Detection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor

Article


Wang, S., Acha, D., Shah, A., Hills, F., Roitt, I., Demosthenous, A. and Bayford, R. 2017. Detection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor. Biosensors and Bioelectronics. 92, pp. 482-488. https://doi.org/10.1016/j.bios.2016.10.077
TypeArticle
TitleDetection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor
AuthorsWang, S., Acha, D., Shah, A., Hills, F., Roitt, I., Demosthenous, A. and Bayford, R.
Abstract

This study presents a novel approach based on a four-electrode electrochemical biosensor for the detection of tau protein – one of the possible markers for the prediction of Alzheimer's disease (AD). The biosensor is based on the formation of stable antibody–antigen complexes on gold microband electrodes covered with a layer of a self-assembled monolayer and protein G. Antibodies were immobilized on the gold electrode surface in an optimal orientation by protein G interaction. Electrochemical impedance spectroscopy was used to analyze impedance change, which revealed a linear response with increasing tau concentrations. The assay is fast (<1 h for incubation and measurement) and very sensitive. The limit of quantification for the full-length 2N4R tau protein is 0.03 pM, a value unaltered when the assay was processed in bovine serum albumin or human serum. This technology could be adapted for the detection of other biomarkers to provide a multiple assay to identify AD progression in a point of care setting.

Research GroupBiophysics and Bioengineering group
PublisherElsevier
JournalBiosensors and Bioelectronics
ISSN0956-5663
Publication dates
Online28 Oct 2016
Print15 Jun 2017
Publication process dates
Deposited08 Nov 2016
Accepted25 Oct 2016
Output statusPublished
Accepted author manuscript
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Copyright Statement

© 2016. This author's accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/

Digital Object Identifier (DOI)https://doi.org/10.1016/j.bios.2016.10.077
LanguageEnglish
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Shiraz, A., Khodadad, D., Nordebo, S., Yerworth, R., Frerichs, I., van Kaam, A., Kallio, M., Papadouri, T., Bayford, R. and Demosthenous, A. 2019. Compressive sensing in electrical impedance tomography for breathing monitoring. Physiological Measurement. 40 (3). https://doi.org/10.1088/1361-6579/ab0daa
Whole body cryotherapy, cold water immersion, or a placebo following resistance exercise: a case of mind over matter?
Wilson, L., Dimitriou, L., Hills, F., Gondek, M. and Cockburn, E. 2019. Whole body cryotherapy, cold water immersion, or a placebo following resistance exercise: a case of mind over matter? European Journal of Applied Physiology. 119 (1), pp. 135-147. https://doi.org/10.1007/s00421-018-4008-7
Focus on advances in electrical impedance tomography
Bayford, R. and Halter, R. 2018. Focus on advances in electrical impedance tomography. Physiological Measurement. 39 (9), p. 090301. https://doi.org/10.1088/1361-6579/aad93e
Urate crystals induce macrophage PAF‑AH secretion which is differentially regulated by TGFβ1 and hydrocortisone
Yagnik, D. and Hills, F. 2018. Urate crystals induce macrophage PAF‑AH secretion which is differentially regulated by TGFβ1 and hydrocortisone. Molecular Medicine Reports. 18 (3), pp. 3506-3512. https://doi.org/10.3892/mmr.2018.9323
Torso shape detection to improve lung monitoring
de Gelidi, S., Seifnaraghi, N., Bardill, A., Tizzard, A., Wu, Y., Sorantin, E., Nordebo, S., Demosthenous, A. and Bayford, R. 2018. Torso shape detection to improve lung monitoring. Physiological Measurement. 39 (7). https://doi.org/10.1088/1361-6579/aacc1c
Determination of natural penicillins in fermentation media by high-performance liquid chromatography using pre-column derivatisation with 1-hydroxybenzotriazole
Shah, A., Adlard, M. and Holt, G. 1988. Determination of natural penicillins in fermentation media by high-performance liquid chromatography using pre-column derivatisation with 1-hydroxybenzotriazole. Analyst. 113 (8), pp. 1197-1200. https://doi.org/10.1039/an9881301197
A parametric model for the changes in the complex valued conductivity of a lung during tidal breathing
Nordebo, S., Dalarsson, M., Khodadad, D., Müller, B., Waldmann, A., Becher, T., Frerichs, I., Sophocleous, L., Sjöberg, D., Seifnaraghi, N. and Bayford, R. 2018. A parametric model for the changes in the complex valued conductivity of a lung during tidal breathing. Journal of Physics D: Applied Physics. 51 (20). https://doi.org/10.1088/1361-6463/aabc04
Clinical performance of a novel textile interface for neonatal chest electrical impedance tomography
Sophocleous, L., Frerichs, I., Miedema, M., Kallio, M., Papadouri, T., Karaoli, C., Becher, T., Tingay, D., van Kaam, A., Bayford, R. and Waldmann, A. 2018. Clinical performance of a novel textile interface for neonatal chest electrical impedance tomography. Physiological Measurement. 39 (4). https://doi.org/10.1088/1361-6579/aab513
Apple cider vinegar (ACV®) displays antimicrobial activity directly against Escherichia coli, Staphylococcus aureus and Candida albican proteins and in vitro monocytes exposed to microbes by inhibiting inflammatory cytokine secretion
Yagnik, D., Serafim, V., Choudhury, M. and Shah, A. 2017. Apple cider vinegar (ACV®) displays antimicrobial activity directly against Escherichia coli, Staphylococcus aureus and Candida albican proteins and in vitro monocytes exposed to microbes by inhibiting inflammatory cytokine secretion. International Conference on Infection Control and Clinical Microbiology. Chicago, USA 25 - 26 Sep 2017 SciTechnol. pp. 73 https://doi.org/10.4172/2329-9541-C1-006
A sensitive assay for clavulanic acid and sulbactam in biological fluids by high-performance liquid chromatography and precolumn derivatization
Shah, A., Adlard, M. and Stride, J. 1990. A sensitive assay for clavulanic acid and sulbactam in biological fluids by high-performance liquid chromatography and precolumn derivatization. Journal of Pharmaceutical and Biomedical Analysis. 8 (5), pp. 437-443. https://doi.org/10.1016/0731-7085(90)80072-W
pH regulation of penicillin production in Aspergillus nidulans
Shah, A., Tilburn, J., Adlard, M. and Arst, H. 1991. pH regulation of penicillin production in Aspergillus nidulans. FEMS microbiology letters. 77 (2-3), pp. 209-212. https://doi.org/10.1111/j.1574-6968.1991.tb04349.x
Can you spot the difference? Analysis of human chorionic gonadotropin (hCG) secreted by common non-trophoblastic and trophoblastic cancers
Gondek, M., Hills, F. and Burczynska, B. 2015. Can you spot the difference? Analysis of human chorionic gonadotropin (hCG) secreted by common non-trophoblastic and trophoblastic cancers. Summer Conference. Middlesex University, London, United Kingdom Jun 2015 Middlesex University.
A human-machine interface using electrical impedance tomography for hand prosthesis control
Wu, Yu, Jiang, Dai, Liu, Xiao, Bayford, Richard and Demosthenous, A. 2018. A human-machine interface using electrical impedance tomography for hand prosthesis control. IEEE Transactions on Biomedical Circuits and Systems. 12 (6), pp. 1322-1333. https://doi.org/10.1109/TBCAS.2018.2878395
A high frame rate wearable EIT system using active electrode ASICs for lung respiration and heart rate monitoring
Wu, Y., Jiang, D., Bardill, A., de Gelidi, S., Bayford, R. and Demosthenous, A. 2018. A high frame rate wearable EIT system using active electrode ASICs for lung respiration and heart rate monitoring. IEEE Transactions on Circuits and Systems I: Regular Papers. 65 (11), pp. 3810-3820. https://doi.org/10.1109/TCSI.2018.2858148
Method optimisation for identification of carbohydrate moieties on human chorionic gonadotropin glycoforms using MALDI-TOF-MS
Gondek, M., Burczynska, B. and Hills, F. 2018. Method optimisation for identification of carbohydrate moieties on human chorionic gonadotropin glycoforms using MALDI-TOF-MS. 45th International Society of Oncology and BioMarkers (ISOBM) 2018 Congress. Hamburg, Germany 24 - 27 Nov 2018
Optimized breath detection algorithm in electrical impedance tomography
Khodadad, D., Nordebo, S., Müller, B., Waldmann, A., Yerworth, R., Becher, T., Frerichs, I., Sophocleous, L., van Kaam, A., Miedema, M., Seifnaraghi, N. and Bayford, R. 2018. Optimized breath detection algorithm in electrical impedance tomography. Physiological Measurement. 39 (9). https://doi.org/10.1088/1361-6579/aad7e6
Basic electrical impedance tomography
Bayford, R. 2018. Basic electrical impedance tomography. in: Simini, F. and Bertemes-Filho, P. (ed.) Bioimpedance in Biomedical Applications and Research Cham, Switzerland Springer. pp. 29-44
Investigation of factors influencing the immunogenicity of hCG as a potential cancer vaccine
Kvirkvelia, N., Chikadze, N., Makinde, J., McBride, J., Porakishvili, N., Hills, F., Martensen, P., Justesen, J., Delves, P., Lund, T. and Roitt, I. 2018. Investigation of factors influencing the immunogenicity of hCG as a potential cancer vaccine. Clinical & Experimental Immunology. 193 (1), pp. 73-83. https://doi.org/10.1111/cei.13131
Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression
Yagnik, D., Serafin, V. and Shah, A. 2018. Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression. Scientific Reports. 8 (1). https://doi.org/10.1038/s41598-017-18618-x
Effect of anthropogenic pollution on the fitness of tetracycline sensitive Shigella flexneri in Thames river water
Maruzani, R., Canali, A., Serafim, V., Pantoja Munoz, L., Shah, A., Perito, B. and Marvasi, M. 2018. Effect of anthropogenic pollution on the fitness of tetracycline sensitive Shigella flexneri in Thames river water. Journal of Environmental Chemical Engineering. 6 (1), pp. 19-27. https://doi.org/10.1016/j.jece.2017.11.069
Analysis of procainamide-derivatised heparan sulphate disaccharides in biological samples using hydrophilic interaction liquid chromatography mass spectrometry
Antia, I., Mathew, K., Yagnik, D., Hills, F. and Shah, A. 2018. Analysis of procainamide-derivatised heparan sulphate disaccharides in biological samples using hydrophilic interaction liquid chromatography mass spectrometry. Analytical and Bioanalytical Chemistry. 410 (1), pp. 131-143. https://doi.org/10.1007/s00216-017-0703-1
The effect of milk on recovery from repeat-sprint cycling in female team-sport athletes
Rankin, P., Lawlor, M., Hills, F., Bell, P., Stevenson, E. and Cockburn, E. 2018. The effect of milk on recovery from repeat-sprint cycling in female team-sport athletes. Applied Physiology, Nutrition, and Metabolism. 43 (2), pp. 113-122. https://doi.org/10.1139/apnm-2017-0275
Fitness analysis of tetracycline resistant and sensitive Shigella flexneri in lethal and sub-lethal concentrations of tetracycline in Thames river water microcosms
Maruzani, R., Shah, A., Pantoja Munoz, L. and Marvasi, M. 2017. Fitness analysis of tetracycline resistant and sensitive Shigella flexneri in lethal and sub-lethal concentrations of tetracycline in Thames river water microcosms. University Research Students Summer Conference 2017. London 2017
Evolutionary trends within the genus Acacia based on the accumulation of non-protein amino acids in seeds
Shah, A., Evans, C., Adlard, M. and Arce, M. 1994. Evolutionary trends within the genus Acacia based on the accumulation of non-protein amino acids in seeds. in: Sprent, J. and McKey, D. (ed.) Advances in Legume Systematics, Part 5: The Nitrogen Factor London, UK The Royal Botanic Gardens, Kew.
