Dynamic modelling of electrical current distribution in the deep structure of the brain
Book chapter
Bayford, R., Tizzard, A. and Liu, X. 2005. Dynamic modelling of electrical current distribution in the deep structure of the brain. in: The 3rd IEE International Seminar on Medical Applications of Signal Processing 2005 (Ref. No. 2005-1119) London,UK The Institution of Engineering and Technology (IET).
Chapter title | Dynamic modelling of electrical current distribution in the deep structure of the brain |
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Authors | Bayford, R., Tizzard, A. and Liu, X. |
Abstract | Over the last decade various neurological disorders have been clinically treated using therapeutic deep brain stimulation (DBS). A fuller understanding of the role of modulating brain activity by electrical current will provide a rational basis for the optimisation of therapeutic effects. It remains unclear how the electrical current injected via the implanted depth electrodes is distributed locally or globally in the brain. This is largely because direct measurement of the distribution is difficult or almost impossible. A limited attempt has been made by some researchers to model the static conditions; however this does not include the dynamic features of the stimulation current. Additionally, the need for geometrically accurate Finite Element meshes of the adult human head is now becoming more acknowledged, and some investigations have been carried out to establish methodologies for their generation This paper presents a new dynamic model of the whole human head using a geometrically accurate forward model that includes scalp, skull, CSF and brain with the correct conductivity parameters. Results of 10Hz sinusoidal stimulation, simulating the therapeutic frequency ranging from 10 to 200Hz, in a case of DBS of the subthalamic nucleus for Parkinson's disease are presented. These results will be validated from measurements taken from both scalp and depth brain electrodes. |
Keywords | deep brain stimulation; Modelling; Application; Brain; Optimisation; Electrodes; finite element meshes; Adult; Human; GENERATION; skull; conductivity; disease |
Research Group | Biophysics and Bioengineering group |
Book title | The 3rd IEE International Seminar on Medical Applications of Signal Processing 2005 (Ref. No. 2005-1119) |
Publisher | The Institution of Engineering and Technology (IET) |
Place of publication | London,UK |
Series | IEEE Digest |
ISBN | |
Hardcover | 0863415709 |
Publication dates | |
05 Dec 2005 | |
Publication process dates | |
Deposited | 28 Aug 2012 |
Output status | Published |
Web address (URL) | https://digital-library.theiet.org/doi/10.1049/ic%3A20050345 |
https://ieeexplore.ieee.org/document/1543132 | |
Digital Object Identifier (DOI) | https://doi.org/10.1049/ic:20050345 |
Language | English |
https://repository.mdx.ac.uk/item/81x14
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