Delves, P.; Roitt, I.

The immune system: first of two parts

Article

Delves, P. and Roitt, I. 2000. The immune system: first of two parts. New England Journal of Medicine. 343 (1), pp. 37-49.

Publication dates
Type	Article
Title	The immune system: first of two parts
Authors	Delves, P. and Roitt, I.
Abstract	The immune system is an organization of cells and molecules with specialized roles in defending against infection. There are two fundamentally different types of responses to invading microbes. Innate (natural) responses occur to the same extent however many times the infectious agent is encountered, whereas acquired (adaptive) responses improve on repeated exposure to a given infection. The innate responses use phagocytic cells (neutrophils, monocytes, and macrophages), cells that release inflammatory mediators (basophils, mast cells, and eosinophils), and natural killer cells. The molecular components of innate responses include complement, acute-phase proteins, and cytokines such as the interferons.
Research Group	Biomarkers for Cancer group
Publisher	Massachusetts Medical Society
Journal	New England Journal of Medicine
ISSN	0028-4793
Print	06 Jul 2000
Publication process dates
Deposited	18 Jun 2009
Output status	Published
Additional information	PubMed PMID: 10882768.
Language	English

Permalink -

https://repository.mdx.ac.uk/item/81qz4

Log in to edit

75
total views
0
total downloads
7
views this month
0
downloads this month

Export as

Related outputs

Locating functionalized gold nanoparticles using electrical impedance tomography

Bayford, R., Damaso, R., Neshatvar, N., Ivanenko, Y., Rademacher, T., Wu, Y., Seifnaraghi, N., Ghali, L., Patel, N., Roitt, I., Nordebo, S. and Demosthenous, A. 2022. Locating functionalized gold nanoparticles using electrical impedance tomography. IEEE Transactions on Biomedical Engineering. 69 (1), pp. 494-502. https://doi.org/10.1109/TBME.2021.3100256

Exploiting the efficacy of Tyro3 and folate receptors to enhance the delivery of gold nanoparticles into colorectal cancer cells in vitro

Patel, N., Ghali, L., Roitt, I., Pantoja Munoz, L. and Bayford, R. 2021. Exploiting the efficacy of Tyro3 and folate receptors to enhance the delivery of gold nanoparticles into colorectal cancer cells in vitro. Nanoscale Advances. 3 (18), pp. 5373-5386. https://doi.org/10.1039/d1na00318f

Investigation of factors influencing the immunogenicity of hCG as a potential cancer vaccine

Kvirkvelia, N., Chikadze, N., Makinde, J., McBride, J., Porakishvili, N., Hills, F., Martensen, P., Justesen, J., Delves, P., Lund, T. and Roitt, I. 2018. Investigation of factors influencing the immunogenicity of hCG as a potential cancer vaccine. Clinical & Experimental Immunology. 193 (1), pp. 73-83. https://doi.org/10.1111/cei.13131

Nanoparticle electrical impedance tomography

Bayford, R., Nordebo, S., Roitt, I., Rademacher, T., Damaso, R., Wu, Y., Seifnaraghi, N. and Demosthenous, A. 2017. Nanoparticle electrical impedance tomography. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography. Hanover, New Hampshire, USA 21 - 24 Jun 2017 Thayer School of Engineering at Dartmouth. pp. 56-56 https://doi.org/10.5281/zenodo.557093

Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro

Gromnicova, R., Davies, H., Sreekanthreddy, P., Romero, I., Lund, T., Roitt, I., Phillips, J. and Male, D. 2013. Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro. PLoS ONE. 8 (12), pp. 1-10. https://doi.org/10.1371/journal.pone.0081043

Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression

Simoes, R., De-Brito, N., Cunha-Costa, H., Morandi, V., Fierro, I., Roitt, I. and Barja-Fidalgo, C. 2017. Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression. International Journal of Cancer. 140 (2), pp. 346-357. https://doi.org/10.1002/ijc.30424

Emerging applications of nanotechnology for diagnosis and therapy of disease: a review

Bayford, R., Rademacher, T., Roitt, I. and Wang, S. 2017. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review. Physiological Measurement. 38 (8). https://doi.org/10.1088/1361-6579/aa7182

Detection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor

Wang, S., Acha, D., Shah, A., Hills, F., Roitt, I., Demosthenous, A. and Bayford, R. 2017. Detection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor. Biosensors and Bioelectronics. 92, pp. 482-488. https://doi.org/10.1016/j.bios.2016.10.077

