Hepatitis C viraemia in adults with type 2 autoimmune hepatitis.

Article

Garson, J., Lenzi, M., Ring, C., Cassani, F., Ballardini, G., Briggs, M., Tedder, R. and Bianchi, F. 1991. Hepatitis C viraemia in adults with type 2 autoimmune hepatitis. Journal of Medical Virology. 34 (4), pp. 223-6.
TypeArticle
TitleHepatitis C viraemia in adults with type 2 autoimmune hepatitis.
AuthorsGarson, J., Lenzi, M., Ring, C., Cassani, F., Ballardini, G., Briggs, M., Tedder, R. and Bianchi, F.
Abstract

Sera from 14 patients with type 2 autoimmune hepatitis (anti-LKM1 positive) were investigated for evidence of hepatitis C virus (HCV) infection. Antibodies to HCV were detected in 13 patients by both commercial and "in-house" ELISAs and also by a second generation recombinant immunoblot assay. Nine of the 13 (69%) anti-HCV positive patients were shown to be viraemic by a polymerase chain reaction-based assay for serum HCV RNA. Neither anti-HCV nor serum HCV RNA were detected in any of 6 controls with primary biliary cirrhosis or in 39 healthy blood donors. These findings strongly suggest a role for HCV in the pathogenesis of type 2 autoimmune hepatitis.

PublisherWiley
JournalJournal of Medical Virology
ISSN0146-6615
Publication dates
Print1991
Publication process dates
Deposited03 Dec 2009
Output statusPublished
LanguageEnglish
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