Designing a new generation of anti-hCG vaccines for cancer therapy

Article

Delves, P., Iles, R., Roitt, I. and Lund, T. 2007. Designing a new generation of anti-hCG vaccines for cancer therapy. Molecular and Cellular Endocrinology. 260-26, pp. 276-281. https://doi.org/10.1016/j.mce.2006.02.018
TypeArticle
TitleDesigning a new generation of anti-hCG vaccines for cancer therapy
AuthorsDelves, P., Iles, R., Roitt, I. and Lund, T.
Abstract

The heterodimeric ‘pregnancy-specific’ hormone human chorionic gonadotropin (hCG) has been used as the basis for a contraceptive vaccine. More recently, the observation that hCG, particularly in the form of the β-chain expressed in the absence of α-chain, is aberrantly expressed in a number of different tumors has opened up a second potential application for such vaccines. Drawbacks of the currently available vaccines are that they are either relatively weakly immunogenic or that they induce antibodies that cross-react with human leuteinizing hormone (hLH). We have explored the possibility of creating mutated versions of the hCG β-chain with improved immunologic properties.

Research GroupBiomarkers for Cancer group
PublisherElsevier
JournalMolecular and Cellular Endocrinology
ISSN0303-7207
Publication dates
Print02 Jan 2007
Publication process dates
Deposited12 Feb 2010
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1016/j.mce.2006.02.018
LanguageEnglish
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