Comparative gene expression profiling of ADAMs, MMPs, TIMPs,EMMPRIN, EGF-R and VEGFA in low grade meningioma

Article


Rooprai, H., Martin, A., King, A., Appadu, U., Jones, H., Selway, R., Gullan, R. and Pilkington, G. 2016. Comparative gene expression profiling of ADAMs, MMPs, TIMPs,EMMPRIN, EGF-R and VEGFA in low grade meningioma. International Journal of Oncology. 49 (6), pp. 2309-2318. https://doi.org/10.3892/ijo.2016.3739
TypeArticle
TitleComparative gene expression profiling of ADAMs, MMPs, TIMPs,EMMPRIN, EGF-R and VEGFA in low grade meningioma
AuthorsRooprai, H., Martin, A., King, A., Appadu, U., Jones, H., Selway, R., Gullan, R. and Pilkington, G.
Abstract

MMPs (matrix metalloproteinases), ADAMs (a disintegrin and metalloproteinase) and TIMPs (tissue inhibitors of metalloproteinases) are implicated in invasion and angiogenesis: both are tissue remodeling processes involving regulated proteolysis of the extracellular matrix, growth factors and their receptors. The expression of these three groups and their correlations with clinical behaviour has been reported in gliomas but a similar comprehensive study in meningiomas is lacking. In the present study, we aimed to evaluate the patterns of expression of 23 MMPs, 4 TIMPs, 8 ADAMs, selective growth factors and their receptors in 17 benign meningiomas using a quantitative real-time polymerase chain reaction (qPCR). Results indicated very high gene expression of 13 proteases, inhibitors and growth factors studied: MMP2 and MMP14, TIMP-1, -2 and -3, ADAM9, 10, 12, 15 and 17, EGF-R, EMMPRIN and VEGF-A, in almost every meningioma.
Expression pattern analysis showed several positive correlations between MMPs, ADAMs, TIMPs and growth factors. Furthermore, our findings suggest that expression of MMP14, ADAM9, 10, 12, 15 and 17, TIMP-2, EGF-R and EMMPRIN reflects histological subtype of meningioma such that fibroblastic subtype had the highest mRNA expression, transitional subtype was intermediate and meningothelial type had the lowest expression. In conclusion, this is the first comprehensive study characterizing gene expression of ADAMs in meningiomas. These neoplasms, although by histological definition benign, have invasive potential. Taken together, the selected elevated gene expression pattern may serve to identify targets for therapeutic intervention or indicators of biological progression and recurrence.

KeywordsADAMs; growth factors; matrix metalloproteases; gene expression; meningiomas
Research GroupBiomarkers for Cancer group
LanguageEnglish
PublisherSpandidos
JournalInternational Journal of Oncology
ISSN1019-6439
Electronic1791-2423
Publication dates
Online18 Oct 2016
Print01 Dec 2016
Publication process dates
Deposited04 May 2017
Accepted06 Jun 2016
Output statusPublished
Publisher's version
Digital Object Identifier (DOI)https://doi.org/10.3892/ijo.2016.3739
Web of Science identifierWOS:000389166000014
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