Inhibition of HIV virus by neutralizing Vhh attached to dual functional liposomes encapsulating dapivirine

Wang, S., Michiels, J., Ariën, K., New, R., Vanham, G. and Roitt, I. 2016. Inhibition of HIV virus by neutralizing Vhh attached to dual functional liposomes encapsulating dapivirine. Nanoscale Research Letters. 11 (1), pp. 1-10. https://doi.org/10.1186/s11671-016-1558-7

Comparison of the calibration standards of three commercially available multiplex kits for human cytokine measurement to WHO standards reveals striking differences

Nechansky, A., Grunt, S., Roitt, I. and Kircheis, R. 2008. Comparison of the calibration standards of three commercially available multiplex kits for human cytokine measurement to WHO standards reveals striking differences. Biomarker Insights. 3, pp. 227-235.

The influence of ligand organization on the rate of uptake of gold nanoparticles by colorectal cancer cells

Lund, T., Callaghan, M., Williams, P., Turmaine, M., Bachmann, C., Rademacher, T., Roitt, I. and Bayford, R. 2011. The influence of ligand organization on the rate of uptake of gold nanoparticles by colorectal cancer cells. Biomaterials. 32 (36), pp. 9776-9784. https://doi.org/10.1016/j.biomaterials.2011.09.018

Screening autoantibody profiles in systemic rheumatic disease with a diagnostic protein microarray that uses a filtration-assisted nanodot array luminometric immunoassay (NALIA)

McBride, J., Gabriel, F., Fordham, J., Kolind, T., Barcenas-Morales, G., Isenberg, D., Swana, M., Delves, P., Lund, T., Cree, I. and Roitt, I. 2008. Screening autoantibody profiles in systemic rheumatic disease with a diagnostic protein microarray that uses a filtration-assisted nanodot array luminometric immunoassay (NALIA). Clinical Chemistry. 54 (5), pp. 883-890. https://doi.org/10.1373/clinchem.2007.098418

Detection of cancer.

Bayford, R., Roitt, I., Rademacher, T., Demosthenous, A. and Iles, R. 2010. Detection of cancer.

A human domain antibody and Lewisb glycoconjugate that inhibit binding of helicobacter pylori to Lewisb receptor and adhesion to human gastric epithelium

Younson, J., O'Mahony, R., Liu, H., Grant, S., Campion, C., Jennings, L., Vaira, D., Kelly, C., Roitt, I. and Holton, J. 2009. A human domain antibody and Lewisb glycoconjugate that inhibit binding of helicobacter pylori to Lewisb receptor and adhesion to human gastric epithelium. Journal of Infectious Diseases. 200 (10), pp. 1574-1582. https://doi.org/10.1086/644596

Designing a new generation of anti-hCG vaccines for cancer therapy

Delves, P., Iles, R., Roitt, I. and Lund, T. 2007. Designing a new generation of anti-hCG vaccines for cancer therapy. Molecular and Cellular Endocrinology. 260-26, pp. 276-281. https://doi.org/10.1016/j.mce.2006.02.018

Refocusing of B-cell responses following a single amino acid substitution in an antigen.

Dalla Chiesa, M., Martensen, P., Simmons, C., Porakishvili, N., Justesen, J., Dougan, G., Roitt, I., Delves, P. and Lund, T. 2001. Refocusing of B-cell responses following a single amino acid substitution in an antigen. Immunology. 103 (2), pp. 172-178. https://doi.org/10.1046/j.1365-2567.2001.01242.x

Tumour burden and Interleukin-2 (IL-2) dose affect the interaction between low-dose total body irradiation and Interleukin-2.

Safwat, A., Aggerholm, N., Roitt, I., Overgaard, J. and Hoklund, M. 2004. Tumour burden and Interleukin-2 (IL-2) dose affect the interaction between low-dose total body irradiation and Interleukin-2. European Journal of Cancer. 40 (9), pp. 1412-1417. https://doi.org/10.1016/j.ejca.2004.01.037

Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells.

Kvirkvelia, N., Vojnovic, I., Warner, T., Athie-Morales, V., Free, P., Rayment, N., Chain, B., Rademacher, T., Lund, T., Roitt, I. and Delves, P. 2002. Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells. Clinical & Experimental Immunology. 127 (2), pp. 263-269. https://doi.org/10.1046/j.1365-2249.2002.01718.x

Low dose total body irradiation augments the therapeutic effect of interleukin-2 in a mouse model for metastatic malignant melanoma.