Recovery following a marathon: a comparison of cold water immersion, whole body cryotherapy and a placebo control
Wilson, L., Cockburn, E., Paice, K., Sinclair, S., Faki, T., Hills, F., Gondek, M., Wood, A. and Dimitriou, L. 2018. Recovery following a marathon: a comparison of cold water immersion, whole body cryotherapy and a placebo control. European Journal of Applied Physiology. 118 (1), pp. 153-163. https://doi.org/10.1007/s00421-017-3757-z
High performance liquid chromatography of non-protein amino acids extracted from Acacia seeds
Shah, A., Younie, D., Adlard, M. and Evans, C. 1992. High performance liquid chromatography of non-protein amino acids extracted from Acacia seeds. Phytochemical Analysis. 3 (1), pp. 20-25. https://doi.org/10.1002/pca.2800030104
Non-protein amino acids in seeds of neotropical species of acacia
Evans, C., Shah, A., Adlard, M. and Arce, M. 1992. Non-protein amino acids in seeds of neotropical species of acacia. Phytochemistry. 32 (1), pp. 123-126. https://doi.org/10.1016/0031-9422(92)80116-V
Development of colorimetric method for the detection of amines bound to solid support
Shah, A., de Biasi, V., Camilleri, P. and Rahman, S. 1997. Development of colorimetric method for the detection of amines bound to solid support. Analytical Communications. 34 (11), pp. 325-328. https://doi.org/10.1039/A705630C
Development of a spectrophotometric method for the measurement of thiols at trace levels
Shah, A., de Biasi, V. and Camilleri, P. 1995. Development of a spectrophotometric method for the measurement of thiols at trace levels. Analytical Proceedings including Analytical Communications. 32 (4), pp. 149-153. https://doi.org/10.1039/AI9953200149
Capillary electrophoresis in the pharmaceutical industry: applications in discovery and chemical development
Hadley, M., Gilges, M., Senior, J., Shah, A. and Camilleri, P. 2000. Capillary electrophoresis in the pharmaceutical industry: applications in discovery and chemical development. Journal of Chromatography B: Biomedical Sciences and Applications. 745 (1), pp. 177-188. https://doi.org/10.1016/S0378-4347(00)00153-5
Development of a protocol for the automated analysis of amino acids in brain tissue samples and microdialysates
Shah, A., de Biasi, V., Taylor, S., Roberts, C., Hemmati, P., Munton, R., West, A., Routledge, C. and Camilleri, P. 1999. Development of a protocol for the automated analysis of amino acids in brain tissue samples and microdialysates. Journal of Chromatography B: Biomedical Sciences and Applications. 735 (2), pp. 133-140. https://doi.org/10.1016/S0378-4347(99)00403-X
Orexin A activates locus coeruleus cell firing and increases arousal in the rat
Hagan, J., Leslie, R., Patel, S., Evans, M., Wattam, T., Holmes, S., Benham, C., Taylor, S., Routledge, C., Hemmati, P., Munton, R., Ashmeade, T., Shah, A., Hatcher, J., Hatcher, P., Jones, D., Smith, M., Piper, D., Hunter, A., Porter, R. and Upton, N. 1999. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proceedings of the National Academy of Sciences. 96 (19), pp. 10911-10916. https://doi.org/10.1073/pnas.96.19.10911
Amino acid neurotransmitters: separation approaches and diagnostic value
Shah, A., Crespi, F. and Heidbreder, C. 2002. Amino acid neurotransmitters: separation approaches and diagnostic value. Journal of Chromatography B. 781 (1-2), pp. 151-163. https://doi.org/10.1016/S1570-0232(02)00621-9
High-performance liquid chromatography/tandem mass spectrometry assay for the determination of 1-methyl-4-phenyl pyridinium (MPP+) in brain tissue homogenates
Hows, M., Ashmeade, T., Billinton, A., Perren, M., Austin, A., Virley, D., Organ, A. and Shah, A. 2004. High-performance liquid chromatography/tandem mass spectrometry assay for the determination of 1-methyl-4-phenyl pyridinium (MPP+) in brain tissue homogenates. Journal of Neuroscience Methods. 137 (2), pp. 221-226. https://doi.org/10.1016/j.jneumeth.2004.02.011
High-performance liquid chromatography/tandem mass spectrometric assay for the simultaneous measurement of dopamine, norepinephrine, 5-hydroxytryptamine and cocaine in biological samples
Hows, M., Lacroix, L., Heidbreder, C., Organ, A. and Shah, A. 2004. High-performance liquid chromatography/tandem mass spectrometric assay for the simultaneous measurement of dopamine, norepinephrine, 5-hydroxytryptamine and cocaine in biological samples. Journal of Neuroscience Methods. 138 (1-2), pp. 123-132. https://doi.org/10.1016/j.jneumeth.2004.03.021
Rapid high-throughput assay for the measurement of amino acids from microdialysates and brain tissue using monolithic C18-bonded reversed-phase columns
Dawson, L., Organ, A., Winter, P., Lacroix, L., Shilliam, C., Heidbreder, C. and Shah, A. 2004. Rapid high-throughput assay for the measurement of amino acids from microdialysates and brain tissue using monolithic C18-bonded reversed-phase columns. Journal of Chromatography B. 807 (2), pp. 235-241. https://doi.org/10.1016/j.jchromb.2004.04.012
Selective antagonism at dopamine D3 receptors enhances monoaminergic and cholinergic neurotransmission in the rat anterior cingulate cortex
Lacroix, L., Hows, M., Shah, A., Hagan, J. and Heidbreder, C. 2003. Selective antagonism at dopamine D3 receptors enhances monoaminergic and cholinergic neurotransmission in the rat anterior cingulate cortex. Neuropsychopharmacology. 28, pp. 839-849. https://doi.org/10.1038/sj.npp.1300114
High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates
Hows, M., Organ, A., Murray, S., Dawson, L., Foxton, R., Heidbreder, C., Hughes, Z., Lacroix, L. and Shah, A. 2002. High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates. Journal of Neuroscience Methods. 121 (1), pp. 33-39. https://doi.org/10.1016/S0165-0270(02)00228-5
Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation
Heidbreder, C., Foxton, R., Cilia, J., Hughes, Z., Shah, A., Atkins, A., Hunter, J., Hagan, J. and Jones, D. 2001. Increased responsiveness of dopamine to atypical, but not typical antipsychotics in the medial prefrontal cortex of rats reared in isolation. Psychopharmacology. 156 (2-3), pp. 338-351. https://doi.org/10.1007/s002130100760
Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries
Tolson, D., Organ, A. and Shah, A. 2001. Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries. Rapid Communications in Mass Spectrometry. 15 (14), pp. 1244-1249. https://doi.org/10.1002/rcm.359
The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines
Senior, J., Shah, A., Monteux, C. and de Biasi, V. 2001. The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines. Journal of Pharmaceutical and Biomedical Analysis. 24 (5-6), pp. 843-848. https://doi.org/10.1016/S0731-7085(00)00551-3
Development and application of a sensitive high performance ion-exchange chromatography method for the simultaneous measurement of dopamine, 5-hydroxytryptamine and norepinephrine in microdialysates from the rat brain
Heidbreder, C., Lacroix, L., Atkins, A., Organ, A., Murray, S., West, A. and Shah, A. 2001. Development and application of a sensitive high performance ion-exchange chromatography method for the simultaneous measurement of dopamine, 5-hydroxytryptamine and norepinephrine in microdialysates from the rat brain. Journal of Neuroscience Methods. 112 (2), pp. 135-144. https://doi.org/10.1016/S0165-0270(01)00460-5
Determination of β-lactams and their biosynthetic intermediates in fermentation media by pre-column derivatisation followed by fluorescence detection
Shah, A. and Adlard, M. 1988. Determination of β-lactams and their biosynthetic intermediates in fermentation media by pre-column derivatisation followed by fluorescence detection. Journal of Chromatography B: Biomedical Sciences and Applications. 424, pp. 325-336. https://doi.org/10.1016/S0378-4347(00)81109-3
Evaluation of expression and function of the H+/myo-inositol transporter HMIT;
Di Daniel, E., Mok, S., Mead, E., Mutinelli, C., Zambello, E., Caberlotto, L., Pell, T., Langmead, C., Shah, A., Duddy, G., Kew, J. and Maycox, P. 2009. Evaluation of expression and function of the H+/myo-inositol transporter HMIT; BMC Cell Biology. 10. https://doi.org/10.1186/1471-2121-10-54
Breath detection using short-time Fourier transform analysis in electrical impedance tomography
Khodadad, D., Nordebo, S., Seifnaraghi, N., Waldmann, A., Müller, B. and Bayford, R. 2017. Breath detection using short-time Fourier transform analysis in electrical impedance tomography. 2017 XXXIInd General Assembly and Scientific Symposium of the International Union of Radio Science (URSI GASS). Montreal, QC, Canada 19 - 23 Aug 2017 Institute of Electrical and Electronics Engineers (IEEE). pp. 2185-2187 https://doi.org/10.23919/URSIGASS.2017.8105231
Parameter studies on optimal absorption and electrophoretic resonances in lossy media
Nordebo, S., Dalarsson, M., Ivanenko, Y., Sjöberg, D. and Bayford, R. 2017. Parameter studies on optimal absorption and electrophoretic resonances in lossy media. 2017 XXXIInd General Assembly and Scientific Symposium of the International Union of Radio Science (URSI GASS). Montreal 19 - 23 Aug 2017 Institute of Electrical and Electronics Engineers (IEEE). pp. 1768-1769 https://doi.org/10.23919/URSIGASS.2017.8105294
Toward on-demand deep brain stimulation using online Parkinson’s disease prediction driven by dynamic detection
Mohammed, A., Zamani, M., Bayford, R. and Demosthenous, A. 2017. Toward on-demand deep brain stimulation using online Parkinson’s disease prediction driven by dynamic detection. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 25 (12), pp. 2441-2452. https://doi.org/10.1109/TNSRE.2017.2722986
