The effectiveness of Intravascular Lithotripsy after sub-optimal non-compliant balloon inflation for treating calcified coronary lesions

Conference poster


Watson, E., Van Wyk, A. and Davies, J. 2022. The effectiveness of Intravascular Lithotripsy after sub-optimal non-compliant balloon inflation for treating calcified coronary lesions. 37th European Cardiology Conference. London 31 Oct - 01 Nov 2022
TypeConference poster
TitleThe effectiveness of Intravascular Lithotripsy after sub-optimal non-compliant balloon inflation for treating calcified coronary lesions
AuthorsWatson, E., Van Wyk, A. and Davies, J.
Abstract

Background
Coronary arterial calcification (CAC) is a significant manifestation associated with atherosclerosis that results in poor clinical and patient outcomes (Budoff et al., 2007; Raggi et al., 2008). Moreover, CAC hinders percutaneous coronary intervention (PCI) for vessel revascularisation, with stent under-expansion and malposition not uncommon (Mousa et al., 2005). Many lesion preparation techniques have been developed, including non-compliant (NC) balloon angioplasty, accompanying debated effectiveness and an increased risk of procedural complications (Barbato et al., 2017). Therefore, the need for a low-risk yet effective CAC modification technique has resulted in the development of Intravascular Lithotripsy (IVL), delivering pressure waves to fracture calcification, and creating greater vessel compliance for stent deployment.
Objectives
This study aimed to evaluate the implementation of IVL after suboptimal NC-balloon inflation for modifying calcified lesions as part of PCI, with vessel measurements as part of a detailed clinical assessment.
Methods
This was a retrospective study acquiring the data of patients (n=30) who underwent IVL therapy after suboptimal NC-balloon inflation as part of PCI. IVL performance was assessed by procedural success (vessel stenosis <50%, <30%, 20%), quantified using angiography, intravascular ultrasound (IVUS) and optical coherence tomography (OCT).
Results
Procedural success was observed in 93% of cases, with 80% ending with <30% stenosis and 47% with <20%. A significant difference was found between lumen diameter measurements after each stage of PCI (H(3)=86.64, p<0.001), with the largest difference observed between pre-procedure and post-stent-deployment. IVUS measurements revealed a significant difference between lumen diameter pre-procedure and post-stent deployment (t=-12.84, p<0.001). OCT measurements revealed a significant difference between lumen diameter and area measurements pre-and post-procedure [F(2,3)=10.70, p=0.043; F(2,3)=17.06, p=0.023].
Conclusion
IVL therapy is an effective lesion preparation technique superior to conventional balloon angioplasty facilitating successful stent deployment. Future research should assess IVL from larger samples employing more routine implementation of intravascular imaging mediating detailed procedural assessment.

Sustainable Development Goals3 Good health and well-being
Middlesex University ThemeHealth & Wellbeing
Conference37th European Cardiology Conference
Publication process dates
Deposited24 Oct 2022
Accepted10 Feb 2022
Output statusPublished
LanguageEnglish
Permalink -

