Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight.
Article
Hills, F., English, J. and Chard, T. 1996. Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight. Journal of Endocrinology. 148 (2), pp. 303-309. https://doi.org/10.1677/joe.0.1480303
Type | Article |
---|---|
Title | Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight. |
Authors | Hills, F., English, J. and Chard, T. |
Abstract | Serum levels of IGF-I and IGF-binding protein (IGFBP-1) have been determined in the maternal circulation between 11 and 42 weeks of gestation in women not in labour (n = 335) and in the maternal and fetal circulations at the time of delivery between 37 and 42 weeks (n = 55). Maternal serum (MS) IGF-I levels increased during pregnancy and showed a significant positive correlation with maternal weight (P = 0.0033) but no correlation with birthweight. The MS IGFBP-1 levels did not change during the second and third trimesters and showed a negative correlation with birthweight, maternal weight, placental weight and MS glucose (P = 0.0002, P < 0.0001, P = 0.047, P = 0.024 respectively). MS IGFBP-1 levels were higher in small-for-gestational age babies than in average-for-gestational weight babies (P = 0.026) and lower in the large-for-gestational weight group (P = 0.048). There was a significant rise in mean MS IGFBP-1 levels during labour (P = 0.0005). These findings suggest that IGFBP-1 may be an important factor in pathological growth retardation. |
Keywords | IGF-I IGFBP-1 Pregnancy Birthweight |
Research Group | Centre for Investigative and Diagnostic Oncology |
Biomarkers for Cancer group | |
Reproductive Biology group | |
Publisher | Society for Endocrinology |
Journal | Journal of Endocrinology |
ISSN | 0022-0795 |
Publication dates | |
Feb 1996 | |
Publication process dates | |
Deposited | 25 Mar 2010 |
Output status | Published |
Digital Object Identifier (DOI) | https://doi.org/10.1677/joe.0.1480303 |
Language | English |
https://repository.mdx.ac.uk/item/8263w
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