eFluorination using cheap and readily available tetrafluoroborate salts

Article

Leech, M.C., Nagornii, D., Walsh, J.M., Kiaku, C., Poole, D.L., Mason, J., Goodall, I.C.A., Devo, P. and Lam, K. 2023. eFluorination using cheap and readily available tetrafluoroborate salts. Organic Letters. 25 (9), p. 1353–1358. https://doi.org/10.1021/acs.orglett.2c04305
TypeArticle
TitleeFluorination using cheap and readily available tetrafluoroborate salts
AuthorsLeech, M.C., Nagornii, D., Walsh, J.M., Kiaku, C., Poole, D.L., Mason, J., Goodall, I.C.A., Devo, P. and Lam, K.
Abstract

A practical electrochemical method for the rapid, safer, and mild synthesis of tertiary hindered alkyl fluorides from carboxylic acids has been developed without the need for hydrofluoric acid salts or non-glass reactors. In this anodic fluorination, collidinium tetrafluoroborate acts as both the supporting electrolyte and fluoride donor. A wide range of functional groups has been shown to be compatible, and the possibility of scale-up using flow electrochemistry has also been demonstrated.

Sustainable Development Goals12 Responsible consumption and production
Middlesex University ThemeSustainability
PublisherAmerican Chemical Society (ACS)
JournalOrganic Letters
ISSN1523-7060
Electronic1523-7052
Publication dates
Online01 Mar 2023
Print10 Mar 2023
Publication process dates
Submitted23 Dec 2022
Deposited02 Jun 2025
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1021/acs.orglett.2c04305
Web of Science identifierWOS:000943083100001
Related Output
Has versionhttps://gala.gre.ac.uk/id/eprint/38717/
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