Switching on kinases: oncogenic activation of BRAF and the PDGFR family

Article

Dibb, N., Dilworth, S. and Mol, C. 2004. Switching on kinases: oncogenic activation of BRAF and the PDGFR family. Nature Reviews Cancer. 4 (9), pp. 718-727. https://doi.org/10.1038/nrc1434
TypeArticle
TitleSwitching on kinases: oncogenic activation of BRAF and the PDGFR family
AuthorsDibb, N., Dilworth, S. and Mol, C.
Abstract

The cytoplasmic serine/threonine kinase BRAF and receptor tyrosine kinases of the platelet-derived growth factor receptor (PDGFR) family are frequently activated in cancer by mutations of an equivalent amino acid. Structural studies have provided important insights into why these very different kinases share similar oncogenic hot spots and why the PDGFR juxtamembrane region is also a frequent oncogenic target. This research has implications for other kinases that are mutated in human tumours and for the treatment of cancer using kinase inhibitors.

Research GroupMolecular Biology group
PublisherNature Publishing Group
JournalNature Reviews Cancer
ISSN1474-175X
Publication dates
PrintSep 2004
Publication process dates
Deposited19 Feb 2013
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1038/nrc1434
LanguageEnglish
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