Abnormal secretion of melatonin and cortisol in relation to sleep disturbances in children with Williams syndrome

Article

Sniecinska-Cooper, A., Iles, R., Butler, S., Jones, H., Bayford, R. and Dimitriou, D. 2015. Abnormal secretion of melatonin and cortisol in relation to sleep disturbances in children with Williams syndrome. Sleep Medicine. 16 (1), pp. 94-100. https://doi.org/10.1016/j.sleep.2014.09.003
TypeArticle
TitleAbnormal secretion of melatonin and cortisol in relation to sleep disturbances in children with Williams syndrome
AuthorsSniecinska-Cooper, A., Iles, R., Butler, S., Jones, H., Bayford, R. and Dimitriou, D.
Abstract

Objective

A high rate of sleep disturbances has been reported in individuals with Williams syndrome (WS) but the underlying aetiology has yet to be identified. Melatonin and cortisol levels display circadian rhythmicity and are known to affect and regulate sleep/wake patterns. The current study examined the levels of these two endocrine markers and explored a possible relationship with sleep patterns in children with WS.

Methods

Twenty-five children with WS and 27 typically developing age- and gender-matched comparison children were recruited. Saliva was collected from each child at three time points: 4–6 pm, before natural bedtime, and after awakening. The levels of salivary melatonin and cortisol were analysed by specific enzyme-linked immunoassays. Sleep patterns were examined using actigraphy and the Children's Sleep Habit Questionnaire.

Results

The WS group had shallower drops in cortisol and less pronounced increase in melatonin at bedtime compared to the controls. Furthermore, they also had significantly higher levels of cortisol before bedtime.

Conclusions

Increased bedtime cortisol and less pronounced rise in melatonin levels before sleep may play a role in the occurrence of sleep disturbances, such as delayed sleep onset, observed in children with WS. As both markers play a significant role in our circadian rhythm and sleep/wake cycle, it is necessary to examine sleep using multi-system analysis.

KeywordsCortisol; Melatonin; Williams syndrome; Developmental disorders; Endocrine sleep markers
Research GroupBiophysics and Bioengineering group
PublisherElsevier
JournalSleep Medicine
ISSN1389-9457
Electronic1878-5506
Publication dates
PrintJan 2015
Publication process dates
Deposited07 May 2015
Accepted01 Sep 2014
Output statusPublished
Additional information

Available online 19 September 2014

Digital Object Identifier (DOI)https://doi.org/10.1016/j.sleep.2014.09.003
Web of Science identifierWOS:000348291900016
LanguageEnglish
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Khodadad, D., Nordebo, S., Seifnaraghi, N., Waldmann, A., Müller, B. and Bayford, R. 2017. Breath detection using short-time Fourier transform analysis in electrical impedance tomography. 2017 XXXIInd General Assembly and Scientific Symposium of the International Union of Radio Science (URSI GASS). Montreal, QC, Canada 19 - 23 Aug 2017 Institute of Electrical and Electronics Engineers (IEEE). pp. 2185-2187 https://doi.org/10.23919/URSIGASS.2017.8105231
Parameter studies on optimal absorption and electrophoretic resonances in lossy media
Nordebo, S., Dalarsson, M., Ivanenko, Y., Sjöberg, D. and Bayford, R. 2017. Parameter studies on optimal absorption and electrophoretic resonances in lossy media. 2017 XXXIInd General Assembly and Scientific Symposium of the International Union of Radio Science (URSI GASS). Montreal 19 - 23 Aug 2017 Institute of Electrical and Electronics Engineers (IEEE). pp. 1768-1769 https://doi.org/10.23919/URSIGASS.2017.8105294
Toward on-demand deep brain stimulation using online Parkinson’s disease prediction driven by dynamic detection
Mohammed, A., Zamani, M., Bayford, R. and Demosthenous, A. 2017. Toward on-demand deep brain stimulation using online Parkinson’s disease prediction driven by dynamic detection. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 25 (12), pp. 2441-2452. https://doi.org/10.1109/TNSRE.2017.2722986
Estimation of thorax shape for forward modelling in lungs EIT
Seifnaraghi, N., Tizzard, A., de Gelidi, S., Khodadad, D., Nordebo, S., Van Kaam, A., Frerichs, I., Waldmann, A., Sorantin, E., Tschauner, S., Demosthenous, A., Christofides, S. and Bayford, R. 2017. Estimation of thorax shape for forward modelling in lungs EIT. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography. Hanover, New Hampshire, USA 21 - 24 Jun 2017 Thayer School of Engineering at Dartmouth. pp. 58-58 https://doi.org/10.5281/zenodo.557093
DICOM for EIT
Yerworth, R. and Bayford, R. 2017. DICOM for EIT. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography. Hanover, New Hampshire, USA 21 - 24 Jun 2017 Thayer School of Engineering at Dartmouth. pp. 46-46 https://doi.org/10.5281/zenodo.557093
Torso shape detection to improve lung monitoring
de Gelidi, S., Bardill, A., Wu, Y., Demosthenous, A., Tizzard, A. and Bayford, R. 2017. Torso shape detection to improve lung monitoring. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography. Hanover, New Hampshire, USA 21 - 24 Jun 2017 Thayer School of Engineering at Dartmouth. pp. 25-25 https://doi.org/10.5281/zenodo.557093
Rapid generation of subject-specific thorax forward models
Tizzard, A. and Bayford, R. 2017. Rapid generation of subject-specific thorax forward models. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography. Hanover, New Hampshire, USA 21 - 24 Jun 2017 Thayer School of Engineering at Dartmouth. pp. 20-20 https://doi.org/10.5281/zenodo.557093
Nanoparticle electrical impedance tomography
Bayford, R., Nordebo, S., Roitt, I., Rademacher, T., Damaso, R., Wu, Y., Seifnaraghi, N. and Demosthenous, A. 2017. Nanoparticle electrical impedance tomography. 18th International Conference on Biomedical Applications of Electrical Impedance Tomography. Hanover, New Hampshire, USA 21 - 24 Jun 2017 Thayer School of Engineering at Dartmouth. pp. 56-56 https://doi.org/10.5281/zenodo.557093
Absorption and optimal plasmonic resonances for small ellipsoidal particles in lossy media
Dalarsson, M., Nordebo, S., Sjöberg, D. and Bayford, R. 2017. Absorption and optimal plasmonic resonances for small ellipsoidal particles in lossy media. Journal of Physics D: Applied Physics. 50 (34). https://doi.org/10.1088/1361-6463/aa7c8a
Continuous Regional Analysis Device for Neonates Lung (CRADL)
Bayford, R., Tizzard, A., Frerichs, I., Weiler, N., Karaoli, C., Christofides, S., Yiannakkaras, C., Rimensberger, P., Nordebo, S., Böhm, S., van Kaam, A., Fifield, B., Knox, C., Steuten, L., de Graaf, G., Yerworth, R., Butterworth, M. and Demosthenous, A. 2016. Continuous Regional Analysis Device for Neonates Lung (CRADL). MEDICON 2016: XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016. Paphos, Cyprus. 31 Mar - 02 Apr 2016 Springer. pp. 172 https://doi.org/10.1007/978-3-319-32703-7_35
Teaching atomic structure as a threshold concept in chemistry for biologists
Loizidou, E. and Jones, H. 2016. Teaching atomic structure as a threshold concept in chemistry for biologists. 253rd American Chemical Society National Meeting & Exposition. San Francisco, CA, USA 02 - 06 Apr 2017
A wideband low-distortion CMOS current driver for tissue impedance analysis
Constantinou, L., Bayford, R. and Demosthenous, A. 2015. A wideband low-distortion CMOS current driver for tissue impedance analysis. IEEE Transactions on Circuits and Systems II: Express Briefs. 62 (2), pp. 154-158. https://doi.org/10.1109/tcsii.2014.2387632
Why is EIT so hard, and what are we doing about it?
Adler, A., Grychtol, B. and Bayford, R. 2015. Why is EIT so hard, and what are we doing about it? Physiological Measurement. 36 (6), pp. 1067-1073. https://doi.org/10.1088/0967-3334/36/6/1067
Medical Physics: forming and testing solutions to clinical problems
Tsapaki, V. and Bayford, R. 2015. Medical Physics: forming and testing solutions to clinical problems. Physica Medica. 31 (7), pp. 738-740. https://doi.org/10.1016/j.ejmp.2015.05.017
Patient specific Parkinson's disease detection for adaptive deep brain stimulation
Mohammed, A., Zamani, M., Bayford, R. and Demosthenous, A. 2015. Patient specific Parkinson's disease detection for adaptive deep brain stimulation. 2015 37th Annual International Conference Of the IEEE Engineering In Medicine And Biology Society (EMBC). Milan, Italy 25 Aug 2015 IEEE. pp. 1528-1531
Enhanced vermiremediation of hydrocarbon contamination using biosurfactant
Popoola, S., Jones, H. and Purchase, D. 2017. Enhanced vermiremediation of hydrocarbon contamination using biosurfactant. SETAC Europe 27th Annual Meeting. Brussels, Belgium 07 - 11 May 2017
16th International Conference on Electrical Bio-impedance and 17th International Conference on Biomedical Applications of Electrical Impedance Tomography (EIT) [Editorial]
Bayford, R. and Olimar, S. 2017. 16th International Conference on Electrical Bio-impedance and 17th International Conference on Biomedical Applications of Electrical Impedance Tomography (EIT) [Editorial]. Physiological Measurement. 38 (6), pp. E8-E9. https://doi.org/10.1088/1361-6579/aa6a5c
Emerging applications of nanotechnology for diagnosis and therapy of disease: a review
Bayford, R., Rademacher, T., Roitt, I. and Wang, S. 2017. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review. Physiological Measurement. 38 (8). https://doi.org/10.1088/1361-6579/aa7182
On the physical limitations for radio frequency absorption in gold nanoparticle suspensions
Nordebo, S., Dalarsson, M., Ivanenko, Y., Sjoeberg, D. and Bayford, R. 2017. On the physical limitations for radio frequency absorption in gold nanoparticle suspensions. Journal of Physics D: Applied Physics. 50 (15). https://doi.org/10.1088/1361-6463/aa5a89
Evaluation of the effectiveness of Eladi Keram for the treatment of acne vulgaris: a randomised controlled pilot study
Appiah, S., Lawley, B., Vu, M., Bell, C. and Jones, H. 2017. Evaluation of the effectiveness of Eladi Keram for the treatment of acne vulgaris: a randomised controlled pilot study. European Journal of Integrative Medicine. 12, pp. 38-43. https://doi.org/10.1016/j.eujim.2017.04.004
Antiinflammatory and hepatoprotective medicinal herbs as potential substitutes for bear bile
Appiah, S., Revitt, D., Jones, H., Vu, M., Simmonds, M. and Bell, C. 2017. Antiinflammatory and hepatoprotective medicinal herbs as potential substitutes for bear bile. in: Zeng, B. and Zhao, K. (ed.) Neurobiology of Chinese Herb Medicine Elsevier.
