Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries
Article
Tolson, D., Organ, A. and Shah, A. 2001. Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries. Rapid Communications in Mass Spectrometry. 15 (14), pp. 1244-1249. https://doi.org/10.1002/rcm.359
Type | Article |
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Title | Development of a high-pressure gradient pumping system for parallel liquid chromatography/mass spectrometry for the analysis of combinatorial libraries |
Authors | Tolson, D., Organ, A. and Shah, A. |
Abstract | Parallel liquid chromatography/mass spectrometer (LC/MS) systems such as the Micromass MUX™ have been commercially available for several years. Until recently, the LC pumping systems available have been a serious limitation to the more widespread adoption of such systems, particularly in good laboratory practice (GLP) environments. In this work, we compare the performance of the Jasco PAR-1500 pumping system, which delivers an equal gradient flow to eight individual flow channels, to that of a conventional system, where the flow is split post pump. Both systems were coupled to a Micromass LCT™ liquid chromatography/electrospray ionisation time-of-flight (LC/ESI-TOF) mass spectrometer equipped with a parallel MUX™ inlet system, used for the analysis of combinatorial libraries. In addition to flow stability, the Jasco system has resulted in a dramatic improvement in chromatographic performance. Copyright © 2001 John Wiley & Sons, Ltd. |
Publisher | Wiley |
Journal | Rapid Communications in Mass Spectrometry |
ISSN | 0951-4198 |
Publication dates | |
Online | 26 Jun 2001 |
01 Jul 2001 | |
Publication process dates | |
Deposited | 01 Nov 2017 |
Accepted | 21 May 2001 |
Output status | Published |
Digital Object Identifier (DOI) | https://doi.org/10.1002/rcm.359 |
Language | English |
https://repository.mdx.ac.uk/item/8741w
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