Screening for Downs Syndrome pregnancy by mass spectral glycofingerprinting hCG-beta core in neat pregnancy urine.

Conference poster

Luttoo, J., Appiah, S., Butler, S. and Iles, R. 2009. Screening for Downs Syndrome pregnancy by mass spectral glycofingerprinting hCG-beta core in neat pregnancy urine. Middlesex University Postgraduate Summer Conference. London, UK
TypeConference poster
TitleScreening for Downs Syndrome pregnancy by mass spectral glycofingerprinting hCG-beta core in neat pregnancy urine.
AuthorsLuttoo, J., Appiah, S., Butler, S. and Iles, R.
ConferenceMiddlesex University Postgraduate Summer Conference
Publication dates
PrintJun 2009
Publication process dates
Deposited04 Jul 2014
Output statusPublished
LanguageEnglish
Permalink -

https://repository.mdx.ac.uk/item/84wx7

Log in to edit
  • 55
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Intentionality for inclusivity - the journey at Middlesex University
Roberts, H., Punev, I., Allardyce, D., Kyprianou, A., Appiah, S., Megeney, A., Calin, A., Gallacher, D. and Mill, R. 2022. Intentionality for inclusivity - the journey at Middlesex University. McGraw Hill.
α-Mangostin and Doxorubicin Combination Synergistically Inhibited Cell Growth, Induced Cell Apoptosis with Increased Bak Protein and Decreased FLT3-ITD Phosphorylation in AML MOLM-13 Cell Line
Osemeke, C., Wen, S., Garelick, H. and Appiah, S. 2021. α-Mangostin and Doxorubicin Combination Synergistically Inhibited Cell Growth, Induced Cell Apoptosis with Increased Bak Protein and Decreased FLT3-ITD Phosphorylation in AML MOLM-13 Cell Line. Clinical Oncology and Research. 4 (8), pp. 1-10. https://doi.org/10.31487/j.COR.2021.08.12
Betulinic Acid–Doxorubicin-Drug combination induced apoptotic death via ROS stimulation in a relapsed AML MOLM-13 cell model
Vu, M., Kassouf, N. and Appiah, S. 2021. Betulinic Acid–Doxorubicin-Drug combination induced apoptotic death via ROS stimulation in a relapsed AML MOLM-13 cell model. Antioxidants. 10 (9). https://doi.org/10.3390/antiox10091456
Doxorubicin selectively induces apoptosis through the inhibition of a novel isoform of Bcl‑2 in acute myeloid leukaemia MOLM‑13 cells with reduced Beclin 1 expression
Vu, M., Kassouf, N., Ofili, R., Lund, T., Bell, C. and Appiah, S. 2020. Doxorubicin selectively induces apoptosis through the inhibition of a novel isoform of Bcl‑2 in acute myeloid leukaemia MOLM‑13 cells with reduced Beclin 1 expression. International Journal of Oncology. 57 (1), pp. 113-121. https://doi.org/10.3892/ijo.2020.5052
Betulinic acid-doxorubicin drug combination synergistically supresses cell viability and enhances apoptotic death in acute myeloid leukaemia cell lines by increasing Bax/Bcl-2 ratio
Vu, M., Kassouf, N., Bell, C. and Appiah, S. 2018. Betulinic acid-doxorubicin drug combination synergistically supresses cell viability and enhances apoptotic death in acute myeloid leukaemia cell lines by increasing Bax/Bcl-2 ratio. NCRI Cancer Conference (2018). Glasgow, Scotland 04 - 06 Nov 2018
The combination of curcumin and doxorubicin shows a selective cytotoxic effect on acute myeloid leukaemia cell line
Hasan, N., Roberts, H., Ghali, L. and Appiah, S. 2018. The combination of curcumin and doxorubicin shows a selective cytotoxic effect on acute myeloid leukaemia cell line. NCRI Cancer Conference (2018). Glasgow, Scotland 04 - 06 Nov 2018
α-Mangostin, singly and in combination with Doxorubicin, as pro-apoptotic agents and protein kinase inhibitors In the AML cell line, Molm13
Osemeke, C., Garelick, H., Wen, S. and Appiah, S. 2018. α-Mangostin, singly and in combination with Doxorubicin, as pro-apoptotic agents and protein kinase inhibitors In the AML cell line, Molm13. EACR Conference Series: A matter of Life or Death. from Basic cell Death Mechanism to Novel cancer Treatment. Amstardam, Netherlands
Doxorubicin combined with Alpha Mangostin as pro-apoptotic agents and as potential kinase inhibitors of acute Myeloid Leukaemia
Osemeke, C., Garelick, H., Wen, S. and Appiah, S. 2017. Doxorubicin combined with Alpha Mangostin as pro-apoptotic agents and as potential kinase inhibitors of acute Myeloid Leukaemia. 2017 NCRI Cancer Conference. Liverpool, UK 05 - 08 Nov 2017
Potential interactions of Alpha Mangostin with Doxorubicin as potential Kinase inhibitors on myeloid leukaemic cell line
Osemeke, C., Garelick, H., Wen, S. and Appiah, S. 2017. Potential interactions of Alpha Mangostin with Doxorubicin as potential Kinase inhibitors on myeloid leukaemic cell line. 2017 Middlesex University Research Student Summer Conference. London, UK 28 - 29 Jun 2017
Combinational effect of phytochemicals on the action of chemotherapy drugs on acute myeloid leukaemic cell lines
Osemeke, C., Garelick, H., Wen, S. and Appiah, S. 2016. Combinational effect of phytochemicals on the action of chemotherapy drugs on acute myeloid leukaemic cell lines. 2016 Middlesex University Research Student Summer Conference. London, UK 29 - 30 Jun 2016
Potential interaction between natural compounds and chemotherapeutic drugs on leukaemia cell line
Osemeke, C., Garelick, H., Wen, S. and Appiah, S. 2015. Potential interaction between natural compounds and chemotherapeutic drugs on leukaemia cell line. 2015 Middlesex University Research Student Summer Conference. Middlesex University, London, United Kingdom 17 - 18 Jun 2015
Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer
Śliwa, A., Kubiczak, M., Szczerba, A., Walkowiak, G., Nowak-Markwitz, E., Burczynska, B., Butler, S., Iles, R., Białas, P. and Jankowska, A. 2019. Regulation of human chorionic gonadotropin beta subunit expression in ovarian cancer. BMC cancer. 19 (1), pp. 1-9. https://doi.org/10.1186/s12885-019-5960-2
Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCGβ
Burczynska, B., Kobrouly, L., Butler, S., Naase, M. and Iles, R. 2014. Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCGβ. Anticancer Research. 34 (5), pp. 2239-2248.