Detecting colorectal cancer using electrical impedance spectroscopy: an ex vivo feasibility study
Pathiraja, A., Ziprin, P., Shiraz, A., Mirnezami, R., Tizzard, A., Brown, B., Demosthenous, A. and Bayford, R. 2017. Detecting colorectal cancer using electrical impedance spectroscopy: an ex vivo feasibility study. Physiological Measurement. 38 (6), pp. 1278-1288. https://doi.org/10.1088/1361-6579/aa68ce
Detection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor
Wang, S., Acha, D., Shah, A., Hills, F., Roitt, I., Demosthenous, A. and Bayford, R. 2017. Detection of the tau protein in human serum by a sensitive four-electrode electrochemical biosensor. Biosensors and Bioelectronics. 92, pp. 482-488. https://doi.org/10.1016/j.bios.2016.10.077
Analysis and compensation for errors in electrical impedance tomography images and ventilation-­related measures due to serial data collection
Yerworth, R., Frerichs, I. and Bayford, R. 2017. Analysis and compensation for errors in electrical impedance tomography images and ventilation-­related measures due to serial data collection. Journal of Clinical Monitoring and Computing. 31 (5), pp. 1093-1101. https://doi.org/10.1007/s10877-016-9920-y
EIT2015: promoting electrical impedance tomography as a non-invasive monitoring technology
Bayford, R. and Solà, J. 2016. EIT2015: promoting electrical impedance tomography as a non-invasive monitoring technology. Physiological Measurement. 37 (6), pp. E3-E4. https://doi.org/10.1088/0967-3334/37/6/E3
A novel active electrode IC for wearable EIT system
Wu, Y., Langlois, P., Bayford, R. and Demosthenous, A. 2016. A novel active electrode IC for wearable EIT system. 16th International Conference on Electrical Bio-Impedance (ICEBI) and 17th International Conference on Electrical Impedance Tomography (EIT). Stockholm 19 - 23 Jun 2016 Zenodo. pp. 138 https://doi.org/10.5281/zenodo.55753
Alternate algorithm to reconstruct shape in wearable device
Tizzard, A., Demosthenous, A. and Bayford, R. 2016. Alternate algorithm to reconstruct shape in wearable device. 16th International Conference on Electrical Bio-Impedance (ICEBI) and 17th International Conference on Electrical Impedance Tomography (EIT). Stockholm 19 - 23 Jun 2016 Zenodo. pp. 128 https://doi.org/10.5281/zenodo.55753
Application of microalgae and fungal-microalgal associations for wastewater treatment
Egede, E., Jones, H., Cook, B., Purchase, D. and Mouradov, A. 2016. Application of microalgae and fungal-microalgal associations for wastewater treatment. in: Purchase, D. (ed.) Fungal Applications in Sustainable Environmental Biotechnology Cham Springer. pp. 143-181
Design of a CMOS active electrode IC for wearable electrical impedance tomography systems
Wu, Y., Langlois, P., Bayford, R. and Demosthenous, A. 2016. Design of a CMOS active electrode IC for wearable electrical impedance tomography systems. 2016 IEEE International Symposium Circuits and Systems (ISCAS). Montreal, QC, Canada 22 - 25 May 2016 Institute of Electrical and Electronics Engineers (IEEE). pp. 846-849 https://doi.org/10.1109/ISCAS.2016.7527373
Comparative gene expression profiling of ADAMs, MMPs, TIMPs,EMMPRIN, EGF-R and VEGFA in low grade meningioma
Rooprai, H., Martin, A., King, A., Appadu, U., Jones, H., Selway, R., Gullan, R. and Pilkington, G. 2016. Comparative gene expression profiling of ADAMs, MMPs, TIMPs,EMMPRIN, EGF-R and VEGFA in low grade meningioma. International Journal of Oncology. 49 (6), pp. 2309-2318. https://doi.org/10.3892/ijo.2016.3739
The mechanisms of detoxification of As(III), dimethylarsinic acid (DMA) and As(V) in the microalga Chlorella vulgaris
Pantoja Munoz, L., Purchase, D., Jones, H., Raab, A., Urgast, D., Feldmann, J. and Garelick, H. 2016. The mechanisms of detoxification of As(III), dimethylarsinic acid (DMA) and As(V) in the microalga Chlorella vulgaris. Aquatic Toxicology. 175, pp. 56-72. https://doi.org/10.1016/j.aquatox.2016.02.020
XVth International Conference on Electrical Bio-Impedance and the XIVth Conference on Electrical Impedance Tomography (Heilbad Heiligenstadt, Germany, 22–25 April 2013)
Bayford, R. and Pliquett, U. 2014. XVth International Conference on Electrical Bio-Impedance and the XIVth Conference on Electrical Impedance Tomography (Heilbad Heiligenstadt, Germany, 22–25 April 2013). Physiological Measurement. 35 (6), pp. 945-946. https://doi.org/10.1088/0967-3334/35/6/915
MPS: improving exact string matching through pattern character frequency, journal of data processing
Sahota, V., Li, M. and Bayford, R. 2013. MPS: improving exact string matching through pattern character frequency, journal of data processing. Journal of Data Processing. 3 (3), pp. 127-137.
The effect of serial data collection on the accuracy of electrical impedance tomography images
Yerworth, R. and Bayford, R. 2013. The effect of serial data collection on the accuracy of electrical impedance tomography images. Physiological Measurement. 34 (6), pp. 659-669. https://doi.org/10.1088/0967-3334/34/6/659
Bioimpedance imaging: an overview of potential clinical applications
Bayford, R. and Tizzard, A. 2012. Bioimpedance imaging: an overview of potential clinical applications. Analyst. 137 (20), pp. 4635-4643. https://doi.org/10.1039/C2AN35874C
Whither lung EIT: where are we, where do we want to go and what do we need to get there?
Adler, A., Amato, M., Arnold, J., Bayford, R., Bodenstein, M. and Böhm, S. 2012. Whither lung EIT: where are we, where do we want to go and what do we need to get there? Physiological Measurement. 33 (5), pp. 679-694. https://doi.org/10.1088/0967-3334/33/5/679
A cable theory based biophysical model of resistance change in crab peripheral nerve and human cerebral cortex during neuronal depolarisation: implications for electrical impedance tomography of fast neural activity in the brain
Liston, A., Bayford, R. and Holder, D. 2012. A cable theory based biophysical model of resistance change in crab peripheral nerve and human cerebral cortex during neuronal depolarisation: implications for electrical impedance tomography of fast neural activity in the brain. Med Biol Eng Comput. 50 (5), pp. 425-437. https://doi.org/10.1007/s11517-012-0901-0
Sources and pathways for pharmaceuticals in the urban water environment
Tuckwell, R., Revitt, D., Garelick, H., Jones, H. and Ellis, J. 2011. Sources and pathways for pharmaceuticals in the urban water environment. 12th International Conference on Urban Drainage. Porto Alegre, Brazil 11 - 16 Sep 2011
Factors influencing the infiltration of pharmaceuticals through soils
Balogh, T., Revitt, D., Jones, H. and Lundy, L. 2011. Factors influencing the infiltration of pharmaceuticals through soils. 12th International Conference on Urban Drainage. Porto Alegre, Brazil 11 - 16 Sep 2011
On the application of frequency selective common mode feedback for multifrequency EIT
Langlois, P., Wu, Y., Bayford, R. and Demosthenous, A. 2015. On the application of frequency selective common mode feedback for multifrequency EIT. Physiological Measurement. 36 (6), pp. 1337-1350. https://doi.org/10.1088/0967-3334/36/6/1337
Determination of urinary cortisol, cortisone and 6-sulfatoxymelatonin using dilute and shoot ultra-high pressure liquid chromatography-tandem mass spectrometry
Sniecinska-Cooper, A., Shah, A., Dimitriou, D., Iles, R., Butler, S. and Bayford, R. 2015. Determination of urinary cortisol, cortisone and 6-sulfatoxymelatonin using dilute and shoot ultra-high pressure liquid chromatography-tandem mass spectrometry. Journal of Chromatography B. 978-79, pp. 18-23. https://doi.org/10.1016/j.jchromb.2014.11.016
Sorption behaviours and transport potentials for selected pharmaceuticals and triclosan in two sterilised soils
Revitt, D., Balogh, T. and Jones, H. 2015. Sorption behaviours and transport potentials for selected pharmaceuticals and triclosan in two sterilised soils. Journal of Soils and Sediments. 15 (3), pp. 594-606. https://doi.org/10.1007/s11368-014-1025-y
Screening for Downs Syndrome pregnancy by mass spectral glycofingerprinting hCG-beta core in neat pregnancy urine.
Luttoo, J., Appiah, S., Butler, S. and Iles, R. 2009. Screening for Downs Syndrome pregnancy by mass spectral glycofingerprinting hCG-beta core in neat pregnancy urine. Middlesex University Postgraduate Summer Conference. London, UK
The mechanisms of arsenic bioremediation from water by the green microalgae Chlorella vulgaris
Pantoja Munoz, L., Purchase, D., Jones, H., Feldmann, J. and Garelick, H. 2014. The mechanisms of arsenic bioremediation from water by the green microalgae Chlorella vulgaris. THE BNASS / TraceSpec Tandem Conference. Aberdeen, Scotland, UK 31 Aug - 04 Sep 2014
Wearable sensors for patient-specific boundary shape estimation to improve the forward model for electrical impedance tomography (EIT) of neonatal lung function
Khor, J., Tizzard, A., Demosthenous, A. and Bayford, R. 2014. Wearable sensors for patient-specific boundary shape estimation to improve the forward model for electrical impedance tomography (EIT) of neonatal lung function. Physiological Measurement. 35 (6), pp. 1149-1161. https://doi.org/10.1088/0967-3334/35/6/1149
High-power CMOS current driver with accurate transconductance for electrical impedance tomography
Constantinou, L., Triantis, I., Bayford, R. and Demosthenous, A. 2014. High-power CMOS current driver with accurate transconductance for electrical impedance tomography. IEEE Transactions on Biomedical Circuits and Systems. 8 (4), pp. 575-583. https://doi.org/10.1109/TBCAS.2013.2285481
Soil mobility of surface applied polyaromatic hydrocarbons in response to simulated rainfall
Revitt, D., Balogh, T. and Jones, H. 2014. Soil mobility of surface applied polyaromatic hydrocarbons in response to simulated rainfall. Environmental Science and Pollution Research. 21 (6), pp. 4209-4219. https://doi.org/10.1007/s11356-013-2231-7
Enhanced determination of As-phytochelatin complexes in Chlorella vulgaris using focused sonication for extraction of water-soluble species
Pantoja Munoz, L., Purchase, D., Jones, H., Feldmann, J. and Garelick, H. 2014. Enhanced determination of As-phytochelatin complexes in Chlorella vulgaris using focused sonication for extraction of water-soluble species. Analytical Methods. 6 (3), pp. 791-797. https://doi.org/10.1039/C3AY41629A
The removal of arsenate from water using iron-modified diatomite (D-Fe): isotherm and column experiments
Pantoja Munoz, L., Jones, H., Garelick, H., Mohamedbakr, H. and Burkitbayev, M. 2014. The removal of arsenate from water using iron-modified diatomite (D-Fe): isotherm and column experiments. Environmental Science and Pollution Research. 21 (1), pp. 495-506. https://doi.org/10.1007/s11356-013-1891-7
Single point biochemical measurement algorithm for early diagnosis of ectopic pregnancy
Butler, S., Abban, T., Borrelli, P., Luttoo, J., Kemp, B. and Iles, R. 2013. Single point biochemical measurement algorithm for early diagnosis of ectopic pregnancy. Clinical Biochemistry. 46 (13-14), pp. 1257-1263. https://doi.org/10.1016/j.clinbiochem.2013.06.019
hCGβ expression by cervical squamous carcinoma - in vivohistological association with tumour invasion and apoptosis
Li, D., Wen, S., Ghali, L., Al-Shalabi, F., Docherty, S., Purkis, P. and Iles, R. 2008. hCGβ expression by cervical squamous carcinoma - in vivohistological association with tumour invasion and apoptosis. Histopathology. 53 (2), pp. 147-155. https://doi.org/10.1111/j.1365-2559.2008.03082.x
Stable knockdown of hCGβ mRNA expression in bladder cancer cells results in significant inhibition of growth
Burczynska, B., Booth, M., Iles, R., Shah, A., Shiled, A. and Butler, S. 2013. Stable knockdown of hCGβ mRNA expression in bladder cancer cells results in significant inhibition of growth. Anticancer Research. 33 (9), pp. 3611-3614.
