Designing a new generation of anti-hCG vaccines for cancer therapy
Article
Delves, P., Iles, R., Roitt, I. and Lund, T. 2007. Designing a new generation of anti-hCG vaccines for cancer therapy. Molecular and Cellular Endocrinology. 260-26, pp. 276-281. https://doi.org/10.1016/j.mce.2006.02.018
Type | Article |
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Title | Designing a new generation of anti-hCG vaccines for cancer therapy |
Authors | Delves, P., Iles, R., Roitt, I. and Lund, T. |
Abstract | The heterodimeric ‘pregnancy-specific’ hormone human chorionic gonadotropin (hCG) has been used as the basis for a contraceptive vaccine. More recently, the observation that hCG, particularly in the form of the β-chain expressed in the absence of α-chain, is aberrantly expressed in a number of different tumors has opened up a second potential application for such vaccines. Drawbacks of the currently available vaccines are that they are either relatively weakly immunogenic or that they induce antibodies that cross-react with human leuteinizing hormone (hLH). We have explored the possibility of creating mutated versions of the hCG β-chain with improved immunologic properties. |
Research Group | Biomarkers for Cancer group |
Publisher | Elsevier |
Journal | Molecular and Cellular Endocrinology |
ISSN | 0303-7207 |
Publication dates | |
02 Jan 2007 | |
Publication process dates | |
Deposited | 12 Feb 2010 |
Output status | Published |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.mce.2006.02.018 |
Language | English |
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