Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies

Article

Brooks, A., Johnson, M., Hills, F., Chard, T., Irvine, R. and Abdalla, H. 1995. Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies. European Journal of Obstetrics & Gynecology and Reproductive Biology. 59 (1), pp. 91-94. https://doi.org/10.1016/0028-2243(94)02014-6
TypeArticle
TitleInsulin-related growth factor binding protein-1 levels in ovum donation pregnancies
AuthorsBrooks, A., Johnson, M., Hills, F., Chard, T., Irvine, R. and Abdalla, H.
Abstract

The finding that endometrial maturation may be delayed following hormone replacement therapy has suggested that a generalised endometrial dysfunction may exist in ovum recipients. In order to investigate this suggestion further, circulating levels of IGFBP-1 were measured in samples taken throughout pregnancies conceived either spontaneously or following ovum donation. When analysed at two-weekly intervals, the serum levels of IGFBP-1 in ovum donation pregnancies failed to show the expected peak towards the end of the first trimester and were significantly reduced at week ten (U = 364.5, p = 0.0002) and twelve (U = 138.0, p = 0.0047). For the remainder of pregnancy, circulating IGFBP-1 levels were similar in both groups. The birth weight of children born to the ovum donation group was not significantly different from a normal control group, suggesting that circulating levels of IGFBP-1 in early pregnancy do not reflect local function and that IGFBP-1 does not have an essential function (in relation to birth weight) in early pregnancy.

KeywordsIGFBP-1PregnancyIVFOvum Donation
Research GroupBiomarkers for Cancer group
Reproductive Biology group
Centre for Investigative & Diagnostic Oncoloy
PublisherElsevier
JournalEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
ISSN0301-2115
Electronic1872-7654
Publication dates
PrintMar 1995
Publication process dates
Deposited25 Mar 2010
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1016/0028-2243(94)02014-6
LanguageEnglish
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