The influence of ligand organization on the rate of uptake of gold nanoparticles by colorectal cancer cells
Lund, T., Callaghan, M., Williams, P., Turmaine, M., Bachmann, C., Rademacher, T., Roitt, I. and Bayford, R. 2011. The influence of ligand organization on the rate of uptake of gold nanoparticles by colorectal cancer cells. Biomaterials. 32 (36), pp. 9776-9784. https://doi.org/10.1016/j.biomaterials.2011.09.018
hCGβ expression by cervical squamous carcinoma: in vivo histological association with tumour invasion and apoptosis
Li, D., Wen, S., Ghali, L., Al-Shalabi, F., Docherty, S., Purkis, P. and Iles, R. 2008. hCGβ expression by cervical squamous carcinoma: in vivo histological association with tumour invasion and apoptosis. Histopathology. 53 (2), pp. 147-155. https://doi.org/10.1111/j.1365-2559.2008.03082.x
Does hCG or hCGβ play a role in cancer cell biology?
Iles, R., Delves, P. and Butler, S. 2010. Does hCG or hCGβ play a role in cancer cell biology? Molecular and Cellular Endocrinology. 329 (1-2), pp. 62-70. https://doi.org/10.1016/j.mce.2010.07.014
Development of Zwitterionic Hydrophilic Liquid Chromatography (ZICⓇHILIC-MS) metabolomics method for Shotgun analysis of human urine
Trivedi, D., Jones, H., Shah, A. and Iles, R. 2012. Development of Zwitterionic Hydrophilic Liquid Chromatography (ZICⓇHILIC-MS) metabolomics method for Shotgun analysis of human urine. Journal of Chromatography & Separation Techniques. 03 (06). https://doi.org/10.4172/2157-7064.1000144
A tripolar current-steering stimulator ASIC for field shaping in deep brain stimulation
Valente, V., Demosthenous, A. and Bayford, R. 2011. A tripolar current-steering stimulator ASIC for field shaping in deep brain stimulation. IEEE Transactions on Biomedical Circuits and Systems. 6 (3), pp. 197-207. https://doi.org/10.1109/TBCAS.2011.2171036
Human Chorionic Gonadotropin (hCG) in the secretome of cultured embryos: hyperglycosylated hCG and hCG-free beta subunit are potential markers for infertility management and treatment
Butler, S., Luttoo, J., Freire, M., Abban, T., Borrelli, P. and Iles, R. 2013. Human Chorionic Gonadotropin (hCG) in the secretome of cultured embryos: hyperglycosylated hCG and hCG-free beta subunit are potential markers for infertility management and treatment. Reproductive Sciences. 20 (9), pp. 1038-1045. https://doi.org/10.1177/1933719112472739
Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy
Hills, F., Iles, R. and Sullivan, M. 2013. Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy. Journal of Perinatal Medicine. 41 (3), pp. 241-249. https://doi.org/10.1515/jpm-2012-0086
New imaging mapping device for the detection and location of rectal cancer
Bayford, R., Borsic, A., Tizzard, A., Kantartzis, P., Liatsis, P. and Demosthenous, A. 2012. New imaging mapping device for the detection and location of rectal cancer. 13th International Conference on Electrical Impedance Tomography (EIT 2012). Tianjin, China 23 - 25 May 2012
Tracking conductivity variations in the absence of accurate state evolution models in electrical impedance tomography
Hashemzadeh, P., Sahota, V., Callaghan, M., El Dib, H., Tizzard, A., Svensson, L. and Bayford, R. 2010. Tracking conductivity variations in the absence of accurate state evolution models in electrical impedance tomography. in: 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE), 2010 IEEE. pp. 1-6
GREIT: a unified approach to 2D linear EIT reconstruction of lung images
Adler, A., Arnold, J., Bayford, R., Borsic, A., Brown, B., Dixon, P., Faes, T., Frerichs, I., Gagnon, H., Garber, Y., Grychtol, B., Hahn, G., Lionheart, W., Malik, A., Patterson, R., Stocks, J., Tizzard, A., Weiler, N. and Wolf, G. 2009. GREIT: a unified approach to 2D linear EIT reconstruction of lung images. Physiological Measurement. 30 (6), pp. S35-S55. https://doi.org/10.1088/0967-3334/30/6/S03
Dynamic electrical impedance tomography image reconstruction of neonate lung function based on linear Kalman filter techniques
El Dib, H., Tizzard, A. and Bayford, R. 2009. Dynamic electrical impedance tomography image reconstruction of neonate lung function based on linear Kalman filter techniques. in: Dössel, O. and Schlegel, W. (ed.) IFMBE Proceedings, World Congress on Medical Physics and Biomedical Engineering September 7 - 12, 2009 Munich, Germany Munich, Germany Springer.
Development of a sensor network for dynamic boundary measurement in neonatal electrical impedance tomography (EIT)
Khor, J., Tizzard, A., Demosthenous, A. and Bayford, R. 2009. Development of a sensor network for dynamic boundary measurement in neonatal electrical impedance tomography (EIT). in: Dössel, O. and Schlegel, W. (ed.) IFMBE Proceedings, World Congress on Medical Physics and Biomedical Engineering September 7 - 12, 2009 Munich, Germany Munich, Germany Springer.
Effects of warping finite element meshes for the forward model of the head in EIT
Tizzard, A., Bayford, R., Horesh, L., Yerworth, R. and Holder, D. 2004. Effects of warping finite element meshes for the forward model of the head in EIT. in: Nowakowski, A. (ed.) Proceedings of the XII International Conference of Electrical Bioimpedance & V Electrical Impedance Tomography Gdansk, Poland Gdansk University of Technology.
Validation of finite element mesh warping for improving the forward model in EIT of brain function
Tizzard, A. and Bayford, R. 2007. Validation of finite element mesh warping for improving the forward model in EIT of brain function. in: Scharfetter, H. and Merwa, R. (ed.) IFMBE Proceedings, Part II - 13th International Conference on Electrical Bioimpedance and 8th Conference on Electrical Impedance Tomography 2007 Graz, Austria Springer Verlag.
Reconstruction algorithms to monitor neonate lung function
Bayford, R., Kantartzis, P., Tizzard, A., Yerworth, R., Liatsis, P. and Demosthenous, A. 2007. Reconstruction algorithms to monitor neonate lung function. in: Scharfetter, H. and Mervwa, R. (ed.) IFMBE Proceedings, Part II - 13th International Conference on Electrical Bioimpedance and 8th Conference on Electrical Impedance Tomography 2007 Graz, Austria Springer Verlag.
Generation and performance of patient-specific forward models for breast imaging with EIT
Tizzard, A., Borsic, A., Halter, R. and Bayford, R. 2010. Generation and performance of patient-specific forward models for breast imaging with EIT. Journal of Physics: Conference Series. 224 (1), pp. 1-4. https://doi.org/10.1088/1742-6596/224/1/012034
A comparison study of electrodes for neonate electrical impedance tomography
Rahal, M., Khor, J., Demosthenous, A., Tizzard, A. and Bayford, R. 2009. A comparison study of electrodes for neonate electrical impedance tomography. Physiological Measurement. 30 (6), pp. 73-84. https://doi.org/10.1088/0967-3334/30/6/S05
Development of a neonate lung reconstruction algorithm using a wavelet AMG and estimated boundary form
Bayford, R., Kantartzis, P., Tizzard, A., Yerworth, R., Liatsis, P. and Demosthenous, A. 2008. Development of a neonate lung reconstruction algorithm using a wavelet AMG and estimated boundary form. Physiological Measurement. 29 (6), pp. S125-S138. https://doi.org/10.1088/0967-3334/29/6/S11
Generating accurate finite element meshes for the forward model of the human head in EIT
Tizzard, A., Horesh, L., Yerworth, R., Holder, D. and Bayford, R. 2005. Generating accurate finite element meshes for the forward model of the human head in EIT. Physiological Measurement. 26 (2), pp. S251-S262.
Solving the forward problem in electrical impedance tomography for the human head using IDEAS (integrated design engineering analysis software), a finite element modelling tool
Bayford, R., Gibson, A., Tizzard, A., Tidswell, T. and Holder, D. 2001. Solving the forward problem in electrical impedance tomography for the human head using IDEAS (integrated design engineering analysis software), a finite element modelling tool. Physiological Measurement. 22 (1), pp. 55-64.
Investigating the mechanism of deep brain stimulation using a dynamic complex model of the head incorporated with the complete model of electrode
Bayford, R., Tizzard, A., Yousif, N. and Liu, X. 2006. Investigating the mechanism of deep brain stimulation using a dynamic complex model of the head incorporated with the complete model of electrode. Clinical Neurophysiology. 117, pp. S219-S220.
Does HCG or HCG-beta play a role in breast cancer cell biology?
Iles, R. and Butler, S. 2010. Does HCG or HCG-beta play a role in breast cancer cell biology? Tumour Biology. 31 (S39).
Ectopic HCG beta may induce epithelialmensenchymal transition on human kera tinocytes in vitro and this could promote tumour progression and invasion.
