Investigation of factors influencing the immunogenicity of hCG as a potential cancer vaccine
Article
Kvirkvelia, N., Chikadze, N., Makinde, J., McBride, J., Porakishvili, N., Hills, F., Martensen, P., Justesen, J., Delves, P., Lund, T. and Roitt, I. 2018. Investigation of factors influencing the immunogenicity of hCG as a potential cancer vaccine. Clinical & Experimental Immunology. 193 (1), pp. 73-83. https://doi.org/10.1111/cei.13131
Type | Article |
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Title | Investigation of factors influencing the immunogenicity of hCG as a potential cancer vaccine |
Authors | Kvirkvelia, N., Chikadze, N., Makinde, J., McBride, J., Porakishvili, N., Hills, F., Martensen, P., Justesen, J., Delves, P., Lund, T. and Roitt, I. |
Abstract | Human hCG and its β‐subunit (hCGβ) are tumour autocrine growth factors whose presence in the serum of cancer patients has been linked to poorer prognosis. Previous studies have shown that vaccines, which target these molecules and/or the 37 amino acid C‐terminal hCGβ peptide (hCGβCTP), induce antibody responses in a majority of human recipients. Here we explored whether the immunogenicity of vaccines containing an hCGβ mutant (hCGβR68E, designed to eliminate cross‐reactivity with luteinizing hormone) or hCGβCTP could be enhanced by coupling the immunogen to different carriers (KLH or Hsp70) using different cross‐linkers (EDC or GAD) and formulated with different adjuvants (RIBI or Montanide ISA720). |
Research Group | Biomarkers for Cancer group |
Publisher | WileyBlackwell |
Journal | Clinical & Experimental Immunology |
ISSN | 0009-9104 |
Electronic | 1365-2249 |
Publication dates | |
Online | 07 May 2018 |
10 Jul 2018 | |
Publication process dates | |
Deposited | 10 Apr 2018 |
Accepted | 28 Feb 2018 |
Output status | Published |
Accepted author manuscript | |
Copyright Statement | This is the peer reviewed version of the following article: Kvirkvelia, N. , Chikadze, N. , Makinde, J. , McBride, J. D., Porakishvili, N. , Hills, F. A., Martensen, P. M., Justesen, J. , Delves, P. J., Lund, T. and Roitt, I. M. (2018), Investigation of factors influencing the immunogenicity of hCG as a potential cancer vaccine. Clin Exp Immunol, 193: 73-83. doi:10.1111/cei.13131, which has been published in final form at https://doi.org/10.1111/cei.13131. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Digital Object Identifier (DOI) | https://doi.org/10.1111/cei.13131 |
Language | English |
https://repository.mdx.ac.uk/item/879v4
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