Influence of tart cherry juice on airway biomarkers of inflammation and oxidative stress following a 42.2km trail run

Conference item

Dimitriou, L., Yagnik, D., Wood, A., Sinclair, S., Paice, K., Wilson, L., Hills, F., Gondek, M., Kwan Xue Bin, K., Howatson, G. and Cockburn, E. 2018. Influence of tart cherry juice on airway biomarkers of inflammation and oxidative stress following a 42.2km trail run. 23rd annual congress of the European College of Sport Science. Dublin, Ireland 04 - 07 Jul 2018
TitleInfluence of tart cherry juice on airway biomarkers of inflammation and oxidative stress following a 42.2km trail run
AuthorsDimitriou, L., Yagnik, D., Wood, A., Sinclair, S., Paice, K., Wilson, L., Hills, F., Gondek, M., Kwan Xue Bin, K., Howatson, G. and Cockburn, E.
Abstract

Introduction
Tart cherry juice (CJ) has been shown to alleviate the development of respiratory symptoms following a Marathon (Dimitriou et al., 2015) by possibly reducing exercise-induced airway inflammation (Verges et al., 2005). Therefore, this study examined the effects of CJ supplementation before and following a 42.2km trail run on biomarkers of airway inflammation and oxidative stress.
Methods
Nineteen recreational runners were randomly assigned to either consumption of CJ or placebo (PL) (age 39 ? 8 years; height 1.75 ? 0.7 m; mass 71.9 ? 8.2 kg; completion time 210 ? 25 min), from 4 days prior to 48h following a 42.2km trail run. Fractional exhaled nitric oxide (FeNO) and hypertonic inhalation-induced sputum (IS) samples were measured immediately before and after the run and then 24h and 48h post run. Both, FeNO and IS are non-invasive methods that can determine the type and severity of airway inflammation. Induced sputum samples were analysed for biomarkers of: a) inflammation (CD163; CD3E; CD44; CD62E; CD66E; Elastase and Interleukin-6 (IL-6)) and b) oxidative stress (protein carbonyls (PC) and superoxide dismutases (SOD)). The percentage of markers expressed on the surface of activated cells was determined using flow cytometry and the remaining biomarkers (IL-6; PC and SOD) were analysed using enzyme-linked immunosorbent assays (ELISA). Data were analysed using magnitude based inferences and results are reported as factor changes.
Results
Compared to PL, CJ was beneficial for changes in CD163 (B-post 1.11 v 0.60, likely moderate; B-48h 1.60 v 0.75, very likely moderate), CD44 (B-48h 1.18 v 0.59, likely moderate), CD62E (B-post 1.08 v 0.69, likely small), CD66E (B-post 0.91 v 0.52, likely moderate; B-48h 1.03 v 0.67, likely small), IL-6 (B-48h 1.32 v 0.83, possible small) and SOD (B-post 1.01 v 0.77, likely small; B-24h 1.14 v 0.80, likely small; B-48h 0.96 v 0.70, likely small). However, CJ was harmful for changes in FENO (B-post 1.09 v 1.28, possible trivial; B-24h 1.04 v 1.21, possible small; B-48h 1.11 v 1.25, possible small) and PC (B-post 1.07 v 1.41, possible small; B-24h 0.99 v 1.22, possible small; B-48h 1.11 v 1.43, possible small). All other effects were unclear.
Conclusion
Airway inflammation biomarkers were decreased in the cherry juice group, whereas an increase was observed in the placebo group. However, cherry juice led to greater increases in FENO and PC compared to placebo. Cherry juice was beneficial for limiting exercise-induced airway inflammation.

Research GroupPhysiology at the London Sport Institute
Conference23rd annual congress of the European College of Sport Science
ISBN
Hardcover9783981841411
Publication dates
Print07 Jul 2018
Publication process dates
Deposited25 Sep 2019
Accepted01 Apr 2018
Output statusPublished
Additional information

23rd Annual Congress of the European College of Sport Science 4th - 7th July 2018, Dublin – Ireland: Book of Abstracts, European College of Sport Science, ISBN: 9783981841411

LanguageEnglish
Book title23rd Annual Congress of the European College of Sport Science 4th - 7th July 2018, Dublin – Ireland: Book of Abstract
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Bone mineral density and aspects of the female athlete triad in elite endurance runners: 1562: Board# 218 June 2 11: 00 AM-12: 30 PM
Pollock, N., Grogan, C., Perry, M., Pedlar, C., Cooke, K., Morrissey, D. and Dimitriou, L. 2010. Bone mineral density and aspects of the female athlete triad in elite endurance runners: 1562: Board# 218 June 2 11: 00 AM-12: 30 PM. ACSM. LWW.