Wen, S., Li, D., Ghali, L. and Iles, R. 2010. Ectopic HCG beta may induce epithelialmensenchymal transition on human kera tinocytes in vitro and this could promote tumour progression and invasion. Tumour Biology. 31 (S44).
Structural modelling of human chorion ic gonadotropin: the effect of nicking and glycosylation on the molecular folding and likely epitope recognition by HCG antibodies.
Butler, S., Gibbons, N., Rehman, S. and Iles, R. 2010. Structural modelling of human chorion ic gonadotropin: the effect of nicking and glycosylation on the molecular folding and likely epitope recognition by HCG antibodies. Tumour Biology. 31 (S46).
Serum biomarkers of collagen metabolism, pyridinoline (PYD) and aminoterminal properptide of type i procollagen (PINP) as diagnostic staging markers of bone metastases in breast cancer patients.
Iles, R., Cheung, K., Robertson, J. and Perrett, D. 2010. Serum biomarkers of collagen metabolism, pyridinoline (PYD) and aminoterminal properptide of type i procollagen (PINP) as diagnostic staging markers of bone metastases in breast cancer patients. Tumour Biology. 31 (S72).
Detection of cancer.
Bayford, R., Roitt, I., Rademacher, T., Demosthenous, A. and Iles, R. 2010. Detection of cancer.
Gonadotropins and gonadotropin receptors: evolutional genetics, signalling mechanisms, extra gonadal function and roles in oncogenesis.
Iles, R. and Butler, S. 2010. Gonadotropins and gonadotropin receptors: evolutional genetics, signalling mechanisms, extra gonadal function and roles in oncogenesis. Molecular and Cellular Endocrinology. 329 (1), pp. 1-2. https://doi.org/10.1016/j.mce.2010.07.024
Biological function of the free β -subunit: expression and treatment target in cancer.
Butler, S. and Iles, R. 2010. Biological function of the free β -subunit: expression and treatment target in cancer. in: Cole, L. (ed.) Human chorionic gonadotropin (hCG). London Elsevier. pp. 153-171
Does hCG or hCGß play a role in cancer cell biology?
Iles, R., Delves, P. and Butler, S. 2010. Does hCG or hCGß play a role in cancer cell biology? Molecular and Cellular Endocrinology. 329 (1-2), pp. 62-70. https://doi.org/10.1016/j.mce.2010.07.014
Technical note: effects of arsenate (AS5+) on growth and production of glutathione (GSH) and phytochelatins (PCS) in Chlorella Vulgaris
Jiang, Y., Purchase, D., Jones, H. and Garelick, H. 2011. Technical note: effects of arsenate (AS5+) on growth and production of glutathione (GSH) and phytochelatins (PCS) in Chlorella Vulgaris. International Journal of Phytoremediation. 13 (8), pp. 834-844. https://doi.org/10.1080/15226514.2010.525560
Remediation technologies for the removal of arsenic from water and wastewater
Garelick, H., Bollinger, J., Bux, K., Caussy, D., Dybowska, A., Ellis, J., Feldmann, J., Jones, H., Priest, N., Shevah, Y., Sneddon, R., Valsami-Jones, E. and Visoottiviseth, P. 2005. Remediation technologies for the removal of arsenic from water and wastewater. 43rd IUPAC General Assembly. Beijing, China 13 - 21 Aug 2005
Composition of intact hormone and free subunits in the human chorionic gonadotrophin-like material found in serum and urine of patients with carcinoma of the bladder.
Iles, R., Lee, C., Oliver, R. and Chard, T. 1990. Composition of intact hormone and free subunits in the human chorionic gonadotrophin-like material found in serum and urine of patients with carcinoma of the bladder. Clinical Endocrinology. 33 (3), pp. 355-364. https://doi.org/10.1111/j.1365-2265.1990.tb00500.x
Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests.
Caulfield, M., Dilkes, M., Iles, R., Handel, B. and Oliver, R. 1990. Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests. Lancet. 335 (8699), p. 1230. https://doi.org/10.1016/0140-6736(90)92761-6
Biological significance of beta hCG, HLA and other membrane antigen expression on bladder tumours and their relationship to tumour infiltrating lymphocytes (TIL)
Oliver, R., Nouri, A., Crosby, D., Iles, R., Naverette, C., Martin, J., Bodmer, W. and Festenstein, H. 1989. Biological significance of beta hCG, HLA and other membrane antigen expression on bladder tumours and their relationship to tumour infiltrating lymphocytes (TIL). International journal of immunogenetics. 16 (4-5), pp. 381-390.
Expression of beta human chorionic gonadotrophin by non-trophoblastic non-endocrine 'normal' and malignant epithelial cells.
Iles, R., Purkis, P., Whitehead, P., Oliver, R. and Chard, T. 1990. Expression of beta human chorionic gonadotrophin by non-trophoblastic non-endocrine 'normal' and malignant epithelial cells. British journal of cancer. 61 (5), pp. 663-666.
Enhancement of ectopic beta-human chorionic gonadotrophin expression by interferon-alpha.
Iles, R. and Chard, T. 1989. Enhancement of ectopic beta-human chorionic gonadotrophin expression by interferon-alpha. Journal of Endocrinology. 123 (3), pp. 501-507. https://doi.org/10.1677/joe.0.1230501
Beta human chorionic gonadotrophin in serum and urine. A marker for metastatic urothelial cancer.
Iles, R., Jenkins, B., Oliver, R., Blandy, J. and Chard, T. 1989. Beta human chorionic gonadotrophin in serum and urine. A marker for metastatic urothelial cancer. British Journal of Urology. 64 (3), pp. 241-244. https://doi.org/10.1111/j.1464-410X.1989.tb06006.x
Immunochemical analysis of the human chorionic gonadotrophin-like material secreted by 'normal' and neoplastic urothelial cells.
Iles, R. and Chard, T. 1989. Immunochemical analysis of the human chorionic gonadotrophin-like material secreted by 'normal' and neoplastic urothelial cells. Journal of molecular endocrinology. 2 (2), pp. 107-112. https://doi.org/10.1677/jme.0.0020107
Amplification or rearrangement of the beta-human chorionic gonadotrophin (beta-hCG)--human LH gene cluster is not responsible for the ectopic production of beta-hCG by bladder tumour cells.
Iles, R., Czepulkowski, B., Young, B. and Chard, T. 1989. Amplification or rearrangement of the beta-human chorionic gonadotrophin (beta-hCG)--human LH gene cluster is not responsible for the ectopic production of beta-hCG by bladder tumour cells. Journal of molecular endocrinology. 2 (2), pp. 113-117. https://doi.org/10.1677/jme.0.0020113
In vitro secretion of human chorionic gonadotrophin by bladder tumour cells.
Iles, R., Oliver, R., Kitau, M., Walker, C. and Chard, T. 1987. In vitro secretion of human chorionic gonadotrophin by bladder tumour cells. British journal of cancer. 55 (6), pp. 623-626.
The measurement of urinary beta core fragment in conjunction with serum CA125 does not aid the differentiation of malignant from benign pelvic masses.
Carter, P., Iles, R., Neven, P., Davies, A., Shepherd, J. and Chard, T. 1993. The measurement of urinary beta core fragment in conjunction with serum CA125 does not aid the differentiation of malignant from benign pelvic masses. Gynecologic Oncology. 51 (3), pp. 368-371. https://doi.org/10.1006/gyno.1993.1305
Bony metastases from breast cancer: a study of foetal antigen 2 as a blood tumour marker.
Cheung, K., Iles, R. and Robertson, J. 2010. Bony metastases from breast cancer: a study of foetal antigen 2 as a blood tumour marker. World Journal of Surgical Oncology. 8 (38). https://doi.org/10.1186/1477-7819-8-38
Purine metabolite levels in pre-ovulatory human follicles may hold the key to ovarian hyper-stimulation syndrome.
Iles, R. and Docherty, S. 2010. Purine metabolite levels in pre-ovulatory human follicles may hold the key to ovarian hyper-stimulation syndrome. Metabolism. https://doi.org/10.1016/j.metabol.2010.04.005
Measurement of human chorionic gonadotrophin (hCG) as a screening test for Down’s Syndrome
Chard, T. and Iles, R. 1994. Measurement of human chorionic gonadotrophin (hCG) as a screening test for Down’s Syndrome. in: Grudzinskas, J., Chard, T., Chapman, M. and Cuckle, H. (ed.) Screening for Down’s Syndrome Cambridge University Press (CUP). pp. 73-84
Electric field characteristics of bipolar impedance sensors.
Kassanos, P., Bayford, R. and Demosthenous, A. 2009. Electric field characteristics of bipolar impedance sensors. 11th International Congress of the IUPESM - Medical Physics and Biomedical Engineering World Congress 2009 - for the benefit of the patient program. Munich, Germany 07 - 12 Sep 2009
A high output impedance current source for wideband bioimpedance measurements.
Hong, H., Bayford, R. and Demosthenous, A. 2009. A high output impedance current source for wideband bioimpedance measurements. 11th International Congress of the IUPESM - Medical Physics and Biomedical Engineering World Congress 2009 - for the benefit of the patient program.. Munich, Germany 07 - 12 Sep 2009
The use of EIT in the detection of regional lung dysfunction in prematurely born neonates.
Zifan, A., Liatsis, P. and Bayford, R. 2009. The use of EIT in the detection of regional lung dysfunction in prematurely born neonates. 11th International Congress of the IUPESM - Medical Physics and Biomedical Engineering World Congress 2009 - for the benefit of the patient program. Munich, Germany 07 - 12 Sep 2009
Electrochemical impedance detection of hCGbeta: preliminary results and analysis in the development of lab on a chip technology.
Bayford, R., Kassanos, P., Demosthenous, A. and Iles, R. 2009. Electrochemical impedance detection of hCGbeta: preliminary results and analysis in the development of lab on a chip technology. 42nd IUPAC Congress: Chemistry Solutions SECC.. Glasgow, Scotland, UK. 02 - 07 Aug 2009
Statistical analysis for brain EIT images using SPM.
Zhang, Y., Passmore, P., Yerworth, R. and Bayford, R. 2005. Statistical analysis for brain EIT images using SPM. Institute of Electrical and Electronics Engineers. pp. 60-67 https://doi.org/10.1109/MEDIVIS.2005.17
Designing a new generation of anti-hCG vaccines for cancer therapy
Delves, P., Iles, R., Roitt, I. and Lund, T. 2007. Designing a new generation of anti-hCG vaccines for cancer therapy. Molecular and Cellular Endocrinology. 260-26, pp. 276-281. https://doi.org/10.1016/j.mce.2006.02.018
Water and health. [Chapter 6 of 'Sustainable water: chemical science priorities summary report']
Green, C., Donner, E., Faulkner, H., Garelick, H., Jones, H., Revitt, D. and Lundy, L. 2007. Water and health. [Chapter 6 of 'Sustainable water: chemical science priorities summary report']. Royal Society of Chemistry.
