Evaluation of the effectiveness of Eladi Keram for the treatment of acne vulgaris: a randomised controlled pilot study

Article

Appiah, S., Lawley, B., Vu, M., Bell, C. and Jones, H. 2017. Evaluation of the effectiveness of Eladi Keram for the treatment of acne vulgaris: a randomised controlled pilot study. European Journal of Integrative Medicine. 12, pp. 38-43. https://doi.org/10.1016/j.eujim.2017.04.004
TypeArticle
TitleEvaluation of the effectiveness of Eladi Keram for the treatment of acne vulgaris: a randomised controlled pilot study
AuthorsAppiah, S., Lawley, B., Vu, M., Bell, C. and Jones, H.
Abstract

Introduction: Acne is a multifactorial and common skin disease which can significantly affect the quality of life of sufferers. In this study, a topical herbal preparation traditionally used in Ayurvedic medicine was evaluated as a treatment for individuals with acne on their shoulders and backs.
Methods: Study participants were randomly assigned either to treatment (Eladi Keram) or vehicle control (coconut oil) groups under double blind conditions and instructed on its daily home application. Standardised lesion counting and acne grading were conducted in accordance with US Food and Drug Administration guidelines and with reference to the Leeds Acne Grading Technique. Participants were assessed for severity of the condition at commencement and on day 28 of treatment.
Results: The treatment group showed improvements of 42% (p < 0.005) on the Investigators Global Assessment scale, a 60% (p < 0.05) reduction in inflammatory lesions, a 59% (p < 0.05) reduction in non-inflammatory lesions, and a 59% (p < 0.005) reduction in combined lesion count. The control group showed no statistically significant changes for these criteria.
Conclusion: This study is the first reported clinical evaluation of Eladi Keram as a treatment for acne and findings suggest that it could be effective in reducing inflammatory and non-inflammatory lesions, warranting further investigation by means of a larger scale clinical trial.

KeywordsEladi Keram; Acne; Dermatology; Skin; Ayurveda; Randomised controlled pilot study
PublisherElsevier
JournalEuropean Journal of Integrative Medicine
ISSN1876-3820
Electronic1876-3839
Publication dates
Online21 Apr 2017
Print01 Jun 2017
Publication process dates
Deposited20 Nov 2017
Submitted12 Dec 2016
Accepted14 Apr 2017
Output statusPublished
Accepted author manuscript
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Copyright Statement

© 2017. This author's accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

Digital Object Identifier (DOI)https://doi.org/10.1016/j.eujim.2017.04.004
Web of Science identifierWOS:000414230000006
LanguageEnglish
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Adeola, S., Revitt, D., Shutes, B., Garelick, H., Jones, H. and Jones, C. 2009. Constructed wetland control of BOD levels in airport runoff. International Journal of Phytoremediation. 11 (1), pp. 1-10. https://doi.org/10.1080/15226510802363220
Case Reports: Arsenic pollution in Thailand, Bangladesh and Hungary
Jones, H., Visoottiviseth, P., Bux, M., Földényi, R., Kováts, N., Borbély, G. and Galbács, Z. 2008. Case Reports: Arsenic pollution in Thailand, Bangladesh and Hungary. in: Garelick, H. and Jones, H. (ed.) Reviews of Environmental Contamination New York Springer.
Factors influencing subjective ranking of driver distractions
Patel, J., Ball, D. and Jones, H. 2008. Factors influencing subjective ranking of driver distractions. Accident Analysis & Prevention. 40 (1), pp. 392-395. https://doi.org/10.1016/j.aap.2007.07.006
Arsenic pollution sources
Garelick, H., Jones, H., Dybowska, A. and Valsami-Jones, E. 2008. Arsenic pollution sources. in: Garelick, H. and Jones, H. (ed.) Reviews of environmental contamination: international perspectives on arsenic pollution and remediation New York Springer.
An investigation of urban water and sediment ecotoxicity in relation to metal concentrations
Lundy, L., Mensah, R., Revitt, D. and Jones, H. 2007. An investigation of urban water and sediment ecotoxicity in relation to metal concentrations. Morrison, G. and Rauch, S. (ed.) 8th Highway and Urban Environment Symposium (8HUES). Nicosia, Cyprus 12 - 14 Jun 2006 Springer. pp. 359-370 https://doi.org/10.1007/978-1-4020-6010-6_32
Resistance to three antimicrobial agents of Campylobacter isolated from organically- and intensively-reared chickens purchased from retail outlets
Soonthornchaikul, N., Garelick, H., Jones, H., Jacobs, J., Ball, D. and Choudhury, M. 2006. Resistance to three antimicrobial agents of Campylobacter isolated from organically- and intensively-reared chickens purchased from retail outlets. International Journal of Antimicrobial Agents. 27 (2), pp. 125-130. https://doi.org/10.1016/j.ijantimicag.2005.09.020
Follicular fluid levels of inhibin A, inhibin B, and activin A levels reflect changes in follicle size but are not independent markers of the oocyte's ability to fertilize
Wen, S., Tozer, A., Butler, S., Bell, C., Docherty, S. and Iles, R. 2006. Follicular fluid levels of inhibin A, inhibin B, and activin A levels reflect changes in follicle size but are not independent markers of the oocyte's ability to fertilize. Fertility and Sterility. 85 (6), pp. 1723-1729. https://doi.org/10.1016/j.fertnstert.2005.11.058
The performance of vegetative treatment systems for highway runoff during dry and wet weather conditions
Revitt, D., Forshaw, M., Jones, H. and Shutes, B. 2004. The performance of vegetative treatment systems for highway runoff during dry and wet weather conditions. Science of the Total Environment. 334-335. https://doi.org/10.1016/j.scitotenv.2004.04.046
Practical experiences of the use of vegetated ponds for the treatment of highway runoff
Revitt, D., Shutes, B., Jones, H., Forshaw, M. and Winter, B. 2003. Practical experiences of the use of vegetated ponds for the treatment of highway runoff. Pratt, C., Davies, J., Newman, A. and Perry, J. (ed.) 2nd National UK Conference on Sustainable Drainage. Coventry, UK 23 - 24 Jun 2003 School of Science and the Environment, Coventry University. pp. 19-29