The potential use of microneedles as an alternative method for skin cancer treatment

Conference poster

Loizidou, E., Yagnik, D., Szalecka, M. and Nguyen, D. 2019. The potential use of microneedles as an alternative method for skin cancer treatment. The World Congress on Advanced Treatments and Technologies in Skin Cancer (Skin-Cancer2019). Vienna, Austria 04 - 05 Apr 2019
TypeConference poster
TitleThe potential use of microneedles as an alternative method for skin cancer treatment
AuthorsLoizidou, E., Yagnik, D., Szalecka, M. and Nguyen, D.
Abstract

Background: Non-melanoma skin cancers (NMSC) are one of the most common cancers in humans, representing 80% of skin cancer cases each year. The majority of NMSCs (80%-90%) occur on the head and neck and surgical excision is typically the treatment of choice. However, this is often accompanied by serious side effects including changes to appearance with immense consequences on the patients’ quality of life. One way to achieve eradication of the cancer with good cosmetic outcome may be by localized, targeted immunotherapy. Delivery, at the tumour site, of therapeutic amounts of cytokines that can trigger natural killer cells may be achieved using microneedle technologies.
Objective: To investigate whether microneedles can provide a core scientific platform from which novel, non-invasive delivery systems can be developed for the direct and localised delivery of therapeutic amounts of cytokines for immunotherapy. Tumour necrosis factor A (TNF-a) is used to investigate the proof-of-principle concept.
Methods: Rapidly dissolving microneedle devices made of carbohydrate formulations were prepared by a low vacuum deposition method, each containing 1μm of TNF-a. Skin diffusion was studied using Franz cells and porcine skin and ELISA to quantify TNF-a in the receptor phase.
Results: Initial data showed that it is possible to integrate within the microneedle formulation (consisting of carboxymethyl cellulose, maltose and trehalose) small doses of TNF-a. Diffusion studies showed enhanced distribution of TNF-a in the skin when used through the microneedle formulation compared to the control (disk without needles consisting of same sugar-TNF-α composition as microneedle array).
Conclusion: Preliminary results show that dissolving microneedles can potentially provide an enhanced non-invasive method for treating skin cancer via the localized delivery of immunotherapeutics. These can be ultimately developed into patches that patients can self-administer thus improving patient compliance and economic burden.

ConferenceThe World Congress on Advanced Treatments and Technologies in Skin Cancer (Skin-Cancer2019)
Publication process dates
Deposited08 Apr 2019
Accepted28 Jan 2019
Output statusPublished
Accepted author manuscript
File Access Level
Restricted
LanguageEnglish
Permalink -

https://repository.mdx.ac.uk/item/8835z

Log in to edit
  • 74
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Identification of a new class of proteasome inhibitors based on a naphthyl-azotricyclic-urea-phenyl scaffold
Allardyce, D., Adu Mantey, P., Szalecka, M., Nkwo, R. and Loizidou, E. 2023. Identification of a new class of proteasome inhibitors based on a naphthyl-azotricyclic-urea-phenyl scaffold. RSC Medicinal Chemistry. 14 (3), pp. 573-582. https://doi.org/10.1039/D2MD00404F
An experimental FTIR-ATR and computational study of H-bonding in ethanol/water mixtures
Zeinalipour-Yazdi, C. and Loizidou, E. 2021. An experimental FTIR-ATR and computational study of H-bonding in ethanol/water mixtures. Chemical Physics. 550 (1), pp. 1-7. https://doi.org/10.1016/j.chemphys.2021.111295
Coenzyme Q10 and vitamin D interventions could ameliorate COVID-19 related cellular bioenergetic dysfunction and cytokine storms
Yagnik, D. 2021. Coenzyme Q10 and vitamin D interventions could ameliorate COVID-19 related cellular bioenergetic dysfunction and cytokine storms. Journal of Immunological Sciences. 5 (3), pp. 1-6. https://doi.org/10.29245/2578-3009/2021/3.1220
Nanoparticle-infused-biodegradable-microneedles as drug-delivery systems: Preparation and characterisation