Mitigating arsenic pollution: bridging the gap between knowledge and practice
Garelick, H. and Jones, H. 2008. Mitigating arsenic pollution: bridging the gap between knowledge and practice. Chemistry International. 30 (4).
New and emerging tomographic imaging techniques in medical and industrial applications. Introduction
Soleimani, M. and Bayford, R. 2009. New and emerging tomographic imaging techniques in medical and industrial applications. Introduction. Philosophical Transactions of the Royal Society A: Mathematical, Physical & Engineering Sciences. 367 (1900), pp. 3017-3019.
Visualization of multidimensional and multimodal tomographic medical imaging data, a case study
Zhang, Y., Passmore, P. and Bayford, R. 2009. Visualization of multidimensional and multimodal tomographic medical imaging data, a case study. Philosophical Transactions of the Royal Society of London. A: Mathematical and Physical Sciences. 367 (1900), pp. 3121-3148. https://doi.org/10.1098/rsta.2009.0084
Comparison of a new integrated current source with the modified Howland circuit for EIT applications
Hong, H., Rahal, M., Demosthenous, A. and Bayford, R. 2009. Comparison of a new integrated current source with the modified Howland circuit for EIT applications. Physiological Measurement. 30 (10), pp. 999-1007. https://doi.org/10.1088/0967-3334/30/10/001
Estradiol, progesterone, testosterone profiles in human follicular fluid and cultured granulosa cells from luteinized pre-ovulatory follicles
Wen, S., Li, D., Tozer, A., Docherty, S. and Iles, R. 2010. Estradiol, progesterone, testosterone profiles in human follicular fluid and cultured granulosa cells from luteinized pre-ovulatory follicles. Reproductive Biology and Endocrinology. 8 (117). https://doi.org/10.1186/1477-7827-8-117
High follicular fluid adenosine levels may be pivotal in the metabolism and recycling of adenosine nucleotides in the human follicle
Wen, S., Perrett, D., Jones, N., Tozer, A., Docherty, S. and Iles, R. 2010. High follicular fluid adenosine levels may be pivotal in the metabolism and recycling of adenosine nucleotides in the human follicle. Metabolism: Clinical and Experimental. 59 (8), pp. 1145-1155. https://doi.org/10.1016/j.metabol.2009.09.037
Urinary concentration of human chorionic gonadotrophin and its fragments as a prognostic marker in bladder cancer
Iles, R., Persad, R., Trivedi, M., Sharma, K., Dickinson, A., Smith, P. and Chard, T. 1996. Urinary concentration of human chorionic gonadotrophin and its fragments as a prognostic marker in bladder cancer. British Journal of Urology. 77 (1), pp. 61-69. https://doi.org/10.1046/j.1464-410X.1996.82910.x
Urinary analysis for Down's syndrome: is the measurement of urinary β-core the future of biochemical screening for Down's syndrome
Iles, R. 1996. Urinary analysis for Down's syndrome: is the measurement of urinary β-core the future of biochemical screening for Down's syndrome. Early Human Development. 47, pp. S41-S45. https://doi.org/10.1016/S0378-3782(96)01818-X
Detection of β-core fragment in second trimester Down's syndrome pregnancies
Cole, L., Isozaki, T., Palomaki, G., Canick, J., Iles, R., Kellner, L., Saller, D. and Cuckle, H. 1996. Detection of β-core fragment in second trimester Down's syndrome pregnancies. Early Human Development. 47, pp. S47-S48. https://doi.org/10.1016/S0378-3782(96)01819-1
Human urothelial carcinomas - a typical disease of the aged: the clinical utility of human chorionic gonadotrophin in patient management and future therapy
Iles, R. and Butler, S. 1998. Human urothelial carcinomas - a typical disease of the aged: the clinical utility of human chorionic gonadotrophin in patient management and future therapy. Experimental Gerontology. 33 (5), pp. 379-391. https://doi.org/10.1016/S0531-5565(98)00016-3
Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer-associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer
Ind, T., Iles, R., Shepherd, J. and Chard, T. 1997. Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer-associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer. British Journal of Obstetrics and Gynaecology. 104 (9), pp. 1024-1029. https://doi.org/10.1111/j.1471-0528.1997.tb12061.x
Comparison of 12 assays for detecting hCG and related molecules in urine samples from Down syndrome pregnancies.
Cole, L., Kellner, L., Isozaki, T., Palomaki, G., Iles, R., Walker, R., Ozaki, M. and Canick, J. 1997. Comparison of 12 assays for detecting hCG and related molecules in urine samples from Down syndrome pregnancies. Prenatal diagnosis. 17 (7), pp. 607-614. https://doi.org/10.1002/(SICI)1097-0223(199707)17:7<607::AID-PD118>3.0.CO;2-7
Measures of urine concentration in maternal urine screening for Down syndrome.
Iles, R., Black, A., Gunn, L., Sehmi, I., Cuckle, H. and Chard, T. 1998. Measures of urine concentration in maternal urine screening for Down syndrome. Prenatal diagnosis. 18 (10), pp. 1006-1009. https://doi.org/10.1002/(SICI)1097-0223(1998100)18:10<1006::AID-PD386>3.0.CO;2-O
Dimerization of urinary beta-core/hCFbetacf: a cause of poor beta-core assay performance in Down syndrome screening studies.
Iles, R., Butler, S. and Jacoby, E. 1999. Dimerization of urinary beta-core/hCFbetacf: a cause of poor beta-core assay performance in Down syndrome screening studies. Prenatal diagnosis. 19 (8), pp. 790-792. https://doi.org/10.1002/(SICI)1097-0223(199908)19:8<790::AID-PD627>3.0.CO;2-Z
Urinary beta-core hCG: Screening for aneuploidies in early pregnancy (11-14 weeks’ gestation).
MacIntosh, M., Nicolaides, K., Noble, P., Chard, T., Gunn, L. and Iles, R. 1997. Urinary beta-core hCG: Screening for aneuploidies in early pregnancy (11-14 weeks’ gestation). Prenatal diagnosis. 17 (5), pp. 401-405. https://doi.org/10.1002/(SICI)1097-0223(199705)17:5<401::AID-PD40>3.0.CO;2-M
Generating surfaces for registration and warping FE meshes for the forward model in EIT of brain function.
Tizzard, A., Holder, D., Bayford, R. and International Federation for Medical and Biological Engineering 2005. Generating surfaces for registration and warping FE meshes for the forward model in EIT of brain function. Springer.
Effects of modelling layers and realistic geometry in reconstruction algorithms for EIT of brain function.
Liston, A., Bagshaw, A., Bayford, R., Tizzard, A., Tidswell, A., Dehghani, H. and Holder, D. 2003. Effects of modelling layers and realistic geometry in reconstruction algorithms for EIT of brain function. 4th Conference on Biomedical Applications of Electrical Impedance Tomography. Manchester, UK 23 - 25 Apr 2003 UMIST, Manchester, UK pp. 19 https://doi.org/10.5281/zenodo.17924
Modelling the effect of eye sockets in the human head using I-DEAS and its implication for imaging impedance change using Electrical Impedance Tomography.
Bayford, R., Gibson, A., Tizzard, A., Liston, A., Tidswell, A., Bagshaw, A. and Holder, D. 2001. Modelling the effect of eye sockets in the human head using I-DEAS and its implication for imaging impedance change using Electrical Impedance Tomography. Grimmes, S., Martinsen, O. and Bruvoll, H. (ed.) Oslo University of Oslo. pp. 391-396
Development of algorithms to image impedance changes inside the human head.
Bayford, R., Bagshaw, A., Liston, A., Tizzard, A. and Holder, D. 2002. Development of algorithms to image impedance changes inside the human head. The First Mummy Range Workshop on Electric Impedance Imaging. Colorado, US Colorado State University
Substantial urinary concentrations of material resembling beta-core fragment of chorionic gonadotropin beta-subunit in mid-menstrual cycle
Neven, P., Iles, R., Howes, I., Sharma, K., Shepherd, J., Edwards, R., Collins, W. and Chard, T. 1993. Substantial urinary concentrations of material resembling beta-core fragment of chorionic gonadotropin beta-subunit in mid-menstrual cycle. Clinical Chemistry. 39 (9), pp. 1857-1860.
Production of placental alkaline phosphatase (PLAP) and PLAP-like material by epithelial germ cell and non-germ cell tumours in vitro
Iles, R., Ind, T. and Chard, T. 1994. Production of placental alkaline phosphatase (PLAP) and PLAP-like material by epithelial germ cell and non-germ cell tumours in vitro. British journal of cancer. 69 (2), pp. 274-278.
Diurnal variation of urinary "hCG beta subunit core fragment" production evaluated in patients with gynecological neoplasms
Neven, P., Iles, R., Carter, P., Shepherd, J. and Chard, T. 1994. Diurnal variation of urinary "hCG beta subunit core fragment" production evaluated in patients with gynecological neoplasms. Clinical Chemistry. 40 (3), pp. 484-485.
Characterisation of the differential expression of marker antigens by normal and malignant endometrial epithelium
Chatzaki, E., Gallagher, C., Iles, R., Ind, T., Nouri, A., Bax, C. and Grudzinskas, J. 1994. Characterisation of the differential expression of marker antigens by normal and malignant endometrial epithelium. British journal of cancer. 69 (6), pp. 1010-1014.
Serum placental-type alkaline phosphatase activity in women with squamous and glandular malignancies of the reproductive tract
Ind, T., Iles, R., Carter, P., Lowe, D., Shepherd, J., Hudson, C. and Chard, T. 1994. Serum placental-type alkaline phosphatase activity in women with squamous and glandular malignancies of the reproductive tract. Journal of Clinical Pathology. 47 (11), pp. 1035-1037.
Measurement of urinary beta core fragment of human chorionic gonadotrophin in women with vulvovaginal malignancy and its prognostic significance
Carter, P., Iles, R., Neven, P., Ind, T., Shepherd, J. and Chard, T. 1995. Measurement of urinary beta core fragment of human chorionic gonadotrophin in women with vulvovaginal malignancy and its prognostic significance. British journal of cancer. 71 (2), pp. 350-353.
The effects of beta-human chorionic gonadotrophin on the in vitro growth of bladder cancer cell lines
Gillott, D., Iles, R. and Chard, T. 1996. The effects of beta-human chorionic gonadotrophin on the in vitro growth of bladder cancer cell lines. British journal of cancer. 73 (3), pp. 323-326.
The temporary anatomical structures prominent in the first trimester may be fulfilling exchange functions assigned to the placenta in the second and third trimester
Docherty, S., Iles, R., Wathen, N. and Chard, T. 1996. The temporary anatomical structures prominent in the first trimester may be fulfilling exchange functions assigned to the placenta in the second and third trimester. Human Reproduction. 11 (6), pp. 1157-1161.
Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer
Crawford, R., Caldwell, C., Iles, R., Lowe, D., Shepherd, J. and Chard, T. 1998. Prognostic significance of the bcl-2 apoptotic family of proteins in primary and recurrent cervical cancer. British journal of cancer. 78 (2), pp. 210-214.
Concentrations of placental protein 14 in uterine flushings from infertile women: validation of the collection technique and method of expression of results
Hamilton, J., Iles, R., Gunn, L., Wilson, C., Lower, A., Chard, T. and Grudzinskas, J. 1998. Concentrations of placental protein 14 in uterine flushings from infertile women: validation of the collection technique and method of expression of results. Human Reproduction. 13 (12), pp. 3357-3362.
The prognostic significance of beta human chorionic gonadotrophin and its metabolites in women with cervical carcinoma
Crawford, R., Iles, R., Carter, P., Caldwell, C., Shepherd, J. and Chard, T. 1998. The prognostic significance of beta human chorionic gonadotrophin and its metabolites in women with cervical carcinoma. Journal of Clinical Pathology. 51 (9), pp. 685-688.
Cross-Reaction with luteinizing hormone ß-Core is responsible for the age-dependent increase of immunoreactive ß-Core fragment of human chorionic gonadotropin in women with nonmalignant conditions
Iles, R., Javid, M., Gunn, L. and Chard, T. 1999. Cross-Reaction with luteinizing hormone ß-Core is responsible for the age-dependent increase of immunoreactive ß-Core fragment of human chorionic gonadotropin in women with nonmalignant conditions. Clinical Chemistry. 45, pp. 532-538.
The beta-subunit of human chorionic gonadotrophin exists as a homodimer
Butler, S., Laidler, P., Porter, J., Kicman, A., Chard, T., Cowan, D. and Iles, R. 1999. The beta-subunit of human chorionic gonadotrophin exists as a homodimer. Journal of molecular endocrinology. 22, pp. 185-192.
Clinical and endocrinological changes after electro-acupuncture treatment in patients with osteoarthritis of the knee
Ahsin, S., Saleem, S., Bhatti, A., Aslam, M. and Iles, R. 2009. Clinical and endocrinological changes after electro-acupuncture treatment in patients with osteoarthritis of the knee. Pain. 147 (1-3), pp. 60-66. https://doi.org/10.1016/j.pain.2009.08.004
Capillary electrophoresis of human follicular fluid
Wen, S., Perrett, D., Patel, P., Li, N., Docherty, S., Tozer, A. and Iles, R. 2009. Capillary electrophoresis of human follicular fluid. Journal of Chromatography B. 877 (31), pp. 3946-3952. https://doi.org/10.1016/j.jchromb.2009.09.046
Robustness of linear and nonlinear reconstruction algorithms for brain EITS.
Yerworth, R., Horesh, L., Bayford, R., Tizzard, A. and Holder, D. 2004. Robustness of linear and nonlinear reconstruction algorithms for brain EITS. Nowakowski, A., Wtorek, J., Bujnowski, A. and Janczulewicz, A. (ed.) Gdansk, Poland Gdansk University of Technology. pp. 499-502
Beyond the linear domain: the way forward in MFEIT reconstruction of the human head.
Horesh, L., Bayford, R., Yerworth, R., Tizzard, A., Ahadzi, G. and Holder, D. 2004. Beyond the linear domain: the way forward in MFEIT reconstruction of the human head. Nowakowski, A., Wtorek, J., Bujnowski, A. and Janczulewicz, A. (ed.) Gdansk, Poland Gdansk University of Technology. pp. 683-686
The xenobiotic impact of sedimentary metals in an urban river
Adeyemi, A., Lundy, L., Revitt, D., Jones, H. and Faulkner, H. 2009. The xenobiotic impact of sedimentary metals in an urban river. International Conference on Xenobiotics in the Urban Water Cycle (Proceedings of). Paphos, Cyprus 11 - 13 Mar 2009
The role of glycosylation in regulating glycoprotein hormone free alpha subunit and free beta subunit combination in the extra-embryonic coelomic fluid of early pregnancy
Blithe, D. and Iles, R. 1995. The role of glycosylation in regulating glycoprotein hormone free alpha subunit and free beta subunit combination in the extra-embryonic coelomic fluid of early pregnancy. Endocrinology. 136 (3), pp. 903-910. https://doi.org/10.1210/en.136.3.903
Two-dimensional finite element modelling of the neonatal head
Gibson, A., Bayford, R. and Holder, D. 2000. Two-dimensional finite element modelling of the neonatal head. Physiological Measurement. 21 (1), pp. 45-52. https://doi.org/10.1088/0967-3334/21/1/306
Validation of a 3D reconstruction algorithm for EIT of human brain function in a realistic head-shaped tank
Tidswell, A., Gibson, A., Bayford, R. and Holder, D. 2001. Validation of a 3D reconstruction algorithm for EIT of human brain function in a realistic head-shaped tank. Physiological Measurement. 22 (1), pp. 177-185. https://doi.org/10.1088/0967-3334/22/1/321
Electrical impedance tomography of human brain activity with a two-dimensional ring of scalp electrodes
Tidswell, A., Gibson, A., Bayford, R. and Holder, D. 2001. Electrical impedance tomography of human brain activity with a two-dimensional ring of scalp electrodes. Physiological Measurement. 22 (1), pp. 167-175. https://doi.org/10.1088/0967-3334/22/1/320
A feasibility study of remote monitoring of asthmatic patients.
Steel, S., Lock, S., Johnson, N., Martinez, Y., Marquilles, E. and Bayford, R. 2002. A feasibility study of remote monitoring of asthmatic patients. Journal of telemedicine and telecare. 8 (5), pp. 290-296.
Design and performance of the UCLH mark 1b 64 channel electrical impedance tomography (EIT) system, optimized for imaging brain function
Yerworth, R., Bayford, R., Cusick, G., Conway, M. and Holder, D. 2002. Design and performance of the UCLH mark 1b 64 channel electrical impedance tomography (EIT) system, optimized for imaging brain function. Physiological Measurement. 23 (1), pp. 149-158. https://doi.org/10.1088/0967-3334/23/1/314
A multi-shell algorithm to reconstruct EIT images of brain function
Liston, A., Bayford, R., Tidswell, A. and Holder, D. 2002. A multi-shell algorithm to reconstruct EIT images of brain function. Physiological Measurement. 23 (1), pp. 105-119. https://doi.org/10.1088/0967-3334/23/1/310
A comparison of headnet electrode arrays for electrical impedance tomography of the human head
Tidswell, A., Bagshaw, A., Holder, D., Yerworth, R., Eadie, L., Murray, S., Morgan, L. and Bayford, R. 2003. A comparison of headnet electrode arrays for electrical impedance tomography of the human head. Physiological Measurement. 24 (2), pp. 527-544. https://doi.org/10.1088/0967-3334/24/2/363
Electrical impedance tomography spectroscopy (EITS) for human head imaging
Yerworth, R., Bayford, R., Brown, B., Milnes, P., Conway, M. and Holder, D. 2003. Electrical impedance tomography spectroscopy (EITS) for human head imaging. Physiological Measurement. 24 (2), pp. 477-489. https://doi.org/10.1088/0967-3334/24/2/358
The application of the generalized vector sample pattern matching method for EIT image reconstruction
Dong, G., Bayford, R., Gao, S., Saito, Y., Yerworth, R., Holder, D. and Yan, W. 2003. The application of the generalized vector sample pattern matching method for EIT image reconstruction. Physiological Measurement. 24 (2), pp. 449-466. https://doi.org/10.1088/0967-3334/24/2/356
Neuromagnetic field strength outside the human head due to impedance changes from neuronal depolarization
Ahadzi, G., Liston, A., Bayford, R. and Holder, D. 2004. Neuromagnetic field strength outside the human head due to impedance changes from neuronal depolarization. Physiological Measurement. 25 (1), pp. 365-378. https://doi.org/10.1088/0967-3334/25/1/040
The spatial resolution improvement of EIT images by GVSPM-FOCUSS algorithm
Dong, G., Liu, H., Bayford, R., Yerworth, R., Gao, S., Holder, D. and Yan, W. 2004. The spatial resolution improvement of EIT images by GVSPM-FOCUSS algorithm. Physiological Measurement. 25 (1), pp. 209-225. https://doi.org/10.1088/0967-3334/25/1/027
The effect of layers in imaging brain function using electrical impedance tomograghy
Liston, A., Bayford, R. and Holder, D. 2004. The effect of layers in imaging brain function using electrical impedance tomograghy. Physiological Measurement. 25 (1), pp. 143-158. https://doi.org/10.1088/0967-3334/25/1/022
Spatial resolution improvement of 3D EIT images by the shrinking sLORETA-FOCUSS algorithm
Dong, G., Liu, H., Bayford, R., Yerworth, R., Schimpf, P. and Yan, W. 2005. Spatial resolution improvement of 3D EIT images by the shrinking sLORETA-FOCUSS algorithm. Physiological Measurement. 26 (2), pp. S199-S208. https://doi.org/10.1088/0967-3334/26/2/019
Multi-frequency electrical impedance tomography (EIT) of the adult human head: initial findings in brain tumours, arteriovenous malformations and chronic stroke, development of an analysis method and calibration
Romsauerova, A., McEwan, A., Horesh, L., Yerworth, R., Bayford, R. and Holder, D. 2006. Multi-frequency electrical impedance tomography (EIT) of the adult human head: initial findings in brain tumours, arteriovenous malformations and chronic stroke, development of an analysis method and calibration. Physiological Measurement. 27 (5), pp. S147-S161. https://doi.org/10.1088/0967-3334/27/5/S13
Factors limiting the application of electrical impedance tomography for identification of regional conductivity changes using scalp electrodes during epileptic seizures in humans
Fabrizi, L., Sparkes, M., Horesh, L., Abascal, J., McEwan, A., Bayford, R., Elwes, R., Binnie, C. and Holder, D. 2006. Factors limiting the application of electrical impedance tomography for identification of regional conductivity changes using scalp electrodes during epileptic seizures in humans. Physiological Measurement. 27 (5), pp. S163-S174. https://doi.org/10.1088/0967-3334/27/5/S14
Design and calibration of a compact multi-frequency EIT system for acute stroke imaging
McEwan, A., Romsauerova, A., Yerworth, R., Horesh, L., Bayford, R. and Holder, D. 2006. Design and calibration of a compact multi-frequency EIT system for acute stroke imaging. Physiological Measurement. 27 (5), pp. S199-S210. https://doi.org/10.1088/0967-3334/27/5/S17
Validation of a finite-element solution for electrical impedance tomography in an anisotropic medium
Abascal, J., Arridge, S., Lionheart, W., Bayford, R. and Holder, D. 2007. Validation of a finite-element solution for electrical impedance tomography in an anisotropic medium. Physiological Measurement. 28 (7), pp. S129-S140. https://doi.org/10.1088/0967-3334/28/7/S10
Use of statistical parametric mapping (SPM) to enhance electrical impedance tomography (EIT) image sets.