Do the adult daughters of PCOS patients develop PCOS and is this due to an androgenized uterine environment-an online epidemiological survey
Ratajczak, A., Iles, R. and Wen, S. 2016. Do the adult daughters of PCOS patients develop PCOS and is this due to an androgenized uterine environment-an online epidemiological survey. Reproductive System & Sexual Disorders: Current Research. 5 (2), pp. 1-5. https://doi.org/10.4172/2161-038X.1000167
Liposome‑delivered baicalein induction of myeloid leukemia K562 cell death via reactive oxygen species generation
Wang, S., Wen, S., Bell, C. and Appiah, S. 2018. Liposome‑delivered baicalein induction of myeloid leukemia K562 cell death via reactive oxygen species generation. Molecular Medicine Reports. 17 (3), pp. 4524-4530. https://doi.org/10.3892/mmr.2018.8396
Evidence for the outcomes and impact of clinical pharmacy: context of UK hospital pharmacy practice
Onatade, R., Appiah, S., Stephens, M. and Garelick, H. 2018. Evidence for the outcomes and impact of clinical pharmacy: context of UK hospital pharmacy practice. European Journal of Hospital Pharmacy. 25 (e1), pp. e21-e28. https://doi.org/10.1136/ejhpharm-2017-001303
Evaluation of the effectiveness of Eladi Keram for the treatment of acne vulgaris: a randomised controlled pilot study
Appiah, S., Lawley, B., Vu, M., Bell, C. and Jones, H. 2017. Evaluation of the effectiveness of Eladi Keram for the treatment of acne vulgaris: a randomised controlled pilot study. European Journal of Integrative Medicine. 12, pp. 38-43. https://doi.org/10.1016/j.eujim.2017.04.004
Phytochemical modulation of apoptosis and autophagy: strategies to overcome chemoresistance in leukaemic stem cells in the bone marrow microenvironment
Owen, H., Appiah, S., Hasan, N., Ghali, L., Elayat, G. and Bell, C. 2017. Phytochemical modulation of apoptosis and autophagy: strategies to overcome chemoresistance in leukaemic stem cells in the bone marrow microenvironment. in: Zeng, B. and Zhao, K. (ed.) Neurobiology of Chinese Herb Medicine Elsevier.
Antiinflammatory and hepatoprotective medicinal herbs as potential substitutes for bear bile
Appiah, S., Revitt, D., Jones, H., Vu, M., Simmonds, M. and Bell, C. 2017. Antiinflammatory and hepatoprotective medicinal herbs as potential substitutes for bear bile. in: Zeng, B. and Zhao, K. (ed.) Neurobiology of Chinese Herb Medicine Elsevier.
Determination of urinary cortisol, cortisone and 6-sulfatoxymelatonin using dilute and shoot ultra-high pressure liquid chromatography-tandem mass spectrometry
Sniecinska-Cooper, A., Shah, A., Dimitriou, D., Iles, R., Butler, S. and Bayford, R. 2015. Determination of urinary cortisol, cortisone and 6-sulfatoxymelatonin using dilute and shoot ultra-high pressure liquid chromatography-tandem mass spectrometry. Journal of Chromatography B. 978-79, pp. 18-23. https://doi.org/10.1016/j.jchromb.2014.11.016
Abnormal secretion of melatonin and cortisol in relation to sleep disturbances in children with Williams syndrome
Sniecinska-Cooper, A., Iles, R., Butler, S., Jones, H., Bayford, R. and Dimitriou, D. 2015. Abnormal secretion of melatonin and cortisol in relation to sleep disturbances in children with Williams syndrome. Sleep Medicine. 16 (1), pp. 94-100. https://doi.org/10.1016/j.sleep.2014.09.003
The role of vitamin In type 2 diabetes
Ali, A., Appiah, S., Shah, A. and Ghali, L. 2014. The role of vitamin In type 2 diabetes. Middlesex University Postgraduate Summer Conference. London, UK 19 Jun 2014
Impact of inulin on bile acids induced colon cancer: antioxidant and anti-proliferative effect of inulin on HCT 116 cell lines
Afolabi, B., Appiah, S., Pachenari, A. and Ghali, L. 2014. Impact of inulin on bile acids induced colon cancer: antioxidant and anti-proliferative effect of inulin on HCT 116 cell lines. Middlesex University Postgraduate Summer Conference. London, UK 19 Jun 2014
Impact of inulin on bile acids induced colon cancer
Afolabi, B., Appiah, S., Pachenari, A. and Ghali, L. 2013. Impact of inulin on bile acids induced colon cancer. Third AACR International Conference on Frontiers in Basic Cancer Research. National Harbor, MD, United States 18 - 22 Sep 2013
Single point biochemical measurement algorithm for early diagnosis of ectopic pregnancy
Butler, S., Abban, T., Borrelli, P., Luttoo, J., Kemp, B. and Iles, R. 2013. Single point biochemical measurement algorithm for early diagnosis of ectopic pregnancy. Clinical Biochemistry. 46 (13-14), pp. 1257-1263. https://doi.org/10.1016/j.clinbiochem.2013.06.019
hCGβ expression by cervical squamous carcinoma - in vivohistological association with tumour invasion and apoptosis
Li, D., Wen, S., Ghali, L., Al-Shalabi, F., Docherty, S., Purkis, P. and Iles, R. 2008. hCGβ expression by cervical squamous carcinoma - in vivohistological association with tumour invasion and apoptosis. Histopathology. 53 (2), pp. 147-155. https://doi.org/10.1111/j.1365-2559.2008.03082.x
Stable knockdown of hCGβ mRNA expression in bladder cancer cells results in significant inhibition of growth
Burczynska, B., Booth, M., Iles, R., Shah, A., Shiled, A. and Butler, S. 2013. Stable knockdown of hCGβ mRNA expression in bladder cancer cells results in significant inhibition of growth. Anticancer Research. 33 (9), pp. 3611-3614.