Estimation of thorax shape for forward modelling in lungs EIT
Seifnaraghi, N., Tizzard, A., de Gelidi, S., Khodadad, D., Nordebo, S., Van Kaam, A., Frerichs, I., Waldmann, A., Sorantin, E., Tschauner, S., Demosthenous, A., Christofides, S. and Bayford, R. 2017. Estimation of thorax shape for forward modelling in lungs EIT. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography. Hanover, New Hampshire, USA 21 - 24 Jun 2017 Thayer School of Engineering at Dartmouth. pp. 58-58 https://doi.org/10.5281/zenodo.557093
DICOM for EIT
Yerworth, R. and Bayford, R. 2017. DICOM for EIT. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography. Hanover, New Hampshire, USA 21 - 24 Jun 2017 Thayer School of Engineering at Dartmouth. pp. 46-46 https://doi.org/10.5281/zenodo.557093
Torso shape detection to improve lung monitoring
de Gelidi, S., Bardill, A., Wu, Y., Demosthenous, A., Tizzard, A. and Bayford, R. 2017. Torso shape detection to improve lung monitoring. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography. Hanover, New Hampshire, USA 21 - 24 Jun 2017 Thayer School of Engineering at Dartmouth. pp. 25-25 https://doi.org/10.5281/zenodo.557093
Rapid generation of subject-specific thorax forward models
Tizzard, A. and Bayford, R. 2017. Rapid generation of subject-specific thorax forward models. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography. Hanover, New Hampshire, USA 21 - 24 Jun 2017 Thayer School of Engineering at Dartmouth. pp. 20-20 https://doi.org/10.5281/zenodo.557093
Nanoparticle electrical impedance tomography
Bayford, R., Nordebo, S., Roitt, I., Rademacher, T., Damaso, R., Wu, Y., Seifnaraghi, N. and Demosthenous, A. 2017. Nanoparticle electrical impedance tomography. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography. Hanover, New Hampshire, USA 21 - 24 Jun 2017 Thayer School of Engineering at Dartmouth. pp. 56-56 https://doi.org/10.5281/zenodo.557093
Absorption and optimal plasmonic resonances for small ellipsoidal particles in lossy media
Dalarsson, M., Nordebo, S., Sjöberg, D. and Bayford, R. 2017. Absorption and optimal plasmonic resonances for small ellipsoidal particles in lossy media. Journal of Physics D: Applied Physics. 50 (34). https://doi.org/10.1088/1361-6463/aa7c8a
Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro
Gromnicova, R., Davies, H., Sreekanthreddy, P., Romero, I., Lund, T., Roitt, I., Phillips, J. and Male, D. 2013. Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro. PLoS ONE. 8 (12), pp. 1-10. https://doi.org/10.1371/journal.pone.0081043
Continuous Regional Analysis Device for Neonates Lung (CRADL)
Bayford, R., Tizzard, A., Frerichs, I., Weiler, N., Karaoli, C., Christofides, S., Yiannakkaras, C., Rimensberger, P., Nordebo, S., Böhm, S., van Kaam, A., Fifield, B., Knox, C., Steuten, L., de Graaf, G., Yerworth, R., Butterworth, M. and Demosthenous, A. 2016. Continuous Regional Analysis Device for Neonates Lung (CRADL). MEDICON 2016: XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. Paphos, Cyprus. 31 Mar - 02 Apr 2016 Springer. pp. 172 https://doi.org/10.1007/978-3-319-32703-7_35
Elucidating the intra-species proteotypes of pseudomonas aeruginosa from cystic fibrosis
Olkun, A., Shah, A. and Shah, H. 2017. Elucidating the intra-species proteotypes of pseudomonas aeruginosa from cystic fibrosis. in: Shah, H. and Gharbia, S. (ed.) MALDI-TOF and Tandem MS for Clinical Microbiology Oxford, UK Wiley. pp. 579-592
Subtyping of Staphylococcus spp. Based upon MALDI-TOF MS data analysis
Xu, Z., Olkun, A., Vranckx, K., Mkrtchyan, H., Shah, A., Pot, B., Cutler, R. and Shah, H. 2017. Subtyping of Staphylococcus spp. Based upon MALDI-TOF MS data analysis. in: Shah, H. and Gharbia, S. (ed.) MALDI-TOF and Tandem MS for Clinical Microbiology Oxford, UK Wiley. pp. 563-578
Determination of antimicrobial resistance using tandem mass spectrometry
Shah, A., Serafim, V., Xu, Z., Mkrtchyan, H. and Shah, H. 2017. Determination of antimicrobial resistance using tandem mass spectrometry. in: Shah, H. and Gharbia, S. (ed.) MALDI-TOF and Tandem MS for Clinical Microbiology Oxford, UK Wiley. pp. 399-418
Microbial DNA analysis by MALDI-TOF mass spectrometry
Honisch, C., Serafim, V., Hennessy, N., Allen, D., Ring, C., Pantoja Munoz, L., Gharbia, S., Shah, A. and Shah, H. 2017. Microbial DNA analysis by MALDI-TOF mass spectrometry. in: Shah, H. and Gharbia, S. (ed.) MALDI-TOF and Tandem MS for Clinical Microbiology Oxford Wiley. pp. 187-209
A wideband low-distortion CMOS current driver for tissue impedance analysis
Constantinou, L., Bayford, R. and Demosthenous, A. 2015. A wideband low-distortion CMOS current driver for tissue impedance analysis. IEEE Transactions on Circuits and Systems II: Express Briefs. 62 (2), pp. 154-158. https://doi.org/10.1109/tcsii.2014.2387632
Why is EIT so hard, and what are we doing about it?
Adler, A., Grychtol, B. and Bayford, R. 2015. Why is EIT so hard, and what are we doing about it? Physiological Measurement. 36 (6), pp. 1067-1073. https://doi.org/10.1088/0967-3334/36/6/1067
Medical Physics: forming and testing solutions to clinical problems
Tsapaki, V. and Bayford, R. 2015. Medical Physics: forming and testing solutions to clinical problems. Physica Medica. 31 (7), pp. 738-740. https://doi.org/10.1016/j.ejmp.2015.05.017
Patient specific Parkinson's disease detection for adaptive deep brain stimulation
Mohammed, A., Zamani, M., Bayford, R. and Demosthenous, A. 2015. Patient specific Parkinson's disease detection for adaptive deep brain stimulation. 2015 37th Annual International Conference Of the IEEE Engineering In Medicine And Biology Society (EMBC). Milan, Italy 25 Aug 2015 IEEE. pp. 1528-1531
Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression
Simoes, R., De-Brito, N., Cunha-Costa, H., Morandi, V., Fierro, I., Roitt, I. and Barja-Fidalgo, C. 2017. Lipoxin A4 selectively programs the profile of M2 tumor-associated macrophages which favour control of tumor progression. International Journal of Cancer. 140 (2), pp. 346-357. https://doi.org/10.1002/ijc.30424
16th International Conference on Electrical Bio-impedance and 17th International Conference on Biomedical Applications of Electrical Impedance Tomography (EIT) [Editorial]
Bayford, R. and Olimar, S. 2017. 16th International Conference on Electrical Bio-impedance and 17th International Conference on Biomedical Applications of Electrical Impedance Tomography (EIT) [Editorial]. Physiological Measurement. 38 (6), pp. E8-E9. https://doi.org/10.1088/1361-6579/aa6a5c
Emerging applications of nanotechnology for diagnosis and therapy of disease: a review
Bayford, R., Rademacher, T., Roitt, I. and Wang, S. 2017. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review. Physiological Measurement. 38 (8). https://doi.org/10.1088/1361-6579/aa7182
Competition intensity and fatigue in elite fencing
Turner, A., Kilduff, L., Mrashall, G., Phillips, J., Noto, A., Buttigeig, C., Gondek, M., Hills, F. and Dimitriou, L. 2017. Competition intensity and fatigue in elite fencing. The Journal of Strength and Conditioning Research. 31 (11), pp. 3128-3136. https://doi.org/10.1519/JSC.0000000000001758
On the physical limitations for radio frequency absorption in gold nanoparticle suspensions
Nordebo, S., Dalarsson, M., Ivanenko, Y., Sjoeberg, D. and Bayford, R. 2017. On the physical limitations for radio frequency absorption in gold nanoparticle suspensions. Journal of Physics D: Applied Physics. 50 (15). https://doi.org/10.1088/1361-6463/aa5a89
Detection and quantification of human chorionic gonadotropin levels in human placental choriocarcinoma cell lines
Gondek, M., Hills, F. and Burczynska, B. 2017. Detection and quantification of human chorionic gonadotropin levels in human placental choriocarcinoma cell lines. Summer Conference 2017. Middlesex University Jun 2017
The effect of plasma volume on changes in biomarkers of muscle damage, inflammation, oxidative stress and leukocyte differentialfollowing a 42.2 km trail run, and the efficacy of recovery interventions
Cockburn, E., Hills, F., Wilson, L., Paice, K., Wood, A. and Dimitriou, L. 2017. The effect of plasma volume on changes in biomarkers of muscle damage, inflammation, oxidative stress and leukocyte differentialfollowing a 42.2 km trail run, and the efficacy of recovery interventions. BASES-FEPSAC Conference 2017. Nottingham, UK 28 - 29 Nov 2017 Taylor & Francis (Routledge). pp. s26
Influence of cold water immersion and cherry juice on recovery following a 42.2km trail run
Paice, K., Dimitriou, L., Wilson, L., Hills, F., Sinclair, S., Gondek, M., Kwan Xue Bin, X., Wood, A. and Cockburn, E. 2017. Influence of cold water immersion and cherry juice on recovery following a 42.2km trail run. BASES-FEPSAC Conference 2017. Nottingham, UK 28 - 29 Nov 2017 Taylor & Francis (Routledge). pp. s92
The influence of cold water immersion on markers of recovery following resistance exercise
Wilson, L., Dimitriou, L., Hills, F., Gondek, M. and Cockburn, E. 2017. The influence of cold water immersion on markers of recovery following resistance exercise. BASES-FEPSAC Conference 2017. Nottingham, UK 28 - 29 Nov 2017 Taylor & Francis (Routledge). pp. s66
Classification of cancer cell lines using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and statistical analysis
Serafim, V., Shah, A., Puiu, M., Andreescu, N., Coricovac, D., Nosyrev, A., Spandidos, D., Tsatsakis, A., Dehelean, C. and Pinzaru, I. 2017. Classification of cancer cell lines using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and statistical analysis. International Journal of Molecular Medicine. 40 (4), pp. 1096-1104. https://doi.org/10.3892/ijmm.2017.3083
