Derivative scores from site accessibility and ranking of miRNA target predictions

Article

Dayem Ullah, A., Sahoo, S., Steinhofel, K. and Albrecht, A. 2012. Derivative scores from site accessibility and ranking of miRNA target predictions. International Journal of Bioinformatics Research and Applications. 8 (3/4), pp. 171-191. https://doi.org/10.1504/IJBRA.2012.048966
TypeArticle
TitleDerivative scores from site accessibility and ranking of miRNA target predictions
AuthorsDayem Ullah, A., Sahoo, S., Steinhofel, K. and Albrecht, A.
Abstract

In the present study, we define derivative scoring functions from PITA and STarMir predictions. The scoring functions are evaluated for up to five selected miRNAs with a relatively large number of validated targets reported by TarBase and miRecords. The average ranking of validated targets returned by PITA and STarMir is compared to the average ranking produced by the new derivatives scores. We obtain an average improvement of 13.6% (STD∼5.7%) relative to the average ranking of validated targets produced by PITA and STarMir.

KeywordsmicroRNA; RNA secondary structure; target prediction; multi-objective optimisation; Pareto front; site accessibility; ranking predictions; bioinformatics; binding regions; duplex conformations
PublisherInderscience
JournalInternational Journal of Bioinformatics Research and Applications
ISSN1744-5485
Publication dates
Print2012
Publication process dates
Deposited11 Nov 2013
Output statusPublished
Digital Object Identifier (DOI)https://doi.org/10.1504/IJBRA.2012.048966
LanguageEnglish
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