hCGβ expression by cervical squamous carcinoma: in vivo histological association with tumour invasion and apoptosis
Li, D., Wen, S., Ghali, L., Al-Shalabi, F., Docherty, S., Purkis, P. and Iles, R. 2008. hCGβ expression by cervical squamous carcinoma: in vivo histological association with tumour invasion and apoptosis. Histopathology. 53 (2), pp. 147-155. https://doi.org/10.1111/j.1365-2559.2008.03082.x
Does hCG or hCGβ play a role in cancer cell biology?
Iles, R., Delves, P. and Butler, S. 2010. Does hCG or hCGβ play a role in cancer cell biology? Molecular and Cellular Endocrinology. 329 (1-2), pp. 62-70. https://doi.org/10.1016/j.mce.2010.07.014
Development of Zwitterionic Hydrophilic Liquid Chromatography (ZICⓇHILIC-MS) metabolomics method for Shotgun analysis of human urine
Trivedi, D., Jones, H., Shah, A. and Iles, R. 2012. Development of Zwitterionic Hydrophilic Liquid Chromatography (ZICⓇHILIC-MS) metabolomics method for Shotgun analysis of human urine. Journal of Chromatography & Separation Techniques. 03 (06). https://doi.org/10.4172/2157-7064.1000144
Human Chorionic Gonadotropin (hCG) in the secretome of cultured embryos: hyperglycosylated hCG and hCG-free beta subunit are potential markers for infertility management and treatment
Butler, S., Luttoo, J., Freire, M., Abban, T., Borrelli, P. and Iles, R. 2013. Human Chorionic Gonadotropin (hCG) in the secretome of cultured embryos: hyperglycosylated hCG and hCG-free beta subunit are potential markers for infertility management and treatment. Reproductive Sciences. 20 (9), pp. 1038-1045. https://doi.org/10.1177/1933719112472739
Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy
Hills, F., Iles, R. and Sullivan, M. 2013. Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy. Journal of Perinatal Medicine. 41 (3), pp. 241-249. https://doi.org/10.1515/jpm-2012-0086
Does HCG or HCG-beta play a role in breast cancer cell biology?
Iles, R. and Butler, S. 2010. Does HCG or HCG-beta play a role in breast cancer cell biology? Tumour Biology. 31 (S39).
Ectopic HCG beta may induce epithelialmensenchymal transition on human kera tinocytes in vitro and this could promote tumour progression and invasion.
Wen, S., Li, D., Ghali, L. and Iles, R. 2010. Ectopic HCG beta may induce epithelialmensenchymal transition on human kera tinocytes in vitro and this could promote tumour progression and invasion. Tumour Biology. 31 (S44).
Structural modelling of human chorion ic gonadotropin: the effect of nicking and glycosylation on the molecular folding and likely epitope recognition by HCG antibodies.
Butler, S., Gibbons, N., Rehman, S. and Iles, R. 2010. Structural modelling of human chorion ic gonadotropin: the effect of nicking and glycosylation on the molecular folding and likely epitope recognition by HCG antibodies. Tumour Biology. 31 (S46).
Serum biomarkers of collagen metabolism, pyridinoline (PYD) and aminoterminal properptide of type i procollagen (PINP) as diagnostic staging markers of bone metastases in breast cancer patients.
Iles, R., Cheung, K., Robertson, J. and Perrett, D. 2010. Serum biomarkers of collagen metabolism, pyridinoline (PYD) and aminoterminal properptide of type i procollagen (PINP) as diagnostic staging markers of bone metastases in breast cancer patients. Tumour Biology. 31 (S72).
Evaluation of herbs as potential alternatives for bear bile and rhino horn used in traditional Chinese medicines: chemical and biological analysis.
Appiah, S. 2006. Evaluation of herbs as potential alternatives for bear bile and rhino horn used in traditional Chinese medicines: chemical and biological analysis. PhD thesis Middlesex University School of Health and Social Sciences
Detection of cancer.
Bayford, R., Roitt, I., Rademacher, T., Demosthenous, A. and Iles, R. 2010. Detection of cancer.
Gonadotropins and gonadotropin receptors: evolutional genetics, signalling mechanisms, extra gonadal function and roles in oncogenesis.
Iles, R. and Butler, S. 2010. Gonadotropins and gonadotropin receptors: evolutional genetics, signalling mechanisms, extra gonadal function and roles in oncogenesis. Molecular and Cellular Endocrinology. 329 (1), pp. 1-2. https://doi.org/10.1016/j.mce.2010.07.024
Biological function of the free β -subunit: expression and treatment target in cancer.
Butler, S. and Iles, R. 2010. Biological function of the free β -subunit: expression and treatment target in cancer. in: Cole, L. (ed.) Human chorionic gonadotropin (hCG). London Elsevier. pp. 153-171
Does hCG or hCGß play a role in cancer cell biology?
Iles, R., Delves, P. and Butler, S. 2010. Does hCG or hCGß play a role in cancer cell biology? Molecular and Cellular Endocrinology. 329 (1-2), pp. 62-70. https://doi.org/10.1016/j.mce.2010.07.014
Composition of intact hormone and free subunits in the human chorionic gonadotrophin-like material found in serum and urine of patients with carcinoma of the bladder.