Low radial BMD is associated with reduced femoral cross sectional area in female ballet dancers
Cooke, K., Dimitriou, L. and McCormack, M. 2007. Low radial BMD is associated with reduced femoral cross sectional area in female ballet dancers. acsm. https://doi.org/10.1249/01.mss.0000273156.09179.ed
Body composition and injuries in professional ballet dancers
Naalchigar, C., McCormack, M., Pelly, J., Wyon, M. and Dimitriou, L. 2013. Body composition and injuries in professional ballet dancers. Proceedings of the International Symposium on Performance Science 2013. pp. 97-98
Regional body composition & muscular strength in female endurance athletes with low and normal radius bone mineral density: preliminary findings
Cooke, K., Dimitriou, L., Smith, N., Lee, S. and Pedlar, C. 2005. Regional body composition & muscular strength in female endurance athletes with low and normal radius bone mineral density: preliminary findings. ECSS.
Applying elite research to the general population
Sharp, N., Dimitriou, L. and Doherty, M. 2003. Applying elite research to the general population. British Journal of Sports Medicine. 37 (4), p. 372. https://doi.org/10.1136/bjsm.37.4.372-a
Bone-mineral density and other features of the female athlete triad in elite endurance runners: a longitudinal and cross-sectional observational study
Pollock, N., Grogan, C., Perry, M., Pedlar, C., Cooke, K., Morrissey, D. and Dimitriou, L. 2010. Bone-mineral density and other features of the female athlete triad in elite endurance runners: a longitudinal and cross-sectional observational study. International Journal of Sport Nutrition and Exercise Metabolism. 20 (5), pp. 418-426.
Strength and conditioning for fencing
Turner, A., Miller, S., Stewart, P., Cree, J., Ingram, R., Dimitriou, L., Moody, J. and Kilduff, L. 2013. Strength and conditioning for fencing. Strength and Conditioning Journal. 35 (1), pp. 1-9. https://doi.org/10.1519/SSC.0b013e31826e7283
Menstrual irregularity, bone mineral density and rib injuries in current and retired female lightweight rowers: 1837: Board# 1 May 29 2: 00 PM-3: 30 PM
Reid, A., Lloyd-Smith, R. and Dimitriou, L. 2008. Menstrual irregularity, bone mineral density and rib injuries in current and retired female lightweight rowers: 1837: Board# 1 May 29 2: 00 PM-3: 30 PM. acsm. LWW.
Team everest: the immune response to high altitude: 1693: Board# 43 May 27 3: 30 PM-5: 00 PM
Dimitriou, L., Chong, C., Dhunnokchand, R., Ranney, J., Jehanli, A., Speedy, T. and Ranney, M. 2009. Team everest: the immune response to high altitude: 1693: Board# 43 May 27 3: 30 PM-5: 00 PM. ACSM. LWW.
Low radial BMD is associated with reduced femoral cross sectional area in female ballet dancers: 797: June 1 8: 30 AM-8: 45 AM
Cooke, K., Dimitriou, L. and McCormack, M. 2007. Low radial BMD is associated with reduced femoral cross sectional area in female ballet dancers: 797: June 1 8: 30 AM-8: 45 AM. ACsm. LWW.
