Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers

Article

Akhtar, A., Wang, S., Ghali, L., Bell, C. and Wen, S. 2017. Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers. Journal of Biomedical Research. 31 (3), pp. 177-188. https://doi.org/10.7555/JBR.31.20160059
TypeArticle
TitleRecent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers
AuthorsAkhtar, A., Wang, S., Ghali, L., Bell, C. and Wen, S.
Abstract

Since arsenic trioxide (ATO) was first approved as the front line therapy for acute promyelocytic leukemia (APL) 25 years ago, its anti-cancer properties for various malignancies have been under intense investigation. However, the clinical successes of ATO in treating hematological cancers have not been translated to solid cancers. This is due to arsenic’s rapid clearance by the body’s immune system before reaching the tumor site. Several attempts have henceforth been made to increase its bioavailability toward solid cancers without increasing its dosage albeit without much success. This review summarizes the past and current utilization of ATO in the medical field with primary focus on the implementation of nanotechnology for ATO delivery to solid cancer cells. Different approaches that have been employed to increase arsenic’s efficacy, specificity and bioavailability to solid cancer cells were evaluated and compared. The potential of combining different approaches or tailoring delivery vehicles to target specific types of solid cancers according to individual cancer characteristics and arsenic chemistry was proposed and discussed.

Keywordsarsenic trioxide; solid cancer; nanotechnology; drug delivery; liposome
PublisherNanjing Medical University Press
JournalJournal of Biomedical Research
ISSN1674-8301
Electronic1876-4819
Publication dates
Online20 Sep 2016
Print31 May 2017
Publication process dates
Deposited31 Oct 2016
Accepted22 Aug 2016
Output statusPublished
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Copyright Statement

© 2017 by the Journal of Biomedical Research. All rights reserved
This is an open access article under the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited.

Digital Object Identifier (DOI)https://doi.org/10.7555/JBR.31.20160059
Web of Science identifierWOS:000406422400002
LanguageEnglish
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