Sully, R., Garelick, H., Loizidou, E., Podoleanu, A. and Gubala, V. 2021. Nanoparticle-infused-biodegradable-microneedles as drug-delivery systems: Preparation and characterisation. Materials Advances. 2 (16), pp. 5432-5442. https://doi.org/10.1039/D1MA00135C
Nanomedicines and microneedles: A guide to their analysis and application
Sully, R., Moore, C., Garelick, H., Loizidou, E., Podoleanu, A. and Gubala, V. 2021. Nanomedicines and microneedles: A guide to their analysis and application. Analytical Methods. 13 (30), pp. 3326-3347. https://doi.org/10.1039/d1ay00954k
Antibacterial apple cider vinegar eradicates methicillin resistant Staphylococcus aureus and resistant Escherichia coli
Yagnik, D., Ward, M. and Shah, A. 2021. Antibacterial apple cider vinegar eradicates methicillin resistant Staphylococcus aureus and resistant Escherichia coli. Scientific Reports. 11 (1), pp. 1-7. https://doi.org/10.1038/s41598-020-78407-x
Influence of tart cherry juice on airway biomarkers of inflammation and oxidative stress following a 42.2km trail run
Dimitriou, L., Yagnik, D., Wood, A., Sinclair, S., Paice, K., Wilson, L., Hills, F., Gondek, M., Kwan Xue Bin, K., Howatson, G. and Cockburn, E. 2018. Influence of tart cherry juice on airway biomarkers of inflammation and oxidative stress following a 42.2km trail run. 23rd annual congress of the European College of Sport Science. Dublin, Ireland 04 - 07 Jul 2018
Size-dependent bond dissociation enthalpies in single-walled carbon nanotubes
Zenalipour-Yazdi, C., Loizidou, E. and Chutia, A. 2019. Size-dependent bond dissociation enthalpies in single-walled carbon nanotubes. Chemical Physics Letters. 731, pp. 1-6. https://doi.org/10.1016/j.cplett.2019.136628
Argyrin B a non-competitive inhibitor of the human immunoproteasome exhibiting preference for β1i
Allardyce, D., Bell, C. and Loizidou, E. 2019. Argyrin B a non-competitive inhibitor of the human immunoproteasome exhibiting preference for β1i. Chemical Biology and Drug Design. 94 (2), pp. 1556-1567. https://doi.org/10.1111/cbdd.13539
Can quantification of Serum Glycans predict Pre-Eclampsia?
Antia, I., Shah, A., Yagnik, D., Syngelaki, A., Nicolaides, K. and Hills, F. 2018. Can quantification of Serum Glycans predict Pre-Eclampsia? International Federation of Placenta Associations Conference (IFPA2018). Jikei University School of Medicine in Tokyo, Japan 21 - 24 Sep 2018 Elsevier. pp. e38-e39 https://doi.org/10.1016/j.placenta.2018.06.004
Urate crystals induce macrophage PAF‑AH secretion which is differentially regulated by TGFβ1 and hydrocortisone
Yagnik, D. and Hills, F. 2018. Urate crystals induce macrophage PAF‑AH secretion which is differentially regulated by TGFβ1 and hydrocortisone. Molecular Medicine Reports. 18 (3), pp. 3506-3512. https://doi.org/10.3892/mmr.2018.9323
Apple cider vinegar (ACV®) displays antimicrobial activity directly against Escherichia coli, Staphylococcus aureus and Candida albican proteins and in vitro monocytes exposed to microbes by inhibiting inflammatory cytokine secretion
Yagnik, D., Serafim, V., Choudhury, M. and Shah, A. 2017. Apple cider vinegar (ACV®) displays antimicrobial activity directly against Escherichia coli, Staphylococcus aureus and Candida albican proteins and in vitro monocytes exposed to microbes by inhibiting inflammatory cytokine secretion. International Conference on Infection Control and Clinical Microbiology. Chicago, USA 25 - 26 Sep 2017 SciTechnol. pp. 73 https://doi.org/10.4172/2329-9541-C1-006
Analysis of argyrin B binding at constitutive and immunoproteasome active sites using molecular modelling and kinetic assays
Allardyce, D., Bell, C. and Loizidou, E. 2017. Analysis of argyrin B binding at constitutive and immunoproteasome active sites using molecular modelling and kinetic assays. Computational Advances in Drug Discovery (Structure Based Drug Design). Lausanne, Switzerland 05 - 08 Sep 2017
Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression
Yagnik, D., Serafin, V. and Shah, A. 2018. Antimicrobial activity of apple cider vinegar against Escherichia coli, Staphylococcus aureus and Candida albicans; downregulating cytokine and microbial protein expression. Scientific Reports. 8 (1). https://doi.org/10.1038/s41598-017-18618-x
Analysis of procainamide-derivatised heparan sulphate disaccharides in biological samples using hydrophilic interaction liquid chromatography mass spectrometry
