Emerging applications in mass spectrometry imaging; enablers and roadblocks

Article


Russo, C., Heaton, C., Flint, L., Voloaca, O., Haywood-Small, S., Clench, M., Francese, S. and Cole, L. 2020. Emerging applications in mass spectrometry imaging; enablers and roadblocks. Journal of Spectral Imaging. 9, pp. 1-21. https://doi.org/10.1255/jsi.2020.a13
TypeArticle
TitleEmerging applications in mass spectrometry imaging; enablers and roadblocks
AuthorsRusso, C., Heaton, C., Flint, L., Voloaca, O., Haywood-Small, S., Clench, M., Francese, S. and Cole, L.
Abstract

Mass spectrometry imaging (MSI) is a powerful and versatile technique able to investigate the spatial distribution of multiple non-labelled endogenous and exogenous analytes simultaneously, within a wide range of samples. Over the last two decades, MSI has found widespread application for an extensive range of disciplines including pre-clinical drug discovery, clinical applications and human identification for forensic purposes. Technical advances in both instrumentation and software capabilities have led to a continual increase in the interest in MSI; however, there are still some limitations. In this review, we discuss the emerging applications in MSI that significantly impact three key areas of mass spectrometry (MS) research—clinical, pre-clinical and forensics—and roadblocks to the expansion of use of MSI in these areas.

Keywordsmass spectrometry imaging (MALDI); secondary ionisation mass spectrometry (SIMS); desorption electrospray ionisation (DESI); laser ablation inductively coupled plasma (LA-ICP); liquid extraction surface analysis (LESA); imaging mass cytometry (IMC); biomolecular imaging; technical advancements; imaging software
Sustainable Development Goals3 Good health and well-being
Middlesex University ThemeHealth & Wellbeing
LanguageEnglish
PublisherIM Publications Open LLP
JournalJournal of Spectral Imaging
ISSN2040-4565
Publication dates
Print26 Oct 2020
Online26 Oct 2020
Publication process dates
Deposited13 Nov 2020
Submitted31 Jul 2020
Accepted14 Oct 2020
Output statusPublished
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Copyright Statement

© 2020 The Authors. This work is licensed under a Creative Commons BY Licence.
This licence permits you to use, share, copy and redistribute the paper in any medium or any format provided that a full citation to the original paper in this journal is given.

Digital Object Identifier (DOI)https://doi.org/10.1255/jsi.2020.a13
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