The insulin-like growth factor system in mammalian pregnancy: a workshop report

Article


Carter, A., Hills, F., O'Gorman, D., Robets, C., Soorana, S., Watson, C. and Westwood, M. 2004. The insulin-like growth factor system in mammalian pregnancy: a workshop report. Placenta. 25 (Supple), pp. S53-S56. https://doi.org/10.1016/j.placenta.2004.01.019
TypeArticle
TitleThe insulin-like growth factor system in mammalian pregnancy: a workshop report
AuthorsCarter, A., Hills, F., O'Gorman, D., Robets, C., Soorana, S., Watson, C. and Westwood, M.
Abstract

The insulin-like growth factors (IGF-I and -II) and their binding proteins (IGFBP-1 to -6) are major players throughout gestation, being involved in implantation, placentation and fetal development. In human pregnancy, alterations of the IGF/IGFBP system are associated with serious complications such as intrauterine growth restriction (IUGR) and pre-eclampsia [1 and 2]. Work on the post-translational modification of IGFBP-1 and its role in trophoblast invasion and fetal growth has furthered our understanding of normal and abnormal pregnancy. Although there are species differences as well as similarities, recent work on transgenic mice offers insight into the IGF/IGFBP system in gestation. The use of conditional knockout of the various components of the IGF/IGFBP system represents a further step in this direction. The aim of this workshop was to bring together these various strands of research.

Research GroupCentre for Investigative & Diagnostic Oncoloy
Biomarkers for Cancer group
Reproductive Biology group
PublisherElsevier
JournalPlacenta
ISSN0143-4004
Publication dates
PrintApr 2004
Publication process dates
Deposited17 Jun 2009
Output statusPublished
Additional information

PubMed PMID: 15033308.

Web address (URL)http://www.sciencedirect.com/science/article/pii/S0143400404000335
Digital Object Identifier (DOI)https://doi.org/10.1016/j.placenta.2004.01.019
LanguageEnglish
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