Long non-coding RNA structure and function: Is there a link?

Article

Zampetaki, A., Albrecht, A. and Steinhofel, K. 2018. Long non-coding RNA structure and function: Is there a link? Frontiers in Physiology. 9. https://doi.org/10.3389/fphys.2018.01201
TypeArticle
TitleLong non-coding RNA structure and function: Is there a link?
AuthorsZampetaki, A., Albrecht, A. and Steinhofel, K.
Abstract

RNA has emerged as the prime target for diagnostics, therapeutics and the development of personalized medicine. In particular, the non-coding RNAs (ncRNAs) that do not encode proteins, display remarkable biochemical versatility. They can fold into complex structures and interact with proteins, DNA and other RNAs, modulating the activity, DNA targets or partners of multiprotein complexes. Thus, ncRNAs confer regulatory plasticity and represent a new layer of epigenetic control that is dysregulated
in disease. Intriguingly, for long non-coding RNAs (lncRNAs, >200 nucleotides length) structural conservation rather than nucleotide sequence conservation seems to be crucial for maintaining their function. LncRNAs tend to acquire complex secondary and
tertiary structures and their functions only impose very subtle sequence constraints. In the present review we will discuss the biochemical assays that can be employed to determine the lncRNA structural configurations. The implications and challenges of
linking function and lncRNA structure to design novel RNA therapeutic approaches will also be analyzed.

PublisherFrontiers Media S.A.
JournalFrontiers in Physiology
ISSN
Electronic1664-042X
Publication dates
Online20 Aug 2018
Print24 Aug 2018
Publication process dates
Deposited29 Aug 2018
Completed30 May 2018
Submitted05 Jun 2018
Accepted10 Aug 2018
Output statusPublished
Publisher's version
License
File Access Level
Open
Additional information

Corrigendum [03 September 2019] see related output

Digital Object Identifier (DOI)https://doi.org/10.3389/fphys.2018.01201
Related Output
RequiresCorrigendum: Long non-coding RNA structure and function: Is there a link?
Requireshttps://doi.org/10.3389/fphys.2019.01127
LanguageEnglish
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Corrigendum: Long non-coding RNA structure and function: Is there a link?
Zampetaki, A., Albrecht, A. and Steinhofel, K. 2019. Corrigendum: Long non-coding RNA structure and function: Is there a link? Frontiers Media S.A.. https://doi.org/10.3389/fphys.2019.01127
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