Mechanism of action of the intrauterine contraceptive device: evidence for a specific biochemical deficiency in the endometrium
Article
Seleem, S., Hills, F., Salem, H., El-Nashar, E. and Chard, T. 1996. Mechanism of action of the intrauterine contraceptive device: evidence for a specific biochemical deficiency in the endometrium. Human Reproduction. 11 (6), pp. 1220-1222.
Type | Article |
---|---|
Title | Mechanism of action of the intrauterine contraceptive device: evidence for a specific biochemical deficiency in the endometrium |
Authors | Seleem, S., Hills, F., Salem, H., El-Nashar, E. and Chard, T. |
Abstract | The precise mechanism of action of the intrauterine contraceptive device (IUCD) is uncertain. In this study we compared the circulating concentrations of a specific endometrial protein, placental protein 14 (PP14), in 62 women with an IUCD and 16 controls. The concentrations of PP14 were substantially lower in IUCD users. There was no difference in the concentrations of another and less specific endometrial protein, insulin-like growth factor binding protein-1 (IGFBP-1). There was no difference in PP14 concentrations between those women with and without intermenstrual bleeding. We conclude that the reduced concentrations of PP14 in IUCD users reflect defective endometrial function in these women, probably related to the contraceptive effect We propose that the measurement of PP14 might be a means of comparing the efficiency of different devices. |
Keywords | ContraceptiveIUCDIGFBP-1 |
Research Group | Biomarkers for Cancer group |
Reproductive Biology group | |
Centre for Investigative and Diagnostic Oncology | |
Publisher | Oxford University Press (OUP) |
Journal | Human Reproduction |
ISSN | 0268-1161 |
Publication dates | |
Jun 1996 | |
Publication process dates | |
Deposited | 25 Mar 2010 |
Output status | Published |
Web address (URL) | http://humrep.oxfordjournals.org/cgi/reprint/11/6/1220 |
Language | English |
https://repository.mdx.ac.uk/item/8263v
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