Substantial urinary concentrations of material resembling beta-core fragment of chorionic gonadotropin beta-subunit in mid-menstrual cycle

Article


Neven, P., Iles, R., Howes, I., Sharma, K., Shepherd, J., Edwards, R., Collins, W. and Chard, T. 1993. Substantial urinary concentrations of material resembling beta-core fragment of chorionic gonadotropin beta-subunit in mid-menstrual cycle. Clinical Chemistry. 39 (9), pp. 1857-1860.
TypeArticle
TitleSubstantial urinary concentrations of material resembling beta-core fragment of chorionic gonadotropin beta-subunit in mid-menstrual cycle
AuthorsNeven, P., Iles, R., Howes, I., Sharma, K., Shepherd, J., Edwards, R., Collins, W. and Chard, T.
Abstract

We measured the day-to-day variations in concentrations of beta-core, luteinizing hormone (LH), and alpha-subunit in urine during the menstrual cycle. The alpha-subunit concentrations showed a pattern similar to that of the LH concentrations. beta-Core-like material was increased during and up to 3 to 4 days after the surge in urine LH. The urine LH concentration was associated with the presence of beta-core immunoreactivity during the urine LH peak. Chromatography showed that, at the peak LH concentration and at 2 days after the LH peak, beta-core immunoreactivity could be accounted for by the presence of a peptide of low molecular mass similar to the beta-core molecule of hCG, but probably originating from the degradation of LH. The prolonged excretion of gonadotropin metabolites in the midcycle must be considered when beta-core is being assessed as a tumor marker.

LanguageEnglish
PublisherAmerican Association for Clinical Chemistry, Inc.
JournalClinical Chemistry
ISSN0009-9147
Publication dates
PrintSep 1993
Publication process dates
Deposited02 Nov 2009
Output statusPublished
Web address (URL)http://www.clinchem.org/cgi/content/abstract/39/9/1857
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