Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours

Article

Green, J., Ikram, M., Vyas, J., Patel, N., Proby, C., Ghali, L., Leigh, I., O'Toole, E. and Storey, A. 2006. Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours. British journal of cancer. 94 (10), pp. 1446-1451.
TypeArticle
TitleOverexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours
AuthorsGreen, J., Ikram, M., Vyas, J., Patel, N., Proby, C., Ghali, L., Leigh, I., O'Toole, E. and Storey, A.
Abstract

The molecular mechanisms that underlie the development of squamous cell skin cancers (SSC) are poorly understood. We have used oligonucleotide microarrays to compare the differences in cellular gene expression between a series of keratinocyte cell that mimic disease progression with the aim of identifying genes that may potentially contribute towards squamous cell carcinoma (SCC) progression in vivo, and in particular to identify markers that may serve as potential therapeutic targets for SCC treatment. Gene expression differences were corroborated by polymerase chain reaction and Western blotting. We identified Axl, a receptor tyrosine kinase with transforming potential that has also been shown to have a role in cell survival, adhesion and chemotaxis, was upregulated in vitro in SCC-derived cells compared to premalignant cells. Extending the investigation to tumour biopsies showed that the Axl protein was overexpressed in vivo in a series of SCCs.

Research GroupBiomarkers for Cancer group
PublisherNature Publishing Group
JournalBritish journal of cancer
ISSN0007-0920
Publication dates
Print22 May 2006
Publication process dates
Deposited18 Jun 2009
Output statusPublished
Additional information

PubMed PMID: 16641895; PubMed Central PMCID: PMC2361292.

Web address (URL)http://www.nature.com/bjc/journal/v94/n10/pdf/6603135a.pdf
LanguageEnglish
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