Iles, R., Lee, C., Oliver, R. and Chard, T. 1990. Composition of intact hormone and free subunits in the human chorionic gonadotrophin-like material found in serum and urine of patients with carcinoma of the bladder. Clinical Endocrinology. 33 (3), pp. 355-364. https://doi.org/10.1111/j.1365-2265.1990.tb00500.x
Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests.
Caulfield, M., Dilkes, M., Iles, R., Handel, B. and Oliver, R. 1990. Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests. Lancet. 335 (8699), p. 1230. https://doi.org/10.1016/0140-6736(90)92761-6
Biological significance of beta hCG, HLA and other membrane antigen expression on bladder tumours and their relationship to tumour infiltrating lymphocytes (TIL)
Oliver, R., Nouri, A., Crosby, D., Iles, R., Naverette, C., Martin, J., Bodmer, W. and Festenstein, H. 1989. Biological significance of beta hCG, HLA and other membrane antigen expression on bladder tumours and their relationship to tumour infiltrating lymphocytes (TIL). International journal of immunogenetics. 16 (4-5), pp. 381-390.
Expression of beta human chorionic gonadotrophin by non-trophoblastic non-endocrine 'normal' and malignant epithelial cells.
Iles, R., Purkis, P., Whitehead, P., Oliver, R. and Chard, T. 1990. Expression of beta human chorionic gonadotrophin by non-trophoblastic non-endocrine 'normal' and malignant epithelial cells. British journal of cancer. 61 (5), pp. 663-666.
Enhancement of ectopic beta-human chorionic gonadotrophin expression by interferon-alpha.
Iles, R. and Chard, T. 1989. Enhancement of ectopic beta-human chorionic gonadotrophin expression by interferon-alpha. Journal of Endocrinology. 123 (3), pp. 501-507. https://doi.org/10.1677/joe.0.1230501
Beta human chorionic gonadotrophin in serum and urine. A marker for metastatic urothelial cancer.
Iles, R., Jenkins, B., Oliver, R., Blandy, J. and Chard, T. 1989. Beta human chorionic gonadotrophin in serum and urine. A marker for metastatic urothelial cancer. British Journal of Urology. 64 (3), pp. 241-244. https://doi.org/10.1111/j.1464-410X.1989.tb06006.x
Immunochemical analysis of the human chorionic gonadotrophin-like material secreted by 'normal' and neoplastic urothelial cells.
Iles, R. and Chard, T. 1989. Immunochemical analysis of the human chorionic gonadotrophin-like material secreted by 'normal' and neoplastic urothelial cells. Journal of molecular endocrinology. 2 (2), pp. 107-112. https://doi.org/10.1677/jme.0.0020107
Amplification or rearrangement of the beta-human chorionic gonadotrophin (beta-hCG)--human LH gene cluster is not responsible for the ectopic production of beta-hCG by bladder tumour cells.
Iles, R., Czepulkowski, B., Young, B. and Chard, T. 1989. Amplification or rearrangement of the beta-human chorionic gonadotrophin (beta-hCG)--human LH gene cluster is not responsible for the ectopic production of beta-hCG by bladder tumour cells. Journal of molecular endocrinology. 2 (2), pp. 113-117. https://doi.org/10.1677/jme.0.0020113
In vitro secretion of human chorionic gonadotrophin by bladder tumour cells.
Iles, R., Oliver, R., Kitau, M., Walker, C. and Chard, T. 1987. In vitro secretion of human chorionic gonadotrophin by bladder tumour cells. British journal of cancer. 55 (6), pp. 623-626.
The measurement of urinary beta core fragment in conjunction with serum CA125 does not aid the differentiation of malignant from benign pelvic masses.
Carter, P., Iles, R., Neven, P., Davies, A., Shepherd, J. and Chard, T. 1993. The measurement of urinary beta core fragment in conjunction with serum CA125 does not aid the differentiation of malignant from benign pelvic masses. Gynecologic Oncology. 51 (3), pp. 368-371. https://doi.org/10.1006/gyno.1993.1305
Bony metastases from breast cancer: a study of foetal antigen 2 as a blood tumour marker.
Cheung, K., Iles, R. and Robertson, J. 2010. Bony metastases from breast cancer: a study of foetal antigen 2 as a blood tumour marker. World Journal of Surgical Oncology. 8 (38). https://doi.org/10.1186/1477-7819-8-38
Purine metabolite levels in pre-ovulatory human follicles may hold the key to ovarian hyper-stimulation syndrome.
Iles, R. and Docherty, S. 2010. Purine metabolite levels in pre-ovulatory human follicles may hold the key to ovarian hyper-stimulation syndrome. Metabolism. https://doi.org/10.1016/j.metabol.2010.04.005
Measurement of human chorionic gonadotrophin (hCG) as a screening test for Down’s Syndrome
Chard, T. and Iles, R. 1994. Measurement of human chorionic gonadotrophin (hCG) as a screening test for Down’s Syndrome. in: Grudzinskas, J., Chard, T., Chapman, M. and Cuckle, H. (ed.) Screening for Down’s Syndrome Cambridge University Press. pp. 73-84
Electrochemical impedance detection of hCGbeta: preliminary results and analysis in the development of lab on a chip technology.
Bayford, R., Kassanos, P., Demosthenous, A. and Iles, R. 2009. Electrochemical impedance detection of hCGbeta: preliminary results and analysis in the development of lab on a chip technology. 42nd IUPAC Congress: Chemistry Solutions SECC.. Glasgow, Scotland, UK. 02 - 07 Aug 2009
Investigation of the safety and efficacy of Chinese herbs traditionally used to treat inflammatory diseases
Appiah, S., Kokubun, T., Bremner, P., Heinrich, M., Bell, C. and Simmonds, M. 2003. Investigation of the safety and efficacy of Chinese herbs traditionally used to treat inflammatory diseases. 10th Annual Symposium on Complementary Health Care. London, UK 21 - 22 Nov 2003
Herbal alternatives to bear bile: effects of scutellaria baicalensis Georgi on IL-6 promoter and CYP3A4 activities.