Rapid identification of E. coli bacteriophages using mass spectrometry
Serafim, V., Ring, C., Pantoja Munoz, L., Shah, H. and Shah, A. 2017. Rapid identification of E. coli bacteriophages using mass spectrometry. Journal of Proteomics and Enzymology. 6 (1), pp. 1-5. https://doi.org/10.4172/2470-1289.1000130
Heparan sulfate disaccharide measurement from biological samples using pre-column derivatization, UPLC-MS and single ion monitoring
Antia, I., Yagnik, D., Pantoja Munoz, L., Shah, A. and Hills, F. 2017. Heparan sulfate disaccharide measurement from biological samples using pre-column derivatization, UPLC-MS and single ion monitoring. Analytical Biochemistry. 530, pp. 17-30. https://doi.org/10.1016/j.ab.2017.04.019
Detecting colorectal cancer using electrical impedance spectroscopy: an ex vivo feasibility study
Pathiraja, A., Ziprin, P., Shiraz, A., Mirnezami, R., Tizzard, A., Brown, B., Demosthenous, A. and Bayford, R. 2017. Detecting colorectal cancer using electrical impedance spectroscopy: an ex vivo feasibility study. Physiological Measurement. 38 (6), pp. 1278-1288. https://doi.org/10.1088/1361-6579/aa68ce
Analysis and compensation for errors in electrical impedance tomography images and ventilation-­related measures due to serial data collection
Yerworth, R., Frerichs, I. and Bayford, R. 2017. Analysis and compensation for errors in electrical impedance tomography images and ventilation-­related measures due to serial data collection. Journal of Clinical Monitoring and Computing. 31 (5), pp. 1093-1101. https://doi.org/10.1007/s10877-016-9920-y
EIT2015: promoting electrical impedance tomography as a non-invasive monitoring technology
Bayford, R. and Solà, J. 2016. EIT2015: promoting electrical impedance tomography as a non-invasive monitoring technology. Physiological Measurement. 37 (6), pp. E3-E4. https://doi.org/10.1088/0967-3334/37/6/E3
A novel active electrode IC for wearable EIT system
Wu, Y., Langlois, P., Bayford, R. and Demosthenous, A. 2016. A novel active electrode IC for wearable EIT system. 16th International Conference on Electrical Bio-Impedance (ICEBI) and 17th International Conference on Electrical Impedance Tomography (EIT). Stockholm 19 - 23 Jun 2016 Zenodo. pp. 138 https://doi.org/10.5281/zenodo.55753
Alternate algorithm to reconstruct shape in wearable device
Tizzard, A., Demosthenous, A. and Bayford, R. 2016. Alternate algorithm to reconstruct shape in wearable device. 16th International Conference on Electrical Bio-Impedance (ICEBI) and 17th International Conference on Electrical Impedance Tomography (EIT). Stockholm 19 - 23 Jun 2016 Zenodo. pp. 128 https://doi.org/10.5281/zenodo.55753
Design of a CMOS active electrode IC for wearable electrical impedance tomography systems
Wu, Y., Langlois, P., Bayford, R. and Demosthenous, A. 2016. Design of a CMOS active electrode IC for wearable electrical impedance tomography systems. 2016 IEEE International Symposium Circuits and Systems (ISCAS). Montreal, QC, Canada 22 - 25 May 2016 Institute of Electrical and Electronics Engineers (IEEE). pp. 846-849 https://doi.org/10.1109/ISCAS.2016.7527373
Inhibition of HIV virus by neutralizing Vhh attached to dual functional liposomes encapsulating dapivirine
Wang, S., Michiels, J., Ariën, K., New, R., Vanham, G. and Roitt, I. 2016. Inhibition of HIV virus by neutralizing Vhh attached to dual functional liposomes encapsulating dapivirine. Nanoscale Research Letters. 11 (1), pp. 1-10. https://doi.org/10.1186/s11671-016-1558-7
XVth International Conference on Electrical Bio-Impedance and the XIVth Conference on Electrical Impedance Tomography (Heilbad Heiligenstadt, Germany, 22–25 April 2013)
Bayford, R. and Pliquett, U. 2014. XVth International Conference on Electrical Bio-Impedance and the XIVth Conference on Electrical Impedance Tomography (Heilbad Heiligenstadt, Germany, 22–25 April 2013). Physiological Measurement. 35 (6), pp. 945-946. https://doi.org/10.1088/0967-3334/35/6/915
MPS: improving exact string matching through pattern character frequency, journal of data processing
Sahota, V., Li, M. and Bayford, R. 2013. MPS: improving exact string matching through pattern character frequency, journal of data processing. Journal of Data Processing. 3 (3), pp. 127-137.
The effect of serial data collection on the accuracy of electrical impedance tomography images
Yerworth, R. and Bayford, R. 2013. The effect of serial data collection on the accuracy of electrical impedance tomography images. Physiological Measurement. 34 (6), pp. 659-669. https://doi.org/10.1088/0967-3334/34/6/659
Bioimpedance imaging: an overview of potential clinical applications
Bayford, R. and Tizzard, A. 2012. Bioimpedance imaging: an overview of potential clinical applications. Analyst. 137 (20), pp. 4635-4643. https://doi.org/10.1039/C2AN35874C
Whither lung EIT: where are we, where do we want to go and what do we need to get there?
Adler, A., Amato, M., Arnold, J., Bayford, R., Bodenstein, M. and Böhm, S. 2012. Whither lung EIT: where are we, where do we want to go and what do we need to get there? Physiological Measurement. 33 (5), pp. 679-694. https://doi.org/10.1088/0967-3334/33/5/679
A cable theory based biophysical model of resistance change in crab peripheral nerve and human cerebral cortex during neuronal depolarisation: implications for electrical impedance tomography of fast neural activity in the brain
Liston, A., Bayford, R. and Holder, D. 2012. A cable theory based biophysical model of resistance change in crab peripheral nerve and human cerebral cortex during neuronal depolarisation: implications for electrical impedance tomography of fast neural activity in the brain. Med Biol Eng Comput. 50 (5), pp. 425-437. https://doi.org/10.1007/s11517-012-0901-0
On the application of frequency selective common mode feedback for multifrequency EIT
Langlois, P., Wu, Y., Bayford, R. and Demosthenous, A. 2015. On the application of frequency selective common mode feedback for multifrequency EIT. Physiological Measurement. 36 (6), pp. 1337-1350. https://doi.org/10.1088/0967-3334/36/6/1337
Determination of urinary cortisol, cortisone and 6-sulfatoxymelatonin using dilute and shoot ultra-high pressure liquid chromatography-tandem mass spectrometry
Sniecinska-Cooper, A., Shah, A., Dimitriou, D., Iles, R., Butler, S. and Bayford, R. 2015. Determination of urinary cortisol, cortisone and 6-sulfatoxymelatonin using dilute and shoot ultra-high pressure liquid chromatography-tandem mass spectrometry. Journal of Chromatography B. 978-79, pp. 18-23. https://doi.org/10.1016/j.jchromb.2014.11.016
Abnormal secretion of melatonin and cortisol in relation to sleep disturbances in children with Williams syndrome
Sniecinska-Cooper, A., Iles, R., Butler, S., Jones, H., Bayford, R. and Dimitriou, D. 2015. Abnormal secretion of melatonin and cortisol in relation to sleep disturbances in children with Williams syndrome. Sleep Medicine. 16 (1), pp. 94-100. https://doi.org/10.1016/j.sleep.2014.09.003
The role of vitamin In type 2 diabetes
Ali, A., Appiah, S., Shah, A. and Ghali, L. 2014. The role of vitamin In type 2 diabetes. Middlesex University Postgraduate Summer Conference. London, UK 19 Jun 2014
Wearable sensors for patient-specific boundary shape estimation to improve the forward model for electrical impedance tomography (EIT) of neonatal lung function
Khor, J., Tizzard, A., Demosthenous, A. and Bayford, R. 2014. Wearable sensors for patient-specific boundary shape estimation to improve the forward model for electrical impedance tomography (EIT) of neonatal lung function. Physiological Measurement. 35 (6), pp. 1149-1161. https://doi.org/10.1088/0967-3334/35/6/1149
High-power CMOS current driver with accurate transconductance for electrical impedance tomography
Constantinou, L., Triantis, I., Bayford, R. and Demosthenous, A. 2014. High-power CMOS current driver with accurate transconductance for electrical impedance tomography. IEEE Transactions on Biomedical Circuits and Systems. 8 (4), pp. 575-583. https://doi.org/10.1109/TBCAS.2013.2285481
Placental syndecan-1 and sulphated glycosaminoglycans are decreased in preeclampsia
Heyer-Chauhan, N., Ovbude, I., Hills, A., Sullivan, M. and Hills, F. 2013. Placental syndecan-1 and sulphated glycosaminoglycans are decreased in preeclampsia. Journal of Perinatal Medicine. https://doi.org/10.1515/jpm-2013-0097
Comparison of the calibration standards of three commercially available multiplex kits for human cytokine measurement to WHO standards reveals striking differences
Nechansky, A., Grunt, S., Roitt, I. and Kircheis, R. 2008. Comparison of the calibration standards of three commercially available multiplex kits for human cytokine measurement to WHO standards reveals striking differences. Biomarker Insights. 3, pp. 227-235.
IGFBP-1 in the placenta, membranes and fetal circulation: levels at term and preterm delivery
Hills, F., Gunn, L., Hardiman, P., Thanaratnam, S. and Chard, T. 1996. IGFBP-1 in the placenta, membranes and fetal circulation: levels at term and preterm delivery. Early Human Development. 44 (1), pp. 71-76.
A high-performance liquid chromatography/tandem mass spectrometry assay for the simultaneous measurement of acetylcholine and clozapine in microdialysis samples
Shah, A. 2013. A high-performance liquid chromatography/tandem mass spectrometry assay for the simultaneous measurement of acetylcholine and clozapine in microdialysis samples. Journal of Chromatography A.
