Mechanism of action of the intrauterine contraceptive device: evidence for a specific biochemical deficiency in the endometrium

Article

Seleem, S., Hills, F., Salem, H., El-Nashar, E. and Chard, T. 1996. Mechanism of action of the intrauterine contraceptive device: evidence for a specific biochemical deficiency in the endometrium. Human Reproduction. 11 (6), pp. 1220-1222.
TypeArticle
TitleMechanism of action of the intrauterine contraceptive device: evidence for a specific biochemical deficiency in the endometrium
AuthorsSeleem, S., Hills, F., Salem, H., El-Nashar, E. and Chard, T.
Abstract

The precise mechanism of action of the intrauterine contraceptive device (IUCD) is uncertain. In this study we compared the circulating concentrations of a specific endometrial protein, placental protein 14 (PP14), in 62 women with an IUCD and 16 controls. The concentrations of PP14 were substantially lower in IUCD users. There was no difference in the concentrations of another and less specific endometrial protein, insulin-like growth factor binding protein-1 (IGFBP-1). There was no difference in PP14 concentrations between those women with and without intermenstrual bleeding. We conclude that the reduced concentrations of PP14 in IUCD users reflect defective endometrial function in these women, probably related to the contraceptive effect We propose that the measurement of PP14 might be a means of comparing the efficiency of different devices.

KeywordsContraceptiveIUCDIGFBP-1
Research GroupBiomarkers for Cancer group
Reproductive Biology group
Centre for Investigative and Diagnostic Oncology
PublisherOxford University Press (OUP)
JournalHuman Reproduction
ISSN0268-1161
Publication dates
PrintJun 1996
Publication process dates
Deposited25 Mar 2010
Output statusPublished
Web address (URL)http://humrep.oxfordjournals.org/cgi/reprint/11/6/1220
LanguageEnglish
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