Appiah, S., Bremner, P., Kokubun, T., Russell, M., Bell, C., Heinrich, M. and Simmonds, M. 2006. Herbal alternatives to bear bile: effects of scutellaria baicalensis Georgi on IL-6 promoter and CYP3A4 activities. 13th Annual Symposium on Complementary Health Care. Exeter, UK 12 - 14 Dec 2006
Plant substances as alternatives for animal products in traditional medicines.
Bell, C., Simmonds, M., Appiah, S. and Howes, M. 2006. Plant substances as alternatives for animal products in traditional medicines. London Department for the Environment, Food and Rural Affairs.
Designing a new generation of anti-hCG vaccines for cancer therapy
Delves, P., Iles, R., Roitt, I. and Lund, T. 2007. Designing a new generation of anti-hCG vaccines for cancer therapy. Molecular and Cellular Endocrinology. 260-26, pp. 276-281. https://doi.org/10.1016/j.mce.2006.02.018
Estradiol, progesterone, testosterone profiles in human follicular fluid and cultured granulosa cells from luteinized pre-ovulatory follicles
Wen, S., Li, D., Tozer, A., Docherty, S. and Iles, R. 2010. Estradiol, progesterone, testosterone profiles in human follicular fluid and cultured granulosa cells from luteinized pre-ovulatory follicles. Reproductive Biology and Endocrinology. 8 (117). https://doi.org/10.1186/1477-7827-8-117
High follicular fluid adenosine levels may be pivotal in the metabolism and recycling of adenosine nucleotides in the human follicle
Wen, S., Perrett, D., Jones, N., Tozer, A., Docherty, S. and Iles, R. 2010. High follicular fluid adenosine levels may be pivotal in the metabolism and recycling of adenosine nucleotides in the human follicle. Metabolism: Clinical and Experimental. 59 (8), pp. 1145-1155. https://doi.org/10.1016/j.metabol.2009.09.037
Urinary concentration of human chorionic gonadotrophin and its fragments as a prognostic marker in bladder cancer
Iles, R., Persad, R., Trivedi, M., Sharma, K., Dickinson, A., Smith, P. and Chard, T. 1996. Urinary concentration of human chorionic gonadotrophin and its fragments as a prognostic marker in bladder cancer. British Journal of Urology. 77 (1), pp. 61-69. https://doi.org/10.1046/j.1464-410X.1996.82910.x
Urinary analysis for Down's syndrome: is the measurement of urinary β-core the future of biochemical screening for Down's syndrome
Iles, R. 1996. Urinary analysis for Down's syndrome: is the measurement of urinary β-core the future of biochemical screening for Down's syndrome. Early Human Development. 47, pp. S41-S45. https://doi.org/10.1016/S0378-3782(96)01818-X
Detection of β-core fragment in second trimester Down's syndrome pregnancies
Cole, L., Isozaki, T., Palomaki, G., Canick, J., Iles, R., Kellner, L., Saller, D. and Cuckle, H. 1996. Detection of β-core fragment in second trimester Down's syndrome pregnancies. Early Human Development. 47, pp. S47-S48. https://doi.org/10.1016/S0378-3782(96)01819-1
Human urothelial carcinomas - a typical disease of the aged: the clinical utility of human chorionic gonadotrophin in patient management and future therapy
Iles, R. and Butler, S. 1998. Human urothelial carcinomas - a typical disease of the aged: the clinical utility of human chorionic gonadotrophin in patient management and future therapy. Experimental Gerontology. 33 (5), pp. 379-391. https://doi.org/10.1016/S0531-5565(98)00016-3
Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer-associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer
Ind, T., Iles, R., Shepherd, J. and Chard, T. 1997. Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer-associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer. British Journal of Obstetrics and Gynaecology. 104 (9), pp. 1024-1029. https://doi.org/10.1111/j.1471-0528.1997.tb12061.x
Comparison of 12 assays for detecting hCG and related molecules in urine samples from Down syndrome pregnancies.
Cole, L., Kellner, L., Isozaki, T., Palomaki, G., Iles, R., Walker, R., Ozaki, M. and Canick, J. 1997. Comparison of 12 assays for detecting hCG and related molecules in urine samples from Down syndrome pregnancies. Prenatal diagnosis. 17 (7), pp. 607-614. https://doi.org/10.1002/(SICI)1097-0223(199707)17:7<607::AID-PD118>3.0.CO;2-7
Measures of urine concentration in maternal urine screening for Down syndrome.
Iles, R., Black, A., Gunn, L., Sehmi, I., Cuckle, H. and Chard, T. 1998. Measures of urine concentration in maternal urine screening for Down syndrome. Prenatal diagnosis. 18 (10), pp. 1006-1009. https://doi.org/10.1002/(SICI)1097-0223(1998100)18:10<1006::AID-PD386>3.0.CO;2-O
Dimerization of urinary beta-core/hCFbetacf: a cause of poor beta-core assay performance in Down syndrome screening studies.
Iles, R., Butler, S. and Jacoby, E. 1999. Dimerization of urinary beta-core/hCFbetacf: a cause of poor beta-core assay performance in Down syndrome screening studies. Prenatal diagnosis. 19 (8), pp. 790-792. https://doi.org/10.1002/(SICI)1097-0223(199908)19:8<790::AID-PD627>3.0.CO;2-Z
Urinary beta-core hCG: Screening for aneuploidies in early pregnancy (11-14 weeks’ gestation).
