Coenzyme Q10 and vitamin D interventions could ameliorate COVID-19 related cellular bioenergetic dysfunction and cytokine storms

Article


Yagnik, D. 2021. Coenzyme Q10 and vitamin D interventions could ameliorate COVID-19 related cellular bioenergetic dysfunction and cytokine storms. Journal of Immunological Sciences. 5 (3), pp. 1-6. https://doi.org/10.29245/2578-3009/2021/3.1220
TypeArticle
TitleCoenzyme Q10 and vitamin D interventions could ameliorate COVID-19 related cellular bioenergetic dysfunction and cytokine storms
AuthorsYagnik, D.
Abstract

The immune response to SARS-CoV-2 varies from asymptomatic or mild symptoms of high temperature, muscle aches and coughs lasting 7 to 14 days to lower respiratory tract infections leading to pneumonia and serious respiratory distress as well as long COVID-19. Complications occur due to an abnormal immune response which involves upregulation of multiple cytokines leading to sustained inflammation which results in the spread of infection to vital organs. The double vaccine roll out has been rapid however vaccine mediated antibodies are not 100% effective against future coronavirus variants which may become increasingly more resistant and easily transmissible to overcome host immunity. Invariably supportive therapies will be needed. Research has shown that coenzyme Q10 and vitamin D deficiencies can have detrimental effects on immune cell defence, function and cytokine secretion promoting inflammation and sepsis especially against microbes. Early interventions including supplementation of these factors could mitigate cellular dysfunction especially in relation to mitochondria bioenergetics and help maintain cell immunity. This is particularly important as chronically ill COVID-19 patients seem to display abnormal immune cell phenotypes in infected organs indicating this could contribute to disease
progression. The immune response and proposed roles of Vitamin D and Coenzyme Q10 in COVID-19 are discussed.

JournalJournal of Immunological Sciences
ISSN2578-3009
Publication dates
Print30 Jul 2021
Publication process dates
Deposited14 Dec 2021
Accepted30 Jul 2021
Output statusPublished
Publisher's version
License
Copyright Statement

© 2021 Yagnik D. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.

Digital Object Identifier (DOI)https://doi.org/10.29245/2578-3009/2021/3.1220
LanguageEnglish
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