The influence of ligand organization on the rate of uptake of gold nanoparticles by colorectal cancer cells
Lund, T., Callaghan, M., Williams, P., Turmaine, M., Bachmann, C., Rademacher, T., Roitt, I. and Bayford, R. 2011. The influence of ligand organization on the rate of uptake of gold nanoparticles by colorectal cancer cells. Biomaterials. 32 (36), pp. 9776-9784. https://doi.org/10.1016/j.biomaterials.2011.09.018
Screening autoantibody profiles in systemic rheumatic disease with a diagnostic protein microarray that uses a filtration-assisted nanodot array luminometric immunoassay (NALIA)
McBride, J., Gabriel, F., Fordham, J., Kolind, T., Barcenas-Morales, G., Isenberg, D., Swana, M., Delves, P., Lund, T., Cree, I. and Roitt, I. 2008. Screening autoantibody profiles in systemic rheumatic disease with a diagnostic protein microarray that uses a filtration-assisted nanodot array luminometric immunoassay (NALIA). Clinical Chemistry. 54 (5), pp. 883-890. https://doi.org/10.1373/clinchem.2007.098418
Fluoxetine administration modulates the cytoskeletal microtubular system in the rat hippocampus
Bianchi, M., Shah, A., Fone, K., Atkins, A., Dawson, L., Heidbreder, C., Hows, M., Hagan, J. and Marsden, C. 2009. Fluoxetine administration modulates the cytoskeletal microtubular system in the rat hippocampus. Synapse. 63 (4), pp. 359-364. https://doi.org/10.1002/syn.20614
Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR
Fricker, A., Mok, M., De la Flor, R., Shah, A., Woolley, M., Dawson, L. and Kew, J. 2009. Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR. Neuropharmacology. 56 (6-7), pp. 1060-1067. https://doi.org/10.1016/j.neuropharm.2009.03.002
Development and application of a liquid chromatography/tandem mass spectrometric assay for measurement of N-acetylaspartate, N-acetylaspartylglutamate and glutamate in brain slice superfusates and tissue extracts
Shah, A., De la Flor, R., Atkins, A., Slone-Murphy, J. and Dawson, L. 2008. Development and application of a liquid chromatography/tandem mass spectrometric assay for measurement of N-acetylaspartate, N-acetylaspartylglutamate and glutamate in brain slice superfusates and tissue extracts. Journal of Chromatography B. 876 (2), pp. 153-158. https://doi.org/10.1016/j.jchromb.2008.10.012
Development of Zwitterionic Hydrophilic Liquid Chromatography (ZICⓇHILIC-MS) metabolomics method for Shotgun analysis of human urine
Trivedi, D., Jones, H., Shah, A. and Iles, R. 2012. Development of Zwitterionic Hydrophilic Liquid Chromatography (ZICⓇHILIC-MS) metabolomics method for Shotgun analysis of human urine. Journal of Chromatography & Separation Techniques. 03 (06). https://doi.org/10.4172/2157-7064.1000144
A tripolar current-steering stimulator ASIC for field shaping in deep brain stimulation
Valente, V., Demosthenous, A. and Bayford, R. 2011. A tripolar current-steering stimulator ASIC for field shaping in deep brain stimulation. IEEE Transactions on Biomedical Circuits and Systems. 6 (3), pp. 197-207. https://doi.org/10.1109/TBCAS.2011.2171036
Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy
Hills, F., Iles, R. and Sullivan, M. 2013. Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy. Journal of Perinatal Medicine. 41 (3), pp. 241-249. https://doi.org/10.1515/jpm-2012-0086
New imaging mapping device for the detection and location of rectal cancer
Bayford, R., Borsic, A., Tizzard, A., Kantartzis, P., Liatsis, P. and Demosthenous, A. 2012. New imaging mapping device for the detection and location of rectal cancer. 13th International Conference on Electrical Impedance Tomography (EIT 2012). Tianjin, China 23 - 25 May 2012
Tracking conductivity variations in the absence of accurate state evolution models in electrical impedance tomography
Hashemzadeh, P., Sahota, V., Callaghan, M., El Dib, H., Tizzard, A., Svensson, L. and Bayford, R. 2010. Tracking conductivity variations in the absence of accurate state evolution models in electrical impedance tomography. in: 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE), 2010 IEEE. pp. 1-6
GREIT: a unified approach to 2D linear EIT reconstruction of lung images
Adler, A., Arnold, J., Bayford, R., Borsic, A., Brown, B., Dixon, P., Faes, T., Frerichs, I., Gagnon, H., Garber, Y., Grychtol, B., Hahn, G., Lionheart, W., Malik, A., Patterson, R., Stocks, J., Tizzard, A., Weiler, N. and Wolf, G. 2009. GREIT: a unified approach to 2D linear EIT reconstruction of lung images. Physiological Measurement. 30 (6), pp. S35-S55. https://doi.org/10.1088/0967-3334/30/6/S03
Dynamic electrical impedance tomography image reconstruction of neonate lung function based on linear Kalman filter techniques
El Dib, H., Tizzard, A. and Bayford, R. 2009. Dynamic electrical impedance tomography image reconstruction of neonate lung function based on linear Kalman filter techniques. in: Dössel, O. and Schlegel, W. (ed.) IFMBE Proceedings, World Congress on Medical Physics and Biomedical Engineering September 7 - 12, 2009 Munich, Germany Munich, Germany Springer.
Development of a sensor network for dynamic boundary measurement in neonatal electrical impedance tomography (EIT)
Khor, J., Tizzard, A., Demosthenous, A. and Bayford, R. 2009. Development of a sensor network for dynamic boundary measurement in neonatal electrical impedance tomography (EIT). in: Dössel, O. and Schlegel, W. (ed.) IFMBE Proceedings, World Congress on Medical Physics and Biomedical Engineering September 7 - 12, 2009 Munich, Germany Munich, Germany Springer.
Effects of warping finite element meshes for the forward model of the head in EIT
Tizzard, A., Bayford, R., Horesh, L., Yerworth, R. and Holder, D. 2004. Effects of warping finite element meshes for the forward model of the head in EIT. in: Nowakowski, A. (ed.) Proceedings of the XII International Conference of Electrical Bioimpedance & V Electrical Impedance Tomography Gdansk, Poland Gdansk University of Technology.
Validation of finite element mesh warping for improving the forward model in EIT of brain function
Tizzard, A. and Bayford, R. 2007. Validation of finite element mesh warping for improving the forward model in EIT of brain function. in: Scharfetter, H. and Merwa, R. (ed.) IFMBE Proceedings, Part II - 13th International Conference on Electrical Bioimpedance and 8th Conference on Electrical Impedance Tomography 2007 Graz, Austria Springer Verlag.
Reconstruction algorithms to monitor neonate lung function
Bayford, R., Kantartzis, P., Tizzard, A., Yerworth, R., Liatsis, P. and Demosthenous, A. 2007. Reconstruction algorithms to monitor neonate lung function. in: Scharfetter, H. and Mervwa, R. (ed.) IFMBE Proceedings, Part II - 13th International Conference on Electrical Bioimpedance and 8th Conference on Electrical Impedance Tomography 2007 Graz, Austria Springer Verlag.
Generation and performance of patient-specific forward models for breast imaging with EIT
Tizzard, A., Borsic, A., Halter, R. and Bayford, R. 2010. Generation and performance of patient-specific forward models for breast imaging with EIT. Journal of Physics: Conference Series. 224 (1), pp. 1-4. https://doi.org/10.1088/1742-6596/224/1/012034
A comparison study of electrodes for neonate electrical impedance tomography
Rahal, M., Khor, J., Demosthenous, A., Tizzard, A. and Bayford, R. 2009. A comparison study of electrodes for neonate electrical impedance tomography. Physiological Measurement. 30 (6), pp. 73-84. https://doi.org/10.1088/0967-3334/30/6/S05
Development of a neonate lung reconstruction algorithm using a wavelet AMG and estimated boundary form
Bayford, R., Kantartzis, P., Tizzard, A., Yerworth, R., Liatsis, P. and Demosthenous, A. 2008. Development of a neonate lung reconstruction algorithm using a wavelet AMG and estimated boundary form. Physiological Measurement. 29 (6), pp. S125-S138. https://doi.org/10.1088/0967-3334/29/6/S11
Generating accurate finite element meshes for the forward model of the human head in EIT
Tizzard, A., Horesh, L., Yerworth, R., Holder, D. and Bayford, R. 2005. Generating accurate finite element meshes for the forward model of the human head in EIT. Physiological Measurement. 26 (2), pp. S251-S262.
Solving the forward problem in electrical impedance tomography for the human head using IDEAS (integrated design engineering analysis software), a finite element modelling tool
Bayford, R., Gibson, A., Tizzard, A., Tidswell, T. and Holder, D. 2001. Solving the forward problem in electrical impedance tomography for the human head using IDEAS (integrated design engineering analysis software), a finite element modelling tool. Physiological Measurement. 22 (1), pp. 55-64.
Investigating the mechanism of deep brain stimulation using a dynamic complex model of the head incorporated with the complete model of electrode
Bayford, R., Tizzard, A., Yousif, N. and Liu, X. 2006. Investigating the mechanism of deep brain stimulation using a dynamic complex model of the head incorporated with the complete model of electrode. Clinical Neurophysiology. 117, pp. S219-S220.
Insulin-like growth factor-II and heparin are anti-apoptotic survival factors in human villous cytotrophoblast
Hills, F., Mehmet, H. and Sullivan, M. 2012. Insulin-like growth factor-II and heparin are anti-apoptotic survival factors in human villous cytotrophoblast. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 163 (1), pp. 11-16. https://doi.org/10.1016/j.ejogrb.2012.03.013
Detection of cancer.
Bayford, R., Roitt, I., Rademacher, T., Demosthenous, A. and Iles, R. 2010. Detection of cancer.
Electric field characteristics of bipolar impedance sensors.
Kassanos, P., Bayford, R. and Demosthenous, A. 2009. Electric field characteristics of bipolar impedance sensors. 11th International Congress of the IUPESM - Medical Physics and Biomedical Engineering World Congress 2009 - for the benefit of the patient program. Munich, Germany 07 - 12 Sep 2009
A high output impedance current source for wideband bioimpedance measurements.
Hong, H., Bayford, R. and Demosthenous, A. 2009. A high output impedance current source for wideband bioimpedance measurements. 11th International Congress of the IUPESM - Medical Physics and Biomedical Engineering World Congress 2009 - for the benefit of the patient program.. Munich, Germany 07 - 12 Sep 2009
The use of EIT in the detection of regional lung dysfunction in prematurely born neonates.
Zifan, A., Liatsis, P. and Bayford, R. 2009. The use of EIT in the detection of regional lung dysfunction in prematurely born neonates. 11th International Congress of the IUPESM - Medical Physics and Biomedical Engineering World Congress 2009 - for the benefit of the patient program. Munich, Germany 07 - 12 Sep 2009
Electrochemical impedance detection of hCGbeta: preliminary results and analysis in the development of lab on a chip technology.
Bayford, R., Kassanos, P., Demosthenous, A. and Iles, R. 2009. Electrochemical impedance detection of hCGbeta: preliminary results and analysis in the development of lab on a chip technology. 42nd IUPAC Congress: Chemistry Solutions SECC.. Glasgow, Scotland, UK. 02 - 07 Aug 2009
Superovulation, IGFBP-1 and birth weight.
Johnson, M., Irvine, R., Hills, F., Bolton, V., Abbas, A., Brooks, A., Allman, A., Chard, T. and Nicolaides, K. 1995. Superovulation, IGFBP-1 and birth weight. European Journal of Obstetrics, Gynaecology and Reproductive Biology. 59 (2), pp. 193-195.
The effects of labor on maternal and fetal levels of insulin-like growth factor binding protein-1
Hills, F., Crawford, R., Harding, S., Farkas, F. and Chard, T. 1994. The effects of labor on maternal and fetal levels of insulin-like growth factor binding protein-1. American Journal of Obstetrics and Gynecology. 171 (5), pp. 1292-1295.
Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies.
Brooks, A., Johnson, M., Hills, F., Chard, T., Irvine, R. and Abdalla, H. 1995. Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies. European Journal of Obstetrics, Gynaecology and Reproductive Biology. 59 (1), pp. 91-94.
Elevated levels of insulin-like growth factor binding protein-1 in fetal distress.
Crawford, R., Hills, F., Farkas, A. and Chard, T. 1995. Elevated levels of insulin-like growth factor binding protein-1 in fetal distress. British Journal of Obstetrics and Gynaecology. 102 (7), pp. 538-540.
Lack of evidence for a circadian rhythm of IGFBP-1 in the mother and fetus during labour.
Harding, S., Mensah, A., Hills, F., Howell, R. and Chard, T. 1995. Lack of evidence for a circadian rhythm of IGFBP-1 in the mother and fetus during labour. British Journal of Obstetrics and Gynaecology. 102 (11), pp. 891-893.
