Induction of death in myeloid leukaemia cells by doxorubicin and betulinic acid, singly and in combination was associated with the regulation of apoptosis, autophagy and the PI3K/Akt pathways
PhD thesis
Vu, M. 2020. Induction of death in myeloid leukaemia cells by doxorubicin and betulinic acid, singly and in combination was associated with the regulation of apoptosis, autophagy and the PI3K/Akt pathways. PhD thesis Middlesex University Science and Technology
Type | PhD thesis |
---|---|
Title | Induction of death in myeloid leukaemia cells by doxorubicin and betulinic acid, singly and in combination was associated with the regulation of apoptosis, autophagy and the PI3K/Akt pathways |
Authors | Vu, M. |
Abstract | Relapsed acute myeloid leukaemia (AML) cells are difficult to eradicate due to their more refractory nature. Deregulation of the B-cell lymphoma 2 (Bcl-2) family of proteins in these cells, which regulates cell death through apoptosis, autophagy and other cell processes, may contribute to this trend. Using chemical agents could modulate these signalling pathways. Drugs such as doxorubicin (Dox) are effective but displayed some clinical drawbacks, while compounds such as betulinic acid (BetA) have shown some interesting activity against cancerous cells. These drugs may complement each other in sensitising and eradicating aggressive AML cells. Therefore, in this study, cell death regulation and induction in AML cell line from a relapsed MLL-rearranged cell model (MOLM-13) was investigated with an established chemotherapy drug Dox and a bioactive compound BetA, singly and in combination. |
Sustainable Development Goals | 3 Good health and well-being |
Middlesex University Theme | Health & Wellbeing |
Department name | Science and Technology |
Institution name | Middlesex University |
Publication dates | |
09 Aug 2022 | |
Publication process dates | |
Deposited | 09 Aug 2022 |
Accepted | 31 Jul 2020 |
Output status | Published |
Accepted author manuscript | |
Language | English |
https://repository.mdx.ac.uk/item/89y34
Download files
39
total views2
total downloads0
views this month0
downloads this month