MacIntosh, M., Nicolaides, K., Noble, P., Chard, T., Gunn, L. and Iles, R. 1997. Urinary beta-core hCG: Screening for aneuploidies in early pregnancy (11-14 weeks’ gestation). Prenatal diagnosis. 17 (5), pp. 401-405. https://doi.org/10.1002/(SICI)1097-0223(199705)17:5<401::AID-PD40>3.0.CO;2-M
Substantial urinary concentrations of material resembling beta-core fragment of chorionic gonadotropin beta-subunit in mid-menstrual cycle
Neven, P., Iles, R., Howes, I., Sharma, K., Shepherd, J., Edwards, R., Collins, W. and Chard, T. 1993. Substantial urinary concentrations of material resembling beta-core fragment of chorionic gonadotropin beta-subunit in mid-menstrual cycle. Clinical Chemistry. 39 (9), pp. 1857-1860.
Production of placental alkaline phosphatase (PLAP) and PLAP-like material by epithelial germ cell and non-germ cell tumours in vitro
Iles, R., Ind, T. and Chard, T. 1994. Production of placental alkaline phosphatase (PLAP) and PLAP-like material by epithelial germ cell and non-germ cell tumours in vitro. British journal of cancer. 69 (2), pp. 274-278.
Diurnal variation of urinary "hCG beta subunit core fragment" production evaluated in patients with gynecological neoplasms
Neven, P., Iles, R., Carter, P., Shepherd, J. and Chard, T. 1994. Diurnal variation of urinary "hCG beta subunit core fragment" production evaluated in patients with gynecological neoplasms. Clinical Chemistry. 40 (3), pp. 484-485.
Characterisation of the differential expression of marker antigens by normal and malignant endometrial epithelium
Chatzaki, E., Gallagher, C., Iles, R., Ind, T., Nouri, A., Bax, C. and Grudzinskas, J. 1994. Characterisation of the differential expression of marker antigens by normal and malignant endometrial epithelium. British journal of cancer. 69 (6), pp. 1010-1014.
Serum placental-type alkaline phosphatase activity in women with squamous and glandular malignancies of the reproductive tract
Ind, T., Iles, R., Carter, P., Lowe, D., Shepherd, J., Hudson, C. and Chard, T. 1994. Serum placental-type alkaline phosphatase activity in women with squamous and glandular malignancies of the reproductive tract. Journal of Clinical Pathology. 47 (11), pp. 1035-1037.
Measurement of urinary beta core fragment of human chorionic gonadotrophin in women with vulvovaginal malignancy and its prognostic significance
Carter, P., Iles, R., Neven, P., Ind, T., Shepherd, J. and Chard, T. 1995. Measurement of urinary beta core fragment of human chorionic gonadotrophin in women with vulvovaginal malignancy and its prognostic significance. British journal of cancer. 71 (2), pp. 350-353.
The effects of beta-human chorionic gonadotrophin on the in vitro growth of bladder cancer cell lines
Gillott, D., Iles, R. and Chard, T. 1996. The effects of beta-human chorionic gonadotrophin on the in vitro growth of bladder cancer cell lines. British journal of cancer. 73 (3), pp. 323-326.
The temporary anatomical structures prominent in the first trimester may be fulfilling exchange functions assigned to the placenta in the second and third trimester
Docherty, S., Iles, R., Wathen, N. and Chard, T. 1996. The temporary anatomical structures prominent in the first trimester may be fulfilling exchange functions assigned to the placenta in the second and third trimester. Human Reproduction. 11 (6), pp. 1157-1161.
Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer
Crawford, R., Caldwell, C., Iles, R., Lowe, D., Shepherd, J. and Chard, T. 1998. Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer. British journal of cancer. 78 (2), pp. 210-214.
Concentrations of placental protein 14 in uterine flushings from infertile women: validation of the collection technique and method of expression of results
Hamilton, J., Iles, R., Gunn, L., Wilson, C., Lower, A., Chard, T. and Grudzinskas, J. 1998. Concentrations of placental protein 14 in uterine flushings from infertile women: validation of the collection technique and method of expression of results. Human Reproduction. 13 (12), pp. 3357-3362.
The prognostic significance of beta human chorionic gonadotrophin and its metabolites in women with cervical carcinoma
Crawford, R., Iles, R., Carter, P., Caldwell, C., Shepherd, J. and Chard, T. 1998. The prognostic significance of beta human chorionic gonadotrophin and its metabolites in women with cervical carcinoma. Journal of Clinical Pathology. 51 (9), pp. 685-688.
Cross-Reaction with luteinizing hormone ß-Core is responsible for the age-dependent increase of immunoreactive ß-Core fragment of human chorionic gonadotropin in women with nonmalignant conditions
Iles, R., Javid, M., Gunn, L. and Chard, T. 1999. Cross-Reaction with luteinizing hormone ß-Core is responsible for the age-dependent increase of immunoreactive ß-Core fragment of human chorionic gonadotropin in women with nonmalignant conditions. Clinical Chemistry. 45, pp. 532-538.
The beta-subunit of human chorionic gonadotrophin exists as a homodimer
Butler, S., Laidler, P., Porter, J., Kicman, A., Chard, T., Cowan, D. and Iles, R. 1999. The beta-subunit of human chorionic gonadotrophin exists as a homodimer. Journal of molecular endocrinology. 22, pp. 185-192.
Clinical and endocrinological changes after electro-acupuncture treatment in patients with osteoarthritis of the knee
Ahsin, S., Saleem, S., Bhatti, A., Aslam, M. and Iles, R. 2009. Clinical and endocrinological changes after electro-acupuncture treatment in patients with osteoarthritis of the knee. Pain. 147 (1-3), pp. 60-66. https://doi.org/10.1016/j.pain.2009.08.004
Capillary electrophoresis of human follicular fluid
Wen, S., Perrett, D., Patel, P., Li, N., Docherty, S., Tozer, A. and Iles, R. 2009. Capillary electrophoresis of human follicular fluid. Journal of Chromatography B. 877 (31), pp. 3946-3952. https://doi.org/10.1016/j.jchromb.2009.09.046
The role of glycosylation in regulating glycoprotein hormone free alpha subunit and free beta subunit combination in the extra-embryonic coelomic fluid of early pregnancy
Blithe, D. and Iles, R. 1995. The role of glycosylation in regulating glycoprotein hormone free alpha subunit and free beta subunit combination in the extra-embryonic coelomic fluid of early pregnancy. Endocrinology. 136 (3), pp. 903-910. https://doi.org/10.1210/en.136.3.903
Can biological markers improve the management of breast cancer patients?