Determinants of Olympic fencing performance and implications for strength and conditioning training
Turner, A., James, N., Dimitriou, L., Greenhalgh, A., Moody, J., Fulcher, D., Mias, E. and Kilduff, L. 2014. Determinants of Olympic fencing performance and implications for strength and conditioning training. The Journal of Strength and Conditioning Research. 28 (10), pp. 3001-3011. https://doi.org/10.1519/JSC.0000000000000478
A time-motion analysis of turns performed by highly ranked Viennese waltz dancers
Prosen, J., James, N., Dimitriou, L., Perš, J. and Vučković, G. 2013. A time-motion analysis of turns performed by highly ranked Viennese waltz dancers. Journal of Human Kinetics. 37 (1). https://doi.org/10.2478/hukin-2013-0025
Influence of a montmorency cherry juice blend on indices of exercise-induced stress and upper respiratory tract symptoms following marathon running—a pilot investigation
Dimitriou, L., Hill, J., Jehnali, A., Dunbar, J., Brouner, J., McHugh, M. and Howatson, G. 2015. Influence of a montmorency cherry juice blend on indices of exercise-induced stress and upper respiratory tract symptoms following marathon running—a pilot investigation. Journal of the International Society of Sports Nutrition. 12 (1), pp. 1-7. https://doi.org/10.1186/s12970-015-0085-8
Bone mineral density, rib pain and other features of the female athlete triad in elite lightweight rowers
Dimitriou, L., Weiler, R., Lloyd-Smith, R., Turner, A., Heath, L., James, N. and Reid, A. 2014. Bone mineral density, rib pain and other features of the female athlete triad in elite lightweight rowers. BMJ Open. 4 (2), pp. 1-9. https://doi.org/10.1136/bmjopen-2013-004369
Circadian effects on the acute responses of salivary cortisol and IgA in well trained swimmers
Dimitriou, L., Sharp, N. and Doherty, M. 2002. Circadian effects on the acute responses of salivary cortisol and IgA in well trained swimmers. British Journal of Sports Medicine. 36 (4), pp. 260-264. https://doi.org/10.1136/bjsm.36.4.260
Comparison of lung volume in Greek swimmers, land based athletes, and sedentary controls using allometric scaling
Doherty, M. and Dimitriou, L. 1997. Comparison of lung volume in Greek swimmers, land based athletes, and sedentary controls using allometric scaling. British Journal of Sports Medicine. 31 (4), pp. 337-341. https://doi.org/10.1136/bjsm.31.4.337
Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation
Yagnik, D. 2014. Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation. International Journal of Inflammation. 2014, pp. 1-6. https://doi.org/10.1155/2014/526496
Placental syndecan-1 and sulphated glycosaminoglycans are decreased in preeclampsia
Heyer-Chauhan, N., Ovbude, I., Hills, A., Sullivan, M. and Hills, F. 2013. Placental syndecan-1 and sulphated glycosaminoglycans are decreased in preeclampsia. Journal of Perinatal Medicine. https://doi.org/10.1515/jpm-2013-0097
IGFBP-1 in the placenta, membranes and fetal circulation: levels at term and preterm delivery
Hills, F., Gunn, L., Hardiman, P., Thanaratnam, S. and Chard, T. 1996. IGFBP-1 in the placenta, membranes and fetal circulation: levels at term and preterm delivery. Early Human Development. 44 (1), pp. 71-76.
Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy
Hills, F., Iles, R. and Sullivan, M. 2013. Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy. Journal of Perinatal Medicine. 41 (3), pp. 241-249. https://doi.org/10.1515/jpm-2012-0086
Insulin-like growth factor-II and heparin are anti-apoptotic survival factors in human villous cytotrophoblast
Hills, F., Mehmet, H. and Sullivan, M. 2012. Insulin-like growth factor-II and heparin are anti-apoptotic survival factors in human villous cytotrophoblast. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 163 (1), pp. 11-16. https://doi.org/10.1016/j.ejogrb.2012.03.013
Superovulation, IGFBP-1 and birth weight.
Johnson, M., Irvine, R., Hills, F., Bolton, V., Abbas, A., Brooks, A., Allman, A., Chard, T. and Nicolaides, K. 1995. Superovulation, IGFBP-1 and birth weight. European Journal of Obstetrics, Gynaecology and Reproductive Biology. 59 (2), pp. 193-195.
The effects of labor on maternal and fetal levels of insulin-like growth factor binding protein-1
Hills, F., Crawford, R., Harding, S., Farkas, F. and Chard, T. 1994. The effects of labor on maternal and fetal levels of insulin-like growth factor binding protein-1. American Journal of Obstetrics and Gynecology. 171 (5), pp. 1292-1295.
Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies.
Brooks, A., Johnson, M., Hills, F., Chard, T., Irvine, R. and Abdalla, H. 1995. Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies. European Journal of Obstetrics, Gynaecology and Reproductive Biology. 59 (1), pp. 91-94.
Elevated levels of insulin-like growth factor binding protein-1 in fetal distress.
Crawford, R., Hills, F., Farkas, A. and Chard, T. 1995. Elevated levels of insulin-like growth factor binding protein-1 in fetal distress. British Journal of Obstetrics and Gynaecology. 102 (7), pp. 538-540.
Lack of evidence for a circadian rhythm of IGFBP-1 in the mother and fetus during labour.