Raised circulating levels of interleukin-6 in women with an intrauterine contraceptive device.
Wolley, J., Saleem, S., Hills, F., Salem, H., El-Nashar, E. and Chard, T. 1996. Raised circulating levels of interleukin-6 in women with an intrauterine contraceptive device. Gynecologic and Obstetric Investigation. 42 (4), pp. 241-243.
Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight.
Hills, F., English, J. and Chard, T. 1996. Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight. Journal of Endocrinology. 148 (2), pp. 303-309. https://doi.org/10.1677/joe.0.1480303
Antenatal dexamethasone therapy does not affect circulating concentrations of insulin-like growth factor binding protein-1.
Ogueh, O., Hills, F., Chard, T. and Johnson, M. 1998. Antenatal dexamethasone therapy does not affect circulating concentrations of insulin-like growth factor binding protein-1. Human Reproduction. 13 (6), pp. 1714-1716. https://doi.org/10.1093/humrep/13.6.1714
Effects of co-trimoxazole, erythromycin, amoxycillin, tetracycline and chloroquine on sperm function in vitro
Hargreaves, C., Rogers, S., Hills, F., Rahman, F., Howell, R. and Homa, S. 1998. Effects of co-trimoxazole, erythromycin, amoxycillin, tetracycline and chloroquine on sperm function in vitro. Human Reproduction. 13 (7), pp. 1878-1886.
Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression
Monk, D., Arnaud, P., Frost, J., Hills, F., Stanier, P., Feil, R. and Moore, G. 2009. Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression. Human Molecular Genetics. 18 (16), pp. 3066-3074. https://doi.org/10.1093/hmg/ddp248
Statistical analysis for brain EIT images using SPM.
Zhang, Y., Passmore, P., Yerworth, R. and Bayford, R. 2005. Statistical analysis for brain EIT images using SPM. Institute of Electrical and Electronics Engineers. pp. 60-67 https://doi.org/10.1109/MEDIVIS.2005.17
A human domain antibody and Lewisb glycoconjugate that inhibit binding of helicobacter pylori to Lewisb receptor and adhesion to human gastric epithelium
Younson, J., O'Mahony, R., Liu, H., Grant, S., Campion, C., Jennings, L., Vaira, D., Kelly, C., Roitt, I. and Holton, J. 2009. A human domain antibody and Lewisb glycoconjugate that inhibit binding of helicobacter pylori to Lewisb receptor and adhesion to human gastric epithelium. Journal of Infectious Diseases. 200 (10), pp. 1574-1582. https://doi.org/10.1086/644596
Designing a new generation of anti-hCG vaccines for cancer therapy
Delves, P., Iles, R., Roitt, I. and Lund, T. 2007. Designing a new generation of anti-hCG vaccines for cancer therapy. Molecular and Cellular Endocrinology. 260-26, pp. 276-281. https://doi.org/10.1016/j.mce.2006.02.018
Refocusing of B-cell responses following a single amino acid substitution in an antigen.
Dalla Chiesa, M., Martensen, P., Simmons, C., Porakishvili, N., Justesen, J., Dougan, G., Roitt, I., Delves, P. and Lund, T. 2001. Refocusing of B-cell responses following a single amino acid substitution in an antigen. Immunology. 103 (2), pp. 172-178. https://doi.org/10.1046/j.1365-2567.2001.01242.x
Tumour burden and Interleukin-2 (IL-2) dose affect the interaction between low-dose total body irradiation and Interleukin-2.
Safwat, A., Aggerholm, N., Roitt, I., Overgaard, J. and Hoklund, M. 2004. Tumour burden and Interleukin-2 (IL-2) dose affect the interaction between low-dose total body irradiation and Interleukin-2. European Journal of Cancer. 40 (9), pp. 1412-1417. https://doi.org/10.1016/j.ejca.2004.01.037
Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells.
Kvirkvelia, N., Vojnovic, I., Warner, T., Athie-Morales, V., Free, P., Rayment, N., Chain, B., Rademacher, T., Lund, T., Roitt, I. and Delves, P. 2002. Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells. Clinical & Experimental Immunology. 127 (2), pp. 263-269. https://doi.org/10.1046/j.1365-2249.2002.01718.x
Low dose total body irradiation augments the therapeutic effect of interleukin-2 in a mouse model for metastatic malignant melanoma.
Safwat, A., Aggerholm, N., Roitt, I., Overgaard, J. and Hoklund, M. 2003. Low dose total body irradiation augments the therapeutic effect of interleukin-2 in a mouse model for metastatic malignant melanoma. Journal of experimental therapeutics & oncology. 3 (4), pp. 161-168. https://doi.org/10.1046/j.1359-4117.2003.01093.x
Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis.
De Bernardis, F., Liu, H., O'Mahony, R., La Valle, R., Bartollino, S., Sandini, S., Grant, S., Brewis, N., Tomlinson, I., Basset, R., Holton, J., Roitt, I. and Cassone, A. 2007. Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis. Journal of Infectious Diseases. 195 (1), pp. 149-157. https://doi.org/10.1086/509891
Comparison of image analysis software packages in the assessment of adhesion of microorganisms to mucosal epithelium using confocal laser scanning microscopy.
O'Mahony, R., Basset, C., Holton, J., Vaira, D. and Roitt, I. 2005. Comparison of image analysis software packages in the assessment of adhesion of microorganisms to mucosal epithelium using confocal laser scanning microscopy. Elsevier. https://doi.org/10.1016/j.mimet.2004.11.020
Changes in the reproductive system of male mice immunized with a GnRH-analogue conjugated to mycobacterial hsp70
Hannesdottir, S., Han, X., Lund, T., Singh, M., Van Der Zee, R., Roitt, I. and Delves, P. 2004. Changes in the reproductive system of male mice immunized with a GnRH-analogue conjugated to mycobacterial hsp70. Reproduction: the official journal of the Society for the Study of Fertility. 128 (3), pp. 365-371. https://doi.org/10.1530/rep.1.00108
Innate immunity and pathogen-host interaction.
Basset, C., Holton, J., O'Mahony, R. and Roitt, I. 2003. Innate immunity and pathogen-host interaction. Vaccine. 21 (Supple), pp. S12-S23. https://doi.org/10.1016/S0264-410X(03)00195-6
Elimination of luteinizing hormone cross-reactive epitopes from human chorionic gonadotropin.
Porakishvili, N., Chiesa, M., Chikadze, N., Martensen, P., Justesen, J., Lund, T., Delves, P. and Roitt, I. 2002. Elimination of luteinizing hormone cross-reactive epitopes from human chorionic gonadotropin. Vaccine. 20 (16), pp. 2053-2059. https://doi.org/10.1016/S0264-410X(02)00051-8
Genes and IgG glycosylation in autoimmune and non-autoimmune strains of mice
Delves, P., Lund, T. and Roitt, I. 2002. Genes and IgG glycosylation in autoimmune and non-autoimmune strains of mice. Trends in Immunology. 23 (4), pp. 213-219. https://doi.org/10.1016/S1471-4906(02)02182-8
The human chorionic gonadotropin-ß arginine68 to glutamic acid substitution fixes the conformation of the C-terminal Peptide
Charrel-Dennis, M., Terrazzini, N., McBride, J., Martensen, P., Justesen, J., Berger, P., Lapthorn, A., Kelly, C., Roitt, I., Delves, P. and Lund, T. 2005. The human chorionic gonadotropin-ß arginine68 to glutamic acid substitution fixes the conformation of the C-terminal Peptide. Molecular Endocrinology. 19 (7), pp. 1803-1811. https://doi.org/10.1210/me.2004-0109
The major hormone-specific epitopes on human chorionic gonadotropin
Charrel-Dennis, M., Jackson, A., Lund, T., Lapthorn, A., Berger, P., Roitt, I. and Delves, P. 2004. The major hormone-specific epitopes on human chorionic gonadotropin. Journal of molecular endocrinology. 32 (2), pp. 571-581.
Immunochemical mapping of gonadotropin
Berger, P., Bidart, J., Delves, P., Dirnhofer, S., Hoermann, R., Isaacs, N., Jackson, A., Klonisch, T., Lapthorn, A., Lund, T., Mann, K., Roitt, I., Schwartz, S. and Wick, G. 1996. Immunochemical mapping of gonadotropin. Molecular and Cellular Endocrinology. 125 (1-2), pp. 33-43. https://doi.org/10.1016/S0303-7207(96)03943-3
New and emerging tomographic imaging techniques in medical and industrial applications. Introduction
Soleimani, M. and Bayford, R. 2009. New and emerging tomographic imaging techniques in medical and industrial applications. Introduction. Philosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences. 367 (1900), pp. 3017-3019.
Visualization of multidimensional and multimodal tomographic medical imaging data, a case study
Zhang, Y., Passmore, P. and Bayford, R. 2009. Visualization of multidimensional and multimodal tomographic medical imaging data, a case study. Philosophical Transactions of the Royal Society of London. A: Mathematical and Physical Sciences. 367 (1900), pp. 3121-3148. https://doi.org/10.1098/rsta.2009.0084
Comparison of a new integrated current source with the modified Howland circuit for EIT applications
Hong, H., Rahal, M., Demosthenous, A. and Bayford, R. 2009. Comparison of a new integrated current source with the modified Howland circuit for EIT applications. Physiological Measurement. 30 (10), pp. 999-1007. https://doi.org/10.1088/0967-3334/30/10/001
Generating surfaces for registration and warping FE meshes for the forward model in EIT of brain function.
Tizzard, A., Holder, D., Bayford, R. and International Federation for Medical and Biological Engineering 2005. Generating surfaces for registration and warping FE meshes for the forward model in EIT of brain function. Springer.
Effects of modelling layers and realistic geometry in reconstruction algorithms for EIT of brain function.
Liston, A., Bagshaw, A., Bayford, R., Tizzard, A., Tidswell, A., Dehghani, H. and Holder, D. 2003. Effects of modelling layers and realistic geometry in reconstruction algorithms for EIT of brain function. 4th Conference on Biomedical Applications of Electrical Impedance Tomography. Manchester, UK 23 - 25 Apr 2003 UMIST, Manchester, UK pp. 19 https://doi.org/10.5281/zenodo.17924
Modelling the effect of eye sockets in the human head using I-DEAS and its implication for imaging impedance change using Electrical Impedance Tomography.
Bayford, R., Gibson, A., Tizzard, A., Liston, A., Tidswell, A., Bagshaw, A. and Holder, D. 2001. Modelling the effect of eye sockets in the human head using I-DEAS and its implication for imaging impedance change using Electrical Impedance Tomography. Grimmes, S., Martinsen, O. and Bruvoll, H. (ed.) Oslo University of Oslo. pp. 391-396
Development of algorithms to image impedance changes inside the human head.
Bayford, R., Bagshaw, A., Liston, A., Tizzard, A. and Holder, D. 2002. Development of algorithms to image impedance changes inside the human head. The First Mummy Range Workshop on Electric Impedance Imaging. Colorado, US Colorado State University
Robustness of linear and nonlinear reconstruction algorithms for brain EITS.