Leake, R., Anderson, L., Dowsett, M., Iles, R., Nicholson, R., Robertson, J., Walker, R. and UKCCR Biomarker group 2000. Can biological markers improve the management of breast cancer patients? British journal of cancer. 82 (10), pp. 1625-1626. https://doi.org/10.1054/bjoc.2000.1159
Biological markers: maintaining standards
Leake, R., Anderson, L., Dowsett, M., Iles, R., Nicholson, R., Robertson, J., Walker, R. and UKCCCR Biomarker group 2000. Biological markers: maintaining standards. British journal of cancer. 82 (10), pp. 1627-1628. https://doi.org/10.1054/bjoc.2000.1158
Determination of the glycoforms of human chorionic gonadotropin b-core fragment by matrix-assisted laser desoption/ionisation time of flight mass spectrometry
Jacoby, E., Kicman, A., Laidler, P. and Iles, R. 2000. Determination of the glycoforms of human chorionic gonadotropin b-core fragment by matrix-assisted laser desoption/ionisation time of flight mass spectrometry. Clinical Chemistry. 46 (11), pp. 1796-1803.
Regulation of endometrial cancer cell growth by luteinising hormone (LH) and follicle stimulating hormone (FSH)
Davies, S., Bax, C., Chatzaki, E., Chard, T. and Iles, R. 2000. Regulation of endometrial cancer cell growth by luteinising hormone (LH) and follicle stimulating hormone (FSH). British journal of cancer. 83 (12), pp. 1730-1734. https://doi.org/10.1054/bjoc.2000.1507
The increase in bladder carcinoma cell population induced by the free beta subunit of human chorionic gonadotrophin is a result of an anti-apoptotic effect and not cell proliferation
Butler, S., Ikram, M., Mathieu, S. and Iles, R. 2000. The increase in bladder carcinoma cell population induced by the free beta subunit of human chorionic gonadotrophin is a result of an anti-apoptotic effect and not cell proliferation. British journal of cancer. 82 (9), pp. 1553-1556. https://doi.org/10.1054/bjoc.2000.1177
The analysis of human amniotic fluid using capillary electrophoresis.
Stewart, C., Iles, R. and Perrett, D. 2001. The analysis of human amniotic fluid using capillary electrophoresis. Electrophoresis. 22 (6), pp. 1136-1142. https://doi.org/10.1002/1522-2683()22:6<1136::AID-ELPS1136>3.0.CO;2-A
High concentrations of CA 125 in uterine flushings: influence of cause of infertility and menstrual cycle day.
Hamilton, J., Iles, R., Gunn, L., Wilson, C., Lower, A. and Grudzinskas, J. 2002. High concentrations of CA 125 in uterine flushings: influence of cause of infertility and menstrual cycle day. Gynecological endocrinology..
Reduction of bladder cancer cell growth in response to hCGb CTP37 vaccinated mouse serum.
Butler, S., Staite, E. and Iles, R. 2003. Reduction of bladder cancer cell growth in response to hCGb CTP37 vaccinated mouse serum. Oncology research. 14 (2), pp. 93-100.
Identification of post-translational modifications resulting from LH beta polymorphisms by matrix-assisted laser desorption time-of-flight mass spectrometric analysis of pituitary LH beta core fragment
Jacoby, E., Kicman, A. and Iles, R. 2003. Identification of post-translational modifications resulting from LH beta polymorphisms by matrix-assisted laser desorption time-of-flight mass spectrometric analysis of pituitary LH beta core fragment. Journal of molecular endocrinology. 30 (2), pp. 239-252. https://doi.org/10.1677/jme.0.0300239
The recently identified homodimeric beta-beta subunit of human chorionic gonadotrophin (hCGbb) is no more biologically active than the free beta subunit (hCGb)
Butler, S. and Iles, R. 2004. The recently identified homodimeric beta-beta subunit of human chorionic gonadotrophin (hCGbb) is no more biologically active than the free beta subunit (hCGb). Tumor Biology. 25 (1-2), pp. 18-23. https://doi.org/10.1159/000077719
Serum amino-terminal propeptide of type 1 procollagen (P1NP) in prostate cancer: a potential predictor of bone metastases and prognosticator for disease progression and survival.
Thurairaja, R., Iles, R., Jefferson, K., McFarlane, J. and Persad, R. 2006. Serum amino-terminal propeptide of type 1 procollagen (P1NP) in prostate cancer: a potential predictor of bone metastases and prognosticator for disease progression and survival. Urologia internationalis. 76 (1), pp. 67-71.
Immunoassay detection of human chorionic gonadotrophin beta (hCGb) expression by prostate cancer is of no clinical significance
Otite, U., Baithun, S., Chinegwundon, F., Nargund, V. and Iles, R. 2006. Immunoassay detection of human chorionic gonadotrophin beta (hCGb) expression by prostate cancer is of no clinical significance. Tumor Biology. 27, pp. 181-186.
Gonadotropins and prostate cancer: revisited.
