The major hormone-specific epitopes on human chorionic gonadotropin
Article
Charrel-Dennis, M., Jackson, A., Lund, T., Lapthorn, A., Berger, P., Roitt, I. and Delves, P. 2004. The major hormone-specific epitopes on human chorionic gonadotropin. Journal of molecular endocrinology. 32 (2), pp. 571-581.
Type | Article |
---|---|
Title | The major hormone-specific epitopes on human chorionic gonadotropin |
Authors | Charrel-Dennis, M., Jackson, A., Lund, T., Lapthorn, A., Berger, P., Roitt, I. and Delves, P. |
Abstract | The hormone human chorionic gonadotrophin (hCG) shows extensive sequence homology with LH. Thus, many of the antigenic epitopes on hCG are shared with LH, leading to immunological cross-reaction between these two hormones. Anti-fertility and anti-cancer vaccines based upon hCG should ideally target only the hCG-specific epitopes. The hCG-unique linear epitopes located in the C-terminal peptide of the hCG beta-chain are well characterised. In contrast, the hCG-specific discontinuous epitopes, termed beta1, beta6 and beta7, have remained poorly defined. By generating hCG beta-chain molecules containing single amino acid substitutions we have identified R10, N13, R60 and Q89 as being important in the formation of the beta1 epitope, with R60 providing a particularly dominant residue. We also show that the amino acid residue Q89 contributes to the beta7 epitope, whilst D61 plays a role in both the beta6 and beta7 epitopes. |
Research Group | Biomarkers for Cancer group |
Publisher | Society for Endocrinology |
Journal | Journal of molecular endocrinology |
ISSN | 0952-5041 |
Publication dates | |
Apr 2004 | |
Publication process dates | |
Deposited | 02 Feb 2010 |
Output status | Published |
Web address (URL) | http://jme.endocrinology-journals.org/cgi/reprint/32/2/571 |
Language | English |
https://repository.mdx.ac.uk/item/822v1
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