Yerworth, R., Horesh, L., Bayford, R., Tizzard, A. and Holder, D. 2004. Robustness of linear and nonlinear reconstruction algorithms for brain EITS. Nowakowski, A., Wtorek, J., Bujnowski, A. and Janczulewicz, A. (ed.) Gdansk, Poland Gdansk University of Technology. pp. 499-502
Beyond the linear domain: the way forward in MFEIT reconstruction of the human head.
Horesh, L., Bayford, R., Yerworth, R., Tizzard, A., Ahadzi, G. and Holder, D. 2004. Beyond the linear domain: the way forward in MFEIT reconstruction of the human head. Nowakowski, A., Wtorek, J., Bujnowski, A. and Janczulewicz, A. (ed.) Gdansk, Poland Gdansk University of Technology. pp. 683-686
Heparin prevents programmed cell death in human trophoblast
Hills, F., Abrahams, V., Gonzalez-Timon, B., Francis, J., Cloke, B., Hinkson, L., Rai, R., Regan, L., Mor, G., Sullivan, M., Lam, E. and Brosens, J. 2006. Heparin prevents programmed cell death in human trophoblast. Molecular Human Reproduction. 12 (4), pp. 237-242.
A low budget luminometer for sensitive chemiluminescent immunoassays
Porakishvili, N., Fordham, J., Charrel-Dennis, M., Delves, P., Lund, T. and Roitt, I. 2000. A low budget luminometer for sensitive chemiluminescent immunoassays. Journal of Immunological Methods. 234 (1-2), pp. 35-42. https://doi.org/10.1016/S0022-1759(99)00198-2
The immune system: second of two parts
Delves, P. and Roitt, I. 2000. The immune system: second of two parts. New England Journal of Medicine. 343 (2), pp. 108-117.
The immune system: first of two parts
Delves, P. and Roitt, I. 2000. The immune system: first of two parts. New England Journal of Medicine. 343 (1), pp. 37-49.
Future prospects for vaccines to control fertility
Delves, P., Lund, T. and Roitt, I. 2002. Future prospects for vaccines to control fertility. Trends in Immunology. 23 (4), pp. 220-221. https://doi.org/10.1016/S1471-4906(02)02183-X
Antifertility vaccines
Delves, P., Lund, T. and Roitt, I. 2002. Antifertility vaccines. Trends in Immunology. 23 (4), pp. 213-219. https://doi.org/10.1016/S1471-4906(02)02182-8
Vaccines for the control of reproduction - status in mammals, and aspects of comparative interest.
Delves, P. and Roitt, I. 2005. Vaccines for the control of reproduction - status in mammals, and aspects of comparative interest. Developments in Biologicals. 121, pp. 265-273.
A longitudinal study of maternal plasma insulin-like growth factor binding protein-1 concentrations during normal pregnancy and pregnancies complicated by pre-eclampsia
Anim-Nyame, N., Hills, F., Soorana, S., Steer, P. and Johnson, M. 2000. A longitudinal study of maternal plasma insulin-like growth factor binding protein-1 concentrations during normal pregnancy and pregnancies complicated by pre-eclampsia. Human Reproduction. 15 (10), pp. 2215-2219. https://doi.org/10.1093/humrep/15.10.2215
Interactions between progesterone receptor isoforms in myometrial cells in human labour
Pieber, D., Allport, V., Hills, F., Johnson, M. and Bennett, P. 2001. Interactions between progesterone receptor isoforms in myometrial cells in human labour. Molecular Human Reproduction. 7 (9), pp. 875-879. https://doi.org/10.1093/molehr/7.9.875
Regulated expression of signal transducer and activator of transcription, Stat5, and its enhancement of PRL expression in human endometrial stromal cells in vitro
Mak, I., Brosens, J., Christian, M., Hills, F., Chamley, L., Regan, L. and White, J. 2002. Regulated expression of signal transducer and activator of transcription, Stat5, and its enhancement of PRL expression in human endometrial stromal cells in vitro. Journal of Clinical Endocrinology and Metabolism. 87 (6), pp. 2581-2588. https://doi.org/10.1210/jc.87.6.2581
Progesterone represses interleukin-8 and cyclo-oxygenase-2 in human lower segment fibroblast cells and amnion epithelial cells
Loudon, J., Elliott, C., Hills, F. and Bennett, P. 2003. Progesterone represses interleukin-8 and cyclo-oxygenase-2 in human lower segment fibroblast cells and amnion epithelial cells. Biology of Reproduction. 69 (1), pp. 331-337.
The relationship between insulin and insulin-like growth factor binding protein-1 is modified by pre-eclampsia.
Anim-Nyame, N., Hills, F., Soorana, S., Steer, P. and Johnson, M. 2003. The relationship between insulin and insulin-like growth factor binding protein-1 is modified by pre-eclampsia. Gynecological endocrinology.. 17 (6), pp. 471-476. https://doi.org/10.1080/09513590312331290408
The insulin-like growth factor system in mammalian pregnancy: a workshop report
Carter, A., Hills, F., O'Gorman, D., Robets, C., Soorana, S., Watson, C. and Westwood, M. 2004. The insulin-like growth factor system in mammalian pregnancy: a workshop report. Placenta. 25 (Supple), pp. S53-S56. https://doi.org/10.1016/j.placenta.2004.01.019
Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human
Monk, D., Sanches, R., Arnaud, P., Apostolidou, S., Hills, F., Abu-Amero, S., Murrell, A., Friess, H., Reik, W. and Stanier, P. 2006. Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human. Human Molecular Genetics. 15 (8), pp. 1259-1269. https://doi.org/10.1093/hmg/ddl041
Two-dimensional finite element modelling of the neonatal head
Gibson, A., Bayford, R. and Holder, D. 2000. Two-dimensional finite element modelling of the neonatal head. Physiological Measurement. 21 (1), pp. 45-52. https://doi.org/10.1088/0967-3334/21/1/306
Validation of a 3D reconstruction algorithm for EIT of human brain function in a realistic head-shaped tank
Tidswell, A., Gibson, A., Bayford, R. and Holder, D. 2001. Validation of a 3D reconstruction algorithm for EIT of human brain function in a realistic head-shaped tank. Physiological Measurement. 22 (1), pp. 177-185. https://doi.org/10.1088/0967-3334/22/1/321
Electrical impedance tomography of human brain activity with a two-dimensional ring of scalp electrodes
Tidswell, A., Gibson, A., Bayford, R. and Holder, D. 2001. Electrical impedance tomography of human brain activity with a two-dimensional ring of scalp electrodes. Physiological Measurement. 22 (1), pp. 167-175. https://doi.org/10.1088/0967-3334/22/1/320
A feasibility study of remote monitoring of asthmatic patients.
Steel, S., Lock, S., Johnson, N., Martinez, Y., Marquilles, E. and Bayford, R. 2002. A feasibility study of remote monitoring of asthmatic patients. Journal of telemedicine and telecare. 8 (5), pp. 290-296.
Design and performance of the UCLH mark 1b 64 channel electrical impedance tomography (EIT) system, optimized for imaging brain function
Yerworth, R., Bayford, R., Cusick, G., Conway, M. and Holder, D. 2002. Design and performance of the UCLH mark 1b 64 channel electrical impedance tomography (EIT) system, optimized for imaging brain function. Physiological Measurement. 23 (1), pp. 149-158. https://doi.org/10.1088/0967-3334/23/1/314
A multi-shell algorithm to reconstruct EIT images of brain function
Liston, A., Bayford, R., Tidswell, A. and Holder, D. 2002. A multi-shell algorithm to reconstruct EIT images of brain function. Physiological Measurement. 23 (1), pp. 105-119. https://doi.org/10.1088/0967-3334/23/1/310
A comparison of headnet electrode arrays for electrical impedance tomography of the human head
Tidswell, A., Bagshaw, A., Holder, D., Yerworth, R., Eadie, L., Murray, S., Morgan, L. and Bayford, R. 2003. A comparison of headnet electrode arrays for electrical impedance tomography of the human head. Physiological Measurement. 24 (2), pp. 527-544. https://doi.org/10.1088/0967-3334/24/2/363
Electrical impedance tomography spectroscopy (EITS) for human head imaging
Yerworth, R., Bayford, R., Brown, B., Milnes, P., Conway, M. and Holder, D. 2003. Electrical impedance tomography spectroscopy (EITS) for human head imaging. Physiological Measurement. 24 (2), pp. 477-489. https://doi.org/10.1088/0967-3334/24/2/358
The application of the generalized vector sample pattern matching method for EIT image reconstruction
Dong, G., Bayford, R., Gao, S., Saito, Y., Yerworth, R., Holder, D. and Yan, W. 2003. The application of the generalized vector sample pattern matching method for EIT image reconstruction. Physiological Measurement. 24 (2), pp. 449-466. https://doi.org/10.1088/0967-3334/24/2/356
Neuromagnetic field strength outside the human head due to impedance changes from neuronal depolarization
Ahadzi, G., Liston, A., Bayford, R. and Holder, D. 2004. Neuromagnetic field strength outside the human head due to impedance changes from neuronal depolarization. Physiological Measurement. 25 (1), pp. 365-378. https://doi.org/10.1088/0967-3334/25/1/040
The spatial resolution improvement of EIT images by GVSPM-FOCUSS algorithm
Dong, G., Liu, H., Bayford, R., Yerworth, R., Gao, S., Holder, D. and Yan, W. 2004. The spatial resolution improvement of EIT images by GVSPM-FOCUSS algorithm. Physiological Measurement. 25 (1), pp. 209-225. https://doi.org/10.1088/0967-3334/25/1/027
The effect of layers in imaging brain function using electrical impedance tomograghy
Liston, A., Bayford, R. and Holder, D. 2004. The effect of layers in imaging brain function using electrical impedance tomograghy. Physiological Measurement. 25 (1), pp. 143-158. https://doi.org/10.1088/0967-3334/25/1/022
Spatial resolution improvement of 3D EIT images by the shrinking sLORETA-FOCUSS algorithm
Dong, G., Liu, H., Bayford, R., Yerworth, R., Schimpf, P. and Yan, W. 2005. Spatial resolution improvement of 3D EIT images by the shrinking sLORETA-FOCUSS algorithm. Physiological Measurement. 26 (2), pp. S199-S208. https://doi.org/10.1088/0967-3334/26/2/019
Multi-frequency electrical impedance tomography (EIT) of the adult human head: initial findings in brain tumours, arteriovenous malformations and chronic stroke, development of an analysis method and calibration
Romsauerova, A., McEwan, A., Horesh, L., Yerworth, R., Bayford, R. and Holder, D. 2006. Multi-frequency electrical impedance tomography (EIT) of the adult human head: initial findings in brain tumours, arteriovenous malformations and chronic stroke, development of an analysis method and calibration. Physiological Measurement. 27 (5), pp. S147-S161. https://doi.org/10.1088/0967-3334/27/5/S13
Factors limiting the application of electrical impedance tomography for identification of regional conductivity changes using scalp electrodes during epileptic seizures in humans
Fabrizi, L., Sparkes, M., Horesh, L., Abascal, J., McEwan, A., Bayford, R., Elwes, R., Binnie, C. and Holder, D. 2006. Factors limiting the application of electrical impedance tomography for identification of regional conductivity changes using scalp electrodes during epileptic seizures in humans. Physiological Measurement. 27 (5), pp. S163-S174. https://doi.org/10.1088/0967-3334/27/5/S14
Design and calibration of a compact multi-frequency EIT system for acute stroke imaging
McEwan, A., Romsauerova, A., Yerworth, R., Horesh, L., Bayford, R. and Holder, D. 2006. Design and calibration of a compact multi-frequency EIT system for acute stroke imaging. Physiological Measurement. 27 (5), pp. S199-S210. https://doi.org/10.1088/0967-3334/27/5/S17
Validation of a finite-element solution for electrical impedance tomography in an anisotropic medium
Abascal, J., Arridge, S., Lionheart, W., Bayford, R. and Holder, D. 2007. Validation of a finite-element solution for electrical impedance tomography in an anisotropic medium. Physiological Measurement. 28 (7), pp. S129-S140. https://doi.org/10.1088/0967-3334/28/7/S10
Use of statistical parametric mapping (SPM) to enhance electrical impedance tomography (EIT) image sets.
