Synthesis of N-Glucosyl Ethyl and Butyl Phosphoramidates

Book chapter


Subratti, A., Jalsa, N.K. and Devo, P. 2021. Synthesis of N-Glucosyl Ethyl and Butyl Phosphoramidates. in: Kosma, P., Wrodnigg, T.M. and Stütz, A. (ed.) Carbohydrate chemistry: Proven synthetic methods, volume 5 CRC Press. pp. 37-42
Chapter titleSynthesis of N-Glucosyl Ethyl and Butyl Phosphoramidates
AuthorsSubratti, A., Jalsa, N.K. and Devo, P.
Abstract

The Staudinger-phosphite reaction has found extensive use in diverse biological applications. A subset of this reaction has been employed in the synthesis of glycosyl phosphoramidates, either conjugated to peptides and proteins or as stand-alone derivatives, which have been proposed as useful building blocks for drug development. All chemicals used were reagent grade and used as purchased, unless otherwise stated. Reaction mixtures were stirred magnetically. Combustion analysis was performed with a PerkinElmer 2400 Series II CHNS/O. The solution was stirred at room temperature and the reaction was monitored by TLC. When the starting material was consumed, the mixture was concentrated in vacuo, diluted with CH2Cl2 and washed with water.

Sustainable Development Goals9 Industry, innovation and infrastructure
Middlesex University ThemeSustainability
Page range37-42
Book titleCarbohydrate chemistry: Proven synthetic methods, volume 5
EditorsKosma, P., Wrodnigg, T.M. and Stütz, A.
PublisherCRC Press
Edition1st Edition
SeriesCarbohydrate Chemistry: Proven Synthetic Methods
ISBN
Hardcover9780815367888
Electronic9781351256087
Paperback9780367561734
Copyright Year2020
Publication dates
Print14 Jan 2021
Online15 Mar 2022
Publication process dates
Deposited26 Sep 2024
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1201/9781351256087-6
Related Output
Is part ofhttps://doi.org/10.1201/9781351256087
Is part ofhttps://www.routledge.com/Carbohydrate-Chemistry-Proven-Synthetic-Methods-Volume-5/Kosma-Stutz-Wrodnigg/p/book/9780815367888
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