Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection?
Article
Iles, R. and Butler, S. 2003. Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection? Clinical Cancer Research. 9 (13), pp. 4666-4673.
Type | Article |
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Title | Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection? |
Authors | Iles, R. and Butler, S. |
Abstract | Since it was first claimed in 1995 that human chorionic gonadotropin (hCG) inhibits HIV-associated Kaposi’s sarcoma (KS), focus has been lost on establishing a credible hypothesis to explain a novel action ascribed to hCG, which is, after all, a pregnancy hormone. After 7 years, no real progress has been made, and there remains no consensus as to which component of hCG preparations is responsible for inducing apoptosis of HIV-associated KS. It would certainly seem apparent that many basic experiments on hCG species have been overlooked in the studies that have been published. Furthermore, the much wider literature concerning the association of hCG with promoting oncogenesis has been ignored. This review puts into context the numerous studies on hCG, HIV-associated KS, and oncogenesis. |
Publisher | American Association for Cancer Research (AACR) |
Journal | Clinical Cancer Research |
ISSN | 1078-0432 |
Publication dates | |
01 Oct 2003 | |
Publication process dates | |
Deposited | 29 Oct 2008 |
Output status | Published |
Additional information | With permission from Clinical Cancer Research/American Association for Cancer Research, 2008. |
Web address (URL) | http://clincancerres.aacrjournals.org/cgi/content/full/9/13/4666 |
Language | English |
https://repository.mdx.ac.uk/item/80w7v
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