Yerworth, R., Zhang, Y., Tidswell, A., Bayford, R. and Holder, D. 2007. Use of statistical parametric mapping (SPM) to enhance electrical impedance tomography (EIT) image sets. Physiological Measurement. 28 (7), pp. S141-S151. https://doi.org/10.1088/0967-3334/28/7/S11
The peri-electrode space is a significant element of the electrode-brain interface in deep brain stimulation: a computational study
Yousif, N., Bayford, R., Bain, P. and Liu, X. 2007. The peri-electrode space is a significant element of the electrode-brain interface in deep brain stimulation: a computational study. Brain Research Bulletin. 74 (5), pp. 361-368. https://doi.org/10.1016/j.brainresbull.2007.07.007
Quantifying the effects of the electrode-brain interface on the crossing electric currents in deep brain recording and stimulation
Yousif, N., Bayford, R., Wang, S. and Liu, X. 2008. Quantifying the effects of the electrode-brain interface on the crossing electric currents in deep brain recording and stimulation. Neuroscience. 152 (3), pp. 683-691. https://doi.org/10.1016/j.neuroscience.2008.01.023
13th International conference on electrical bioimpedance and 8th conference on electrical impedance tomography
Bayford, R. and Scharfetter, H. 2008. 13th International conference on electrical bioimpedance and 8th conference on electrical impedance tomography. Physiological Measurement. 29 (6), pp. E1-E2. https://doi.org/10.1088/0967-3334/29/6/E01
The influence of reactivity of the electrode-brain interface on the crossing electric current in therapeutic deep brain stimulation
Yousif, N., Bayford, R. and Liu, X. 2008. The influence of reactivity of the electrode-brain interface on the crossing electric current in therapeutic deep brain stimulation. Neuroscience. 156 (3), pp. 597-606. https://doi.org/10.1016/j.neuroscience.2008.07.051
Comparison of methods for optimal choice of the regularization parameter for linear electrical impedance tomography of brain function
Abascal, J., Arridge, S., Bayford, R. and Holder, D. 2008. Comparison of methods for optimal choice of the regularization parameter for linear electrical impedance tomography of brain function. Physiological Measurement. 29 (11), pp. 1319-1334. https://doi.org/10.1088/0967-3334/29/11/007
Towards the development of an electrochemical biosensor for hCGβ detection
Kassanos, P., Iles, R., Bayford, R. and Demosthenous, A. 2008. Towards the development of an electrochemical biosensor for hCGβ detection. Physiological Measurement. 29 (6), pp. S241-S254. https://doi.org/10.1088/0967-3334/29/6/S21
Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats
Bianchi, M., Fone, K., Shah, A., Atkins, A., Dawson, L., Heidbreder, C., Hagan, J. and Marsden, C. 2009. Chronic fluoxetine differentially modulates the hippocampal microtubular and serotonergic system in grouped and isolation reared rats. European Neuropsychopharmacology. 19 (11), pp. 778-790. https://doi.org/10.1016/j.euroneuro.2009.06.005
Task based visualization of 5D brain EIT data
Zhang, Y., Passmore, P. and Bayford, R. 2009. Task based visualization of 5D brain EIT data. SAC09: The 2009 ACM Symposium on Applied Computing. Honolulu Hawaii, USA 08 - 12 Mar 2009 New York Association for Computing Machinery (ACM). pp. 831-835 https://doi.org/10.1145/1529282.1529459
Improving the finite element forward model of the human head by warping using elastic deformation
Tizzard, A. and Bayford, R. 2007. Improving the finite element forward model of the human head by warping using elastic deformation. Physiological Measurement. 28 (7), pp. 163-182. https://doi.org/10.1088/0967-3334/28/7/S13
STOX1 is not imprinted and is not likely to be involved in preeclampsia.
Hills, F., Iglesias-Platas, I., Jebbink, J. and Monk, D. 2007. STOX1 is not imprinted and is not likely to be involved in preeclampsia. Nature Genetics. 39 (3), pp. 279-280. https://doi.org/10.1038/ng0307-279
Limited evolutionary conservation of imprinting in the human placenta
Hills, F., Apostolidou, S., Arnaud, P. and Monk, D. 2006. Limited evolutionary conservation of imprinting in the human placenta. Proceedings of the National Academy of Sciences. 103 (17), pp. 6623-6628. https://doi.org/10.1073/pnas.0511031103
A comparison of techniques to optimize measurement of voltage changes in electrical impedance tomography by minimizing phase shift errors
Bayford, R., Eadie, L., Fitzgerald, A. and Holder, D. 2002. A comparison of techniques to optimize measurement of voltage changes in electrical impedance tomography by minimizing phase shift errors. IEEE Transactions on Medical Imaging. 21 (6), pp. 668-675. https://doi.org/10.1109/TMI.2002.800577
Bioimpedance; tomography (electrical impedance tomography).
Bayford, R. 2006. Bioimpedance; tomography (electrical impedance tomography). Annual Review of Biomedical Engineering. 8 (1), pp. 63-91. https://doi.org/10.1146/annurev.bioeng.8.061505.095716
Using the GRID to improve the computation speed of electrical impedance tomography (EIT) reconstruction algorithms
Bayford, R., Fritschy, J., Holder, D. and Horesh, L. 2005. Using the GRID to improve the computation speed of electrical impedance tomography (EIT) reconstruction algorithms. Physiological Measurement.
Use of anisotropic modelling in electrical impedance tomography: description of method and preliminary assessment of utility in imaging brain function in the adult human head
Abascal, J., Arridge, S., Atkinson, D., Horesh, R., Fabrizi, L., De Lucia, M., Horesh, L., Bayford, R. and Holder, D. 2008. Use of anisotropic modelling in electrical impedance tomography: description of method and preliminary assessment of utility in imaging brain function in the adult human head. NeuroImage. 43 (2), pp. 258-268. https://doi.org/10.1016/j.neuroimage.2008.07.023
The use of a European telemedicine system to examine the effects of pollutants and allergens on asthmatic respiratory health
Crabbe, H., Barber, A., Bayford, R., Hamilton, R., Jarrett, D. and Machin, N. 2004. The use of a European telemedicine system to examine the effects of pollutants and allergens on asthmatic respiratory health. Science of the Total Environment. https://doi.org/10.1016/j.scitotenv.2004.04.045
EIT images with improved spatial resolution using a realistic head model
Dong, G., Bayford, R., Liu, H., Zhou, Y. and Yan, W. 2006. EIT images with improved spatial resolution using a realistic head model. 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. New York, NY, USA 31 Aug - 03 Sep 2006 IEEE. pp. 1134-1137 https://doi.org/10.1109/IEMBS.2006.259794
Dynamic modelling of electrical current distribution in the deep structure of the brain
Bayford, R., Tizzard, A. and Liu, X. 2005. Dynamic modelling of electrical current distribution in the deep structure of the brain. in: The 3rd IEE International Seminar on Medical Applications of Signal Processing 2005 (Ref. No. 2005-1119) London,UK The Institution of Engineering and Technology (IET).
Applications of GRID in clinical neurophysiology and electrical impedance tomography of brain function
Fritschy, J., Horesh, L., Holder, D. and Bayford, R. 2005. Applications of GRID in clinical neurophysiology and electrical impedance tomography of brain function. Solomonides, T., McClatchey, R., Breton, V., Legré, Y., and Nørager, S. (ed.) Healthgrid 2005: 3rd annual conference of the Healthgrid association. Oxford, UK 2005 IOS Press. pp. 138-145
Visualization and post-processing of 5D Brain Images
Zhang, Y., Passmore, P. and Bayford, R. 2005. Visualization and post-processing of 5D Brain Images. 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Shanghai, China 01 - 04 Sep 2005 IEEE. pp. 1083-1086 https://doi.org/10.1109/IEMBS.2005.1616607
Regulation of human villous trophoblast by insulin-like growth factors and insulin-like growth factor-binding protein-1
Hills, F., Chard, T., Elder, M. and Sullivan, M. 2004. Regulation of human villous trophoblast by insulin-like growth factors and insulin-like growth factor-binding protein-1. Journal of Endocrinology. 183 (3), pp. 487-496. https://doi.org/10.1677/joe.1.05867
Electrical impedance tomography of human brain function using reconstruction algorithms based on the finite element method
Tizzard, A., Bagshaw, A., Bayford, R. and Liston, A. 2003. Electrical impedance tomography of human brain function using reconstruction algorithms based on the finite element method. NeuroImage. 20 (2), pp. 752-764. https://doi.org/10.1016/S1053-8119(03)00301-X
Three-dimensional electrical impedance tomography of human brain activity
Tidswell, A., Gibson, A., Bayford, R. and Holder, D. 2001. Three-dimensional electrical impedance tomography of human brain activity. NeuroImage. 13 (2), pp. 283-294. https://doi.org/10.1006/nimg.2000.0698
Polyclonal anti-tumor necrosis factor-alpha Fab used as an ancillary treatment for severe malaria
Looareesuwan, S., Sjorstrom, L., Krudsood, S., Wilairatana, P., Porter, R., Hills, F. and Warrell, D. 1999. Polyclonal anti-tumor necrosis factor-alpha Fab used as an ancillary treatment for severe malaria. The American Journal of Tropical Medicine and Hygiene. 61 (1), pp. 26-33. https://doi.org/10.4269/ajtmh.1999.61.26
Mechanism of action of the intrauterine contraceptive device: evidence for a specific biochemical deficiency in the endometrium
Seleem, S., Hills, F., Salem, H., El-Nashar, E. and Chard, T. 1996. Mechanism of action of the intrauterine contraceptive device: evidence for a specific biochemical deficiency in the endometrium. Human Reproduction. 11 (6), pp. 1220-1222.
Application of constrained optimisation techniques inelectrical impedance tomography
Bayford, R. 1994. Application of constrained optimisation techniques inelectrical impedance tomography. PhD thesis Middlesex University School of Science and Technology