A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants
Article
Marano, R., Fernandes, T., Manaia, C., Nunes, O., Morrison, D., Berendonk, T., Kreuzinger, N., Telson, T., Corno, G., Fatta-Kassinos, D., Merlin, C., Topp, E., Jurkevitch, E., Henn, L., Scott, A., Heß, S., Slipko, K., Laht, M., Kisand, V., Di Cesare, A., Karaolia, P., Michael, S., Petre, A., Rosal, R., Pruden, A., Riquelme, V., Agüera, A., Esteban, B., Luczkiewicz, A., Kalinowska, A., Leonard, A., Gaze, W., Adegoke, A., Stenstrom, T., Pollice, A., Salerno, C., Schwermer, C., Krzeminski, P., Guilloteau, H., Donner, E., Drigo, B., Libralato, G., Guida, M., Bürgmann, H., Beck, K., Garelick, H., Tacão, M., Henriques, I., Martínez-Alcalá, I., Guillén-Navarro, J., Popowska, M., Piotrowska, M., Quintela-Baluja, M., Bunce, J., Polo-López, M., Nahim-Granados, S., Pons, M., Milakovic, M., Udikovic-Kolic, N., Ory, J., Ousmane, T., Caballero, P., Oliver, A., Rodriguez-Mozaz, S., Balcazar, J., Jäger, T., Schwartz, T., Yang, Y., Zou, S., Lee, Y., Yoon, Y., Herzog, B., Mayrhofer, H., Prakash, O., Nimonkar, Y., Heath, E., Baraniak, A., Abreu-Silva, J., Choudhury, M., Pantoja Munoz, L., Krizanovic, S., Brunetti, G., Maile-Moskowitz, A., Brown, C. and Cytryn, E. 2020. A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants. Environment International. 144, pp. 1-11. https://doi.org/10.1016/j.envint.2020.106035
| Type | Article |
|---|---|
| Title | A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants |
| Authors | Marano, R., Fernandes, T., Manaia, C., Nunes, O., Morrison, D., Berendonk, T., Kreuzinger, N., Telson, T., Corno, G., Fatta-Kassinos, D., Merlin, C., Topp, E., Jurkevitch, E., Henn, L., Scott, A., Heß, S., Slipko, K., Laht, M., Kisand, V., Di Cesare, A., Karaolia, P., Michael, S., Petre, A., Rosal, R., Pruden, A., Riquelme, V., Agüera, A., Esteban, B., Luczkiewicz, A., Kalinowska, A., Leonard, A., Gaze, W., Adegoke, A., Stenstrom, T., Pollice, A., Salerno, C., Schwermer, C., Krzeminski, P., Guilloteau, H., Donner, E., Drigo, B., Libralato, G., Guida, M., Bürgmann, H., Beck, K., Garelick, H., Tacão, M., Henriques, I., Martínez-Alcalá, I., Guillén-Navarro, J., Popowska, M., Piotrowska, M., Quintela-Baluja, M., Bunce, J., Polo-López, M., Nahim-Granados, S., Pons, M., Milakovic, M., Udikovic-Kolic, N., Ory, J., Ousmane, T., Caballero, P., Oliver, A., Rodriguez-Mozaz, S., Balcazar, J., Jäger, T., Schwartz, T., Yang, Y., Zou, S., Lee, Y., Yoon, Y., Herzog, B., Mayrhofer, H., Prakash, O., Nimonkar, Y., Heath, E., Baraniak, A., Abreu-Silva, J., Choudhury, M., Pantoja Munoz, L., Krizanovic, S., Brunetti, G., Maile-Moskowitz, A., Brown, C. and Cytryn, E. |
| Abstract | The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings, no such schemes exist for monitoring antibiotic-resistant bacteria in the environment. In this transnational study, we developed, validated, and tested a low-cost surveillance and easy to implement approach to evaluate antibiotic resistance in wastewater treatment plants (WWTPs) by targeting cefotaxime-resistant (CTX-R) coliforms as indicators. The rationale for this approach was: i) coliform quantification methods are internationally accepted as indicators of fecal contamination in recreational waters and are therefore routinely applied in analytical labs; ii) CTX-R coliforms are clinically relevant, associated with extended-spectrum β-lactamases (ESBLs), and are rare in pristine environments. We analyzed 57 WWTPs in 22 countries across Europe, Asia, Africa, Australia, and North America. CTX-R coliforms were ubiquitous in raw sewage and their relative abundance varied significantly (<0.1% to 38.3%), being positively correlated (p < 0.001) with regional atmospheric temperatures. Although most WWTPs removed large proportions of CTX-R coliforms, loads over 10 colony-forming units per mL were occasionally observed in final effluents. We demonstrate that CTX-R coliform monitoring is a feasible and affordable approach to assess wastewater antibiotic resistance status. [Abstract copyright: Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.] |
| Keywords | Antibiotic resistance; Coliforms; ESBLs; Wastewater treatment; Water reuse |
| Research Group | Research Group on Development of Intelligent Environments |
| Publisher | Elsevier |
| Journal | Environment International |
| ISSN | 0160-4120 |
| Electronic | 1873-6750 |
| Publication dates | |
| Online | 21 Aug 2020 |
| 30 Nov 2020 | |
| Publication process dates | |
| Deposited | 07 Sep 2020 |
| Submitted | 10 May 2020 |
| Accepted | 03 Aug 2020 |
| Output status | Published |
| Publisher's version | License |
| Copyright Statement | © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. |
| Digital Object Identifier (DOI) | https://doi.org/10.1016/j.envint.2020.106035 |
| Web of Science identifier | WOS:000580630100043 |
| Language | English |
Permalink -
https://repository.mdx.ac.uk/item/890y1
Download files
65
total views12
total downloads2
views this month1
downloads this month