The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines

Article

Senior, J., Shah, A., Monteux, C. and de Biasi, V. 2001. The evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines. Journal of Pharmaceutical and Biomedical Analysis. 24 (5-6), pp. 843-848. https://doi.org/10.1016/S0731-7085(00)00551-3
TypeArticle
TitleThe evaluation of interdigitated array electrodes for the measurement of catecholamines and indoleamines
AuthorsSenior, J., Shah, A., Monteux, C. and de Biasi, V.
Abstract

The use of Interdigitated Array (IDA) Microelectrodes for detection of low levels of biogenic amines has been demonstrated in stationary solutions and flow systems [M. Morita, et al., Electrochemica Acta 42 (20--21) (1997) 3177--3183]. This technique is highly sensitive. We have evaluated this technology as applied to High Pressure Liquid Chromatography with Electrochemical Detection (HPLC-EC) for analysis of microdialysate and tissue samples. With this new technology we demonstrated a x 10 fold increase in sensitivity in comparison to our existing technology. We are now able to detect dopamine at a level of 53 x 10(-18) moles on column and serotonin at 26 x 10(-18) moles on column. This technology now permits analysis of biogenic amines in samples from brain areas not previously amenable to this type of experiment.

PublisherElsevier
JournalJournal of Pharmaceutical and Biomedical Analysis
ISSN0731-7085
Publication dates
Online07 Mar 2001
Print31 Mar 2001
Publication process dates
Deposited01 Nov 2017
Submitted02 Jun 2000
Accepted20 Nov 2000
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1016/S0731-7085(00)00551-3
LanguageEnglish
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