Artificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media

Article

Loizidou, E., Zeinalipour-Yazdi, C. and Sun, L. 2004. Artificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media. Biomacromolecules. 5 (5), pp. 1647-1652. https://doi.org/10.1021/bm0497320
TypeArticle
TitleArtificial receptor-attached amphiphilic copolymer for barbiturate binding in aqueous media
AuthorsLoizidou, E., Zeinalipour-Yazdi, C. and Sun, L.
Abstract

A water-soluble self-associating amphiphilic copolymer was employed to provide a microenvironment for the solvation of a hydrogen-bonding barbiturate artificial receptor, to facilitate molecular recognition in water. The receptor-attached amphiphilic polymer (RP) was synthesized through random copolymerization of 3% (mol) barbiturate receptor-monomer, 70% (mol) 3-sulfopropyl methacrylate, and 27% (mol) n-dodecyl acrylate. Difference UV spectra of pH 6.5 aqueous solutions of phenobarbital and receptor-polymer (RP) gave peaks and valleys at 272 and 301 nm respectively, consistent with binding characteristics of monomeric barbiturate receptors in chloroform. Specific association between phenobarbital and the receptor-polymer was further indicated based on investigations of a receptor-free control polymer (CP) of similar polar/nonpolar monomer ratio. Micellar electrokinetic chromatography was applied for studying polymer-phenobarbital association, by capillary electrophoresis.

PublisherAmerican Chemical Society
JournalBiomacromolecules
ISSN1525-7797
Electronic1526-4602
Publication dates
Online15 Jul 2004
Print01 Sep 2004
Publication process dates
Submitted04 May 2004
Deposited05 Mar 2015
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1021/bm0497320
LanguageEnglish
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