Switching on kinases: oncogenic activation of BRAF and the PDGFR family

Article


Dibb, N., Dilworth, S. and Mol, C. 2004. Switching on kinases: oncogenic activation of BRAF and the PDGFR family. Nature Reviews Cancer. 4 (9), pp. 718-727. https://doi.org/10.1038/nrc1434
TypeArticle
TitleSwitching on kinases: oncogenic activation of BRAF and the PDGFR family
AuthorsDibb, N., Dilworth, S. and Mol, C.
Abstract

The cytoplasmic serine/threonine kinase BRAF and receptor tyrosine kinases of the platelet-derived growth factor receptor (PDGFR) family are frequently activated in cancer by mutations of an equivalent amino acid. Structural studies have provided important insights into why these very different kinases share similar oncogenic hot spots and why the PDGFR juxtamembrane region is also a frequent oncogenic target. This research has implications for other kinases that are mutated in human tumours and for the treatment of cancer using kinase inhibitors.

Research GroupMolecular Biology group
PublisherNature Publishing Group
JournalNature Reviews Cancer
ISSN1474-175X
Publication dates
PrintSep 2004
Publication process dates
Deposited19 Feb 2013
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1038/nrc1434
LanguageEnglish
Permalink -

https://repository.mdx.ac.uk/item/83yxx

  • 36
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Modelling and validating three-dimensional human breast and cancerous human breast tissues in vitro
Zuk, A., Burczynska, B., Li, D., Ghali, L., Dilworth, S. and Wen, S. 2020. Modelling and validating three-dimensional human breast and cancerous human breast tissues in vitro. Clinical Oncology and Research. 3 (4), pp. 1-9. https://doi.org/10.31487/j.COR.2020.04.05
Modelling and validating three dimensional human normal cervix and cervical cancer tissues in vitro
Zuk, A., Wen, S., Dilworth, S., Li, D. and Ghali, L. 2017. Modelling and validating three dimensional human normal cervix and cervical cancer tissues in vitro. Journal of Biomedical Research. 31 (3), pp. 240-247. https://doi.org/10.7555/JBR.31.20160150
A novel treatment strategy for ovarian cancer based on immunization against zona pellucida protein (ZP) 3
Rahman, N., Bennink, H., Chrusciel, M., Sharp, V., Zimmerman, Y., Dina, R., Li, X., Ellonen, A., Rivero-Müller, A., Dilworth, S., Ghaem-Maghami, S., Vainio, O. and Huhtaniemi, I. 2012. A novel treatment strategy for ovarian cancer based on immunization against zona pellucida protein (ZP) 3. The FASEB Journal. 26 (1), pp. 324-333. https://doi.org/10.1096/fj.11-192468
A functional interaction between RIP140 and PGC-1α regulates the expression of the lipid droplet protein CIDEA
Hallberg, M., Morganstein, D., Kiskinis, E., Shah, K., Kralli, A., Dilworth, S., White, R., Parker, M. and Christian, M. 2008. A functional interaction between RIP140 and PGC-1α regulates the expression of the lipid droplet protein CIDEA. Molecular and cellular biology. 28 (22), pp. 6785-6795. https://doi.org/10.1128/MCB.00504-08
Polyoma virus middle T antigen and its role in identifying cancer-related molecules
Dilworth, S. 2002. Polyoma virus middle T antigen and its role in identifying cancer-related molecules. Nature Reviews Cancer. 2 (12), pp. 951-956. https://doi.org/10.1038/nrc946
Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division
Stubbs, S., Stark, J., Dilworth, S., Franks, S. and Hardy, K. 2007. Abnormal preantral folliculogenesis in polycystic ovaries is associated with increased granulosa cell division. The Journal of Clinical Endocrinology and Metabolism. 92 (11), pp. 4418-4426. https://doi.org/10.1210/jc.2007-0729
Rapid activation of ATM on DNA flanking double-strand breaks
You, Z., Bailis, J., Johnson, S., Dilworth, S. and Hunter, T. 2007. Rapid activation of ATM on DNA flanking double-strand breaks. Nature Cell Biology. 9 (11), pp. 1311-1318. https://doi.org/10.1038/ncb1651
RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes
Kiskinis, E., Hallberg, M., Christian, M., Olofsson, M., Dilworth, S., White, R. and Parker, M. 2007. RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes. The EMBO Journal. 26 (23), pp. 4831-4840. https://doi.org/10.1038/sj.emboj.7601908
Polyoma virus and simian virus 40 as cancer models: history and perspectives
Atkin, S., Griffin, B. and Dilworth, S. 2009. Polyoma virus and simian virus 40 as cancer models: history and perspectives. Seminars in Cancer Biology. 19 (4), pp. 211-217. https://doi.org/10.1016/j.semcancer.2009.03.001
Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated protein kinase and target of rapamycin signalling pathways
Rider, M., Hussain, N., Dilworth, S. and Storey, K. 2009. Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated protein kinase and target of rapamycin signalling pathways. Molecular and Cellular Biochemistry. 332 (1-2), pp. 207-213. https://doi.org/10.1007/s11010-009-0193-3
AMP-activated protein kinase and metabolic regulation in cold-hardy insects
Rider, M., Hussain, N., Dilworth, S., Storey, J. and Storey, K. 2011. AMP-activated protein kinase and metabolic regulation in cold-hardy insects. Journal of Insect Physiology. 57 (11), pp. 1453-1462. https://doi.org/10.1016/j.jinsphys.2011.07.006
Polyomavirus middle T-antigen is a transmembrane protein that binds signaling proteins in discrete subcellular membrane sites
Zhou, A., Ichaso, N., Adamarek, A., Zila, V., Forstova, J., Dibb, N. and Dilworth, S. 2011. Polyomavirus middle T-antigen is a transmembrane protein that binds signaling proteins in discrete subcellular membrane sites. Journal of Virology. 85 (7), pp. 3046-3054. https://doi.org/10.1128/JVI.02209-10