Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies.
Article
Brooks, A., Johnson, M., Hills, F., Chard, T., Irvine, R. and Abdalla, H. 1995. Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies. European Journal of Obstetrics, Gynaecology and Reproductive Biology. 59 (1), pp. 91-94.
Type | Article |
---|---|
Title | Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies. |
Authors | Brooks, A., Johnson, M., Hills, F., Chard, T., Irvine, R. and Abdalla, H. |
Abstract | The finding that endometrial maturation may be delayed following hormone replacement therapy has suggested that a generalised endometrial dysfunction may exist in ovum recipients. In order to investigate this suggestion further, circulating levels of IGFBP-1 were measured in samples taken throughout pregnancies conceived either spontaneously or following ovum donation. When analysed at two-weekly intervals, the serum levels of IGFBP-1 in ovum donation pregnancies failed to show the expected peak towards the end of the first trimester and were significantly reduced at week ten (U = 364.5, p = 0.0002) and twelve (U = 138.0, p = 0.0047). For the remainder of pregnancy, circulating IGFBP-1 levels were similar in both groups. The birth weight of children born to the ovum donation group was not significantly different from a normal control group, suggesting that circulating levels of IGFBP-1 in early pregnancy do not reflect local function and that IGFBP-1 does not have an essential function (in relation to birth weight) in early pregnancy. |
Keywords | IGFBP-1 Pregnancy IVF Ovum Donation |
Research Group | Biomarkers for Cancer group |
Reproductive Biology group | |
Centre for Investigative and Diagnostic Oncology | |
Publisher | Elsevier |
Journal | European Journal of Obstetrics, Gynaecology and Reproductive Biology |
ISSN | 0921-8750 |
Publication dates | |
Mar 1995 | |
Publication process dates | |
Deposited | 25 Mar 2010 |
Output status | Published |
Language | English |
https://repository.mdx.ac.uk/item/82644
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