Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers
Article
Akhtar, A., Wang, S., Ghali, L., Bell, C. and Wen, S. 2017. Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers. Journal of Biomedical Research. 31 (3), pp. 177-188. https://doi.org/10.7555/JBR.31.20160059
Type | Article |
---|---|
Title | Recent advances in arsenic trioxide encapsulated nanoparticles as drug delivery agents to solid cancers |
Authors | Akhtar, A., Wang, S., Ghali, L., Bell, C. and Wen, S. |
Abstract | Since arsenic trioxide (ATO) was first approved as the front line therapy for acute promyelocytic leukemia (APL) 25 years ago, its anti-cancer properties for various malignancies have been under intense investigation. However, the clinical successes of ATO in treating hematological cancers have not been translated to solid cancers. This is due to arsenic’s rapid clearance by the body’s immune system before reaching the tumor site. Several attempts have henceforth been made to increase its bioavailability toward solid cancers without increasing its dosage albeit without much success. This review summarizes the past and current utilization of ATO in the medical field with primary focus on the implementation of nanotechnology for ATO delivery to solid cancer cells. Different approaches that have been employed to increase arsenic’s efficacy, specificity and bioavailability to solid cancer cells were evaluated and compared. The potential of combining different approaches or tailoring delivery vehicles to target specific types of solid cancers according to individual cancer characteristics and arsenic chemistry was proposed and discussed. |
Keywords | arsenic trioxide; solid cancer; nanotechnology; drug delivery; liposome |
Publisher | Nanjing Medical University Press |
Journal | Journal of Biomedical Research |
ISSN | 1674-8301 |
Electronic | 1876-4819 |
Publication dates | |
Online | 20 Sep 2016 |
31 May 2017 | |
Publication process dates | |
Deposited | 31 Oct 2016 |
Accepted | 22 Aug 2016 |
Output status | Published |
Publisher's version | License |
Copyright Statement | © 2017 by the Journal of Biomedical Research. All rights reserved |
Digital Object Identifier (DOI) | https://doi.org/10.7555/JBR.31.20160059 |
Web of Science identifier | WOS:000406422400002 |
Language | English |
https://repository.mdx.ac.uk/item/86v06
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