Yerworth, R., Zhang, Y., Tidswell, A., Bayford, R. and Holder, D. 2007. Use of statistical parametric mapping (SPM) to enhance electrical impedance tomography (EIT) image sets. Physiological Measurement. 28 (7), pp. S141-S151. https://doi.org/10.1088/0967-3334/28/7/S11
The peri-electrode space is a significant element of the electrode-brain interface in deep brain stimulation: a computational study
Yousif, N., Bayford, R., Bain, P. and Liu, X. 2007. The peri-electrode space is a significant element of the electrode-brain interface in deep brain stimulation: a computational study. Brain Research Bulletin. 74 (5), pp. 361-368. https://doi.org/10.1016/j.brainresbull.2007.07.007
Quantifying the effects of the electrode-brain interface on the crossing electric currents in deep brain recording and stimulation
Yousif, N., Bayford, R., Wang, S. and Liu, X. 2008. Quantifying the effects of the electrode-brain interface on the crossing electric currents in deep brain recording and stimulation. Neuroscience. 152 (3), pp. 683-691. https://doi.org/10.1016/j.neuroscience.2008.01.023
13th International conference on electrical bioimpedance and 8th conference on electrical impedance tomography
Bayford, R. and Scharfetter, H. 2008. 13th International conference on electrical bioimpedance and 8th conference on electrical impedance tomography. Physiological Measurement. 29 (6), pp. E1-E2. https://doi.org/10.1088/0967-3334/29/6/E01
The influence of reactivity of the electrode-brain interface on the crossing electric current in therapeutic deep brain stimulation
Yousif, N., Bayford, R. and Liu, X. 2008. The influence of reactivity of the electrode-brain interface on the crossing electric current in therapeutic deep brain stimulation. Neuroscience. 156 (3), pp. 597-606. https://doi.org/10.1016/j.neuroscience.2008.07.051
Comparison of methods for optimal choice of the regularization parameter for linear electrical impedance tomography of brain function
Abascal, J., Arridge, S., Bayford, R. and Holder, D. 2008. Comparison of methods for optimal choice of the regularization parameter for linear electrical impedance tomography of brain function. Physiological Measurement. 29 (11), pp. 1319-1334. https://doi.org/10.1088/0967-3334/29/11/007
Can biological markers improve the management of breast cancer patients?
Leake, R., Anderson, L., Dowsett, M., Iles, R., Nicholson, R., Robertson, J., Walker, R. and UKCCR Biomarker group 2000. Can biological markers improve the management of breast cancer patients? British journal of cancer. 82 (10), pp. 1625-1626. https://doi.org/10.1054/bjoc.2000.1159
Biological markers: maintaining standards
Leake, R., Anderson, L., Dowsett, M., Iles, R., Nicholson, R., Robertson, J., Walker, R. and UKCCCR Biomarker group 2000. Biological markers: maintaining standards. British journal of cancer. 82 (10), pp. 1627-1628. https://doi.org/10.1054/bjoc.2000.1158
Determination of the glycoforms of human chorionic gonadotropin b-core fragment by matrix-assisted laser desoption/ionisation time of flight mass spectrometry
Jacoby, E., Kicman, A., Laidler, P. and Iles, R. 2000. Determination of the glycoforms of human chorionic gonadotropin b-core fragment by matrix-assisted laser desoption/ionisation time of flight mass spectrometry. Clinical Chemistry. 46 (11), pp. 1796-1803.
Regulation of endometrial cancer cell growth by luteinising hormone (LH) and follicle stimulating hormone (FSH)
Davies, S., Bax, C., Chatzaki, E., Chard, T. and Iles, R. 2000. Regulation of endometrial cancer cell growth by luteinising hormone (LH) and follicle stimulating hormone (FSH). British journal of cancer. 83 (12), pp. 1730-1734. https://doi.org/10.1054/bjoc.2000.1507
The increase in bladder carcinoma cell population induced by the free beta subunit of human chorionic gonadotrophin is a result of an anti-apoptotic effect and not cell proliferation
Butler, S., Ikram, M., Mathieu, S. and Iles, R. 2000. The increase in bladder carcinoma cell population induced by the free beta subunit of human chorionic gonadotrophin is a result of an anti-apoptotic effect and not cell proliferation. British journal of cancer. 82 (9), pp. 1553-1556. https://doi.org/10.1054/bjoc.2000.1177
The analysis of human amniotic fluid using capillary electrophoresis.
Stewart, C., Iles, R. and Perrett, D. 2001. The analysis of human amniotic fluid using capillary electrophoresis. Electrophoresis. 22 (6), pp. 1136-1142. https://doi.org/10.1002/1522-2683()22:6<1136::AID-ELPS1136>3.0.CO;2-A
High concentrations of CA 125 in uterine flushings: influence of cause of infertility and menstrual cycle day.
Hamilton, J., Iles, R., Gunn, L., Wilson, C., Lower, A. and Grudzinskas, J. 2002. High concentrations of CA 125 in uterine flushings: influence of cause of infertility and menstrual cycle day. Gynecological endocrinology..
Reduction of bladder cancer cell growth in response to hCGb CTP37 vaccinated mouse serum.
Butler, S., Staite, E. and Iles, R. 2003. Reduction of bladder cancer cell growth in response to hCGb CTP37 vaccinated mouse serum. Oncology research. 14 (2), pp. 93-100.
Identification of post-translational modifications resulting from LH beta polymorphisms by matrix-assisted laser desorption time-of-flight mass spectrometric analysis of pituitary LH beta core fragment
Jacoby, E., Kicman, A. and Iles, R. 2003. Identification of post-translational modifications resulting from LH beta polymorphisms by matrix-assisted laser desorption time-of-flight mass spectrometric analysis of pituitary LH beta core fragment. Journal of molecular endocrinology. 30 (2), pp. 239-252. https://doi.org/10.1677/jme.0.0300239
The recently identified homodimeric beta-beta subunit of human chorionic gonadotrophin (hCGbb) is no more biologically active than the free beta subunit (hCGb)
Butler, S. and Iles, R. 2004. The recently identified homodimeric beta-beta subunit of human chorionic gonadotrophin (hCGbb) is no more biologically active than the free beta subunit (hCGb). Tumor Biology. 25 (1-2), pp. 18-23. https://doi.org/10.1159/000077719
Serum amino-terminal propeptide of type 1 procollagen (P1NP) in prostate cancer: a potential predictor of bone metastases and prognosticator for disease progression and survival.
Thurairaja, R., Iles, R., Jefferson, K., McFarlane, J. and Persad, R. 2006. Serum amino-terminal propeptide of type 1 procollagen (P1NP) in prostate cancer: a potential predictor of bone metastases and prognosticator for disease progression and survival. Urologia internationalis. 76 (1), pp. 67-71.
Immunoassay detection of human chorionic gonadotrophin beta (hCGb) expression by prostate cancer is of no clinical significance
Otite, U., Baithun, S., Chinegwundon, F., Nargund, V. and Iles, R. 2006. Immunoassay detection of human chorionic gonadotrophin beta (hCGb) expression by prostate cancer is of no clinical significance. Tumor Biology. 27, pp. 181-186.
Gonadotropins and prostate cancer: revisited.
Thwaini, A., Naase, M., Chinegwundon, F., Baithun, S., Ghali, L., Shergill, I. and Iles, R. 2006. Gonadotropins and prostate cancer: revisited. Urologia internationalis. 77 (4), pp. 289-296. https://doi.org/10.1159/000096330
Ectopic hCGbeta expression by epithelial cancer: malignant behaviour, metastasis and inhibition of tumor cell apoptosis
Iles, R. 2007. Ectopic hCGbeta expression by epithelial cancer: malignant behaviour, metastasis and inhibition of tumor cell apoptosis. Molecular and Cellular Endocrinology. 260-26, pp. 264-270. https://doi.org/10.1016/j.mce.2006.02.019
An introduction to mass spectrometry based proteomics-detection and characterization of gonadotropins and related molecules
Kicman, A., Parkin, M. and Iles, R. 2007. An introduction to mass spectrometry based proteomics-detection and characterization of gonadotropins and related molecules. Molecular and Cellular Endocrinology. 260-26, pp. 212-227. https://doi.org/10.1016/j.mce.2006.02.022
Towards the development of an electrochemical biosensor for hCGβ detection
Kassanos, P., Iles, R., Bayford, R. and Demosthenous, A. 2008. Towards the development of an electrochemical biosensor for hCGβ detection. Physiological Measurement. 29 (6), pp. S241-S254. https://doi.org/10.1088/0967-3334/29/6/S21
The role of glycoprotein hormones in endometrial cancer. (in Part 7: Hormones & hormone receptor)
Bax, C., Davies, S., Chatzaki, E., Butler, S. and Iles, R. 2003. The role of glycoprotein hormones in endometrial cancer. (in Part 7: Hormones & hormone receptor). in: Nishida, M. and Kuramoto, H. (ed.) Cell and molecular biology of endometrial carcinoma. London Springer. pp. 195-206
Molecular cell biology and genetic disorders
Iles, R. 2009. Molecular cell biology and genetic disorders. in: Kumar, P. and Clark, M. (ed.) Kumar & Clark’s clinical medicine. Edinburgh Elsevier Saunders. pp. 19-52
Chapter 1: Basic sciences: the cell.
Iles, R. 2008. Chapter 1: Basic sciences: the cell. in: Nargund, V., Raghavan, D. and Sandler, H. (ed.) Urological oncology. London Springer. pp. 3-36
Task based visualization of 5D brain EIT data
Zhang, Y., Passmore, P. and Bayford, R. 2009. Task based visualization of 5D brain EIT data. SAC09: The 2009 ACM Symposium on Applied Computing. Honolulu Hawaii, USA 08 - 12 Mar 2009 New York Association for Computing Machinery (ACM). pp. 831-835 https://doi.org/10.1145/1529282.1529459
Constructed wetland control of BOD levels in airport runoff
Adeola, S., Revitt, D., Shutes, B., Garelick, H., Jones, H. and Jones, C. 2009. Constructed wetland control of BOD levels in airport runoff. International Journal of Phytoremediation. 11 (1), pp. 1-10. https://doi.org/10.1080/15226510802363220
Improving the finite element forward model of the human head by warping using elastic deformation
Tizzard, A. and Bayford, R. 2007. Improving the finite element forward model of the human head by warping using elastic deformation. Physiological Measurement. 28 (7), pp. 163-182. https://doi.org/10.1088/0967-3334/28/7/S13
Human chorionic gonadotropin isoforms in the diagnosis of ectopic pregnancy
Iles, R., Borrelli, P., Butler, S. and Staite, E. 2003. Human chorionic gonadotropin isoforms in the diagnosis of ectopic pregnancy. Clinical Chemistry. 49 (12), pp. 2045-2049. https://doi.org/10.1373/clinchem.2003.022095
A comparison of techniques to optimize measurement of voltage changes in electrical impedance tomography by minimizing phase shift errors
Bayford, R., Eadie, L., Fitzgerald, A. and Holder, D. 2002. A comparison of techniques to optimize measurement of voltage changes in electrical impedance tomography by minimizing phase shift errors. IEEE Transactions on Medical Imaging. 21 (6), pp. 668-675. https://doi.org/10.1109/TMI.2002.800577
Bioimpedance; tomography (electrical impedance tomography).