Antia, I., Mathew, K., Yagnik, D., Hills, F. and Shah, A. 2018. Analysis of procainamide-derivatised heparan sulphate disaccharides in biological samples using hydrophilic interaction liquid chromatography mass spectrometry. Analytical and Bioanalytical Chemistry. 410 (1), pp. 131-143. https://doi.org/10.1007/s00216-017-0703-1
Platelet activating acetylhydrolase involved in inflammation resolution in macrophages and neutrophils which have been stimulated with urate crystals
Yagnik, D. 2015. Platelet activating acetylhydrolase involved in inflammation resolution in macrophages and neutrophils which have been stimulated with urate crystals. The 12th World Congress on Inflammation. Boston, USA 08 - 12 Aug 2015 Springer. https://doi.org/10.1007/s00011-015-0839-4
Teaching atomic structure as a threshold concept in chemistry for biologists
Loizidou, E. and Jones, H. 2016. Teaching atomic structure as a threshold concept in chemistry for biologists. 253rd American Chemical Society National Meeting & Exposition. San Francisco, CA, USA 02 - 06 Apr 2017
Heparan sulfate disaccharide measurement from biological samples using pre-column derivatization, UPLC-MS and single ion monitoring
Antia, I., Yagnik, D., Pantoja Munoz, L., Shah, A. and Hills, F. 2017. Heparan sulfate disaccharide measurement from biological samples using pre-column derivatization, UPLC-MS and single ion monitoring. Analytical Biochemistry. 530, pp. 17-30. https://doi.org/10.1016/j.ab.2017.04.019
Study of the cap structure of (3,3), (4,4) and (5,5)-SWCNTs: application of the sphere-in-contact model
Zeinalipour-Yazdi, C. and Loizidou, E. 2017. Study of the cap structure of (3,3), (4,4) and (5,5)-SWCNTs: application of the sphere-in-contact model. Carbon. 115, pp. 819-827. https://doi.org/10.1016/j.carbon.2017.01.074
Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis
Loizidou, E., Inoue, N., Ashton-Barnett, J., Barrow, D. and Allender, C. 2016. Evaluation of geometrical effects of microneedles on skin penetration by CT scan and finite element analysis. European Journal of Pharmaceutics and Biopharmaceutics. 107, pp. 1-6. https://doi.org/10.1016/j.ejpb.2016.06.023
AB diblock and ABC triblock amphiphilic copolymers containing fluorine
Loizidou, E., Haralambous, D., Vamvakaki, M., Patrickios, C., Krasia, T. and Antonietti, M. 2001. AB diblock and ABC triblock amphiphilic copolymers containing fluorine. 221th ACS National Meeting. San Diego, CA, USA 01 Apr 2001
Characterization of amphiphilic polymers covalently attached with Pirkle-concept chiral selectors for chiral seperations by Merck
Loizidou, E., Zhang, K. and Sun, L. 2002. Characterization of amphiphilic polymers covalently attached with Pirkle-concept chiral selectors for chiral seperations by Merck. 224th ACS National Meeting. 18 Aug 2002
Molecular recognition of barbiturate artificial receptor covalently bound to an amphiphilic copolymer
Loizidou, E. and Sun, L. 2003. Molecular recognition of barbiturate artificial receptor covalently bound to an amphiphilic copolymer. International Symposium on the Synthesis and Characterization of Macromolecules. Amsterdam, Netherlands 07 - 11 Feb 2003
Structure-based computational analysis of the implications of subtype specific polymorphisms on the efficacy of integrase inhibitors
Loizidou, E., Kousiappa, I., Zeinalipour-Yazdi, C., Van De Vijver, D. and Kostrikis, L. 2009. Structure-based computational analysis of the implications of subtype specific polymorphisms on the efficacy of integrase inhibitors. 7th European HIV Drug Resistance Workshop. Stockholm, Sweden
Rational design of argyrin analogues as selective inhibitors of the proteasome
Loizidou, E. and Zeinalipour-Yazdi, C. 2012. Rational design of argyrin analogues as selective inhibitors of the proteasome. COST Conference on Personalised Medicine. Larnaca, Cyprus 17 - 22 Jun 2012
Design of argyrin analogues as proteasome inhibitors with subunit specicificity
Loizidou, E. and Zeinalipour-Yazdi, C. 2014. Design of argyrin analogues as proteasome inhibitors with subunit specicificity. 247th ACS National Meeting. Dallas, TX, USA 16 - 20 Mar 2014
Simulating the effect of geometry on the structural properties of microneedles
