Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression
Article
Simoes, R., De-Brito, N., Cunha-Costa, H., Morandi, V., Fierro, I., Roitt, I. and Barja-Fidalgo, C. 2017. Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression. International Journal of Cancer. 140 (2), pp. 346-357. https://doi.org/10.1002/ijc.30424
Type | Article |
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Title | Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression |
Authors | Simoes, R., De-Brito, N., Cunha-Costa, H., Morandi, V., Fierro, I., Roitt, I. and Barja-Fidalgo, C. |
Abstract | In tumor microenvironments, the macrophage population is heterogeneous, but some macrophages can acquire tumor-promoting characteristics. These tumor-associated macrophages (TAM) exhibit an M2-like profile, with deficient production of NO and ROS, characteristics of pro-inflammatory M1 cytotoxic macrophages. The results show an unexpected effect of lipoxin, which induces in TAM a change from an M2- to an M1-like profile, thereby triggering tumor cell apoptosis and down-modulating the tumor progression. |
Research Group | Biomarkers for Cancer group |
Publisher | Wiley |
Journal | International Journal of Cancer |
ISSN | 0020-7136 |
Electronic | 1097-0215 |
Publication dates | |
Online | 31 Oct 2016 |
15 Jan 2017 | |
Publication process dates | |
Deposited | 04 May 2017 |
Accepted | 30 Aug 2016 |
Output status | Published |
Accepted author manuscript | |
Copyright Statement | This is the peer reviewed version of the following article: Simões, R. L., De-Brito, N. M., Cunha-Costa, H., Morandi, V., Fierro, I. M., Roitt, I. M. and Barja-Fidalgo, C. (2017), Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression. Int. J. Cancer, 140: 346–357. doi:10.1002/ijc.30424, which has been published in final form at http://dx.doi.org/10.1002/ijc.30424. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Digital Object Identifier (DOI) | https://doi.org/10.1002/ijc.30424 |
Language | English |
https://repository.mdx.ac.uk/item/86yy3
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