Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression

Article


Simoes, R., De-Brito, N., Cunha-Costa, H., Morandi, V., Fierro, I., Roitt, I. and Barja-Fidalgo, C. 2017. Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression. International Journal of Cancer. 140 (2), pp. 346-357. https://doi.org/10.1002/ijc.30424
TypeArticle
TitleLipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression
AuthorsSimoes, R., De-Brito, N., Cunha-Costa, H., Morandi, V., Fierro, I., Roitt, I. and Barja-Fidalgo, C.
Abstract

In tumor microenvironments, the macrophage population is heterogeneous, but some macrophages can acquire tumor-promoting characteristics. These tumor-associated macrophages (TAM) exhibit an M2-like profile, with deficient production of NO and ROS, characteristics of pro-inflammatory M1 cytotoxic macrophages. The results show an unexpected effect of lipoxin, which induces in TAM a change from an M2- to an M1-like profile, thereby triggering tumor cell apoptosis and down-modulating the tumor progression.

Research GroupBiomarkers for Cancer group
LanguageEnglish
PublisherWiley
JournalInternational Journal of Cancer
ISSN0020-7136
Electronic1097-0215
Publication dates
Online31 Oct 2016
Print15 Jan 2017
Publication process dates
Deposited04 May 2017
Accepted30 Aug 2016
Output statusPublished
Accepted author manuscript
Copyright Statement

This is the peer reviewed version of the following article: Simões, R. L., De-Brito, N. M., Cunha-Costa, H., Morandi, V., Fierro, I. M., Roitt, I. M. and Barja-Fidalgo, C. (2017), Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression. Int. J. Cancer, 140: 346–357. doi:10.1002/ijc.30424, which has been published in final form at http://dx.doi.org/10.1002/ijc.30424. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

Digital Object Identifier (DOI)https://doi.org/10.1002/ijc.30424
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