Nanoparticle-infused-biodegradable-microneedles as drug-delivery systems: Preparation and characterisation
Article
Sully, R., Garelick, H., Loizidou, E., Podoleanu, A. and Gubala, V. 2021. Nanoparticle-infused-biodegradable-microneedles as drug-delivery systems: Preparation and characterisation. Materials Advances. 2 (16), pp. 5432-5442. https://doi.org/10.1039/D1MA00135C
Type | Article |
---|---|
Title | Nanoparticle-infused-biodegradable-microneedles as drug-delivery systems: Preparation and characterisation |
Authors | Sully, R., Garelick, H., Loizidou, E., Podoleanu, A. and Gubala, V. |
Abstract | For almost two decades, scientists were exploring the use of nanoparticles as drug vesicles capable of protecting their cargo and deliver it to the target site while evading detection by the body. However, their translation to clinical use has been slower than expected. To a large degree, this is due to the difficulty to formulate the nanomaterial into a usable form, in which they retain their unique, size-dependent properties without aggregating into a bulk material. In this work, we describe a simple methodology for synthesising novel biodegradable microneedle systems infused with silica nanoparticles (SiNP). SiNP were doped with small library of model anti-cancer drugs or drug surrogates before being characterised and encapsulated into biodegradable microneedles. Detailed preparation and characterisation methods for both the nanoparticles and the microneedles-infused with nanoparticles is presented here. We demonstrated the distribution of the nanoparticles within the microneedle matrix in a uniform, un-aggregated form, which enabled the release of the nanoparticles in a sustained manner. Formulating nanomaterial into biodegradable, hydrogel-like microneedles showed to be effective in preserving their colloidal properties, whilst simultaneously enabling the transdermal delivery of the nanomaterial into the body. Although the concepts of nanoparticles and biodegradable microneedles have been researched individually, the combination of the two, to the best of our knowledge, offers a new pathway to nanomedicine-related applications. |
Research Group | Biophysics and Bioengineering group |
Publisher | Royal Society of Chemistry |
Journal | Materials Advances |
ISSN | 2633-5409 |
Electronic | 2633-5409 |
Publication dates | |
Online | 08 Jul 2021 |
21 Aug 2021 | |
Publication process dates | |
Deposited | 16 Jul 2021 |
Accepted | 07 Jul 2021 |
Output status | Published |
Publisher's version | |
Accepted author manuscript | File Access Level Restricted |
Copyright Statement | © Author(s). Open Access Article. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence http://creativecommons.org/licenses/by-nc/3.0/. |
Additional information | This article can be cited before page numbers have been issued, to do this please use: R. E. Sully, H. |
Digital Object Identifier (DOI) | https://doi.org/10.1039/D1MA00135C |
Web of Science identifier | WOS:000676030600001 |
Language | English |
https://repository.mdx.ac.uk/item/896w4
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