Bayford, R. 2006. Bioimpedance; tomography (electrical impedance tomography). Annual Review of Biomedical Engineering. 8 (1), pp. 63-91. https://doi.org/10.1146/annurev.bioeng.8.061505.095716
Using the GRID to improve the computation speed of electrical impedance tomography (EIT) reconstruction algorithms
Bayford, R., Fritschy, J., Holder, D. and Horesh, L. 2005. Using the GRID to improve the computation speed of electrical impedance tomography (EIT) reconstruction algorithms. Physiological Measurement.
The free monomeric beta subunit of human chorionic gonadotrophin (hCG beta) and the recently identified homodimeric beta-beta subunit (hCG beta beta) both have autocrine growth effects
Butler, S. and Iles, R. 2004. The free monomeric beta subunit of human chorionic gonadotrophin (hCG beta) and the recently identified homodimeric beta-beta subunit (hCG beta beta) both have autocrine growth effects. Tumor Biology. 25 (1-2), pp. 18-23. https://doi.org/10.1159/000077719
Enhanced affinity capture MALDI-TOF MS: orientation of an immunoglobulin G using recombinant protein G
Iles, R., Bansal, S., Jacoby, E., Neubert, H., Cowan, D. and Kicman, A. 2002. Enhanced affinity capture MALDI-TOF MS: orientation of an immunoglobulin G using recombinant protein G. Analytical Chemistry. 74 (15), pp. 3677-3683. https://doi.org/10.1021/ac025558z
Identification of placental transforming growth factor-beta and bikunin metabolites as contaminants of pharmaceutical human chorionic gonadotrophin preparations by proteomic techniques
Iles, R., Kicman, A., Malatos, S. and Neubert, H. 2005. Identification of placental transforming growth factor-beta and bikunin metabolites as contaminants of pharmaceutical human chorionic gonadotrophin preparations by proteomic techniques. Molecular and Cellular Proteomics. 4 (7), pp. 984-992. https://doi.org/10.1074/mcp.M500085-MCP200
Use of anisotropic modelling in electrical impedance tomography: description of method and preliminary assessment of utility in imaging brain function in the adult human head
Abascal, J., Arridge, S., Atkinson, D., Horesh, R., Fabrizi, L., De Lucia, M., Horesh, L., Bayford, R. and Holder, D. 2008. Use of anisotropic modelling in electrical impedance tomography: description of method and preliminary assessment of utility in imaging brain function in the adult human head. NeuroImage. 43 (2), pp. 258-268. https://doi.org/10.1016/j.neuroimage.2008.07.023
The use of a European telemedicine system to examine the effects of pollutants and allergens on asthmatic respiratory health
Crabbe, H., Barber, A., Bayford, R., Hamilton, R., Jarrett, D. and Machin, N. 2004. The use of a European telemedicine system to examine the effects of pollutants and allergens on asthmatic respiratory health. Science of the Total Environment. https://doi.org/10.1016/j.scitotenv.2004.04.045
Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection?
Iles, R. and Butler, S. 2003. Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection? Clinical Cancer Research. 9 (13), pp. 4666-4673.
Case Reports: Arsenic pollution in Thailand, Bangladesh and Hungary
Jones, H., Visoottiviseth, P., Bux, M., Földényi, R., Kováts, N., Borbély, G. and Galbács, Z. 2008. Case Reports: Arsenic pollution in Thailand, Bangladesh and Hungary. in: Garelick, H. and Jones, H. (ed.) Reviews of Environmental Contamination New York Springer.
Factors influencing subjective ranking of driver distractions
Patel, J., Ball, D. and Jones, H. 2008. Factors influencing subjective ranking of driver distractions. Accident Analysis & Prevention. 40 (1), pp. 392-395. https://doi.org/10.1016/j.aap.2007.07.006
Arsenic pollution sources
Garelick, H., Jones, H., Dybowska, A. and Valsami-Jones, E. 2008. Arsenic pollution sources. in: Garelick, H. and Jones, H. (ed.) Reviews of environmental contamination: international perspectives on arsenic pollution and remediation New York Springer.
Human granulosa-lutein cell in vitro production of progesterone, inhibin A, inhibin B, and activin A are dependent on follicular size and not the presence of the oocyte
Wen, S., Tozer, A., Li, D., Docherty, S., Al-Shawaf, T. and Iles, R. 2008. Human granulosa-lutein cell in vitro production of progesterone, inhibin A, inhibin B, and activin A are dependent on follicular size and not the presence of the oocyte. Fertility and Sterility. 89 (5), pp. 1406-1413. https://doi.org/10.1016/j.fertnstert.2007.03.086
An investigation of urban water and sediment ecotoxicity in relation to metal concentrations
Lundy, L., Mensah, R., Revitt, D. and Jones, H. 2007. An investigation of urban water and sediment ecotoxicity in relation to metal concentrations. Morrison, G. and Rauch, S. (ed.) 8th Highway and Urban Environment Symposium (8HUES). Nicosia, Cyprus 12 - 14 Jun 2006 Springer. pp. 359-370 https://doi.org/10.1007/978-1-4020-6010-6_32
Resistance to three antimicrobial agents of Campylobacter isolated from organically- and intensively-reared chickens purchased from retail outlets
Soonthornchaikul, N., Garelick, H., Jones, H., Jacobs, J., Ball, D. and Choudhury, M. 2006. Resistance to three antimicrobial agents of Campylobacter isolated from organically- and intensively-reared chickens purchased from retail outlets. International Journal of Antimicrobial Agents. 27 (2), pp. 125-130. https://doi.org/10.1016/j.ijantimicag.2005.09.020
EIT images with improved spatial resolution using a realistic head model
Dong, G., Bayford, R., Liu, H., Zhou, Y. and Yan, W. 2006. EIT images with improved spatial resolution using a realistic head model. 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. New York, NY, USA 31 Aug - 03 Sep 2006 IEEE. pp. 1134-1137 https://doi.org/10.1109/IEMBS.2006.259794
Follicular fluid levels of inhibin A, inhibin B, and activin A levels reflect changes in follicle size but are not independent markers of the oocyte's ability to fertilize
Wen, S., Tozer, A., Butler, S., Bell, C., Docherty, S. and Iles, R. 2006. Follicular fluid levels of inhibin A, inhibin B, and activin A levels reflect changes in follicle size but are not independent markers of the oocyte's ability to fertilize. Fertility and Sterility. 85 (6), pp. 1723-1729. https://doi.org/10.1016/j.fertnstert.2005.11.058
Dynamic modelling of electrical current distribution in the deep structure of the brain
Bayford, R., Tizzard, A. and Liu, X. 2005. Dynamic modelling of electrical current distribution in the deep structure of the brain. in: The 3rd IEE International Seminar on Medical Applications of Signal Processing 2005 (Ref. No. 2005-1119) London,UK The Institution of Engineering and Technology (IET).
Applications of GRID in clinical neurophysiology and electrical impedance tomography of brain function
Fritschy, J., Horesh, L., Holder, D. and Bayford, R. 2005. Applications of GRID in clinical neurophysiology and electrical impedance tomography of brain function. Solomonides, T., McClatchey, R., Breton, V., Legré, Y., and Nørager, S. (ed.) Healthgrid 2005: 3rd annual conference of the Healthgrid association. Oxford, UK 2005 IOS Press. pp. 138-145
Visualization and post-processing of 5D Brain Images
Zhang, Y., Passmore, P. and Bayford, R. 2005. Visualization and post-processing of 5D Brain Images. 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Shanghai, China 01 - 04 Sep 2005 IEEE. pp. 1083-1086 https://doi.org/10.1109/IEMBS.2005.1616607
The effects of 'coasting' on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome
Tozer, A., Iles, R., Iammarrone, E., Gillott, C., Al-Shawaf, T. and Grudzinskas, J. 2004. The effects of 'coasting' on follicular fluid concentrations of vascular endothelial growth factor in women at risk of developing ovarian hyperstimulation syndrome. Human Reproduction. 19 (3), pp. 522-528. https://doi.org/10.1093/humrep/deh096
Characteristics of populations of granulosa cells from individual follicles in women undergoing 'coasting' during controlled ovarian stimulation (COS) for IVF
Tozer, A., Iles, R., Iammarrone, E., Gillott, C., Wen, S., Al-Shawaf, T. and Grudzinskas, J. 2004. Characteristics of populations of granulosa cells from individual follicles in women undergoing 'coasting' during controlled ovarian stimulation (COS) for IVF. Human Reproduction. 19 (11), pp. 2561-2568. https://doi.org/10.1093/humrep/deh487
The performance of vegetative treatment systems for highway runoff during dry and wet weather conditions
Revitt, D., Forshaw, M., Jones, H. and Shutes, B. 2004. The performance of vegetative treatment systems for highway runoff during dry and wet weather conditions. Science of the Total Environment. 334-335. https://doi.org/10.1016/j.scitotenv.2004.04.046
Electrical impedance tomography of human brain function using reconstruction algorithms based on the finite element method
Tizzard, A., Bagshaw, A., Bayford, R. and Liston, A. 2003. Electrical impedance tomography of human brain function using reconstruction algorithms based on the finite element method. NeuroImage. 20 (2), pp. 752-764. https://doi.org/10.1016/S1053-8119(03)00301-X
Practical experiences of the use of vegetated ponds for the treatment of highway runoff
Revitt, D., Shutes, B., Jones, H., Forshaw, M. and Winter, B. 2003. Practical experiences of the use of vegetated ponds for the treatment of highway runoff. Pratt, C., Davies, J., Newman, A. and Perry, J. (ed.) 2nd National UK Conference on Sustainable Drainage. Coventry, UK 23 - 24 Jun 2003 School of Science and the Environment, Coventry University. pp. 19-29
Three-dimensional electrical impedance tomography of human brain activity
Tidswell, A., Gibson, A., Bayford, R. and Holder, D. 2001. Three-dimensional electrical impedance tomography of human brain activity. NeuroImage. 13 (2), pp. 283-294. https://doi.org/10.1006/nimg.2000.0698
Application of constrained optimisation techniques inelectrical impedance tomography
Bayford, R. 1994. Application of constrained optimisation techniques inelectrical impedance tomography. PhD thesis Middlesex University School of Science and Technology