Polyoma virus middle T antigen and its role in identifying cancer-related molecules

Article

Dilworth, S. 2002. Polyoma virus middle T antigen and its role in identifying cancer-related molecules. Nature Reviews Cancer. 2 (12), pp. 951-956. https://doi.org/10.1038/nrc946
TypeArticle
TitlePolyoma virus middle T antigen and its role in identifying cancer-related molecules
AuthorsDilworth, S.
Abstract

Most cancer researchers take for granted some of the basic concepts about the molecular changes that underlie tumorigenesis. These include the principles that tyrosine kinases and the phosphorylation of phosphatidylinositol by phosphatidylinositol 3-kinases are important in the signalling pathways that control proliferation and apoptosis, and hence cancer formation. However, how many know that a small DNA mouse virus was crucial in establishing both of these tenets?

Research GroupMolecular Biology group
PublisherNature Publishing Group
JournalNature Reviews Cancer
ISSN1474-175X
Publication dates
PrintDec 2002
Publication process dates
Deposited19 Feb 2013
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1038/nrc946
LanguageEnglish
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