Publisher's version | License File Access Level Open |
Copyright Statement | Copyright: Crown Copyright © 2023 Published by Elsevier Ltd. |
Web address (URL) | https://www.sciencedirect.com/science/article/pii/S2405844023062588 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.heliyon.2023.e19050 |
Language | English |
https://repository.mdx.ac.uk/item/1q1xw4
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