Safwat, A., Aggerholm, N., Roitt, I., Overgaard, J. and Hoklund, M. 2003. Low dose total body irradiation augments the therapeutic effect of interleukin-2 in a mouse model for metastatic malignant melanoma. Journal of experimental therapeutics & oncology. 3 (4), pp. 161-168. https://doi.org/10.1046/j.1359-4117.2003.01093.x

Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis.

De Bernardis, F., Liu, H., O'Mahony, R., La Valle, R., Bartollino, S., Sandini, S., Grant, S., Brewis, N., Tomlinson, I., Basset, R., Holton, J., Roitt, I. and Cassone, A. 2007. Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis. Journal of Infectious Diseases. 195 (1), pp. 149-157. https://doi.org/10.1086/509891

Comparison of image analysis software packages in the assessment of adhesion of microorganisms to mucosal epithelium using confocal laser scanning microscopy.

O'Mahony, R., Basset, C., Holton, J., Vaira, D. and Roitt, I. 2005. Comparison of image analysis software packages in the assessment of adhesion of microorganisms to mucosal epithelium using confocal laser scanning microscopy. Elsevier. https://doi.org/10.1016/j.mimet.2004.11.020

Changes in the reproductive system of male mice immunized with a GnRH-analogue conjugated to mycobacterial hsp70

Hannesdottir, S., Han, X., Lund, T., Singh, M., Van Der Zee, R., Roitt, I. and Delves, P. 2004. Changes in the reproductive system of male mice immunized with a GnRH-analogue conjugated to mycobacterial hsp70. Reproduction: the official journal of the Society for the Study of Fertility. 128 (3), pp. 365-371. https://doi.org/10.1530/rep.1.00108

Innate immunity and pathogen-host interaction.

Basset, C., Holton, J., O'Mahony, R. and Roitt, I. 2003. Innate immunity and pathogen-host interaction. Vaccine. 21 (Supple), pp. S12-S23. https://doi.org/10.1016/S0264-410X(03)00195-6

Elimination of luteinizing hormone cross-reactive epitopes from human chorionic gonadotropin.

Porakishvili, N., Chiesa, M., Chikadze, N., Martensen, P., Justesen, J., Lund, T., Delves, P. and Roitt, I. 2002. Elimination of luteinizing hormone cross-reactive epitopes from human chorionic gonadotropin. Vaccine. 20 (16), pp. 2053-2059. https://doi.org/10.1016/S0264-410X(02)00051-8

Genes and IgG glycosylation in autoimmune and non-autoimmune strains of mice

Delves, P., Lund, T. and Roitt, I. 2002. Genes and IgG glycosylation in autoimmune and non-autoimmune strains of mice. Trends in Immunology. 23 (4), pp. 213-219. https://doi.org/10.1016/S1471-4906(02)02182-8

The human chorionic gonadotropin-ß arginine68 to glutamic acid substitution fixes the conformation of the C-terminal Peptide

Charrel-Dennis, M., Terrazzini, N., McBride, J., Martensen, P., Justesen, J., Berger, P., Lapthorn, A., Kelly, C., Roitt, I., Delves, P. and Lund, T. 2005. The human chorionic gonadotropin-ß arginine68 to glutamic acid substitution fixes the conformation of the C-terminal Peptide. Molecular Endocrinology. 19 (7), pp. 1803-1811. https://doi.org/10.1210/me.2004-0109

The major hormone-specific epitopes on human chorionic gonadotropin

Charrel-Dennis, M., Jackson, A., Lund, T., Lapthorn, A., Berger, P., Roitt, I. and Delves, P. 2004. The major hormone-specific epitopes on human chorionic gonadotropin. Journal of molecular endocrinology. 32 (2), pp. 571-581.

Immunochemical mapping of gonadotropin

Berger, P., Bidart, J., Delves, P., Dirnhofer, S., Hoermann, R., Isaacs, N., Jackson, A., Klonisch, T., Lapthorn, A., Lund, T., Mann, K., Roitt, I., Schwartz, S. and Wick, G. 1996. Immunochemical mapping of gonadotropin. Molecular and Cellular Endocrinology. 125 (1-2), pp. 33-43. https://doi.org/10.1016/S0303-7207(96)03943-3

A low budget luminometer for sensitive chemiluminescent immunoassays

Porakishvili, N., Fordham, J., Charrel-Dennis, M., Delves, P., Lund, T. and Roitt, I. 2000. A low budget luminometer for sensitive chemiluminescent immunoassays. Journal of Immunological Methods. 234 (1-2), pp. 35-42. https://doi.org/10.1016/S0022-1759(99)00198-2