Harding, S., Mensah, A., Hills, F., Howell, R. and Chard, T. 1995. Lack of evidence for a circadian rhythm of IGFBP-1 in the mother and fetus during labour. British Journal of Obstetrics and Gynaecology. 102 (11), pp. 891-893.
Raised circulating levels of interleukin-6 in women with an intrauterine contraceptive device.
Wolley, J., Saleem, S., Hills, F., Salem, H., El-Nashar, E. and Chard, T. 1996. Raised circulating levels of interleukin-6 in women with an intrauterine contraceptive device. Gynecologic and Obstetric Investigation. 42 (4), pp. 241-243.
Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight.
Hills, F., English, J. and Chard, T. 1996. Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birthweight and maternal weight. Journal of Endocrinology. 148 (2), pp. 303-309. https://doi.org/10.1677/joe.0.1480303
Antenatal dexamethasone therapy does not affect circulating concentrations of insulin-like growth factor binding protein-1.
Ogueh, O., Hills, F., Chard, T. and Johnson, M. 1998. Antenatal dexamethasone therapy does not affect circulating concentrations of insulin-like growth factor binding protein-1. Human Reproduction. 13 (6), pp. 1714-1716. https://doi.org/10.1093/humrep/13.6.1714
Effects of co-trimoxazole, erythromycin, amoxycillin, tetracycline and chloroquine on sperm function in vitro
Hargreaves, C., Rogers, S., Hills, F., Rahman, F., Howell, R. and Homa, S. 1998. Effects of co-trimoxazole, erythromycin, amoxycillin, tetracycline and chloroquine on sperm function in vitro. Human Reproduction. 13 (7), pp. 1878-1886.
Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression
Monk, D., Arnaud, P., Frost, J., Hills, F., Stanier, P., Feil, R. and Moore, G. 2009. Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression. Human Molecular Genetics. 18 (16), pp. 3066-3074. https://doi.org/10.1093/hmg/ddp248
Heparin prevents programmed cell death in human trophoblast
Hills, F., Abrahams, V., Gonzalez-Timon, B., Francis, J., Cloke, B., Hinkson, L., Rai, R., Regan, L., Mor, G., Sullivan, M., Lam, E. and Brosens, J. 2006. Heparin prevents programmed cell death in human trophoblast. Molecular Human Reproduction. 12 (4), pp. 237-242.
A longitudinal study of maternal plasma insulin-like growth factor binding protein-1 concentrations during normal pregnancy and pregnancies complicated by pre-eclampsia
Anim-Nyame, N., Hills, F., Soorana, S., Steer, P. and Johnson, M. 2000. A longitudinal study of maternal plasma insulin-like growth factor binding protein-1 concentrations during normal pregnancy and pregnancies complicated by pre-eclampsia. Human Reproduction. 15 (10), pp. 2215-2219. https://doi.org/10.1093/humrep/15.10.2215
Interactions between progesterone receptor isoforms in myometrial cells in human labour
Pieber, D., Allport, V., Hills, F., Johnson, M. and Bennett, P. 2001. Interactions between progesterone receptor isoforms in myometrial cells in human labour. Molecular Human Reproduction. 7 (9), pp. 875-879. https://doi.org/10.1093/molehr/7.9.875
Regulated expression of signal transducer and activator of transcription, Stat5, and its enhancement of PRL expression in human endometrial stromal cells in vitro
Mak, I., Brosens, J., Christian, M., Hills, F., Chamley, L., Regan, L. and White, J. 2002. Regulated expression of signal transducer and activator of transcription, Stat5, and its enhancement of PRL expression in human endometrial stromal cells in vitro. Journal of Clinical Endocrinology and Metabolism. 87 (6), pp. 2581-2588. https://doi.org/10.1210/jc.87.6.2581
Progesterone represses interleukin-8 and cyclo-oxygenase-2 in human lower segment fibroblast cells and amnion epithelial cells
Loudon, J., Elliott, C., Hills, F. and Bennett, P. 2003. Progesterone represses interleukin-8 and cyclo-oxygenase-2 in human lower segment fibroblast cells and amnion epithelial cells. Biology of Reproduction. 69 (1), pp. 331-337.
The relationship between insulin and insulin-like growth factor binding protein-1 is modified by pre-eclampsia.
