Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation

Article


Yagnik, D. 2014. Macrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation. International Journal of Inflammation. 2014, pp. 1-6. https://doi.org/10.1155/2014/526496
TypeArticle
TitleMacrophage derived platelet activating factor implicated in the resolution phase of gouty inflammation
AuthorsYagnik, D.
Abstract

Human blood derived in vitro differentiated monocytes or macrophages are a population of cells which have been investigated over the years to determine the role these cells play in the resolution phase of gout. Macrophages are able to phagocytose monosodium urate monohydrate (MSU) crystals without releasing inflammatory factors. This study analysed macrophage platelet activating factor secretion and its possible role in the pathway of gout resolution. Analysis of sunatants from in vitro differentiated macrophages stimulated with MSU crystals revealed the secretion of platelet activating factor (PAF) mean ± SEM; ng/mL per 106 cells. This secretion was absent in immature monocytes treated similarly. When these monocytes were pretreated with recombinant human PAF-acetylhydrolase (rhuPAF-AH) and MSU crystals resulted in TNFα suppression. Addition of WEB2086, a platelet activating factor (PAF) antagonist, to differentiated macrophages with MSU crystals unmasked TNFα secretion mean ± SEM; ng/mL per 106 cells. This study identifies a role for PAF and the PAF receptor antagonist in the pathway by which macrophages ingest MSU crystals and resolve the concomitant inflammation.

Research GroupBiomarkers for Cancer group
PublisherHindawi
JournalInternational Journal of Inflammation
ISSN2090-8040
Electronic2042-0099
Publication dates
Print24 Sep 2014
Publication process dates
Deposited15 Jun 2017
Submitted16 Jun 2014
Accepted05 Sep 2014
Output statusPublished
Publisher's version
License
Copyright Statement

Copyright © 2014 Darshna Yagnik. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Digital Object Identifier (DOI)https://doi.org/10.1155/2014/526496
Web of Science identifierMEDLINE:25328755
LanguageEnglish
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