A method to assess bioavailability of antibiotics in anthropogenic polluted ecosystems by using a bacterial fitness test
Article
Marvasi, M., Canali, A., Perito, B., Shah, A. and Serafim, V. 2019. A method to assess bioavailability of antibiotics in anthropogenic polluted ecosystems by using a bacterial fitness test. Journal of Microbiological Methods. 167, pp. 1-5. https://doi.org/10.1016/j.mimet.2019.105724
Type | Article |
---|---|
Title | A method to assess bioavailability of antibiotics in anthropogenic polluted ecosystems by using a bacterial fitness test |
Authors | Marvasi, M., Canali, A., Perito, B., Shah, A. and Serafim, V. |
Abstract | Antibiotics released in the environment exert a selective pressure on the resident microbiota. It is well accepted that the mere measurement of antibiotics does not reflect the actual bioavailability. In fact, antibiotics can be adsorbed or complexed to particles and/or chemicals in water and soil. Bioavailable concentrations of antibiotics in soil and water are subjected to great uncertainty, therefore biological assays are increasingly recognized as that allow an indirect determination of the residual antibiotic activity. Here we propose how a fitness test for bacteria can be used to qualitatively assess the bioavailability of a specific antibiotic in the environment. The findings show that by using a pair of resistant and sensitive bacterial strains, the resulting fitness can indirectly reflect antibiotic bioavailability. Hence, this test can be used as a complementary assay to other biological and |
Publisher | Elsevier |
Journal | Journal of Microbiological Methods |
ISSN | 0167-7012 |
Publication dates | |
Online | 06 Nov 2019 |
01 Dec 2019 | |
Publication process dates | |
Deposited | 05 Nov 2019 |
Accepted | 15 Sep 2019 |
Output status | Published |
Accepted author manuscript | License |
Accepted author manuscript | License |
Accepted author manuscript | License |
Accepted author manuscript | License |
Accepted author manuscript | License |
Copyright Statement | © 2019. This author's accepted manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.mimet.2019.105724 |
Language | English |
https://repository.mdx.ac.uk/item/8891z
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Accepted author manuscript
A method to assess bioavailability of antibiotics in anthropogenic polluted ecosystems by using a bacterial fitness test_MIMET_2019.pdf | ||
License: CC BY-NC-ND 4.0 |
A method to assess bioavailability of antibiotics in anthropogenic polluted ecosystems by using a bacterial fitness test_Table I.pdf | ||
License: CC BY-NC-ND 4.0 |
A method to assess bioavailability of antibiotics in anthropogenic polluted ecosystems by using a bacterial fitness test_Figure 1_v1.pdf | ||
License: CC BY-NC-ND 4.0 |
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