Loizidou, E., Ashton-Barnett, J., Barrow, D. and Allender, C. 2014. Simulating the effect of geometry on the structural properties of microneedles. Perspectives in Percutaneous Penetration Fourteenth International Conference including FP7 HIPODERM Symposium on High Potency Dermatologicals. La Grande Motte, France 23 - 25 Apr 2014
Structural properties of sugar microneedles: a finite element analysis
Loizidou, E., Barrow, D. and Allender, C. 2014. Structural properties of sugar microneedles: a finite element analysis. Perspectives in Percutaneous Penetration Fourteenth International Conference including FP7 HIPODERM Symposium on High Potency Dermatologicals. La Grande Motte, France 23 - 25 Apr 2014
Implications of HIV-1 M group polymorphisms on intergase inhibitor efficacy and resistance: genetic and structural in-silico analyses
Loizidou, E., Kousiappa, I., Zeinalipour-Yazdi, C., Van De Vijver, D. and Kostrikis, L. 2009. Implications of HIV-1 M group polymorphisms on intergase inhibitor efficacy and resistance: genetic and structural in-silico analyses. Biochemistry. 48 (1), pp. 4-6. https://doi.org/10.1021/bi8019349
Molecular recognition of barbiturate artificial receptor covalently bound to an amphiphilic copolymer
Loizidou, E. and Sun, L. 2003. Molecular recognition of barbiturate artificial receptor covalently bound to an amphiphilic copolymer. 226th ACS National Meeting. New York, New York, USA 07 - 11 Sep 2003
Part I: total synthesis of azaspiracid-3 Part II: molecular recognition studies in aqueous solutions facilitated by a receptor-modified polymer
Loizidou, E. 2006. Part I: total synthesis of azaspiracid-3 Part II: molecular recognition studies in aqueous solutions facilitated by a receptor-modified polymer. PhD thesis University of California San Diego / San Diego State University Chemistry
HIV-1 integrase inhibitors: from biology to chemotherapeutics
Loizidou, E., Nicolaou, C., Nicolaides, A. and Kostrikis, L. 2007. HIV-1 integrase inhibitors: from biology to chemotherapeutics. Current HIV Research. 5 (4), pp. 365-388. https://doi.org/10.2174/157016207781023965
Multi-objective optimization methods in de novo drug design
Nicolaou, C., Kannas, C. and Loizidou, E. 2012. Multi-objective optimization methods in de novo drug design. Mini Reviews in Medicinal Chemistry. 12 (10), pp. 979-987. https://doi.org/10.2174/138955712802762284
Structural assignment and total synthesis of azaspiracid-1
Frederick, M., Cole, K., Petrovic, G., Loizidou, E. and Nicolaou, K. 2007. Structural assignment and total synthesis of azaspiracid-1. in: Botana, L. (ed.) Phycotoxins: chemistry and biochemistry Ames, Iowa WileyBlackwell. pp. 297-309
Computational inhibition studies of the human proteasome by argyrin-based analogues with subunit specificity
Loizidou, E. and Zeinalipour-Yazdi, C. 2014. Computational inhibition studies of the human proteasome by argyrin-based analogues with subunit specificity. Chemical Biology and Drug Design. 84 (1), pp. 99-107. https://doi.org/10.1111/cbdd.12298
Receptor-attached amphiphilic terpolymer for selective drug recognition in aqueous solutions
Loizidou, E., Sun, L. and Zeinalipour-Yazdi, C. 2011. Receptor-attached amphiphilic terpolymer for selective drug recognition in aqueous solutions. Journal of Molecular Recognition. 24 (4), pp. 678-686. https://doi.org/10.1002/jmr.1098
Analysis of binding parameters of HIV-1 integrase inhibitors: correlates of drug inhibition and resistance
Loizidou, E., Zeinalipour-Yazdi, C., Christofides, T. and Kostrikis, L. 2009. Analysis of binding parameters of HIV-1 integrase inhibitors: correlates of drug inhibition and resistance. Bioorganic & Medicinal Chemistry. 17 (13), pp. 4806-4818. https://doi.org/10.1016/j.bmc.2009.04.058
Second generation total synthesis of azaspiracids-1, -2 and -3
Nicolaou, K., Frederick, M., Loizidou, E., Petrovic, G., Cole, K., Koftis, T. and Yamada, Y. 2006. Second generation total synthesis of azaspiracids-1, -2 and -3. Chemistry: an Asian Journal. 1 (1-2), pp. 245-263. https://doi.org/10.1002/asia.200600059
Structural characterization and transdermal delivery studies on sugar microneedles: experimental and finite element modelling analyses
