pH regulation of penicillin production in Aspergillus nidulans

Article

Shah, A., Tilburn, J., Adlard, M. and Arst, H. 1991. pH regulation of penicillin production in Aspergillus nidulans. FEMS microbiology letters. 77 (2-3), pp. 209-212. https://doi.org/10.1111/j.1574-6968.1991.tb04349.x
TypeArticle
TitlepH regulation of penicillin production in Aspergillus nidulans
AuthorsShah, A., Tilburn, J., Adlard, M. and Arst, H.
Abstract

As shown by both bioassay and high-performance liquid chromatographic (HPLC) analysis, penicillin G production by Aspergillus nidulans is subject to regulation by the pH of the growth medium. Penicillin titres were highest at alkaline pH and in strains carrying mutations in the regulatory gene pacC which mimics the effects of growth at alkaline pH. They were lowest at acid pH and in strains carrying mutations in the palA, palB, palC, palE or palF genes which mimic the effects of growth at acid pH.

Research GroupBiomarkers for Cancer group
PublisherOxford University Press (OUP)
JournalFEMS microbiology letters
ISSN0378-1097
Publication dates
Print01 Jan 1991
Publication process dates
Deposited02 Feb 2018
Accepted09 Nov 1990
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1111/j.1574-6968.1991.tb04349.x
LanguageEnglish
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