Hepatitis C viraemia in United Kingdom blood donors: a multicentre study
Article
Garson, J., Clewley, J., Simmonds, P., Zhang, L., Mori, J., Ring, C., Follett, E., Dow, B., Martin, S. and Gunson, H. 1992. Hepatitis C viraemia in United Kingdom blood donors: a multicentre study. Vox Sanguinis. 62 (4), pp. 218-223. https://doi.org/10.1111/j.1423-0410.1992.tb01202.x
Type | Article |
---|---|
Title | Hepatitis C viraemia in United Kingdom blood donors: a multicentre study |
Authors | Garson, J., Clewley, J., Simmonds, P., Zhang, L., Mori, J., Ring, C., Follett, E., Dow, B., Martin, S. and Gunson, H. |
Abstract | Of 10,633 blood donations tested in three regional blood transfusion centres with two commercial first generation screening assays for antibodies to the hepatitis C virus (HCV), 65 (0.61%) were found to be repeatedly reactive in one or both assays. Five of the 65 were confirmed positive by recombinant immunoblot assay (Ortho RIBA-2) and a further 4 were judged indeterminate. All 5 RIBA-2 positive donations and 1 of the 4 RIBA-2 indeterminates were shown to be viraemic by HCV-RNA polymerase chain reaction (PCR) assays performed at three independent reference laboratories. The remaining 56 screen test reactive donations proved negative by RIBA-2 and, with 1 exception, negative by PCR. We conclude that while first generation anti-HCV screening assays generate a high proportion of false reactions when screening low prevalence populations, results of the RIBA-2 confirmatory test correlate well with PCR findings and thus indirectly with both hepatitis C viraemia and infectivity. |
Research Group | Visual Culture and Curating cluster |
Publisher | WileyBlackwell |
Journal | Vox Sanguinis |
ISSN | 0042-9007 |
Publication dates | |
May 1992 | |
Publication process dates | |
Deposited | 03 Dec 2009 |
Output status | Published |
Additional information | Article first published online: 5 MAR 2009 |
Digital Object Identifier (DOI) | https://doi.org/10.1111/j.1423-0410.1992.tb01202.x |
Language | English |
https://repository.mdx.ac.uk/item/81z84
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