eHydrogenation: hydrogen-free electrochemical hydrogenation

Article

Russo, C., Leech, M.C., Walsh, J.M., Higham, J.I., Giannessi, L., Lambert, E., Kiaku, C., Poole, D.L., Mason, J., Goodall, C.A.I., Devo, P., Giustiniano, M., Radi, M. and Lam, K. 2023. eHydrogenation: hydrogen-free electrochemical hydrogenation. Angewandte Chemie International Edition. 62 (38). https://doi.org/10.1002/anie.202309563
TypeArticle
TitleeHydrogenation: hydrogen-free electrochemical hydrogenation
AuthorsRusso, C., Leech, M.C., Walsh, J.M., Higham, J.I., Giannessi, L., Lambert, E., Kiaku, C., Poole, D.L., Mason, J., Goodall, C.A.I., Devo, P., Giustiniano, M., Radi, M. and Lam, K.
Abstract

Hydrogenation reactions are staple transformations commonly used across scientific fields to synthesise pharmaceuticals, natural products, and various functional materials. However, the vast majority of these reactions require the use of a toxic and costly catalyst leading to unpractical, hazardous and often functionally limited conditions. Herein, we report a new, general, practical, efficient, mild and high‐yielding hydrogen‐free electrochemical method for the reduction of alkene, alkyne, nitro and azido groups. Finally, this method has been applied to deuterium labelling.

KeywordsAnodic Oxidation; Deuteration; Diimide Reduction; Electrochemistry; Hydrogenation
Sustainable Development Goals12 Responsible consumption and production
Middlesex University ThemeSustainability
PublisherWiley
Gesellschaft Deutscher Chemiker
JournalAngewandte Chemie International Edition
ISSN1433-7851
Electronic1521-3773
Publication dates
Online14 Aug 2023
Print18 Sep 2023
Publication process dates
Submitted05 Jul 2023
Accepted04 Aug 2023
Deposited13 Jan 2025
Output statusPublished
Publisher's version
License
File Access Level
Open
Copyright Statement

© 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Digital Object Identifier (DOI)https://doi.org/10.1002/anie.202309563
Web of Science identifierWOS:001049313300001
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