Anim-Nyame, N., Hills, F., Soorana, S., Steer, P. and Johnson, M. 2003. The relationship between insulin and insulin-like growth factor binding protein-1 is modified by pre-eclampsia. Gynecological endocrinology.. 17 (6), pp. 471-476. https://doi.org/10.1080/09513590312331290408
The insulin-like growth factor system in mammalian pregnancy: a workshop report
Carter, A., Hills, F., O'Gorman, D., Robets, C., Soorana, S., Watson, C. and Westwood, M. 2004. The insulin-like growth factor system in mammalian pregnancy: a workshop report. Placenta. 25 (Supple), pp. S53-S56. https://doi.org/10.1016/j.placenta.2004.01.019
Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human
Monk, D., Sanches, R., Arnaud, P., Apostolidou, S., Hills, F., Abu-Amero, S., Murrell, A., Friess, H., Reik, W. and Stanier, P. 2006. Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human. Human Molecular Genetics. 15 (8), pp. 1259-1269. https://doi.org/10.1093/hmg/ddl041
Monocyte Fc gamma receptor expression in patients undergoing coronary artery bypass grafting
Stefanou, D., Asimakopoulos, G., Yagnik, D., Haskard, D., Anderson, J., Philippidis, P., Landis, R. and Taylor, K. 2004. Monocyte Fc gamma receptor expression in patients undergoing coronary artery bypass grafting. Annals of Thoracic Surgery. 77 (3), pp. 951-955.
STOX1 is not imprinted and is not likely to be involved in preeclampsia.
Hills, F., Iglesias-Platas, I., Jebbink, J. and Monk, D. 2007. STOX1 is not imprinted and is not likely to be involved in preeclampsia. Nature Genetics. 39 (3), pp. 279-280. https://doi.org/10.1038/ng0307-279
Limited evolutionary conservation of imprinting in the human placenta
Hills, F., Apostolidou, S., Arnaud, P. and Monk, D. 2006. Limited evolutionary conservation of imprinting in the human placenta. Proceedings of the National Academy of Sciences. 103 (17), pp. 6623-6628. https://doi.org/10.1073/pnas.0511031103
Macrophage release of transforming growth factor beta1 during resolution of monododium urate monohydrate crystal-induced inflammation
Yagnik, D., Evans, B., Florey, O., Mason, J., Landis, R. and Haskard, D. 2004. Macrophage release of transforming growth factor beta1 during resolution of monododium urate monohydrate crystal-induced inflammation. Arthritis and Rheumatism. 50 (7), pp. 2273-2280. https://doi.org/10.1002/art.20317
Regulation of human villous trophoblast by insulin-like growth factors and insulin-like growth factor-binding protein-1
Hills, F., Chard, T., Elder, M. and Sullivan, M. 2004. Regulation of human villous trophoblast by insulin-like growth factors and insulin-like growth factor-binding protein-1. Journal of Endocrinology. 183 (3), pp. 487-496. https://doi.org/10.1677/joe.1.05867
Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages
Landis, R., Yagnik, D., Florey, O., Philippidis, P., Emons, V., Mason, J. and Haskard, D. 2002. Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages. Arthritis and Rheumatism. 46 (11), pp. 3026-3033. https://doi.org/10.1002/art.10614
Noninflammatory phagocytosis of monosodium urate monohydrate crystals by mouse macrophages: implications for the control of joint inflammation in gout
Yagnik, D., Hillyer, P., Marshall, D., Smythe, C., Krausz, T., Haskard, D. and Landis, R. 2000. Noninflammatory phagocytosis of monosodium urate monohydrate crystals by mouse macrophages: implications for the control of joint inflammation in gout. Arthritis and Rheumatism. 43 (8), pp. 1779-1789. https://doi.org/10.1002/1529-0131(200008)43:8<1779::aid-anr14>3.0.co;2-2
Polyclonal anti-tumor necrosis factor-alpha Fab used as an ancillary treatment for severe malaria
Looareesuwan, S., Sjorstrom, L., Krudsood, S., Wilairatana, P., Porter, R., Hills, F. and Warrell, D. 1999. Polyclonal anti-tumor necrosis factor-alpha Fab used as an ancillary treatment for severe malaria. The American Journal of Tropical Medicine and Hygiene. 61 (1), pp. 26-33. https://doi.org/10.4269/ajtmh.1999.61.26
Mechanism of action of the intrauterine contraceptive device: evidence for a specific biochemical deficiency in the endometrium
Seleem, S., Hills, F., Salem, H., El-Nashar, E. and Chard, T. 1996. Mechanism of action of the intrauterine contraceptive device: evidence for a specific biochemical deficiency in the endometrium. Human Reproduction. 11 (6), pp. 1220-1222.