https://repository.mdx.ac.uk/item/8q1z6

  • 66
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month

Export as

Related outputs

Recurrence of atrial fibrillation post catheter ablation or cardioversion using cardiac implantable electronic device data
Akthar, W., Van Wyk, A. and Wright, I. 2023. Recurrence of atrial fibrillation post catheter ablation or cardioversion using cardiac implantable electronic device data. SCST Annual Conference 2023. Birmingham, UK 24 - 24 Nov 2023
Parental perception of childhood obesity
Van Wyk, A. 2022. Parental perception of childhood obesity. 15th European Public Health Conference - Strengthening health systems: improving population health and being prepared for the unexpected. Berlin, Germany 09 - 12 Nov 2022 Oxford University Press (OUP). pp. iii585-iii586 https://doi.org/10.1093/eurpub/ckac131.432
Technology-enhanced learning and teaching in echocardiography: a systematic review
Susiku, E. and Van Wyk, A. 2021. Technology-enhanced learning and teaching in echocardiography: a systematic review. NET2021 Conference. Virtual 01 - 03 Sep 2021
Cold water immersion offers no functional or perceptual benefit compared to a sham intervention during a resistance training program
Wilson, L., Dimitriou, L., Hills, F., Gondek, M., Van Wyk, A., Turek, V., Rivkin, T., Villiere, A., Jarvis, P., Miller, S., Turner, A. and Cockburn, E. 2021. Cold water immersion offers no functional or perceptual benefit compared to a sham intervention during a resistance training program. The Journal of Strength and Conditioning Research. 35 (10), pp. 2720-2727. https://doi.org/10.1519/jsc.0000000000004097
Context-aware support for cardiac health monitoring using federated machine learning
Ogbuabor, G., Augusto, J., Moseley, R. and Van Wyk, A. 2021. Context-aware support for cardiac health monitoring using federated machine learning. Bramer, M. and Ellis, R. (ed.) 41st SGAI International Conference on Artificial Intelligence (AI-2021). Cambridge, England [Online] 14 - 16 Dec 2021 Springer. pp. 267-281 https://doi.org/10.1007/978-3-030-91100-3_22
A pilot study to determine whether repeated post-exercise cryotherapy exposure augments physiological and perceptual responses to cold
Wilson, L., Dimitriou, L., Hills, F., Gondek, M., Van Wyk, A., Turek, V., Rivkin, T., Villiere, A., Jarvis, P., Miller, S., Turner, A. and Cockburn, E. 2020. A pilot study to determine whether repeated post-exercise cryotherapy exposure augments physiological and perceptual responses to cold. 25th Annual Congress of the European College of Sport Science. Virtual (due to Covid-19), initial venue Sevilla, Andalucia, Spain 28 - 30 Oct 2020
Context-aware approach for cardiac rehabilitation monitoring
Ogbuabor, G., Augusto, J., Moseley, R. and Van Wyk, A. 2020. Context-aware approach for cardiac rehabilitation monitoring. Iglesias, C., Novella, J., Ricci, A., Pinto, D. and Roman, D. (ed.) 4th International Workshop on Citizen-Centric Smart Cities Services (CCSCS 2020). Madrid, Spain 22 - 23 Jun 2020 IOS Press. pp. 167-176 https://doi.org/10.3233/AISE200039
Does e-learning alongside a social media platform enhance or hinder learning in clinical physiology - NET2017 Conference
Van Wyk, A. 2017. Does e-learning alongside a social media platform enhance or hinder learning in clinical physiology - NET2017 Conference. NET2017 (Networking for Education in Healthcare). Churchill College, University of Cambridge 05 - 06 Sep 2017
Context-aware system for cardiac condition monitoring and management: a survey
Ogbuabor, G., Augusto, J., Moseley, R. and Van Wyk, A. 2020. Context-aware system for cardiac condition monitoring and management: a survey. Behaviour and Information Technology. 41 (4), pp. 759-776. https://doi.org/10.1080/0144929X.2020.1836255
ADAPT: Approach to Develop context-Aware solutions for Personalised asthma managemenT
Quinde, M., Augusto, J., Khan, N. and Van Wyk, A. 2020. ADAPT: Approach to Develop context-Aware solutions for Personalised asthma managemenT. Journal of Biomedical Informatics. 111, pp. 1-20. https://doi.org/10.1016/j.jbi.2020.103586
Context-aware solutions for asthma condition management: a survey
Quinde, M., Khan, N., Augusto, J., Van Wyk, A. and Stewart, J. 2020. Context-aware solutions for asthma condition management: a survey. Universal Access in the Information Society. 19 (3), pp. 571-593. https://doi.org/10.1007/s10209-018-0641-5
The effect of carbohydrate dose and timing on timed effort and time to exhaustion within a simulated cycle race in male professional cyclists
Girling, W., Pujdak, M., Dimitriou, L., Van Wyk, A., Vidal, M., Peterca, J., Curtis, C. and Paice, K. 2019. The effect of carbohydrate dose and timing on timed effort and time to exhaustion within a simulated cycle race in male professional cyclists. British Association of Sport Exercise Sciences: BASES Conference 2019. Leicester, UK 19 - 20 Nov 2019 Taylor & Francis (Routledge). pp. 25-26
A Human-in-The-Loop context-aware system allowing the application of case-based reasoning for asthma management
Quinde, M., Khan, N., Augusto, J. and Van Wyk, A. 2019. A Human-in-The-Loop context-aware system allowing the application of case-based reasoning for asthma management. Duffy, V. (ed.) 21st International Conference on Human-Computer Interaction (HCI International 2019). Orlando, USA 26 - 31 Jul 2019 Springer. pp. 125-140 https://doi.org/10.1007/978-3-030-22219-2_10