Emerging applications in mass spectrometry imaging; enablers and roadblocks

Article

Russo, C., Heaton, C., Flint, L., Voloaca, O., Haywood-Small, S., Clench, M., Francese, S. and Cole, L. 2020. Emerging applications in mass spectrometry imaging; enablers and roadblocks. Journal of Spectral Imaging. 9, pp. 1-21. https://doi.org/10.1255/jsi.2020.a13
TypeArticle
TitleEmerging applications in mass spectrometry imaging; enablers and roadblocks
AuthorsRusso, C., Heaton, C., Flint, L., Voloaca, O., Haywood-Small, S., Clench, M., Francese, S. and Cole, L.
Abstract

Mass spectrometry imaging (MSI) is a powerful and versatile technique able to investigate the spatial distribution of multiple non-labelled endogenous and exogenous analytes simultaneously, within a wide range of samples. Over the last two decades, MSI has found widespread application for an extensive range of disciplines including pre-clinical drug discovery, clinical applications and human identification for forensic purposes. Technical advances in both instrumentation and software capabilities have led to a continual increase in the interest in MSI; however, there are still some limitations. In this review, we discuss the emerging applications in MSI that significantly impact three key areas of mass spectrometry (MS) research—clinical, pre-clinical and forensics—and roadblocks to the expansion of use of MSI in these areas.

Keywordsmass spectrometry imaging (MALDI); secondary ionisation mass spectrometry (SIMS); desorption electrospray ionisation (DESI); laser ablation inductively coupled plasma (LA-ICP); liquid extraction surface analysis (LESA); imaging mass cytometry (IMC); biomolecular imaging; technical advancements; imaging software
Sustainable Development Goals3 Good health and well-being
Middlesex University ThemeHealth & Wellbeing
PublisherIM Publications Open LLP
JournalJournal of Spectral Imaging
ISSN2040-4565
Publication dates
Print26 Oct 2020
Online26 Oct 2020
Publication process dates
Deposited13 Nov 2020
Submitted31 Jul 2020
Accepted14 Oct 2020
Output statusPublished
Publisher's version
License
Copyright Statement

© 2020 The Authors. This work is licensed under a Creative Commons BY Licence.
This licence permits you to use, share, copy and redistribute the paper in any medium or any format provided that a full citation to the original paper in this journal is given.

Digital Object Identifier (DOI)https://doi.org/10.1255/jsi.2020.a13
LanguageEnglish
Permalink -

https://repository.mdx.ac.uk/item/892q2

Log in to edit

Download files

Publisher's version
I09_a13.pdf
License: CC BY 4.0

  • 31
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Emerging applications in mass spectrometry imaging; enablers and roadblocks
Russo, C., Heaton, C., Flint, L., Voloaca, O., Haywood-Small, S., Clench, M., Francese, S. and Cole, L. 2020. Emerging applications in mass spectrometry imaging; enablers and roadblocks. Journal of Spectral Imaging. 9. https://doi.org/10.1255/jsi.2020.a13
Non-invasive screening of breast cancer from fingertip smears—a proof of concept study
Russo, C., Wyld, L., Da Costa Aubreu, M., Bury, C., Heaton, C., Cole, L. and Francese, S. 2023. Non-invasive screening of breast cancer from fingertip smears—a proof of concept study. Scientific Reports. 13 (1). https://doi.org/10.1038/s41598-023-29036-7
Application of MALDI-TOF MS in bioremediation and environmental research
Russo, C. and Purchase, D. 2023. Application of MALDI-TOF MS in bioremediation and environmental research. in: Shah, H.N., Gharbia, S.E., Shah, A., Tranfield, E.Y. and Thompson, K.C. (ed.) Microbiological Identification using MALDI-TOF and Tandem Mass Spectrometry: Industrial and Environmental Applications Wiley. pp. 255-282
Label-free quantitative proteomics and substrate-based mass spectrometry imaging of xenobiotic metabolizing enzymes in ex vivo human skin and a human living skin equivalent model
Couto, N., Newton, J., Russo, C., Karunakaran, E., Achour, B., Al-Majdoub, Z., Sidaway, J., Rostami-Hodjegan, A., Clench, M. and Barber, J. 2021. Label-free quantitative proteomics and substrate-based mass spectrometry imaging of xenobiotic metabolizing enzymes in ex vivo human skin and a human living skin equivalent model. Drug Metabolism and Disposition. 49 (1), pp. 39-52. https://doi.org/10.1124/dmd.120.000168
Fingermarks as a new proteomic specimen: state of the art and perspective of in situ proteomics
Francese, S. and Russo, C. 2019. Fingermarks as a new proteomic specimen: state of the art and perspective of in situ proteomics. in: Merkley, E. (ed.) Applications in Forensic Proteomics: Protein Identification and Profiling American Chemical Society.
Quantitative investigation of terbinafine hydrochloride absorption into a living skin equivalent model by MALDI-MSI
Russo, C., Brickelbank, N., Duckett, C., Mellor, S., Rumbelow, S. and Clench, M. 2018. Quantitative investigation of terbinafine hydrochloride absorption into a living skin equivalent model by MALDI-MSI. Analytical Chemistry. 90 (16), pp. 10031-10038. https://doi.org/10.1021/acs.analchem.8b02648
Mass spectrometry imaging of 3D tissue models
Russo, C., Lewis, E., Flint, L. and Clench, M. 2018. Mass spectrometry imaging of 3D tissue models. Proteomics. 18 (14). https://doi.org/10.1002/pmic.201700462