Thwaini, A., Naase, M., Chinegwundon, F., Baithun, S., Ghali, L., Shergill, I. and Iles, R. 2006. Gonadotropins and prostate cancer: revisited. Urologia internationalis. 77 (4), pp. 289-296. https://doi.org/10.1159/000096330
Ectopic hCGbeta expression by epithelial cancer: malignant behaviour, metastasis and inhibition of tumor cell apoptosis
Iles, R. 2007. Ectopic hCGbeta expression by epithelial cancer: malignant behaviour, metastasis and inhibition of tumor cell apoptosis. Molecular and Cellular Endocrinology. 260-26, pp. 264-270. https://doi.org/10.1016/j.mce.2006.02.019
An introduction to mass spectrometry based proteomics-detection and characterization of gonadotropins and related molecules
Kicman, A., Parkin, M. and Iles, R. 2007. An introduction to mass spectrometry based proteomics-detection and characterization of gonadotropins and related molecules. Molecular and Cellular Endocrinology. 260-26, pp. 212-227. https://doi.org/10.1016/j.mce.2006.02.022
Towards the development of an electrochemical biosensor for hCGβ detection
Kassanos, P., Iles, R., Bayford, R. and Demosthenous, A. 2008. Towards the development of an electrochemical biosensor for hCGβ detection. Physiological Measurement. 29 (6), pp. S241-S254. https://doi.org/10.1088/0967-3334/29/6/S21
The role of glycoprotein hormones in endometrial cancer. (in Part 7: Hormones & hormone receptor)
Bax, C., Davies, S., Chatzaki, E., Butler, S. and Iles, R. 2003. The role of glycoprotein hormones in endometrial cancer. (in Part 7: Hormones & hormone receptor). in: Nishida, M. and Kuramoto, H. (ed.) Cell and molecular biology of endometrial carcinoma. London Springer. pp. 195-206
Molecular cell biology and genetic disorders
Iles, R. 2009. Molecular cell biology and genetic disorders. in: Kumar, P. and Clark, M. (ed.) Kumar & Clark’s clinical medicine. Edinburgh Elsevier Saunders. pp. 19-52
Chapter 1: Basic sciences: the cell.
Iles, R. 2008. Chapter 1: Basic sciences: the cell. in: Nargund, V., Raghavan, D. and Sandler, H. (ed.) Urological oncology. London Springer. pp. 3-36
Human chorionic gonadotropin isoforms in the diagnosis of ectopic pregnancy
Iles, R., Borrelli, P., Butler, S. and Staite, E. 2003. Human chorionic gonadotropin isoforms in the diagnosis of ectopic pregnancy. Clinical Chemistry. 49 (12), pp. 2045-2049. https://doi.org/10.1373/clinchem.2003.022095
The free monomeric beta subunit of human chorionic gonadotrophin (hCG beta) and the recently identified homodimeric beta-beta subunit (hCG beta beta) both have autocrine growth effects
Butler, S. and Iles, R. 2004. The free monomeric beta subunit of human chorionic gonadotrophin (hCG beta) and the recently identified homodimeric beta-beta subunit (hCG beta beta) both have autocrine growth effects. Tumor Biology. 25 (1-2), pp. 18-23. https://doi.org/10.1159/000077719
Enhanced affinity capture MALDI-TOF MS: orientation of an immunoglobulin G using recombinant protein G
Iles, R., Bansal, S., Jacoby, E., Neubert, H., Cowan, D. and Kicman, A. 2002. Enhanced affinity capture MALDI-TOF MS: orientation of an immunoglobulin G using recombinant protein G. Analytical Chemistry. 74 (15), pp. 3677-3683. https://doi.org/10.1021/ac025558z
Identification of placental transforming growth factor-beta and bikunin metabolites as contaminants of pharmaceutical human chorionic gonadotrophin preparations by proteomic techniques
Iles, R., Kicman, A., Malatos, S. and Neubert, H. 2005. Identification of placental transforming growth factor-beta and bikunin metabolites as contaminants of pharmaceutical human chorionic gonadotrophin preparations by proteomic techniques. Molecular and Cellular Proteomics. 4 (7), pp. 984-992. https://doi.org/10.1074/mcp.M500085-MCP200
Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection?
Iles, R. and Butler, S. 2003. Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection? Clinical Cancer Research. 9 (13), pp. 4666-4673.
Human granulosa-lutein cell in vitro production of progesterone, inhibin A, inhibin B, and activin A are dependent on follicular size and not the presence of the oocyte
Wen, S., Tozer, A., Li, D., Docherty, S., Al-Shawaf, T. and Iles, R. 2008. Human granulosa-lutein cell in vitro production of progesterone, inhibin A, inhibin B, and activin A are dependent on follicular size and not the presence of the oocyte. Fertility and Sterility. 89 (5), pp. 1406-1413. https://doi.org/10.1016/j.fertnstert.2007.03.086
Follicular fluid levels of inhibin A, inhibin B, and activin A levels reflect changes in follicle size but are not independent markers of the oocyte's ability to fertilize
Wen, S., Tozer, A., Butler, S., Bell, C., Docherty, S. and Iles, R. 2006. Follicular fluid levels of inhibin A, inhibin B, and activin A levels reflect changes in follicle size but are not independent markers of the oocyte's ability to fertilize. Fertility and Sterility. 85 (6), pp. 1723-1729. https://doi.org/10.1016/j.fertnstert.2005.11.058
The effects of 'coasting' on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome
Tozer, A., Iles, R., Iammarrone, E., Gillott, C., Al-Shawaf, T. and Grudzinskas, J. 2004. The effects of 'coasting' on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome. Human Reproduction. 19 (3), pp. 522-528. https://doi.org/10.1093/humrep/deh096
Characteristics of populations of granulosa cells from individual follicles in women undergoing 'coasting' during controlled ovarian stimulation (COS) for IVF
Tozer, A., Iles, R., Iammarrone, E., Gillott, C., Wen, S., Al-Shawaf, T. and Grudzinskas, J. 2004. Characteristics of populations of granulosa cells from individual follicles in women undergoing 'coasting' during controlled ovarian stimulation (COS) for IVF. Human Reproduction. 19 (11), pp. 2561-2568. https://doi.org/10.1093/humrep/deh487