Loizidou, E., Williams, N., Barrow, D., Eaton, M., McCrory, J., Evans, S. and Allender, C. 2015. Structural characterization and transdermal delivery studies on sugar microneedles: experimental and finite element modelling analyses. European Journal of Pharmaceutics and Biopharmaceutics. 89, pp. 224-231. https://doi.org/10.1016/j.ejpb.2014.11.023
Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation
Yagnik, D. 2014. Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation. International Journal of Inflammation. 2014, pp. 1-6. https://doi.org/10.1155/2014/526496
Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3
Nicolaou, K., Frederick, M., Petrovic, G., Cole, K. and Loizidou, E. 2006. Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3. Angewandte Chemie International Edition. 45 (16), pp. 2609-2615. https://doi.org/10.1002/anie.200600295
Total synthesis and structural elucidation of azaspiracid-1 : construction of key building blocks for originally proposed structure
Nicolaou, K., Pihko, P., Bernal, F., Frederick, M., Qian, W., Uesaka, N., Diedrichs, N., Hinrichs, J., Koftis, T., Loizidou, E., Petrovic, G., Rodriquez, M., Sarlah, D. and Zou, N. 2006. Total synthesis and structural elucidation of azaspiracid-1 : construction of key building blocks for originally proposed structure. Journal of the American Chemical Society. 128 (7), pp. 2244-2257. https://doi.org/10.1021/ja0547477
Studies toward the synthesis of azadirachtin, part 2 : construction of fully functionalized ABCD ring frameworks and unusual intramolecular reactions induced by close-proximity effects
Nicolaou, K., Sasmal, P., Koftis, T., Converso, A., Loizidou, E., Kaiser, F., Roecker, A., Dellios, C., Sun, X. and Petrovic, G. 2005. Studies toward the synthesis of azadirachtin, part 2 : construction of fully functionalized ABCD ring frameworks and unusual intramolecular reactions induced by close-proximity effects. Angewandte Chemie International Edition. 44 (22), pp. 3447-3452. https://doi.org/10.1002/anie.200500217
Artificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media
Loizidou, E., Zeinalipour-Yazdi, C. and Sun, L. 2004. Artificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media. Biomacromolecules. 5 (5), pp. 1647-1652. https://doi.org/10.1021/bm0497320
Monocyte Fc gamma receptor expression in patients undergoing coronary artery bypass grafting
Stefanou, D., Asimakopoulos, G., Yagnik, D., Haskard, D., Anderson, J., Philippidis, P., Landis, R. and Taylor, K.M. 2004. Monocyte Fc gamma receptor expression in patients undergoing coronary artery bypass grafting. Annals of Thoracic Surgery. 77 (3), pp. 951-955. https://doi.org/10.1016/j.athoracsur.2003.09.026
Macrophage release of transforming growth factor beta1 during resolution of monododium urate monohydrate crystal-induced inflammation
Yagnik, D., Evans, B., Florey, O., Mason, J., Landis, R. and Haskard, D. 2004. Macrophage release of transforming growth factor beta1 during resolution of monododium urate monohydrate crystal-induced inflammation. Arthritis and Rheumatism. 50 (7), pp. 2273-2280. https://doi.org/10.1002/art.20317
Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages
Landis, R., Yagnik, D., Florey, O., Philippidis, P., Emons, V., Mason, J. and Haskard, D. 2002. Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages. Arthritis and Rheumatism. 46 (11), pp. 3026-3033. https://doi.org/10.1002/art.10614
Synthesis and characterization of novel networks with nano-engineered structures: cross-linked star homopolymers
Vamvakaki, M., Hadjiyiannakou, S., Loizidou, E. and Patrickios, C. 2001. Synthesis and characterization of novel networks with nano-engineered structures: cross-linked star homopolymers. Chemistry of Materials. 13 (12), pp. 4738-4744. https://doi.org/10.1021/cm010569e
Noninflammatory phagocytosis of monosodium urate monohydrate crystals by mouse macrophages: implications for the control of joint inflammation in gout
Yagnik, D., Hillyer, P., Marshall, D., Smythe, C., Krausz, T., Haskard, D. and Landis, R. 2000. Noninflammatory phagocytosis of monosodium urate monohydrate crystals by mouse macrophages: implications for the control of joint inflammation in gout. Arthritis and Rheumatism. 43 (8), pp. 1779-1789. https://doi.org/10.1002/1529-0131(200008)43:8<1779::aid-anr14>3.0.co;2-2