Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries

Article

Tolson, D., Organ, A. and Shah, A. 2001. Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries. Rapid Communications in Mass Spectrometry. 15 (14), pp. 1244-1249. https://doi.org/10.1002/rcm.359
TypeArticle
TitleDevelopment of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries
AuthorsTolson, D., Organ, A. and Shah, A.
Abstract

Parallel liquid chromatography/mass spectrometer (LC/MS) systems such as the Micromass MUX™ have been commercially available for several years. Until recently, the LC pumping systems available have been a serious limitation to the more widespread adoption of such systems, particularly in good laboratory practice (GLP) environments. In this work, we compare the performance of the Jasco PAR-1500 pumping system, which delivers an equal gradient flow to eight individual flow channels, to that of a conventional system, where the flow is split post pump. Both systems were coupled to a Micromass LCT™ liquid chromatography/electrospray ionisation time-of-flight (LC/ESI-TOF) mass spectrometer equipped with a parallel MUX™ inlet system, used for the analysis of combinatorial libraries. In addition to flow stability, the Jasco system has resulted in a dramatic improvement in chromatographic performance. Copyright © 2001 John Wiley & Sons, Ltd.

PublisherWiley
JournalRapid Communications in Mass Spectrometry
ISSN0951-4198
Publication dates
Online26 Jun 2001
Print01 Jul 2001
Publication process dates
Deposited01 Nov 2017
Accepted21 May 2001
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1002/rcm.359
LanguageEnglish
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